| Definition | Mycobacterium sp. MCS chromosome, complete genome. |
|---|---|
| Accession | NC_008146 |
| Length | 5,705,448 |
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The map label for this gene is lepA
Identifier: 108800459
GI number: 108800459
Start: 3720821
End: 3722740
Strand: Reverse
Name: lepA
Synonym: Mmcs_3493
Alternate gene names: 108800459
Gene position: 3722740-3720821 (Counterclockwise)
Preceding gene: 108800463
Following gene: 108800458
Centisome position: 65.25
GC content: 66.77
Gene sequence:
>1920_bases TTGTGCCGTCGGGCACCACGGTCGATACCCTTGAGGTGCGCACACGCGCCCCGTCGCGACGTCTACCAGGAGATTCCCAT CAGCAGCTTCGCCGACCAGACCTTCACCGCGCCGGCGCAGATTCGGAACTTCTGCATCATCGCGCACATCGACCACGGCA AGTCCACGCTGGCCGACCGGATGCTGGGCATCACCGGCGTCGTCGCGGATCGCGACATGCGCGCGCAGTACCTCGACCGG ATGGACATCGAGCGGGAGCGCGGCATCACGATCAAGGCGCAGAACGTGCGGCTGCCGTGGGAGGTCAACGGAGAGAAGTT CGTCCTGCACCTCATCGACACCCCCGGCCACGTCGACTTCACCTACGAGGTGTCCCGTGCGCTGGAGGCGTGCGAGGGCG CGATCCTGCTGGTCGACGCCGCCCAGGGCATCGAGGCGCAGACGCTGGCCAACCTGTACCTGGCGTTGGACCGCGACCTG GCCATCATCCCGGTGCTCAACAAGATCGACCTGCCCGCGGCCGACCCGGACCGCTACGCCGGCGAACTGGCCCACATCAT CGGCTGCGAACCGTCCGATGTCCTGCGGGTCTCCGGTAAGACCGGCGCAGGCGTCAGGGAACTGCTCGACGAGGTGGTGC GGCTGGTGCCGCCGCCGACCGGCGACGCCGATGCCCCGGCCCGCGCCATGATCTTCGACTCCGTCTACGACATCTACCGC GGCGTGGTCACCTACGTCCGCGTCGTCGACGGCAAGATCACCCCCCGCGAGCGCATCGCGATGATGTCGACCGGTGCCAC CCACGAGCTGCTCGAGGTCGGCATCGTCTCGCCCGATCCCAAACCCTCGGCCGGTCTGGGTGTCGGAGAGGTCGGCTACC TGATCACCGGCGTGAAGGACGTCCGCCAGTCGAAGGTCGGTGACACCGTCACGACCGCCCGCCACGGCGCGAAGGAGGCC CTCACCGGGTACCGCGAGCCGCGGCCGATGGTCTACTCCGGCCTGTATCCGGTCGACGGGTCCGACTACCCGGTGCTGCG CGAGGCGCTGGACAAACTGCAGCTCAACGACGCGGCGCTGACGTACGAACCCGAGACCTCGGTGGCGCTGGGCTTCGGGT TCCGCTGCGGCTTCCTCGGCCTGCTGCACATGGAGATCACCCGTGAACGCCTCGAGCGCGAGTTCAACCTCGACCTGATC TCGACGGCGCCCAACGTGGTCTACCGCGTCGAGAAGGACGACGGTACCGAGATCGTGGTCACGAACCCGTCGGACTGGCC CGAGGGCAAGGTCCGCACCGTCTACGAACCGGTCGTGAAGACCACCGTGATCGCGCCGAGCGAGTTCATCGGCACCATCA TGGAGCTCTGTCAGTCCCGCCGCGGCGAACTCGGCGGCATGGACTACCTGTCGCCCGAGCGCGTGGAGCTGCGCTACACG ATGCCGTTGGGCGAGATCATCTTCGACTTCTTCGACTCGCTGAAGTCCCGCACCCGCGGCTACGCCAGCCTCGACTACGA GGAGGCAGGCGAACAGGAGGCCGACCTGGTCAAGGTCGACATCCTGTTGCAGGGTGAGGCCGTCGACGCGTTCAGCGCGA TCGTGCACAAGGACGGTGCGTCGGCTTACGGCAACAAGATGACCACCAAGCTCAAGGAACTGATCCCGCGTCAGCAGTTC GAAGTGCCCGTCCAGGCGGCCGTCGGCTCGAGGATCATCGCCCGCGAGAACATCCGCGCCATCCGCAAGGACGTGCTGTC CAAGTGCTACGGCGGTGACATCACCCGGAAGCGCAAACTGCTCGAGAAGCAGAAGGAAGGCAAGAAGCGGATGAAGACCA TCGGCCGGGTCGACGTCCCGCAGGAGGCGTTCGTCGCCGCGCTGTCCACCGACGCCGCCGGGGACAAACCCAAGAAGTAG
Upstream 100 bases:
>100_bases CTTCGGCGCCTCCTGGAACACCAGTTTCTCCGCCAACCGCTGAAACGTCTTCCATTGCGACGCCATGTTTTCGAGCATAG TTCAGGAAGGGCGGGCGCGA
Downstream 100 bases:
>100_bases CCCGAACGGTCGCACCGGCCGCGTCCGCGTGCTAGAGAAAGGCATGCGCACACCACGCCTGGCCGCGATGCTGGCCGGCG CGTGTCTGCTCTCGGCCGGT
Product: GTP-binding protein LepA
Products: NA
Alternate protein names: EF-4; Ribosomal back-translocase LepA
Number of amino acids: Translated: 639; Mature: 639
Protein sequence:
>639_residues MCRRAPRSIPLRCAHAPRRDVYQEIPISSFADQTFTAPAQIRNFCIIAHIDHGKSTLADRMLGITGVVADRDMRAQYLDR MDIERERGITIKAQNVRLPWEVNGEKFVLHLIDTPGHVDFTYEVSRALEACEGAILLVDAAQGIEAQTLANLYLALDRDL AIIPVLNKIDLPAADPDRYAGELAHIIGCEPSDVLRVSGKTGAGVRELLDEVVRLVPPPTGDADAPARAMIFDSVYDIYR GVVTYVRVVDGKITPRERIAMMSTGATHELLEVGIVSPDPKPSAGLGVGEVGYLITGVKDVRQSKVGDTVTTARHGAKEA LTGYREPRPMVYSGLYPVDGSDYPVLREALDKLQLNDAALTYEPETSVALGFGFRCGFLGLLHMEITRERLEREFNLDLI STAPNVVYRVEKDDGTEIVVTNPSDWPEGKVRTVYEPVVKTTVIAPSEFIGTIMELCQSRRGELGGMDYLSPERVELRYT MPLGEIIFDFFDSLKSRTRGYASLDYEEAGEQEADLVKVDILLQGEAVDAFSAIVHKDGASAYGNKMTTKLKELIPRQQF EVPVQAAVGSRIIARENIRAIRKDVLSKCYGGDITRKRKLLEKQKEGKKRMKTIGRVDVPQEAFVAALSTDAAGDKPKK
Sequences:
>Translated_639_residues MCRRAPRSIPLRCAHAPRRDVYQEIPISSFADQTFTAPAQIRNFCIIAHIDHGKSTLADRMLGITGVVADRDMRAQYLDR MDIERERGITIKAQNVRLPWEVNGEKFVLHLIDTPGHVDFTYEVSRALEACEGAILLVDAAQGIEAQTLANLYLALDRDL AIIPVLNKIDLPAADPDRYAGELAHIIGCEPSDVLRVSGKTGAGVRELLDEVVRLVPPPTGDADAPARAMIFDSVYDIYR GVVTYVRVVDGKITPRERIAMMSTGATHELLEVGIVSPDPKPSAGLGVGEVGYLITGVKDVRQSKVGDTVTTARHGAKEA LTGYREPRPMVYSGLYPVDGSDYPVLREALDKLQLNDAALTYEPETSVALGFGFRCGFLGLLHMEITRERLEREFNLDLI STAPNVVYRVEKDDGTEIVVTNPSDWPEGKVRTVYEPVVKTTVIAPSEFIGTIMELCQSRRGELGGMDYLSPERVELRYT MPLGEIIFDFFDSLKSRTRGYASLDYEEAGEQEADLVKVDILLQGEAVDAFSAIVHKDGASAYGNKMTTKLKELIPRQQF EVPVQAAVGSRIIARENIRAIRKDVLSKCYGGDITRKRKLLEKQKEGKKRMKTIGRVDVPQEAFVAALSTDAAGDKPKK >Mature_639_residues MCRRAPRSIPLRCAHAPRRDVYQEIPISSFADQTFTAPAQIRNFCIIAHIDHGKSTLADRMLGITGVVADRDMRAQYLDR MDIERERGITIKAQNVRLPWEVNGEKFVLHLIDTPGHVDFTYEVSRALEACEGAILLVDAAQGIEAQTLANLYLALDRDL AIIPVLNKIDLPAADPDRYAGELAHIIGCEPSDVLRVSGKTGAGVRELLDEVVRLVPPPTGDADAPARAMIFDSVYDIYR GVVTYVRVVDGKITPRERIAMMSTGATHELLEVGIVSPDPKPSAGLGVGEVGYLITGVKDVRQSKVGDTVTTARHGAKEA LTGYREPRPMVYSGLYPVDGSDYPVLREALDKLQLNDAALTYEPETSVALGFGFRCGFLGLLHMEITRERLEREFNLDLI STAPNVVYRVEKDDGTEIVVTNPSDWPEGKVRTVYEPVVKTTVIAPSEFIGTIMELCQSRRGELGGMDYLSPERVELRYT MPLGEIIFDFFDSLKSRTRGYASLDYEEAGEQEADLVKVDILLQGEAVDAFSAIVHKDGASAYGNKMTTKLKELIPRQQF EVPVQAAVGSRIIARENIRAIRKDVLSKCYGGDITRKRKLLEKQKEGKKRMKTIGRVDVPQEAFVAALSTDAAGDKPKK
Specific function: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- transloc
COG id: COG0481
COG function: function code M; Membrane GTPase LepA
Gene ontology:
Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the GTP-binding elongation factor family. LepA subfamily
Homologues:
Organism=Homo sapiens, GI157426893, Length=603, Percent_Identity=47.0978441127695, Blast_Score=609, Evalue=1e-174, Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=42.8571428571429, Blast_Score=121, Evalue=2e-27, Organism=Homo sapiens, GI310132016, Length=110, Percent_Identity=40, Blast_Score=101, Evalue=3e-21, Organism=Homo sapiens, GI310110807, Length=110, Percent_Identity=40, Blast_Score=101, Evalue=3e-21, Organism=Homo sapiens, GI310123363, Length=110, Percent_Identity=40, Blast_Score=101, Evalue=3e-21, Organism=Homo sapiens, GI18390331, Length=146, Percent_Identity=39.041095890411, Blast_Score=100, Evalue=3e-21, Organism=Homo sapiens, GI4503483, Length=145, Percent_Identity=37.9310344827586, Blast_Score=100, Evalue=4e-21, Organism=Homo sapiens, GI25306287, Length=147, Percent_Identity=44.2176870748299, Blast_Score=97, Evalue=3e-20, Organism=Homo sapiens, GI19923640, Length=147, Percent_Identity=44.2176870748299, Blast_Score=97, Evalue=4e-20, Organism=Homo sapiens, GI25306283, Length=147, Percent_Identity=44.2176870748299, Blast_Score=97, Evalue=4e-20, Organism=Homo sapiens, GI217272892, Length=134, Percent_Identity=34.3283582089552, Blast_Score=81, Evalue=3e-15, Organism=Homo sapiens, GI217272894, Length=134, Percent_Identity=34.3283582089552, Blast_Score=81, Evalue=3e-15, Organism=Homo sapiens, GI53729339, Length=268, Percent_Identity=29.1044776119403, Blast_Score=75, Evalue=1e-13, Organism=Homo sapiens, GI53729337, Length=268, Percent_Identity=29.1044776119403, Blast_Score=75, Evalue=1e-13, Organism=Escherichia coli, GI1788922, Length=593, Percent_Identity=53.9629005059022, Blast_Score=629, Evalue=0.0, Organism=Escherichia coli, GI48994988, Length=487, Percent_Identity=28.7474332648871, Blast_Score=143, Evalue=3e-35, Organism=Escherichia coli, GI1789738, Length=187, Percent_Identity=33.1550802139037, Blast_Score=88, Evalue=2e-18, Organism=Escherichia coli, GI1790835, Length=181, Percent_Identity=32.5966850828729, Blast_Score=86, Evalue=6e-18, Organism=Escherichia coli, GI1789559, Length=307, Percent_Identity=28.0130293159609, Blast_Score=77, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17557151, Length=615, Percent_Identity=41.3008130081301, Blast_Score=467, Evalue=1e-132, Organism=Caenorhabditis elegans, GI71988811, Length=137, Percent_Identity=40.8759124087591, Blast_Score=103, Evalue=3e-22, Organism=Caenorhabditis elegans, GI71988819, Length=137, Percent_Identity=40.8759124087591, Blast_Score=103, Evalue=4e-22, Organism=Caenorhabditis elegans, GI17556745, Length=153, Percent_Identity=35.2941176470588, Blast_Score=96, Evalue=5e-20, Organism=Caenorhabditis elegans, GI17533571, Length=144, Percent_Identity=39.5833333333333, Blast_Score=94, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17506493, Length=156, Percent_Identity=35.2564102564103, Blast_Score=93, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17552882, Length=149, Percent_Identity=32.8859060402685, Blast_Score=82, Evalue=8e-16, Organism=Saccharomyces cerevisiae, GI6323320, Length=597, Percent_Identity=45.2261306532663, Blast_Score=537, Evalue=1e-153, Organism=Saccharomyces cerevisiae, GI6323098, Length=150, Percent_Identity=38.6666666666667, Blast_Score=108, Evalue=3e-24, Organism=Saccharomyces cerevisiae, GI6322359, Length=113, Percent_Identity=45.1327433628319, Blast_Score=106, Evalue=1e-23, Organism=Saccharomyces cerevisiae, GI6324707, Length=144, Percent_Identity=38.8888888888889, Blast_Score=102, Evalue=1e-22, Organism=Saccharomyces cerevisiae, GI6320593, Length=144, Percent_Identity=38.8888888888889, Blast_Score=102, Evalue=1e-22, Organism=Saccharomyces cerevisiae, GI6324166, Length=144, Percent_Identity=40.2777777777778, Blast_Score=92, Evalue=3e-19, Organism=Saccharomyces cerevisiae, GI6325337, Length=329, Percent_Identity=26.1398176291793, Blast_Score=64, Evalue=9e-11, Organism=Saccharomyces cerevisiae, GI6319594, Length=329, Percent_Identity=26.1398176291793, Blast_Score=64, Evalue=9e-11, Organism=Drosophila melanogaster, GI78706572, Length=598, Percent_Identity=44.4816053511706, Blast_Score=538, Evalue=1e-153, Organism=Drosophila melanogaster, GI28574573, Length=137, Percent_Identity=43.0656934306569, Blast_Score=108, Evalue=2e-23, Organism=Drosophila melanogaster, GI24582462, Length=150, Percent_Identity=37.3333333333333, Blast_Score=101, Evalue=1e-21, Organism=Drosophila melanogaster, GI24585709, Length=148, Percent_Identity=35.8108108108108, Blast_Score=94, Evalue=4e-19, Organism=Drosophila melanogaster, GI24585711, Length=148, Percent_Identity=35.8108108108108, Blast_Score=94, Evalue=4e-19, Organism=Drosophila melanogaster, GI24585713, Length=148, Percent_Identity=35.8108108108108, Blast_Score=94, Evalue=4e-19, Organism=Drosophila melanogaster, GI221458488, Length=156, Percent_Identity=37.1794871794872, Blast_Score=89, Evalue=1e-17, Organism=Drosophila melanogaster, GI21357743, Length=146, Percent_Identity=34.9315068493151, Blast_Score=87, Evalue=4e-17,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): LEPA_MYCSJ (A3Q2A6)
Other databases:
- EMBL: CP000580 - RefSeq: YP_001071774.1 - ProteinModelPortal: A3Q2A6 - SMR: A3Q2A6 - STRING: A3Q2A6 - EnsemblBacteria: EBMYCT00000050456 - GeneID: 4879217 - GenomeReviews: CP000580_GR - KEGG: mjl:Mjls_3506 - eggNOG: COG0481 - GeneTree: EBGT00050000015348 - HOGENOM: HBG286375 - OMA: YDSYRGV - PhylomeDB: A3Q2A6 - ProtClustDB: PRK05433 - BioCyc: MSP164757:MJLS_3506-MONOMER - GO: GO:0006412 - HAMAP: MF_00071 - InterPro: IPR009022 - InterPro: IPR006297 - InterPro: IPR013842 - InterPro: IPR000795 - InterPro: IPR005225 - InterPro: IPR000640 - InterPro: IPR009000 - Gene3D: G3DSA:3.30.70.240 - PRINTS: PR00315 - SMART: SM00838 - TIGRFAMs: TIGR01393 - TIGRFAMs: TIGR00231
Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF06421 LepA_C; SSF54980 EFG_III_V; SSF50447 Translat_factor
EC number: NA
Molecular weight: Translated: 70588; Mature: 70588
Theoretical pI: Translated: 5.63; Mature: 5.63
Prosite motif: PS00301 EFACTOR_GTP
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MCRRAPRSIPLRCAHAPRRDVYQEIPISSFADQTFTAPAQIRNFCIIAHIDHGKSTLADR CCCCCCCCCCEEECCCCHHHHHHHCCCCHHCCCCCCCHHHHCCEEEEEEECCCHHHHHHH MLGITGVVADRDMRAQYLDRMDIERERGITIKAQNVRLPWEVNGEKFVLHLIDTPGHVDF HHHHHHEECCCHHHHHHHHHHCCHHHCCCEEEECCEECCEEECCCEEEEEEECCCCCEEE TYEVSRALEACEGAILLVDAAQGIEAQTLANLYLALDRDLAIIPVLNKIDLPAADPDRYA EHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHH GELAHIIGCEPSDVLRVSGKTGAGVRELLDEVVRLVPPPTGDADAPARAMIFDSVYDIYR HHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH GVVTYVRVVDGKITPRERIAMMSTGATHELLEVGIVSPDPKPSAGLGVGEVGYLITGVKD HHHHHHHHHCCCCCHHHHHEECCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCHHH VRQSKVGDTVTTARHGAKEALTGYREPRPMVYSGLYPVDGSDYPVLREALDKLQLNDAAL HHHHHCCCHHHHHHCCHHHHHHCCCCCCCEEEECEECCCCCCCHHHHHHHHHHCCCCCEE TYEPETSVALGFGFRCGFLGLLHMEITRERLEREFNLDLISTAPNVVYRVEKDDGTEIVV EECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCEEEE TNPSDWPEGKVRTVYEPVVKTTVIAPSEFIGTIMELCQSRRGELGGMDYLSPERVELRYT ECCCCCCCCCCHHHHHHHHHHEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE MPLGEIIFDFFDSLKSRTRGYASLDYEEAGEQEADLVKVDILLQGEAVDAFSAIVHKDGA CCHHHHHHHHHHHHHHHCCCCEECCHHHCCCCCCCEEEEEEEEECCHHHHHHHHHHCCCC SAYGNKMTTKLKELIPRQQFEVPVQAAVGSRIIARENIRAIRKDVLSKCYGGDITRKRKL CHHCHHHHHHHHHHCCHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH LEKQKEGKKRMKTIGRVDVPQEAFVAALSTDAAGDKPKK HHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCC >Mature Secondary Structure MCRRAPRSIPLRCAHAPRRDVYQEIPISSFADQTFTAPAQIRNFCIIAHIDHGKSTLADR CCCCCCCCCCEEECCCCHHHHHHHCCCCHHCCCCCCCHHHHCCEEEEEEECCCHHHHHHH MLGITGVVADRDMRAQYLDRMDIERERGITIKAQNVRLPWEVNGEKFVLHLIDTPGHVDF HHHHHHEECCCHHHHHHHHHHCCHHHCCCEEEECCEECCEEECCCEEEEEEECCCCCEEE TYEVSRALEACEGAILLVDAAQGIEAQTLANLYLALDRDLAIIPVLNKIDLPAADPDRYA EHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHH GELAHIIGCEPSDVLRVSGKTGAGVRELLDEVVRLVPPPTGDADAPARAMIFDSVYDIYR HHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH GVVTYVRVVDGKITPRERIAMMSTGATHELLEVGIVSPDPKPSAGLGVGEVGYLITGVKD HHHHHHHHHCCCCCHHHHHEECCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCHHH VRQSKVGDTVTTARHGAKEALTGYREPRPMVYSGLYPVDGSDYPVLREALDKLQLNDAAL HHHHHCCCHHHHHHCCHHHHHHCCCCCCCEEEECEECCCCCCCHHHHHHHHHHCCCCCEE TYEPETSVALGFGFRCGFLGLLHMEITRERLEREFNLDLISTAPNVVYRVEKDDGTEIVV EECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCEEEE TNPSDWPEGKVRTVYEPVVKTTVIAPSEFIGTIMELCQSRRGELGGMDYLSPERVELRYT ECCCCCCCCCCHHHHHHHHHHEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE MPLGEIIFDFFDSLKSRTRGYASLDYEEAGEQEADLVKVDILLQGEAVDAFSAIVHKDGA CCHHHHHHHHHHHHHHHCCCCEECCHHHCCCCCCCEEEEEEEEECCHHHHHHHHHHCCCC SAYGNKMTTKLKELIPRQQFEVPVQAAVGSRIIARENIRAIRKDVLSKCYGGDITRKRKL CHHCHHHHHHHHHHCCHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH LEKQKEGKKRMKTIGRVDVPQEAFVAALSTDAAGDKPKK HHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: NA