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The map label for this gene is proA

Identifier: 108800504

GI number: 108800504

Start: 3764331

End: 3765578

Strand: Reverse

Name: proA

Synonym: Mmcs_3538

Alternate gene names: 108800504

Gene position: 3765578-3764331 (Counterclockwise)

Preceding gene: 108800509

Following gene: 108800503

Centisome position: 66.0

GC content: 70.67

Gene sequence:

>1248_bases
ATGAGTGTGCACGCCCCCGCAGCTCCTGACCTGCGCACCGAGGTCCACGACGCCGCCCGCCGGGCCCGGGTCGCCTCGCG
CACGCTGGCGACGCTGTCGACCGAGACCAAGAACCGCGCGCTGCGTGCGGCCGCCGACCGGGTGCTCATGGATGCGCACC
TCATCATCGCGGGCAACGAGCGCGACCTCGAGAAGGCCAGGGCGGCGGGCACACCCGACGCGATGCTCGACCGGCTGGCG
CTCAACCCGCAGCGCATCGACGGGGTGGCCGCCGGCCTGCGCCAGGTGGCGAGCCTGCCCGATCCGGTCGGTGAGGTGTT
GCGGGGTAACACGCTGGTCAACGGGCTGCAGCTGCGTCAGCAGCGGGTTCCGCTCGGCGTGGTCGGCATCGTCTACGAGG
GGCGGCCCAACGTCACCGTCGACGCGTTCGGGCTGACGCTGAAATCCGGCAACGCGGTGCTGCTGCGCGGCAGTTCGTCG
GCCGCGCACTCCAACGCCGCGCTCGTCGACTCGCTGCGGGCGGCGCTGGTCGCCGAGGGTCTCGACGCCAACGCGGTGCA
GCTGCTGCCCAGCCACGATCGGGCCAGCGTCACCCACCTCATCCAGGCCCGCGGTCTGGTCGACGTCGTGATCCCGCGCG
GCGGCGCAGGCCTCATCGACGCCGTCGTGCGCGACGCCCAGGTCCCCACGATCGAGACGGGCGTCGGCAACTGCCACGTC
TACGTGCATTCCGCCGCGGACCTCGACATGGCCGAGACCATCCTGCTCAACGCCAAGACCCGTCGGCCGAGCGTGTGCAA
CGCGGCCGAATCGGTACTGATCGACGCCGCCATCGCCGAGGAGGCCGTACCCCGGCTCACCAAGGCGCTGCAGGACGCCG
GAGTGACCGTGCACGCCGACCCCACCGAGGAGGAACTGCGCGCCGAATTCCTCTCGATGGACATCGCGCTGGCGGTGGTC
GACGGCGTCGACGCGGCCATCGCCCACGTCAACGAATACGGCTCCGGTCACACCGAGGCCATCGTCACCGCCGATCTTGC
TGCCGCGCAACGGTTCACCGAACGGGTGGACGCGGCCGCGGTGATGGTCAACGCCTCGACGGCGTTCACCGACGGTGAGC
AGTTCGGATTCGGCGCCGAGATCGGCATCTCCACCCAGAAGCTGCACGCCCGCGGCCCGATGGGTCTGCCAGAATTGACG
TCAACCAAGTGGATTGTCTGGGGAGACGGCCACACCCGCCCTGCCTGA

Upstream 100 bases:

>100_bases
GACACGCGCCGCCGCCATGGGCGTAACGCTAGACCAGCGGTGGACGGCGGTGACCCTGACACGCGTCGGCCGGCCCCGCC
ACCTTCGATACGCTGGACTG

Downstream 100 bases:

>100_bases
TACAGGAGATGTGATTTGAGCGTCCCCGCACGTCCCGCGCCGCTGTTCGCCGACATCGACGACGTCGCGCGCCGGCTCGC
CGAGACCGGATACCTGCCCG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MSVHAPAAPDLRTEVHDAARRARVASRTLATLSTETKNRALRAAADRVLMDAHLIIAGNERDLEKARAAGTPDAMLDRLA
LNPQRIDGVAAGLRQVASLPDPVGEVLRGNTLVNGLQLRQQRVPLGVVGIVYEGRPNVTVDAFGLTLKSGNAVLLRGSSS
AAHSNAALVDSLRAALVAEGLDANAVQLLPSHDRASVTHLIQARGLVDVVIPRGGAGLIDAVVRDAQVPTIETGVGNCHV
YVHSAADLDMAETILLNAKTRRPSVCNAAESVLIDAAIAEEAVPRLTKALQDAGVTVHADPTEEELRAEFLSMDIALAVV
DGVDAAIAHVNEYGSGHTEAIVTADLAAAQRFTERVDAAAVMVNASTAFTDGEQFGFGAEIGISTQKLHARGPMGLPELT
STKWIVWGDGHTRPA

Sequences:

>Translated_415_residues
MSVHAPAAPDLRTEVHDAARRARVASRTLATLSTETKNRALRAAADRVLMDAHLIIAGNERDLEKARAAGTPDAMLDRLA
LNPQRIDGVAAGLRQVASLPDPVGEVLRGNTLVNGLQLRQQRVPLGVVGIVYEGRPNVTVDAFGLTLKSGNAVLLRGSSS
AAHSNAALVDSLRAALVAEGLDANAVQLLPSHDRASVTHLIQARGLVDVVIPRGGAGLIDAVVRDAQVPTIETGVGNCHV
YVHSAADLDMAETILLNAKTRRPSVCNAAESVLIDAAIAEEAVPRLTKALQDAGVTVHADPTEEELRAEFLSMDIALAVV
DGVDAAIAHVNEYGSGHTEAIVTADLAAAQRFTERVDAAAVMVNASTAFTDGEQFGFGAEIGISTQKLHARGPMGLPELT
STKWIVWGDGHTRPA
>Mature_414_residues
SVHAPAAPDLRTEVHDAARRARVASRTLATLSTETKNRALRAAADRVLMDAHLIIAGNERDLEKARAAGTPDAMLDRLAL
NPQRIDGVAAGLRQVASLPDPVGEVLRGNTLVNGLQLRQQRVPLGVVGIVYEGRPNVTVDAFGLTLKSGNAVLLRGSSSA
AHSNAALVDSLRAALVAEGLDANAVQLLPSHDRASVTHLIQARGLVDVVIPRGGAGLIDAVVRDAQVPTIETGVGNCHVY
VHSAADLDMAETILLNAKTRRPSVCNAAESVLIDAAIAEEAVPRLTKALQDAGVTVHADPTEEELRAEFLSMDIALAVVD
GVDAAIAHVNEYGSGHTEAIVTADLAAAQRFTERVDAAAVMVNASTAFTDGEQFGFGAEIGISTQKLHARGPMGLPELTS
TKWIVWGDGHTRPA

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=421, Percent_Identity=36.5795724465558, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI21361368, Length=421, Percent_Identity=36.5795724465558, Blast_Score=249, Evalue=3e-66,
Organism=Escherichia coli, GI1786438, Length=408, Percent_Identity=47.3039215686275, Blast_Score=372, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17569969, Length=412, Percent_Identity=36.8932038834951, Blast_Score=257, Evalue=6e-69,
Organism=Caenorhabditis elegans, GI17569967, Length=412, Percent_Identity=36.8932038834951, Blast_Score=257, Evalue=8e-69,
Organism=Saccharomyces cerevisiae, GI6324899, Length=428, Percent_Identity=35.2803738317757, Blast_Score=246, Evalue=4e-66,
Organism=Drosophila melanogaster, GI21357643, Length=407, Percent_Identity=35.8722358722359, Blast_Score=253, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_MYCSJ (A3Q2E3)

Other databases:

- EMBL:   CP000580
- RefSeq:   YP_001071811.1
- ProteinModelPortal:   A3Q2E3
- SMR:   A3Q2E3
- STRING:   A3Q2E3
- EnsemblBacteria:   EBMYCT00000050780
- GeneID:   4879254
- GenomeReviews:   CP000580_GR
- KEGG:   mjl:Mjls_3543
- eggNOG:   COG0014
- GeneTree:   EBGT00050000015663
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- PhylomeDB:   A3Q2E3
- ProtClustDB:   PRK00197
- BioCyc:   MSP164757:MJLS_3543-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 43483; Mature: 43352

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVHAPAAPDLRTEVHDAARRARVASRTLATLSTETKNRALRAAADRVLMDAHLIIAGNE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCC
RDLEKARAAGTPDAMLDRLALNPQRIDGVAAGLRQVASLPDPVGEVLRGNTLVNGLQLRQ
HHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHH
QRVPLGVVGIVYEGRPNVTVDAFGLTLKSGNAVLLRGSSSAAHSNAALVDSLRAALVAEG
HCCCEEEEEEEEECCCCEEEEEEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHCC
LDANAVQLLPSHDRASVTHLIQARGLVDVVIPRGGAGLIDAVVRDAQVPTIETGVGNCHV
CCCCEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCCEEECCCCEEEE
YVHSAADLDMAETILLNAKTRRPSVCNAAESVLIDAAIAEEAVPRLTKALQDAGVTVHAD
EEEECCCCCHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
PTEEELRAEFLSMDIALAVVDGVDAAIAHVNEYGSGHTEAIVTADLAAAQRFTERVDAAA
CCHHHHHHHHHHHHEEEEEECCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHEE
VMVNASTAFTDGEQFGFGAEIGISTQKLHARGPMGLPELTSTKWIVWGDGHTRPA
EEEECCCEECCCCCCCCCCEECCCHHHEECCCCCCCCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
SVHAPAAPDLRTEVHDAARRARVASRTLATLSTETKNRALRAAADRVLMDAHLIIAGNE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCC
RDLEKARAAGTPDAMLDRLALNPQRIDGVAAGLRQVASLPDPVGEVLRGNTLVNGLQLRQ
HHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHH
QRVPLGVVGIVYEGRPNVTVDAFGLTLKSGNAVLLRGSSSAAHSNAALVDSLRAALVAEG
HCCCEEEEEEEEECCCCEEEEEEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHCC
LDANAVQLLPSHDRASVTHLIQARGLVDVVIPRGGAGLIDAVVRDAQVPTIETGVGNCHV
CCCCEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCCEEECCCCEEEE
YVHSAADLDMAETILLNAKTRRPSVCNAAESVLIDAAIAEEAVPRLTKALQDAGVTVHAD
EEEECCCCCHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
PTEEELRAEFLSMDIALAVVDGVDAAIAHVNEYGSGHTEAIVTADLAAAQRFTERVDAAA
CCHHHHHHHHHHHHEEEEEECCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHEE
VMVNASTAFTDGEQFGFGAEIGISTQKLHARGPMGLPELTSTKWIVWGDGHTRPA
EEEECCCEECCCCCCCCCCEECCCHHHEECCCCCCCCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA