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The map label for this gene is fadR [H]

Identifier: 108801186

GI number: 108801186

Start: 4480911

End: 4481576

Strand: Reverse

Name: fadR [H]

Synonym: Mmcs_4222

Alternate gene names: 108801186

Gene position: 4481576-4480911 (Counterclockwise)

Preceding gene: 108801189

Following gene: 108801185

Centisome position: 78.55

GC content: 64.41

Gene sequence:

>666_bases
ATGGGTGTCAATCGTGAGCGTCGCGGACGCGGAGATGAGGTCGAGGTGAGCGCGAGCGCCGAACTGGAGTCGGATGTCAA
AGGTCGGATACTCGATGCCGCGGCCGAGGCCTTCATGGCGCGCGGGTTCGCGAACACCACCATCGACGACATCGCCGATG
AGGTGGGTGCCACCAAGGGGCTGATCTACTACCACTTCCGGTCGAAGTTCGACATCTTCCTCGCGGTCTATCAGGACGGG
ATGCGCCGGGTGCGCGAACGCGTCGAACCGCATTCGACCGCACCGGGTACCGGCTTCGAGCGGCTGCACGCGATGTCCGT
CGCGCACCTGGAGAACCTCATGACCGAGTTGGGTTACCACCACGTGGTGCATCAGGGTGTGCGCCATCAGGATTCGACGG
CGTTGAAGGTGCGGCAGCGGGACGCACTGACCGCGCTGAACGAGCTACGACGTGACTACGAGCGGATGTTCCGCCGAGTC
ATCGCCGAGGGGATCGCCGACGGGTCACTGCGAAAAGTGGACGAAGCGCTCGCGACCCGGACCCTGCTCAGTAACCTCAA
CGCCGTCGATGTCTGGTATCGCAGGATCGACGGTCAGACCGACGAGGAGATTCGCGCGCTGGCCGGCGATGTGGTCGACC
TGCTGATCGGGGGACTCGGCGCCTGA

Upstream 100 bases:

>100_bases
CGTCACGGTCGCGCGTGGGAGAGCTGATTTGCCGTGTACCGAGTGGCGTGAAACGCCCTCACCAGGGATACTACTGAGTA
TTATCGTAACGAGGGTCACA

Downstream 100 bases:

>100_bases
GGGTCGGTCGAACAGCGTCCCGATGAAGAGGGGTGGGCATGGCGTTGGCGCTCAAGCCGATTGGCGAATGAGCACGAATC
GCACGCAGGCGCCCGCCCGA

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MGVNRERRGRGDEVEVSASAELESDVKGRILDAAAEAFMARGFANTTIDDIADEVGATKGLIYYHFRSKFDIFLAVYQDG
MRRVRERVEPHSTAPGTGFERLHAMSVAHLENLMTELGYHHVVHQGVRHQDSTALKVRQRDALTALNELRRDYERMFRRV
IAEGIADGSLRKVDEALATRTLLSNLNAVDVWYRRIDGQTDEEIRALAGDVVDLLIGGLGA

Sequences:

>Translated_221_residues
MGVNRERRGRGDEVEVSASAELESDVKGRILDAAAEAFMARGFANTTIDDIADEVGATKGLIYYHFRSKFDIFLAVYQDG
MRRVRERVEPHSTAPGTGFERLHAMSVAHLENLMTELGYHHVVHQGVRHQDSTALKVRQRDALTALNELRRDYERMFRRV
IAEGIADGSLRKVDEALATRTLLSNLNAVDVWYRRIDGQTDEEIRALAGDVVDLLIGGLGA
>Mature_220_residues
GVNRERRGRGDEVEVSASAELESDVKGRILDAAAEAFMARGFANTTIDDIADEVGATKGLIYYHFRSKFDIFLAVYQDGM
RRVRERVEPHSTAPGTGFERLHAMSVAHLENLMTELGYHHVVHQGVRHQDSTALKVRQRDALTALNELRRDYERMFRRVI
AEGIADGSLRKVDEALATRTLLSNLNAVDVWYRRIDGQTDEEIRALAGDVVDLLIGGLGA

Specific function: Transcriptional regulator in fatty acid degradation. Represses transcription of genes required for fatty acid transport and beta-oxidation, including acdA, fadA, fadB, fadE, fadF, fadG, fadH, fadM, fadN, lcfA and lcfB. Binding of FadR to DNA is specifical

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR001647
- InterPro:   IPR013570 [H]

Pfam domain/function: PF08359 TetR_C_4; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24707; Mature: 24576

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVNRERRGRGDEVEVSASAELESDVKGRILDAAAEAFMARGFANTTIDDIADEVGATKG
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
LIYYHFRSKFDIFLAVYQDGMRRVRERVEPHSTAPGTGFERLHAMSVAHLENLMTELGYH
EEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
HVVHQGVRHQDSTALKVRQRDALTALNELRRDYERMFRRVIAEGIADGSLRKVDEALATR
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
TLLSNLNAVDVWYRRIDGQTDEEIRALAGDVVDLLIGGLGA
HHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GVNRERRGRGDEVEVSASAELESDVKGRILDAAAEAFMARGFANTTIDDIADEVGATKG
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
LIYYHFRSKFDIFLAVYQDGMRRVRERVEPHSTAPGTGFERLHAMSVAHLENLMTELGYH
EEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
HVVHQGVRHQDSTALKVRQRDALTALNELRRDYERMFRRVIAEGIADGSLRKVDEALATR
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
TLLSNLNAVDVWYRRIDGQTDEEIRALAGDVVDLLIGGLGA
HHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]