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The map label for this gene is fadE12 [H]

Identifier: 108800709

GI number: 108800709

Start: 3996509

End: 3997723

Strand: Reverse

Name: fadE12 [H]

Synonym: Mmcs_3744

Alternate gene names: 108800709

Gene position: 3997723-3996509 (Counterclockwise)

Preceding gene: 108800710

Following gene: 108800708

Centisome position: 70.07

GC content: 64.12

Gene sequence:

>1215_bases
GTGCAACAGTCTTTTTCGAACACAGAGGAGAACCAAGTGTCGGGCGGTATGAATTTCGAACTGACCGAAGACCAGCAGCT
GATCTACAAATCGGTCAGCGAGCTCGCCGCGCGGTTCGACGACCAGTACTGGATGGAGAAGGACTCCAACCACGAGTTCC
CCACCGAGTTCTACGACGCCATCGCCGGCGGCGGCTGGCTCGGGATGACGATTCCCGAGGAGTACGGCGGCCACGGGCTC
GGGATCACCGAGGCCACGCTGCTCGCCGAGGCGGTGGCGCGATCGGGCGGCGGGATGAACGCGGCCAGTTCCATCCACAT
GTCGATCTTCGGGATGCACCCGGTGGTCAAACACGGCTCCGACGAGCTCAAGGCCCGCACCCTGCCGCGCATCGCCAGTG
GTGATCTGCACGTCTGCTTCGGCGTCACCGAACCCGGTGCGGGACTGGACACGTCGCGCATCACCACGTTCGCCAAGCGG
GACGGCGACAGTTATGTGGTCAACGGCAGGAAGGTCTGGATCTCCAAGGCGCTGGAGTCGGAGAAGATCCTGCTGCTCAC
CCGCACCACACCGTATGACGAGGTCACCAAGAAGACCGACGGTATGACGCTGTTCATGACCGACCTCGACCGCGCGCACG
TCGACATCCGCCCGATTGCGAAGATGGGCCGCAACGCGGTCAGCTCCAACGAATTGTTCATCGACGATCTGCGCATCCCG
GTCGAGGACCGCGTCGGCGAGGAGGGCAGGGGGTTCTTCTACATCCTCGACGGCCTCAACCCCGAGCGCATGCTGATCGC
CGCCGAGGCGCTCGGCATCGGCCGGATCGCATTGGACAAGGCCGTCAAGTACGCCAATGACCGGCACGTCTTCGACCGCC
CGATCGGGATGAACCAGGGCATCCAGTTCCCGTTGGCCGATTCGCTGGCGCGCCTCGATGCCGCGGAACTGATGCTGCGC
AAGGCGACCTGGCTCTACGACAACGGCAAATCCTGTGGGCGCGAGGCGAATACGGCGAAGTACCTGTGCGCCGACGCGGG
ATTCACCGCGGCCGACCGCGCGCTGCAGACCCACGGCGGGATGGGGTATGCCGAGGAGTACCACGTCGCACGCTTCTTCC
GTGAGGCGCGGTTGATGAAGATCGCCCCCGTCAGCCAGGAGATGATCCTCAACTTCCTCGGTTCCCACGTCCTCGGCCTG
CCAAGGAGCTACTGA

Upstream 100 bases:

>100_bases
ACTTCCAGGCCAACGCCAAGGCGGTCACCGGCGCCCGCGACTGATCTGCGGGGACGTTCACCGGTGCGGCGGCGGCAGCT
GATCGCGCCGGTGAACTGCT

Downstream 100 bases:

>100_bases
CATGAGCTACTTCGACCTGACCGGACGGGCCGCGATGGTGACCGGCGCGGGCGCGGGCGGGGGGATCGGTGCCGCGGTCG
CCGCGGCCCTGGCTCAGGCC

Product: acyl-CoA dehydrogenase-like protein

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MQQSFSNTEENQVSGGMNFELTEDQQLIYKSVSELAARFDDQYWMEKDSNHEFPTEFYDAIAGGGWLGMTIPEEYGGHGL
GITEATLLAEAVARSGGGMNAASSIHMSIFGMHPVVKHGSDELKARTLPRIASGDLHVCFGVTEPGAGLDTSRITTFAKR
DGDSYVVNGRKVWISKALESEKILLLTRTTPYDEVTKKTDGMTLFMTDLDRAHVDIRPIAKMGRNAVSSNELFIDDLRIP
VEDRVGEEGRGFFYILDGLNPERMLIAAEALGIGRIALDKAVKYANDRHVFDRPIGMNQGIQFPLADSLARLDAAELMLR
KATWLYDNGKSCGREANTAKYLCADAGFTAADRALQTHGGMGYAEEYHVARFFREARLMKIAPVSQEMILNFLGSHVLGL
PRSY

Sequences:

>Translated_404_residues
MQQSFSNTEENQVSGGMNFELTEDQQLIYKSVSELAARFDDQYWMEKDSNHEFPTEFYDAIAGGGWLGMTIPEEYGGHGL
GITEATLLAEAVARSGGGMNAASSIHMSIFGMHPVVKHGSDELKARTLPRIASGDLHVCFGVTEPGAGLDTSRITTFAKR
DGDSYVVNGRKVWISKALESEKILLLTRTTPYDEVTKKTDGMTLFMTDLDRAHVDIRPIAKMGRNAVSSNELFIDDLRIP
VEDRVGEEGRGFFYILDGLNPERMLIAAEALGIGRIALDKAVKYANDRHVFDRPIGMNQGIQFPLADSLARLDAAELMLR
KATWLYDNGKSCGREANTAKYLCADAGFTAADRALQTHGGMGYAEEYHVARFFREARLMKIAPVSQEMILNFLGSHVLGL
PRSY
>Mature_404_residues
MQQSFSNTEENQVSGGMNFELTEDQQLIYKSVSELAARFDDQYWMEKDSNHEFPTEFYDAIAGGGWLGMTIPEEYGGHGL
GITEATLLAEAVARSGGGMNAASSIHMSIFGMHPVVKHGSDELKARTLPRIASGDLHVCFGVTEPGAGLDTSRITTFAKR
DGDSYVVNGRKVWISKALESEKILLLTRTTPYDEVTKKTDGMTLFMTDLDRAHVDIRPIAKMGRNAVSSNELFIDDLRIP
VEDRVGEEGRGFFYILDGLNPERMLIAAEALGIGRIALDKAVKYANDRHVFDRPIGMNQGIQFPLADSLARLDAAELMLR
KATWLYDNGKSCGREANTAKYLCADAGFTAADRALQTHGGMGYAEEYHVARFFREARLMKIAPVSQEMILNFLGSHVLGL
PRSY

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=388, Percent_Identity=32.4742268041237, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI187960098, Length=367, Percent_Identity=30.5177111716621, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4557231, Length=367, Percent_Identity=30.5177111716621, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4501859, Length=392, Percent_Identity=28.0612244897959, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI7656849, Length=386, Percent_Identity=30.3108808290155, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=27.5132275132275, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI226958414, Length=341, Percent_Identity=28.4457478005865, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI4501857, Length=351, Percent_Identity=29.0598290598291, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI21361497, Length=352, Percent_Identity=27.2727272727273, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI76496475, Length=370, Percent_Identity=29.7297297297297, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI4557235, Length=370, Percent_Identity=29.7297297297297, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI4503943, Length=356, Percent_Identity=28.3707865168539, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI7669494, Length=356, Percent_Identity=28.3707865168539, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI211971008, Length=319, Percent_Identity=25.0783699059561, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI48976061, Length=319, Percent_Identity=25.0783699059561, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI38505218, Length=289, Percent_Identity=26.643598615917, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=32.7272727272727, Blast_Score=201, Evalue=5e-53,
Organism=Escherichia coli, GI1786223, Length=384, Percent_Identity=29.4270833333333, Blast_Score=169, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17534899, Length=376, Percent_Identity=30.8510638297872, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=30.1587301587302, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17569725, Length=383, Percent_Identity=30.8093994778068, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17506239, Length=379, Percent_Identity=26.3852242744063, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17508101, Length=380, Percent_Identity=26.3157894736842, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17538396, Length=375, Percent_Identity=26.9333333333333, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17505929, Length=330, Percent_Identity=30.9090909090909, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71985184, Length=381, Percent_Identity=27.8215223097113, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71990804, Length=281, Percent_Identity=29.5373665480427, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17551932, Length=344, Percent_Identity=28.1976744186047, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17533517, Length=348, Percent_Identity=28.1609195402299, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI32563615, Length=227, Percent_Identity=30.3964757709251, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71985192, Length=317, Percent_Identity=28.7066246056782, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17534353, Length=390, Percent_Identity=26.4102564102564, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=25.2747252747253, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17531909, Length=245, Percent_Identity=24.4897959183673, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356377, Length=362, Percent_Identity=30.1104972375691, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24660351, Length=371, Percent_Identity=32.3450134770889, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24646207, Length=381, Percent_Identity=30.9711286089239, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24666513, Length=397, Percent_Identity=27.7078085642317, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI21355753, Length=395, Percent_Identity=27.5949367088608, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI281363737, Length=399, Percent_Identity=28.5714285714286, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI19920834, Length=334, Percent_Identity=29.6407185628743, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 44638; Mature: 44638

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQSFSNTEENQVSGGMNFELTEDQQLIYKSVSELAARFDDQYWMEKDSNHEFPTEFYDA
CCCCCCCCCHHHHCCCCCEEECCHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHH
IAGGGWLGMTIPEEYGGHGLGITEATLLAEAVARSGGGMNAASSIHMSIFGMHPVVKHGS
HCCCCEEECCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCHHHHCCC
DELKARTLPRIASGDLHVCFGVTEPGAGLDTSRITTFAKRDGDSYVVNGRKVWISKALES
HHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCEEEECCEEEEEEHHCCC
EKILLLTRTTPYDEVTKKTDGMTLFMTDLDRAHVDIRPIAKMGRNAVSSNELFIDDLRIP
CEEEEEECCCCHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHCCCCCCCCCEEEECCCCC
VEDRVGEEGRGFFYILDGLNPERMLIAAEALGIGRIALDKAVKYANDRHVFDRPIGMNQG
HHHCCCCCCCEEEEEECCCCCCCEEEEEHHCCCCHHHHHHHHHHCCCCEEECCCCCCCCC
IQFPLADSLARLDAAELMLRKATWLYDNGKSCGREANTAKYLCADAGFTAADRALQTHGG
CCCCHHHHHHHHHHHHHHHHHHHEEEECCHHCCCCCCCCEEEEECCCCHHHHHHHHHCCC
MGYAEEYHVARFFREARLMKIAPVSQEMILNFLGSHVLGLPRSY
CCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQQSFSNTEENQVSGGMNFELTEDQQLIYKSVSELAARFDDQYWMEKDSNHEFPTEFYDA
CCCCCCCCCHHHHCCCCCEEECCHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHH
IAGGGWLGMTIPEEYGGHGLGITEATLLAEAVARSGGGMNAASSIHMSIFGMHPVVKHGS
HCCCCEEECCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCHHHHCCC
DELKARTLPRIASGDLHVCFGVTEPGAGLDTSRITTFAKRDGDSYVVNGRKVWISKALES
HHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCEEEECCEEEEEEHHCCC
EKILLLTRTTPYDEVTKKTDGMTLFMTDLDRAHVDIRPIAKMGRNAVSSNELFIDDLRIP
CEEEEEECCCCHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHCCCCCCCCCEEEECCCCC
VEDRVGEEGRGFFYILDGLNPERMLIAAEALGIGRIALDKAVKYANDRHVFDRPIGMNQG
HHHCCCCCCCEEEEEECCCCCCCEEEEEHHCCCCHHHHHHHHHHCCCCEEECCCCCCCCC
IQFPLADSLARLDAAELMLRKATWLYDNGKSCGREANTAKYLCADAGFTAADRALQTHGG
CCCCHHHHHHHHHHHHHHHHHHHEEEECCHHCCCCCCCCEEEEECCCCHHHHHHHHHCCC
MGYAEEYHVARFFREARLMKIAPVSQEMILNFLGSHVLGLPRSY
CCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]