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The map label for this gene is fadA [H]

Identifier: 108800706

GI number: 108800706

Start: 3993357

End: 3994508

Strand: Reverse

Name: fadA [H]

Synonym: Mmcs_3741

Alternate gene names: 108800706

Gene position: 3994508-3993357 (Counterclockwise)

Preceding gene: 108800707

Following gene: 108800705

Centisome position: 70.01

GC content: 70.57

Gene sequence:

>1152_bases
ATGCGCGAAACCGTCATCGTCGAAGCCGTCCGCACGCCGGTGGGCAAGCGCAACGGCGGCCTGTCCGGCATGCACGCCGC
GGACCTGTCGGCCGTCGTCCTCAACGAACTGGTCCTGCGGGCCGGGATCGAACCCGATGTCGTCGACGACGTCATCTGGG
GTTGCGTCTCCCAGGTCGGCGACCAGTCCAGCAACATCGGCCGGTTCGCCGTGCTCGCCGCCGGCTGGCCCGAGCACATC
CCGGGCACCACCGTGAACCGCGCCTGCGGTTCGAGTCAGCAGGCGCTGGACTTCGCCGTGCACGCGGTGATGTCGGGTCA
GCAGGACATCGTCGTCGCCGGCGGTGTGGAGGTGATGAGCCGCGTGCCGCTGGGTTCGGCGCGAGCCACCGGCATGCCGT
ACGGGCCGAAGGTGCTCGAGCGGTACCGCGACTTCAGCTTCAACCAGGGCATCTCGGCCGAGCTGATCGCCGAGAAGTGG
GGTTTCTCGCGCACCCGCCTCGACGAGTACTCGGCGAGATCGCACGAGCTGGCCGCAAAGGCGCAGGACGCGAAGGCTTT
CGACGCGCAGATCGTCCCGGTGTTCACCGGGGAGGACACCGCGCCGGTGGTCGCCGACGAAGGTGTGCGGCGCGGCACGT
CGGTGGAGAAGCTGGCCGGACTGAAGCCGGCGTTCCGCGACGACGGGGTGATCCACGCGGGGAACTCCTCGCAGATCTCC
GACGGTGCGGCGGCGCTGCTGGTGATGACCGCGGACAACGCCGTCCAGCTGGGGCTGACGCCGATCGTGCGGTACCGCGC
CGGCGCGGTGGCAGGCGCCGACCCCGTGCTCATGCTCACCGGGCCCATCCCGGCCACGGAGAAGGTGCTGCACAAGGCGG
GCGTCGGCATCGACGAGATCGGCGTGTTCGAGGTCAACGAGGCGTTCGCGCCGGTGCCGCTGGCGTGGCTCGCCGACACC
GGTGCGGCCGAGGAGCGGCTCAACCCGCTCGGTGGCGCCATCGCACTCGGCCACCCGCTCGGCGCCTCCGGCGCGGTGCT
GATGACCCGGATGGTGCACCACATGCGCGACAACGGCATCCGGTACGGACTGCAGACCATGTGCGAGGGCGGCGGCACGG
CCAACGCGACCCTCGTCGAACTCATCGCCTAG

Upstream 100 bases:

>100_bases
GGCTGGGCCTGTCCGCCGACGAGATCGCCGCGCTGCGTGAGCAGGGCGCGGTCGGTCCGGCACAGTCATAGCCGCCACGC
GTACGAACCAGGAGCACCCC

Downstream 100 bases:

>100_bases
ACCACTTCCGCCGACCAGGAGGACCCGAGCGTGCGCCGAGACCTGTTCACCGACGACCACGACGCCTTCCGGCAGCTGGC
CCGCGACTTCGTCGAGAAGG

Product: acetyl-CoA C-acyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MRETVIVEAVRTPVGKRNGGLSGMHAADLSAVVLNELVLRAGIEPDVVDDVIWGCVSQVGDQSSNIGRFAVLAAGWPEHI
PGTTVNRACGSSQQALDFAVHAVMSGQQDIVVAGGVEVMSRVPLGSARATGMPYGPKVLERYRDFSFNQGISAELIAEKW
GFSRTRLDEYSARSHELAAKAQDAKAFDAQIVPVFTGEDTAPVVADEGVRRGTSVEKLAGLKPAFRDDGVIHAGNSSQIS
DGAAALLVMTADNAVQLGLTPIVRYRAGAVAGADPVLMLTGPIPATEKVLHKAGVGIDEIGVFEVNEAFAPVPLAWLADT
GAAEERLNPLGGAIALGHPLGASGAVLMTRMVHHMRDNGIRYGLQTMCEGGGTANATLVELIA

Sequences:

>Translated_383_residues
MRETVIVEAVRTPVGKRNGGLSGMHAADLSAVVLNELVLRAGIEPDVVDDVIWGCVSQVGDQSSNIGRFAVLAAGWPEHI
PGTTVNRACGSSQQALDFAVHAVMSGQQDIVVAGGVEVMSRVPLGSARATGMPYGPKVLERYRDFSFNQGISAELIAEKW
GFSRTRLDEYSARSHELAAKAQDAKAFDAQIVPVFTGEDTAPVVADEGVRRGTSVEKLAGLKPAFRDDGVIHAGNSSQIS
DGAAALLVMTADNAVQLGLTPIVRYRAGAVAGADPVLMLTGPIPATEKVLHKAGVGIDEIGVFEVNEAFAPVPLAWLADT
GAAEERLNPLGGAIALGHPLGASGAVLMTRMVHHMRDNGIRYGLQTMCEGGGTANATLVELIA
>Mature_383_residues
MRETVIVEAVRTPVGKRNGGLSGMHAADLSAVVLNELVLRAGIEPDVVDDVIWGCVSQVGDQSSNIGRFAVLAAGWPEHI
PGTTVNRACGSSQQALDFAVHAVMSGQQDIVVAGGVEVMSRVPLGSARATGMPYGPKVLERYRDFSFNQGISAELIAEKW
GFSRTRLDEYSARSHELAAKAQDAKAFDAQIVPVFTGEDTAPVVADEGVRRGTSVEKLAGLKPAFRDDGVIHAGNSSQIS
DGAAALLVMTADNAVQLGLTPIVRYRAGAVAGADPVLMLTGPIPATEKVLHKAGVGIDEIGVFEVNEAFAPVPLAWLADT
GAAEERLNPLGGAIALGHPLGASGAVLMTRMVHHMRDNGIRYGLQTMCEGGGTANATLVELIA

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=388, Percent_Identity=37.8865979381443, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=35.5294117647059, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI4501853, Length=387, Percent_Identity=36.4341085271318, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI4557237, Length=392, Percent_Identity=35.969387755102, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI167614485, Length=394, Percent_Identity=32.741116751269, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI194353979, Length=380, Percent_Identity=25.7894736842105, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI48994986, Length=392, Percent_Identity=42.8571428571429, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI1787663, Length=403, Percent_Identity=40.9429280397022, Blast_Score=273, Evalue=9e-75,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=40.8163265306122, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI87082165, Length=394, Percent_Identity=39.3401015228426, Blast_Score=236, Evalue=1e-63,
Organism=Escherichia coli, GI1788683, Length=405, Percent_Identity=30.6172839506173, Blast_Score=177, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=39.2307692307692, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=31.025641025641, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=32.7058823529412, Blast_Score=184, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI17535921, Length=391, Percent_Identity=31.2020460358056, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=383, Percent_Identity=27.4151436031332, Blast_Score=131, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6325229, Length=408, Percent_Identity=32.843137254902, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322031, Length=387, Percent_Identity=33.8501291989664, Blast_Score=179, Evalue=9e-46,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=37.1501272264631, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24640423, Length=389, Percent_Identity=33.4190231362468, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI17648125, Length=395, Percent_Identity=33.1645569620253, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=32.0754716981132, Blast_Score=174, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 39973; Mature: 39973

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRETVIVEAVRTPVGKRNGGLSGMHAADLSAVVLNELVLRAGIEPDVVDDVIWGCVSQVG
CCCEEEEHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
DQSSNIGRFAVLAAGWPEHIPGTTVNRACGSSQQALDFAVHAVMSGQQDIVVAGGVEVMS
CCCCCCCEEEEEECCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHH
RVPLGSARATGMPYGPKVLERYRDFSFNQGISAELIAEKWGFSRTRLDEYSARSHELAAK
HCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHCHHHHHHHH
AQDAKAFDAQIVPVFTGEDTAPVVADEGVRRGTSVEKLAGLKPAFRDDGVIHAGNSSQIS
HHCCCCCCCEEEEEEECCCCCCEECCCCCCCCCCHHHHHCCCCCCCCCCEEECCCCCCCC
DGAAALLVMTADNAVQLGLTPIVRYRAGAVAGADPVLMLTGPIPATEKVLHKAGVGIDEI
CCCEEEEEEECCCCEEECCHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCC
GVFEVNEAFAPVPLAWLADTGAAEERLNPLGGAIALGHPLGASGAVLMTRMVHHMRDNGI
CEEEECCCCCCCCHHHHCCCCCHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCH
RYGLQTMCEGGGTANATLVELIA
HHHHHHHHCCCCCCCHHHHEEEC
>Mature Secondary Structure
MRETVIVEAVRTPVGKRNGGLSGMHAADLSAVVLNELVLRAGIEPDVVDDVIWGCVSQVG
CCCEEEEHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
DQSSNIGRFAVLAAGWPEHIPGTTVNRACGSSQQALDFAVHAVMSGQQDIVVAGGVEVMS
CCCCCCCEEEEEECCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHH
RVPLGSARATGMPYGPKVLERYRDFSFNQGISAELIAEKWGFSRTRLDEYSARSHELAAK
HCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHCHHHHHHHH
AQDAKAFDAQIVPVFTGEDTAPVVADEGVRRGTSVEKLAGLKPAFRDDGVIHAGNSSQIS
HHCCCCCCCEEEEEEECCCCCCEECCCCCCCCCCHHHHHCCCCCCCCCCEEECCCCCCCC
DGAAALLVMTADNAVQLGLTPIVRYRAGAVAGADPVLMLTGPIPATEKVLHKAGVGIDEI
CCCEEEEEEECCCCEEECCHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCC
GVFEVNEAFAPVPLAWLADTGAAEERLNPLGGAIALGHPLGASGAVLMTRMVHHMRDNGI
CEEEECCCCCCCCHHHHCCCCCHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCH
RYGLQTMCEGGGTANATLVELIA
HHHHHHHHCCCCCCCHHHHEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA