Click here to switch to the map view.

The map label for this gene is hemN [H]

Identifier: 108800439

GI number: 108800439

Start: 3699901

End: 3701079

Strand: Reverse

Name: hemN [H]

Synonym: Mmcs_3473

Alternate gene names: 108800439

Gene position: 3701079-3699901 (Counterclockwise)

Preceding gene: 108800445

Following gene: 108800438

Centisome position: 64.87

GC content: 74.47

Gene sequence:

>1179_bases
GTGAGCCTCCGAACCGCCCCCGTACGCGCGCCGGAACTGGCCGCCACCGCGGGTCGGCCGTTCGGCCTCTACATCCACGT
CCCGTTCTGCGCGACCCGCTGCGGCTACTGCGACTTCAACACCTACACCCCGGCGGAGGCGGGCGGGGCCAACCCCGAGG
GCTGGCTGGTCGCGATGCGCCAGGAGTTGGCGCTCGCGGCCCGGACGTTGGGGACGCCGCCGCCGGTGCGGACCGTCTTC
GTCGGCGGTGGCACCCCGTCGCTGCTGGGCGGTGCGGGTCTGACCGCGGTGCTGGCCGCGGTGCGCGAGCACTTCGATCT
GGCGCCCGGCGCCGAGGTCACCACCGAGGCCAACCCGGAGTCGTCGGGACCCGAACTGTTCGACGCGCTGCTGGCCGCCG
GCTACACCCGCGTCTCGCTCGGTATGCAGTCGACGGCCCGCCATGTCCTCAAGGTGCTCGACCGGTTGCATTCCCCCGGC
CGCGCGGTGGCCGCCGCCGGAGAGGCGCGCGCAGCCGGCTTCGGGCACGTCAACCTCGACCTGATCTACGGCACGCCGGG
GGAGACTGACGACGACCTGCGCCGGTCCGCCGACGCCGCGATCGGGGCGGGGGTCGACCACGTGTCGGCCTACGCGCTGG
TGGTCGAGGACGGGACGGCCCTGGCCCGCCGGGTGCGGCGCGGTGAGGTGACCGCCCCCGACGACGACGTGCTGGCGGCG
CGGTACGAACTGCTCGACGCGCGGCTGGGCGAGGCCGGGTTCGACTGGTACGAGGTGTCGAACTGGGCCAGGTCCGGCGG
CGAGTGCCGCCACAACCTCGGCTACTGGGCCGGCGGCGAATGGTGGGGGGTCGGGCCGGGGGCGCACGGCTTCCTGGGCG
ACACCCGGTGGTGGAACGTCAAGCATCCCAACGCCTATGCCACCGCGCTGGGCGACGGGGCACTGCCCGTCTCCGATTTC
GAGGTGCTCGACCCGGCCGCGCGGCACACCGAGGACGTGATGCTGCGGGTGCGGCTGCGCAGCGGTCTGCCGCTGGACAT
GCTGACCGCCGACGAGCGGAGTCGCGTCGGCACCGTGGTGGCCGACGGCCTCGCGGTGGTCGACGGGGCGGCGCTGGTCC
TCACCGACCGTGGCCGCCTGCTCGCCGACGGTGTGGTGCGCACGCTGCTCGCCGACTGA

Upstream 100 bases:

>100_bases
CCGGGCCATATTTGCGCTCGCGGTGAGCAAAAGTCGCCCCAGGCCCCGCGGATCGGCCGCGGGATTACGCCATCTGACGT
CGCGCTGGGACGATGGAGAG

Downstream 100 bases:

>100_bases
ATCCGACCGGAGGTGGTCGCCCCGGATCGGCGCGGCTGTGCCATCATTGCCCGCATGTCGAGGGACTTAGGCAAGGCTAA
CCAATTGGCACCCGGCCTCC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSLRTAPVRAPELAATAGRPFGLYIHVPFCATRCGYCDFNTYTPAEAGGANPEGWLVAMRQELALAARTLGTPPPVRTVF
VGGGTPSLLGGAGLTAVLAAVREHFDLAPGAEVTTEANPESSGPELFDALLAAGYTRVSLGMQSTARHVLKVLDRLHSPG
RAVAAAGEARAAGFGHVNLDLIYGTPGETDDDLRRSADAAIGAGVDHVSAYALVVEDGTALARRVRRGEVTAPDDDVLAA
RYELLDARLGEAGFDWYEVSNWARSGGECRHNLGYWAGGEWWGVGPGAHGFLGDTRWWNVKHPNAYATALGDGALPVSDF
EVLDPAARHTEDVMLRVRLRSGLPLDMLTADERSRVGTVVADGLAVVDGAALVLTDRGRLLADGVVRTLLAD

Sequences:

>Translated_392_residues
MSLRTAPVRAPELAATAGRPFGLYIHVPFCATRCGYCDFNTYTPAEAGGANPEGWLVAMRQELALAARTLGTPPPVRTVF
VGGGTPSLLGGAGLTAVLAAVREHFDLAPGAEVTTEANPESSGPELFDALLAAGYTRVSLGMQSTARHVLKVLDRLHSPG
RAVAAAGEARAAGFGHVNLDLIYGTPGETDDDLRRSADAAIGAGVDHVSAYALVVEDGTALARRVRRGEVTAPDDDVLAA
RYELLDARLGEAGFDWYEVSNWARSGGECRHNLGYWAGGEWWGVGPGAHGFLGDTRWWNVKHPNAYATALGDGALPVSDF
EVLDPAARHTEDVMLRVRLRSGLPLDMLTADERSRVGTVVADGLAVVDGAALVLTDRGRLLADGVVRTLLAD
>Mature_391_residues
SLRTAPVRAPELAATAGRPFGLYIHVPFCATRCGYCDFNTYTPAEAGGANPEGWLVAMRQELALAARTLGTPPPVRTVFV
GGGTPSLLGGAGLTAVLAAVREHFDLAPGAEVTTEANPESSGPELFDALLAAGYTRVSLGMQSTARHVLKVLDRLHSPGR
AVAAAGEARAAGFGHVNLDLIYGTPGETDDDLRRSADAAIGAGVDHVSAYALVVEDGTALARRVRRGEVTAPDDDVLAAR
YELLDARLGEAGFDWYEVSNWARSGGECRHNLGYWAGGEWWGVGPGAHGFLGDTRWWNVKHPNAYATALGDGALPVSDFE
VLDPAARHTEDVMLRVRLRSGLPLDMLTADERSRVGTVVADGLAVVDGAALVLTDRGRLLADGVVRTLLAD

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=274, Percent_Identity=41.6058394160584, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1789325, Length=386, Percent_Identity=32.3834196891192, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI87082341, Length=409, Percent_Identity=25.1833740831296, Blast_Score=120, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 41298; Mature: 41167

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLRTAPVRAPELAATAGRPFGLYIHVPFCATRCGYCDFNTYTPAEAGGANPEGWLVAMR
CCCCCCCCCCCCHHHHCCCCEEEEEECCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
QELALAARTLGTPPPVRTVFVGGGTPSLLGGAGLTAVLAAVREHFDLAPGAEVTTEANPE
HHHHHHHHHCCCCCCCEEEEECCCCCHHHCCCCHHHHHHHHHHHCCCCCCCCEEECCCCC
SSGPELFDALLAAGYTRVSLGMQSTARHVLKVLDRLHSPGRAVAAAGEARAAGFGHVNLD
CCCHHHHHHHHHCCCHHEECCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEE
LIYGTPGETDDDLRRSADAAIGAGVDHVSAYALVVEDGTALARRVRRGEVTAPDDDVLAA
EEECCCCCCHHHHHHHHHHHHCCCCHHHEEEEEEEECCHHHHHHHHCCCCCCCCCHHHHH
RYELLDARLGEAGFDWYEVSNWARSGGECRHNLGYWAGGEWWGVGPGAHGFLGDTRWWNV
HHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHCCCCCCCCCEECCCCCCCCCCCCCCEEEC
KHPNAYATALGDGALPVSDFEVLDPAARHTEDVMLRVRLRSGLPLDMLTADERSRVGTVV
CCCCHHEEECCCCCCCCCCHHHCCHHHHHHHHHEEEEEHHCCCCEEEECCCCHHHCCHHH
ADGLAVVDGAALVLTDRGRLLADGVVRTLLAD
HCCEEEECCCEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SLRTAPVRAPELAATAGRPFGLYIHVPFCATRCGYCDFNTYTPAEAGGANPEGWLVAMR
CCCCCCCCCCCHHHHCCCCEEEEEECCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
QELALAARTLGTPPPVRTVFVGGGTPSLLGGAGLTAVLAAVREHFDLAPGAEVTTEANPE
HHHHHHHHHCCCCCCCEEEEECCCCCHHHCCCCHHHHHHHHHHHCCCCCCCCEEECCCCC
SSGPELFDALLAAGYTRVSLGMQSTARHVLKVLDRLHSPGRAVAAAGEARAAGFGHVNLD
CCCHHHHHHHHHCCCHHEECCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEE
LIYGTPGETDDDLRRSADAAIGAGVDHVSAYALVVEDGTALARRVRRGEVTAPDDDVLAA
EEECCCCCCHHHHHHHHHHHHCCCCHHHEEEEEEEECCHHHHHHHHCCCCCCCCCHHHHH
RYELLDARLGEAGFDWYEVSNWARSGGECRHNLGYWAGGEWWGVGPGAHGFLGDTRWWNV
HHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHCCCCCCCCCEECCCCCCCCCCCCCCEEEC
KHPNAYATALGDGALPVSDFEVLDPAARHTEDVMLRVRLRSGLPLDMLTADERSRVGTVV
CCCCHHEEECCCCCCCCCCHHHCCHHHHHHHHHEEEEEHHCCCCEEEECCCCHHHCCHHH
ADGLAVVDGAALVLTDRGRLLADGVVRTLLAD
HCCEEEECCCEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]