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The map label for this gene is yfeW [C]

Identifier: 108801058

GI number: 108801058

Start: 4363340

End: 4364557

Strand: Reverse

Name: yfeW [C]

Synonym: Mmcs_4094

Alternate gene names: 108801058

Gene position: 4364557-4363340 (Counterclockwise)

Preceding gene: 108801059

Following gene: 108801053

Centisome position: 76.5

GC content: 69.38

Gene sequence:

>1218_bases
ATGAAGAGGGGTACCCGGCACCTGCTGAGCCTTGCGGCGCTGGTGACGGCCCTCCTGCTCGCCGGCTGCTCCTCCCCGGA
ACCGCAGGCACTGCGCACGATCGACCCGCAGGAGCTCCAGCAGGTCGTCGACGGACTCGCGCGCGAACTGACGGTGCCCG
GCGCTCTTGTGCTCGCGCACACCCCGCAGGGCCGTTTCACCGCCGCGGCCGGCACCACCGAACTCGGCGCGCAGGATCCG
CCGTCCGCCGACACCCACTTCCGCATCGCCTCCAACACCAAGACCATGACGGCGGCGCTGATCGTGCTGCTCGCCCAGGA
CGGCAAGGTCCGATTCGACGACCCCGTCACCGACTGGGTCCCGGACGTGCCGAACGGCGAGAACATCACCGTCGCACAGC
TTCTCACCATGCGCAGCGGTCTCTACGGCTACACGGGCGACGAGGCGCTGTCGGCCGCCATGGACGCCGACCCCCAAAAG
CCTTGGACGCCGGCGGAAGTGCTGGCCATCGCCTTCCGGCATCCGCCACAGTTCGCGCCCGACTCCGCCTACGAGTACAG
CAACACCAACTACGCGCTCCTCGGCCTCATCGCCGAGAAGGCCGGCGGCCAACCGCTGGCCCGGCAGTTCCGCGACCGGT
TGTTCGGCCCCGTCGGCCTGACCCAGACGTCCCTGCCCGCCGCCGACGACACCACCATGCCCACGCCCTATTCGCACGGC
TACATGTACGGCGGAAGCTTCTACGCCCTGGCCGACGAGCCGTATCCCGCCGACATGCAGGCCGCCGCCCGCGCCGGGAC
ACTGCAGCCCGTCGACTACACCAACCAGAACTCCTCGTACGCGACCGCCGCGGGTGGCGCGATCTCGACGGCCGACGATC
TGGCCACCTGGATGAAGGCGCTCGTCACCGGGAAGGTCTTCGACGCCGACCACCACCGCCAGTGGACGGGCAGCCTGCGC
CCCGAGGACCCGGCCGCCCCCGACGGTCAGCAGTACGGGTACGGGATCTCCTATCAGCGGTTCGGCCCGAACGCCGCGAT
GTACTACCACGGCGGGGAACTGCCCGGTTTCAACTCGTTCATGGGTTACGACCCGGACAACGACGTGACCCTGGTGATCT
GGACGAACCTCACGCTGTCGCCGGACGGCCGGACCACCGCCCAGGCGATGCTGGCCCCGATGCTCGAGCAGATCTACGCC
GGGTTGTCGCTGGGATGA

Upstream 100 bases:

>100_bases
CCTCGCTCGCCAACCTCGCCGCCTGTGTGGAAACCCGACGGTGAGCGCGCGCCGGGGTTAAGGTCCGGCTGAGGGGGTCC
ATCACCGAGGCGGTGGCGTG

Downstream 100 bases:

>100_bases
ACATCAGCCGCCGACGTGTGTCGCACCTGTGACCTGACCGCGACGGGGACCGTGAACGCTCGTTGGGGTGGCGGTGGTCG
AGATGATCTATCTGGTGGCG

Product: Serine-type D-Ala-D-Ala carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MKRGTRHLLSLAALVTALLLAGCSSPEPQALRTIDPQELQQVVDGLARELTVPGALVLAHTPQGRFTAAAGTTELGAQDP
PSADTHFRIASNTKTMTAALIVLLAQDGKVRFDDPVTDWVPDVPNGENITVAQLLTMRSGLYGYTGDEALSAAMDADPQK
PWTPAEVLAIAFRHPPQFAPDSAYEYSNTNYALLGLIAEKAGGQPLARQFRDRLFGPVGLTQTSLPAADDTTMPTPYSHG
YMYGGSFYALADEPYPADMQAAARAGTLQPVDYTNQNSSYATAAGGAISTADDLATWMKALVTGKVFDADHHRQWTGSLR
PEDPAAPDGQQYGYGISYQRFGPNAAMYYHGGELPGFNSFMGYDPDNDVTLVIWTNLTLSPDGRTTAQAMLAPMLEQIYA
GLSLG

Sequences:

>Translated_405_residues
MKRGTRHLLSLAALVTALLLAGCSSPEPQALRTIDPQELQQVVDGLARELTVPGALVLAHTPQGRFTAAAGTTELGAQDP
PSADTHFRIASNTKTMTAALIVLLAQDGKVRFDDPVTDWVPDVPNGENITVAQLLTMRSGLYGYTGDEALSAAMDADPQK
PWTPAEVLAIAFRHPPQFAPDSAYEYSNTNYALLGLIAEKAGGQPLARQFRDRLFGPVGLTQTSLPAADDTTMPTPYSHG
YMYGGSFYALADEPYPADMQAAARAGTLQPVDYTNQNSSYATAAGGAISTADDLATWMKALVTGKVFDADHHRQWTGSLR
PEDPAAPDGQQYGYGISYQRFGPNAAMYYHGGELPGFNSFMGYDPDNDVTLVIWTNLTLSPDGRTTAQAMLAPMLEQIYA
GLSLG
>Mature_405_residues
MKRGTRHLLSLAALVTALLLAGCSSPEPQALRTIDPQELQQVVDGLARELTVPGALVLAHTPQGRFTAAAGTTELGAQDP
PSADTHFRIASNTKTMTAALIVLLAQDGKVRFDDPVTDWVPDVPNGENITVAQLLTMRSGLYGYTGDEALSAAMDADPQK
PWTPAEVLAIAFRHPPQFAPDSAYEYSNTNYALLGLIAEKAGGQPLARQFRDRLFGPVGLTQTSLPAADDTTMPTPYSHG
YMYGGSFYALADEPYPADMQAAARAGTLQPVDYTNQNSSYATAAGGAISTADDLATWMKALVTGKVFDADHHRQWTGSLR
PEDPAAPDGQQYGYGISYQRFGPNAAMYYHGGELPGFNSFMGYDPDNDVTLVIWTNLTLSPDGRTTAQAMLAPMLEQIYA
GLSLG

Specific function: Catalyzes distinct carboxypeptidation and transpeptidation reactions during the last stages of wall peptidoglycan synthesis. Mistaking a beta-lactam antibiotic molecule for a normal substrate (i.e., a D-alanyl-D-alanine- terminated peptide), it becomes im

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S12 family [H]

Homologues:

Organism=Escherichia coli, GI87082101, Length=329, Percent_Identity=25.531914893617, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 43324; Mature: 43324

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRGTRHLLSLAALVTALLLAGCSSPEPQALRTIDPQELQQVVDGLARELTVPGALVLAH
CCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEE
TPQGRFTAAAGTTELGAQDPPSADTHFRIASNTKTMTAALIVLLAQDGKVRFDDPVTDWV
CCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHEECCCCEEECCCHHHHC
PDVPNGENITVAQLLTMRSGLYGYTGDEALSAAMDADPQKPWTPAEVLAIAFRHPPQFAP
CCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCC
DSAYEYSNTNYALLGLIAEKAGGQPLARQFRDRLFGPVGLTQTSLPAADDTTMPTPYSHG
CCCCCCCCCCEEEEEEEHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
YMYGGSFYALADEPYPADMQAAARAGTLQPVDYTNQNSSYATAAGGAISTADDLATWMKA
EEECCEEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHH
LVTGKVFDADHHRQWTGSLRPEDPAAPDGQQYGYGISYQRFGPNAAMYYHGGELPGFNSF
HHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCC
MGYDPDNDVTLVIWTNLTLSPDGRTTAQAMLAPMLEQIYAGLSLG
CCCCCCCCEEEEEEECEEECCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKRGTRHLLSLAALVTALLLAGCSSPEPQALRTIDPQELQQVVDGLARELTVPGALVLAH
CCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEE
TPQGRFTAAAGTTELGAQDPPSADTHFRIASNTKTMTAALIVLLAQDGKVRFDDPVTDWV
CCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHEECCCCEEECCCHHHHC
PDVPNGENITVAQLLTMRSGLYGYTGDEALSAAMDADPQKPWTPAEVLAIAFRHPPQFAP
CCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCC
DSAYEYSNTNYALLGLIAEKAGGQPLARQFRDRLFGPVGLTQTSLPAADDTTMPTPYSHG
CCCCCCCCCCEEEEEEEHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
YMYGGSFYALADEPYPADMQAAARAGTLQPVDYTNQNSSYATAAGGAISTADDLATWMKA
EEECCEEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHH
LVTGKVFDADHHRQWTGSLRPEDPAAPDGQQYGYGISYQRFGPNAAMYYHGGELPGFNSF
HHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCC
MGYDPDNDVTLVIWTNLTLSPDGRTTAQAMLAPMLEQIYAGLSLG
CCCCCCCCEEEEEEECEEECCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3830154; 7925404; 3030739; 2175384; 2386365; 3997832; 7490745 [H]