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The map label for this gene is gltC [H]

Identifier: 108800455

GI number: 108800455

Start: 3717270

End: 3718241

Strand: Reverse

Name: gltC [H]

Synonym: Mmcs_3489

Alternate gene names: 108800455

Gene position: 3718241-3717270 (Counterclockwise)

Preceding gene: 108800456

Following gene: 108800454

Centisome position: 65.17

GC content: 71.91

Gene sequence:

>972_bases
GTGCCGCCGTACGGTCACAACGTGTTCGATGTCCGCCGGCTCGTGGTGTTGCGCGAAGTGGTGCGCTGCGGCTCGCTCAG
CGCGGCGGCGGTGTCGTTGAACTACACCACGTCCGCGGTCTCCCAGCAGATCACGGCGCTGGAACGGGATGTCGGCGCCA
AACTGCTCGAGCGGGGTCCGTCCGGTACCCGTGTCACCGCGGCGGGCACCCGGCTGCTCGAACACACCGACGTGATCCTG
GGCGCCGTCACCGCTGCCGAACAGGATTTGGCACGGGCGGCATCGGCGGTGCCCGACACGCTGCGCGTCGCCTCGTTCAG
CAGCGCCGCCGCGACGATCCTGCCGCGGGTGATCACCCGGCTCCGGCATGAATATCCCACCACCGGAATCGAATTGGTGA
CCGCCGATCCGGACGACGGGGTGGCGCTGCTGGGCGCCGACGGTGCGGACGCGGCCATGGTCACCGAGGTGCCCGGCGAG
CCGCCGGAATTCCGGGGGGTGTACACCGTGCCCGTCTACGACGACGAGTTCTTCGTGGTGCTGCCCCGTGACCATCGATT
CGCCGCTGCGGTGGAGGTGCCCTTCGAGGCGCTGGCCGCCGAGCGGTGGGTGGTGAGCACCGCGACGGGCACCTGCCCCG
ACACCCGGGTGTTCCACACCGCCTGCCGGCGTGCGGGTTTCGATCCGCAGGTGACCTTCCGCGCCGACGACTACGGCACG
GTGCAGGGGATGGTCGCCGCCGGCATGGGTGTCTCACTCGTCCCGTCGCTGGCCGCGTGGGCAGCGCGCGGCGACGTCGC
GGTGCGCCGGCTCACTCACCGGCCGGTGCGCCGGGTCGCCGTGGCGACCGCCGCGGAGCCCGCCGCGGCCTCGGCGCTGG
CGCGGTTGGTGTCGCTCATGGCGGACACCGGCGCGCGACTGCGGGCCCGCGGTGTATTCAGTGTTCCTGCAAGCCCTTCC
AGCGTCGCTTGA

Upstream 100 bases:

>100_bases
GGAAGTCGCGCACCCGGGCGCATCCCGACGTCGCCGAACTGCATCACGGCATCACCCGGTGATTGCGTCGGCCTGATCGC
AATGCTGTCGGCGCCTCGCG

Downstream 100 bases:

>100_bases
ACCGTCTTCCGCCGCACCGGAGTCACCCCTACCGTCGCACTGAACGGCCATCGACGAAAGGACCCACCCCCGATGACCAT
CACGCCCGAGACCACCGCCC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MPPYGHNVFDVRRLVVLREVVRCGSLSAAAVSLNYTTSAVSQQITALERDVGAKLLERGPSGTRVTAAGTRLLEHTDVIL
GAVTAAEQDLARAASAVPDTLRVASFSSAAATILPRVITRLRHEYPTTGIELVTADPDDGVALLGADGADAAMVTEVPGE
PPEFRGVYTVPVYDDEFFVVLPRDHRFAAAVEVPFEALAAERWVVSTATGTCPDTRVFHTACRRAGFDPQVTFRADDYGT
VQGMVAAGMGVSLVPSLAAWAARGDVAVRRLTHRPVRRVAVATAAEPAAASALARLVSLMADTGARLRARGVFSVPASPS
SVA

Sequences:

>Translated_323_residues
MPPYGHNVFDVRRLVVLREVVRCGSLSAAAVSLNYTTSAVSQQITALERDVGAKLLERGPSGTRVTAAGTRLLEHTDVIL
GAVTAAEQDLARAASAVPDTLRVASFSSAAATILPRVITRLRHEYPTTGIELVTADPDDGVALLGADGADAAMVTEVPGE
PPEFRGVYTVPVYDDEFFVVLPRDHRFAAAVEVPFEALAAERWVVSTATGTCPDTRVFHTACRRAGFDPQVTFRADDYGT
VQGMVAAGMGVSLVPSLAAWAARGDVAVRRLTHRPVRRVAVATAAEPAAASALARLVSLMADTGARLRARGVFSVPASPS
SVA
>Mature_322_residues
PPYGHNVFDVRRLVVLREVVRCGSLSAAAVSLNYTTSAVSQQITALERDVGAKLLERGPSGTRVTAAGTRLLEHTDVILG
AVTAAEQDLARAASAVPDTLRVASFSSAAATILPRVITRLRHEYPTTGIELVTADPDDGVALLGADGADAAMVTEVPGEP
PEFRGVYTVPVYDDEFFVVLPRDHRFAAAVEVPFEALAAERWVVSTATGTCPDTRVFHTACRRAGFDPQVTFRADDYGTV
QGMVAAGMGVSLVPSLAAWAARGDVAVRRLTHRPVRRVAVATAAEPAAASALARLVSLMADTGARLRARGVFSVPASPSS
VA

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=252, Percent_Identity=27.3809523809524, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790262, Length=251, Percent_Identity=27.0916334661355, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788748, Length=305, Percent_Identity=25.9016393442623, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI2367136, Length=249, Percent_Identity=26.1044176706827, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787879, Length=253, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87081904, Length=124, Percent_Identity=33.0645161290323, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787530, Length=250, Percent_Identity=25.2, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1787601, Length=183, Percent_Identity=25.1366120218579, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788296, Length=249, Percent_Identity=24.0963855421687, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789639, Length=143, Percent_Identity=30.0699300699301, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788887, Length=263, Percent_Identity=25.0950570342205, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788481, Length=201, Percent_Identity=29.8507462686567, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI157672245, Length=254, Percent_Identity=23.6220472440945, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33971; Mature: 33840

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPYGHNVFDVRRLVVLREVVRCGSLSAAAVSLNYTTSAVSQQITALERDVGAKLLERGP
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
SGTRVTAAGTRLLEHTDVILGAVTAAEQDLARAASAVPDTLRVASFSSAAATILPRVITR
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHH
LRHEYPTTGIELVTADPDDGVALLGADGADAAMVTEVPGEPPEFRGVYTVPVYDDEFFVV
HHHHCCCCCEEEEEECCCCCEEEEECCCCCCEEEECCCCCCCCCCCEEEEEEECCCEEEE
LPRDHRFAAAVEVPFEALAAERWVVSTATGTCPDTRVFHTACRRAGFDPQVTFRADDYGT
ECCCCCEEEEEECCHHHHHHCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCH
VQGMVAAGMGVSLVPSLAAWAARGDVAVRRLTHRPVRRVAVATAAEPAAASALARLVSLM
HHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ADTGARLRARGVFSVPASPSSVA
HCCCCCEEECEEEECCCCCCCCC
>Mature Secondary Structure 
PPYGHNVFDVRRLVVLREVVRCGSLSAAAVSLNYTTSAVSQQITALERDVGAKLLERGP
CCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
SGTRVTAAGTRLLEHTDVILGAVTAAEQDLARAASAVPDTLRVASFSSAAATILPRVITR
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHH
LRHEYPTTGIELVTADPDDGVALLGADGADAAMVTEVPGEPPEFRGVYTVPVYDDEFFVV
HHHHCCCCCEEEEEECCCCCEEEEECCCCCCEEEECCCCCCCCCCCEEEEEEECCCEEEE
LPRDHRFAAAVEVPFEALAAERWVVSTATGTCPDTRVFHTACRRAGFDPQVTFRADDYGT
ECCCCCEEEEEECCHHHHHHCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCH
VQGMVAAGMGVSLVPSLAAWAARGDVAVRRLTHRPVRRVAVATAAEPAAASALARLVSLM
HHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ADTGARLRARGVFSVPASPSSVA
HCCCCCEEECEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]