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The map label for this gene is dctA [H]

Identifier: 108801140

GI number: 108801140

Start: 4439275

End: 4440651

Strand: Reverse

Name: dctA [H]

Synonym: Mmcs_4176

Alternate gene names: 108801140

Gene position: 4440651-4439275 (Counterclockwise)

Preceding gene: 108801143

Following gene: 108801137

Centisome position: 77.83

GC content: 67.68

Gene sequence:

>1377_bases
ATGAGCGTCACCCTCGACCCACCGCCCGAGGCACCCGCCGCCAAGCGGCGCGACCGCACCCACTGGCTCTACATCGCCGT
CATCGTGGCCGTGGTGGCCGGTGTGGCGGTCGGAATACTGGCGCCCGAGGTGGGCAAGAGCGTCGGCGTGCTCGGCAGCA
TGTTCGTCGACCTGATCAAGATGATGATCGCACCGGTCATCTTCTGCACGATCGTGCTGGGCATCGGCTCGGTCGCCAAG
GCCGCCACCGTCGGCAAGGTCGGTGGTCTGGCGTTCGTGTACTTCCTGGTGATGTCCACCTTCGCGCTGGCGATCGGCCT
GGTGGTCGGCAACATCCTGCACCCCGGCACCGGGATGAACCTGTCGGAGAGCACGGCGGGCAAGGGCGCCGAACTGGCCG
AGAAGGCCCACGAGTCCGGCGGACTGCTGGACTTCGTACAGGGCATCATCCCCGACACCCTGGTCTCGGCGCTGACCGCG
GGCAGTGTGCTGCAGGCGCTGTTCGTCGCGCTGCTGGTCGGTTTCGCGCTGCAGGCGATGGGACGCTCCGGTGAGCCGAT
CCTGCGCGGCGTCGAGCACCTGCAGAAGCTGGTCTTCAAGATCCTGGTGATGATCCTGTGGCTGGCGCCCATCGGGGCGT
TCGGCGCGATCGCCAACGTCGTCGGCCAAACCGGTTGGGCCGCAGTCACACAACTGCTCACACTGATGCTCGGCTTCTAC
CTCACCTGCGCGGTGTTCGTCTTCGGGGTGCTCGGCGCCCTGATGCGGGCGGTGGCAGGCGTCTCGATCTTCAAGCTCGT
CCGCTACCTGGCCCGCGAATACCTGCTGATCGTGTCGACCTCGTCCTCGGAGTCGGCGCTGCCGCGGCTGATCGCGAAGA
TGGAACACCTCGGGGTCGAGCGGAGCACCGTCGGCGTCGTCGTGCCGACCGGCTACTCGTTCAACCTCGACGGCACCGCG
ATCTACCTGACGATGGCATCGCTGTTCATCGCAGGCGCGCTGGGTGATCCGCTGTCGCTGCCCGAGCAGATCGGTCTGCT
GGTGTTCATGATCGTCGCCTCCAAGGGCGCTGCCGGGGTGACCGGTGCGGGGCTCGCCACGCTCGCCGCCGGTCTGCAGA
GCCACCGTCCCGACCTGCTCGACGGCGTCGGCCTGATTGTCGGGATCGATCGGTTCATGTCGGAAGCCCGTGCGGTGACG
AACTTCTCGGGCAACGCGGTGGCCACCATCCTGGTCGGGTCGTGGACCAAGACCCTCGACCGCGACCGGGTGGATGCGGT
GCTGCGCGGAGACGATCCGTTCGACGAGCTCACCATGGTCGACGACCATGCCGCCGACACCCGGCGTGCCGAGGAGCGCG
TGCCCGCACCGGCGTAG

Upstream 100 bases:

>100_bases
ACCGGCACCTCCGTTGAACGAAATGAACTAAAACGTGACCTGGCTCACGTCCTGGCCGAACCTACTTGCAGACCGCACCC
GATGTCGACCTGGAGGATCC

Downstream 100 bases:

>100_bases
GGCACGACCGGAACGACCCGACCGGTGTCCCGTCCCGGTCGGGTCTTCCGGCGCGTATCAGGCCGTGCAGTTCAGCGTGA
CCGAGACCGACCGGCCGACG

Product: sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSVTLDPPPEAPAAKRRDRTHWLYIAVIVAVVAGVAVGILAPEVGKSVGVLGSMFVDLIKMMIAPVIFCTIVLGIGSVAK
AATVGKVGGLAFVYFLVMSTFALAIGLVVGNILHPGTGMNLSESTAGKGAELAEKAHESGGLLDFVQGIIPDTLVSALTA
GSVLQALFVALLVGFALQAMGRSGEPILRGVEHLQKLVFKILVMILWLAPIGAFGAIANVVGQTGWAAVTQLLTLMLGFY
LTCAVFVFGVLGALMRAVAGVSIFKLVRYLAREYLLIVSTSSSESALPRLIAKMEHLGVERSTVGVVVPTGYSFNLDGTA
IYLTMASLFIAGALGDPLSLPEQIGLLVFMIVASKGAAGVTGAGLATLAAGLQSHRPDLLDGVGLIVGIDRFMSEARAVT
NFSGNAVATILVGSWTKTLDRDRVDAVLRGDDPFDELTMVDDHAADTRRAEERVPAPA

Sequences:

>Translated_458_residues
MSVTLDPPPEAPAAKRRDRTHWLYIAVIVAVVAGVAVGILAPEVGKSVGVLGSMFVDLIKMMIAPVIFCTIVLGIGSVAK
AATVGKVGGLAFVYFLVMSTFALAIGLVVGNILHPGTGMNLSESTAGKGAELAEKAHESGGLLDFVQGIIPDTLVSALTA
GSVLQALFVALLVGFALQAMGRSGEPILRGVEHLQKLVFKILVMILWLAPIGAFGAIANVVGQTGWAAVTQLLTLMLGFY
LTCAVFVFGVLGALMRAVAGVSIFKLVRYLAREYLLIVSTSSSESALPRLIAKMEHLGVERSTVGVVVPTGYSFNLDGTA
IYLTMASLFIAGALGDPLSLPEQIGLLVFMIVASKGAAGVTGAGLATLAAGLQSHRPDLLDGVGLIVGIDRFMSEARAVT
NFSGNAVATILVGSWTKTLDRDRVDAVLRGDDPFDELTMVDDHAADTRRAEERVPAPA
>Mature_457_residues
SVTLDPPPEAPAAKRRDRTHWLYIAVIVAVVAGVAVGILAPEVGKSVGVLGSMFVDLIKMMIAPVIFCTIVLGIGSVAKA
ATVGKVGGLAFVYFLVMSTFALAIGLVVGNILHPGTGMNLSESTAGKGAELAEKAHESGGLLDFVQGIIPDTLVSALTAG
SVLQALFVALLVGFALQAMGRSGEPILRGVEHLQKLVFKILVMILWLAPIGAFGAIANVVGQTGWAAVTQLLTLMLGFYL
TCAVFVFGVLGALMRAVAGVSIFKLVRYLAREYLLIVSTSSSESALPRLIAKMEHLGVERSTVGVVVPTGYSFNLDGTAI
YLTMASLFIAGALGDPLSLPEQIGLLVFMIVASKGAAGVTGAGLATLAAGLQSHRPDLLDGVGLIVGIDRFMSEARAVTN
FSGNAVATILVGSWTKTLDRDRVDAVLRGDDPFDELTMVDDHAADTRRAEERVPAPA

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI66773030, Length=511, Percent_Identity=23.4833659491194, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI169790839, Length=480, Percent_Identity=23.9583333333333, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI5032093, Length=415, Percent_Identity=26.2650602409639, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI21314632, Length=402, Percent_Identity=25.1243781094527, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI194239697, Length=269, Percent_Identity=28.996282527881, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI223468566, Length=289, Percent_Identity=26.643598615917, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI223468564, Length=289, Percent_Identity=26.643598615917, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI4827012, Length=288, Percent_Identity=26.7361111111111, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI40254478, Length=297, Percent_Identity=24.2424242424242, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI262359914, Length=355, Percent_Identity=23.3802816901408, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1789947, Length=415, Percent_Identity=48.1927710843374, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI1790514, Length=383, Percent_Identity=34.7258485639687, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1789473, Length=329, Percent_Identity=27.0516717325228, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788024, Length=402, Percent_Identity=24.3781094527363, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17537407, Length=487, Percent_Identity=23.8193018480493, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71983099, Length=512, Percent_Identity=24.21875, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71983106, Length=497, Percent_Identity=24.3460764587525, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71996953, Length=416, Percent_Identity=24.2788461538462, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI193206654, Length=482, Percent_Identity=23.4439834024896, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24583025, Length=417, Percent_Identity=26.1390887290168, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17137668, Length=417, Percent_Identity=26.1390887290168, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24583023, Length=417, Percent_Identity=26.1390887290168, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281360481, Length=474, Percent_Identity=24.6835443037975, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281360483, Length=474, Percent_Identity=24.6835443037975, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17137666, Length=474, Percent_Identity=24.6835443037975, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 47693; Mature: 47562

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
SVTLDPPPEAPAAKRRDRTHWLYIAVIVAVVAGVAVGILAPEVGKSVGVLGSMFVDLIK
CCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MMIAPVIFCTIVLGIGSVAKAATVGKVGGLAFVYFLVMSTFALAIGLVVGNILHPGTGMN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LSESTAGKGAELAEKAHESGGLLDFVQGIIPDTLVSALTAGSVLQALFVALLVGFALQAM
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRSGEPILRGVEHLQKLVFKILVMILWLAPIGAFGAIANVVGQTGWAAVTQLLTLMLGFY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LTCAVFVFGVLGALMRAVAGVSIFKLVRYLAREYLLIVSTSSSESALPRLIAKMEHLGVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCC
RSTVGVVVPTGYSFNLDGTAIYLTMASLFIAGALGDPLSLPEQIGLLVFMIVASKGAAGV
CCCCEEEEECCEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCC
TGAGLATLAAGLQSHRPDLLDGVGLIVGIDRFMSEARAVTNFSGNAVATILVGSWTKTLD
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHH
RDRVDAVLRGDDPFDELTMVDDHAADTRRAEERVPAPA
HHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA