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The map label for this gene is ispH [H]

Identifier: 108801069

GI number: 108801069

Start: 4372956

End: 4373957

Strand: Reverse

Name: ispH [H]

Synonym: Mmcs_4105

Alternate gene names: 108801069

Gene position: 4373957-4372956 (Counterclockwise)

Preceding gene: 108801074

Following gene: 108801068

Centisome position: 76.66

GC content: 68.66

Gene sequence:

>1002_bases
ATGCCGCCGACGATCAACATGGGGATTCCGGGTGCGTCCAGCTCGGTGACGGGCGGTGTCTCCGGTAAGCGAGTTCTGCT
GGCCGAGCCGCGCGGATACTGCGCAGGGGTGGACCGCGCCGTGGAGACCGTCGAGCGTGCGCTCGAGAAGCACGGCGCTC
CGGTGTACGTGCGCCACGAGATCGTGCACAACCGCTACGTCGTGGACACGCTCGCCAAGGCCGGCGCCGTGTTCGTGGAA
CAGACCGACGAGGTGCCCGAGGGCGCCATCGTCGTGTTTTCCGCCCACGGCGTGGCGCCGACCGTGCACGTCGAGGCGGC
CGCGCGCAACCTGAAGACCATCGACGCCACCTGCCCGCTGGTGACGAAGGTGCACAACGAGGCCAAACGCTTCGCCCGCG
ACGACTACGACATCCTGCTCGTCGGCCACGAAGGCCACGAGGAGGTCGTCGGCACCGCCGGTGAGGCGCCCGACCACGTT
CAGGTCGTCGACAACCCCGACGCGGTCGACAAGGTCACCGTGCGCGACCCCGACAAGGTCATCTGGCTGTCCCAGACCAC
CCTGAGCGTCGACGAGACCATGGAGACGGTGCGCCGGCTGCGGGAGAAGTTCCCGACGTTGCAGGACCCGCCCAGCGACG
ACATCTGCTACGCCACCCAGAACCGCCAGGTCGCGGTCAAGGCGATGGCGCCGGAGTGCGAACTCGTCATCGTCGTCGGC
TCGAAGAACTCGTCGAACTCGGTGCGGCTGGTCGAGGTGGCCCTCGGCGCCGGATCCGACGCGGCACATCTGGTCGACTA
CGCCGAGGACATCGATCCGACCTGGCTCAACGGTGTCACCACGGTCGGCGTGACCTCGGGCGCGTCGGTGCCGGAGGTCC
TGGTGCGCGGTGTGCTCGACCGGCTCGCCGAATACGGGTACGGAACCGTGCAGCCGGTGACGACCGCCAACGAGACACTG
GTGTTCGCGCTGCCCAGGGAGATCCGGCCCGCTCGCAGCTGA

Upstream 100 bases:

>100_bases
ACGGCGGCGCCGACCAGCAGACGAACCCCATAGGGTGCGGTAGCCATGCCGACAGCCTACGGCTGGGCGGACGGTGGCAT
CGGTCAGTACCCTTGGAGTC

Downstream 100 bases:

>100_bases
GTCGCTTCCCTACGCTGGGGGCGTGTTCTTCTTCCTGTTCGGCCTGTCCACCAAGCAGCAGTACCTCGGCGCCGGGCAGA
CCCGCACCTGTCCGCGCTGT

Product: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MPPTINMGIPGASSSVTGGVSGKRVLLAEPRGYCAGVDRAVETVERALEKHGAPVYVRHEIVHNRYVVDTLAKAGAVFVE
QTDEVPEGAIVVFSAHGVAPTVHVEAAARNLKTIDATCPLVTKVHNEAKRFARDDYDILLVGHEGHEEVVGTAGEAPDHV
QVVDNPDAVDKVTVRDPDKVIWLSQTTLSVDETMETVRRLREKFPTLQDPPSDDICYATQNRQVAVKAMAPECELVIVVG
SKNSSNSVRLVEVALGAGSDAAHLVDYAEDIDPTWLNGVTTVGVTSGASVPEVLVRGVLDRLAEYGYGTVQPVTTANETL
VFALPREIRPARS

Sequences:

>Translated_333_residues
MPPTINMGIPGASSSVTGGVSGKRVLLAEPRGYCAGVDRAVETVERALEKHGAPVYVRHEIVHNRYVVDTLAKAGAVFVE
QTDEVPEGAIVVFSAHGVAPTVHVEAAARNLKTIDATCPLVTKVHNEAKRFARDDYDILLVGHEGHEEVVGTAGEAPDHV
QVVDNPDAVDKVTVRDPDKVIWLSQTTLSVDETMETVRRLREKFPTLQDPPSDDICYATQNRQVAVKAMAPECELVIVVG
SKNSSNSVRLVEVALGAGSDAAHLVDYAEDIDPTWLNGVTTVGVTSGASVPEVLVRGVLDRLAEYGYGTVQPVTTANETL
VFALPREIRPARS
>Mature_332_residues
PPTINMGIPGASSSVTGGVSGKRVLLAEPRGYCAGVDRAVETVERALEKHGAPVYVRHEIVHNRYVVDTLAKAGAVFVEQ
TDEVPEGAIVVFSAHGVAPTVHVEAAARNLKTIDATCPLVTKVHNEAKRFARDDYDILLVGHEGHEEVVGTAGEAPDHVQ
VVDNPDAVDKVTVRDPDKVIWLSQTTLSVDETMETVRRLREKFPTLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGS
KNSSNSVRLVEVALGAGSDAAHLVDYAEDIDPTWLNGVTTVGVTSGASVPEVLVRGVLDRLAEYGYGTVQPVTTANETLV
FALPREIRPARS

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family [H]

Homologues:

Organism=Escherichia coli, GI1786212, Length=309, Percent_Identity=52.4271844660194, Blast_Score=325, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451 [H]

Pfam domain/function: PF02401 LYTB [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 35682; Mature: 35550

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPTINMGIPGASSSVTGGVSGKRVLLAEPRGYCAGVDRAVETVERALEKHGAPVYVRHE
CCCEECCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEE
IVHNRYVVDTLAKAGAVFVEQTDEVPEGAIVVFSAHGVAPTVHVEAAARNLKTIDATCPL
HHHCHHHHHHHHHCCEEEEECCCCCCCCEEEEEECCCCCCEEEHHHHHCCCEEECCCCHH
VTKVHNEAKRFARDDYDILLVGHEGHEEVVGTAGEAPDHVQVVDNPDAVDKVTVRDPDKV
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHCCCCCCCCCEEEECCCCCCCEEEECCCCCE
IWLSQTTLSVDETMETVRRLREKFPTLQDPPSDDICYATQNRQVAVKAMAPECELVIVVG
EEEECCEECHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEEEEECCCCEEEEEEC
SKNSSNSVRLVEVALGAGSDAAHLVDYAEDIDPTWLNGVTTVGVTSGASVPEVLVRGVLD
CCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCHHHCCEEEEEECCCCCHHHHHHHHHHH
RLAEYGYGTVQPVTTANETLVFALPREIRPARS
HHHHCCCCCCCEECCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure 
PPTINMGIPGASSSVTGGVSGKRVLLAEPRGYCAGVDRAVETVERALEKHGAPVYVRHE
CCEECCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEE
IVHNRYVVDTLAKAGAVFVEQTDEVPEGAIVVFSAHGVAPTVHVEAAARNLKTIDATCPL
HHHCHHHHHHHHHCCEEEEECCCCCCCCEEEEEECCCCCCEEEHHHHHCCCEEECCCCHH
VTKVHNEAKRFARDDYDILLVGHEGHEEVVGTAGEAPDHVQVVDNPDAVDKVTVRDPDKV
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHCCCCCCCCCEEEECCCCCCCEEEECCCCCE
IWLSQTTLSVDETMETVRRLREKFPTLQDPPSDDICYATQNRQVAVKAMAPECELVIVVG
EEEECCEECHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEEEEECCCCEEEEEEC
SKNSSNSVRLVEVALGAGSDAAHLVDYAEDIDPTWLNGVTTVGVTSGASVPEVLVRGVLD
CCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCHHHCCEEEEEECCCCCHHHHHHHHHHH
RLAEYGYGTVQPVTTANETLVFALPREIRPARS
HHHHCCCCCCCEECCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA