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The map label for this gene is ndk [H]

Identifier: 108800518

GI number: 108800518

Start: 3781077

End: 3781526

Strand: Reverse

Name: ndk [H]

Synonym: Mmcs_3552

Alternate gene names: 108800518

Gene position: 3781526-3781077 (Counterclockwise)

Preceding gene: 108800519

Following gene: 108800517

Centisome position: 66.28

GC content: 68.67

Gene sequence:

>450_bases
TTGACTGTTCCCGAAACCGGGGCCGGTACGCTGTCCGCCGTGACTGAGCGGACCCTGGTTCTGATCAAGCCCGACGGCGT
GCAACGGCGCCTGGTCGGGGAAATTCTCGGCCGGATCGAGCGCAAGGGTCTGACCCTCGCCGCGCTCGAACTGAAGACCG
TCGACGACGAACTGGCCCGGCGGCACTACGCCGAGCACGAGGGCAAGCCGTTCTTCGGTTCGCTGCTGGAATTCATCACC
TCGGGCCCCGTGGTCGCCGCGATCGTCGAGGGTCCGCGCGCGATCGCCGCATTCCGTCAGATCGCCGGCGGCACCGATCC
GGTGGAGAAGGCCACACCCGGCACCATCCGCGCCGACCTGGCCCTGGTCACCCAGGACAACCTGGTGCACGGCTCCGATT
CGCCGGAGTCCGCGGCCCGCGAAATCGACCTCTGGTTCCCCGGCCGCTGA

Upstream 100 bases:

>100_bases
CGCCCAATCCGCCGTCGCGTTCCCGCGACGATCTCCGCCGCTTCGTGCACCGCTGGCTGGGTGGGGCCATCATGGCCCAG
AACCGCCTCTGAGCTGCGCA

Downstream 100 bases:

>100_bases
CGTTTGTTTGCGGCGCCTGGTCGGTGGGCGCCGCGTCGTGTGGGATACTGGTCGCGGGTAGCCGGACTTCAACCAGAGTT
CGTCGCCCGAATGAAGACTT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 149; Mature: 148

Protein sequence:

>149_residues
MTVPETGAGTLSAVTERTLVLIKPDGVQRRLVGEILGRIERKGLTLAALELKTVDDELARRHYAEHEGKPFFGSLLEFIT
SGPVVAAIVEGPRAIAAFRQIAGGTDPVEKATPGTIRADLALVTQDNLVHGSDSPESAAREIDLWFPGR

Sequences:

>Translated_149_residues
MTVPETGAGTLSAVTERTLVLIKPDGVQRRLVGEILGRIERKGLTLAALELKTVDDELARRHYAEHEGKPFFGSLLEFIT
SGPVVAAIVEGPRAIAAFRQIAGGTDPVEKATPGTIRADLALVTQDNLVHGSDSPESAAREIDLWFPGR
>Mature_148_residues
TVPETGAGTLSAVTERTLVLIKPDGVQRRLVGEILGRIERKGLTLAALELKTVDDELARRHYAEHEGKPFFGSLLEFITS
GPVVAAIVEGPRAIAAFRQIAGGTDPVEKATPGTIRADLALVTQDNLVHGSDSPESAAREIDLWFPGR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=131, Percent_Identity=53.4351145038168, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI4826862, Length=140, Percent_Identity=46.4285714285714, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI38045913, Length=144, Percent_Identity=44.4444444444444, Blast_Score=130, Evalue=4e-31,
Organism=Homo sapiens, GI4557797, Length=134, Percent_Identity=46.2686567164179, Blast_Score=130, Evalue=5e-31,
Organism=Homo sapiens, GI66392203, Length=139, Percent_Identity=44.6043165467626, Blast_Score=127, Evalue=3e-30,
Organism=Homo sapiens, GI66392227, Length=134, Percent_Identity=45.5223880597015, Blast_Score=127, Evalue=5e-30,
Organism=Homo sapiens, GI66392205, Length=134, Percent_Identity=45.5223880597015, Blast_Score=127, Evalue=5e-30,
Organism=Homo sapiens, GI4505409, Length=134, Percent_Identity=45.5223880597015, Blast_Score=127, Evalue=5e-30,
Organism=Homo sapiens, GI66392192, Length=134, Percent_Identity=45.5223880597015, Blast_Score=127, Evalue=5e-30,
Organism=Homo sapiens, GI37574614, Length=149, Percent_Identity=34.8993288590604, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI7019465, Length=149, Percent_Identity=34.8993288590604, Blast_Score=84, Evalue=3e-17,
Organism=Homo sapiens, GI5031951, Length=134, Percent_Identity=38.0597014925373, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=32.5925925925926, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1788866, Length=131, Percent_Identity=45.8015267175573, Blast_Score=120, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17506807, Length=132, Percent_Identity=46.969696969697, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=50.7352941176471, Blast_Score=144, Evalue=5e-36,
Organism=Drosophila melanogaster, GI45549037, Length=139, Percent_Identity=45.3237410071942, Blast_Score=136, Evalue=5e-33,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=34.3283582089552, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15951; Mature: 15820

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVPETGAGTLSAVTERTLVLIKPDGVQRRLVGEILGRIERKGLTLAALELKTVDDELAR
CCCCCCCCCHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHH
RHYAEHEGKPFFGSLLEFITSGPVVAAIVEGPRAIAAFRQIAGGTDPVEKATPGTIRADL
HHHHHCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
ALVTQDNLVHGSDSPESAAREIDLWFPGR
EEEECCCEECCCCCHHHHHHEEEEECCCC
>Mature Secondary Structure 
TVPETGAGTLSAVTERTLVLIKPDGVQRRLVGEILGRIERKGLTLAALELKTVDDELAR
CCCCCCCCHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHH
RHYAEHEGKPFFGSLLEFITSGPVVAAIVEGPRAIAAFRQIAGGTDPVEKATPGTIRADL
HHHHHCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
ALVTQDNLVHGSDSPESAAREIDLWFPGR
EEEECCCEECCCCCHHHHHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA