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The map label for this gene is drrB [H]

Identifier: 108801223

GI number: 108801223

Start: 4524411

End: 4525259

Strand: Reverse

Name: drrB [H]

Synonym: Mmcs_4259

Alternate gene names: 108801223

Gene position: 4525259-4524411 (Counterclockwise)

Preceding gene: 108801224

Following gene: 108801220

Centisome position: 79.31

GC content: 67.49

Gene sequence:

>849_bases
ATGACCGCCGTCGAATCACGGCAGTCCGACCAGGCCCGCCGGCCGCTCACACACCGCACCAACCTGGTGCAGCAGTCGTG
GATCATGGTCAAGCGCAACATGATCCACACCAAGCGGATGCCGGAGATGCTCAGCGACGTGACTGCGCAGCCGATCATGT
TCGTGCTGCTGTTCGCGTTCGTGTTCGGGGCGTCGATCACCAATACCGGCGGCGCGTCCTACCGGGAGTTCCTGCTGCCC
GGCATCCAGGCGCAGACCATCGTGTTCTCGGCGTTCGTGGTGGCCTCCGGCATCACCGCCGACGTCGAGAAGGGCATCAT
CGACCGGTTCCGGTCGCTGCCGATCTCGCGGTCCTCGGTGCTCATCGGACGCAGCATCGCCAGCGTGATCCACTCGTCGC
TCGGGGTGTTCGTGATGGCGCTGACCGGTCTGGCGATCGGGTGGCGGATCCGGGGCAGCGTGGGCGAGGCGGTGCTGGCG
TTCGCGCTGCTGCTGCTGTTCGGGTTCGGGATGATCTGGTTCGGCATCCTCATCGGCTCGCTGATGCGCACCGTCGAGGC
GGTCAACGGCGTCATGTTCACCGCACTGTTCCCGATGACGTTCCTGGCCAACACCTTCGTGCCGACCGAGCCGATGCCGC
ACTGGCTCCGGGTGATCGCCGAGTGGAATCCGGTCTCCTCGCTGGCGCAGGCGATGCGGGAACTATGGGGCAACGGCGGC
CCGGCGGCACCGGATGCGCAGTTGCCGCTGCACCACCCGGTGCTGGCGACGGTGCTGTGGTCCCTGGTGCTGACGGCGGT
GTTCGCCCCGTTCGCCCTGCGCGCTTACGCGAGGCGCACGGGGGGGTAG

Upstream 100 bases:

>100_bases
GTGACATCGAGGTCGACGACATCGGACTGTCGCGGCCCAGCCTCGACGACGTGTTCCTGTCGCTGACCGGCCATCGCACC
GAGGACGAGGAGGCCACCGC

Downstream 100 bases:

>100_bases
CCGCGCGCGCCAACCGCTGCTTCCAGTTCGGCCAGTGACCGCTCGGTACGTTCTGTCACCGTGGCGATGTCGGGCATCAC
CTCGGCCCCGGCCACCCAGC

Product: ABC-2 type transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MTAVESRQSDQARRPLTHRTNLVQQSWIMVKRNMIHTKRMPEMLSDVTAQPIMFVLLFAFVFGASITNTGGASYREFLLP
GIQAQTIVFSAFVVASGITADVEKGIIDRFRSLPISRSSVLIGRSIASVIHSSLGVFVMALTGLAIGWRIRGSVGEAVLA
FALLLLFGFGMIWFGILIGSLMRTVEAVNGVMFTALFPMTFLANTFVPTEPMPHWLRVIAEWNPVSSLAQAMRELWGNGG
PAAPDAQLPLHHPVLATVLWSLVLTAVFAPFALRAYARRTGG

Sequences:

>Translated_282_residues
MTAVESRQSDQARRPLTHRTNLVQQSWIMVKRNMIHTKRMPEMLSDVTAQPIMFVLLFAFVFGASITNTGGASYREFLLP
GIQAQTIVFSAFVVASGITADVEKGIIDRFRSLPISRSSVLIGRSIASVIHSSLGVFVMALTGLAIGWRIRGSVGEAVLA
FALLLLFGFGMIWFGILIGSLMRTVEAVNGVMFTALFPMTFLANTFVPTEPMPHWLRVIAEWNPVSSLAQAMRELWGNGG
PAAPDAQLPLHHPVLATVLWSLVLTAVFAPFALRAYARRTGG
>Mature_281_residues
TAVESRQSDQARRPLTHRTNLVQQSWIMVKRNMIHTKRMPEMLSDVTAQPIMFVLLFAFVFGASITNTGGASYREFLLPG
IQAQTIVFSAFVVASGITADVEKGIIDRFRSLPISRSSVLIGRSIASVIHSSLGVFVMALTGLAIGWRIRGSVGEAVLAF
ALLLLFGFGMIWFGILIGSLMRTVEAVNGVMFTALFPMTFLANTFVPTEPMPHWLRVIAEWNPVSSLAQAMRELWGNGGP
AAPDAQLPLHHPVLATVLWSLVLTAVFAPFALRAYARRTGG

Specific function: Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 30814; Mature: 30683

Theoretical pI: Translated: 11.66; Mature: 11.66

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVESRQSDQARRPLTHRTNLVQQSWIMVKRNMIHTKRMPEMLSDVTAQPIMFVLLFAF
CCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFGASITNTGGASYREFLLPGIQAQTIVFSAFVVASGITADVEKGIIDRFRSLPISRSSV
HHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHH
LIGRSIASVIHSSLGVFVMALTGLAIGWRIRGSVGEAVLAFALLLLFGFGMIWFGILIGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMRTVEAVNGVMFTALFPMTFLANTFVPTEPMPHWLRVIAEWNPVSSLAQAMRELWGNGG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCC
PAAPDAQLPLHHPVLATVLWSLVLTAVFAPFALRAYARRTGG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TAVESRQSDQARRPLTHRTNLVQQSWIMVKRNMIHTKRMPEMLSDVTAQPIMFVLLFAF
CCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFGASITNTGGASYREFLLPGIQAQTIVFSAFVVASGITADVEKGIIDRFRSLPISRSSV
HHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHH
LIGRSIASVIHSSLGVFVMALTGLAIGWRIRGSVGEAVLAFALLLLFGFGMIWFGILIGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMRTVEAVNGVMFTALFPMTFLANTFVPTEPMPHWLRVIAEWNPVSSLAQAMRELWGNGG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCC
PAAPDAQLPLHHPVLATVLWSLVLTAVFAPFALRAYARRTGG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]