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The map label for this gene is lgrD [H]

Identifier: 108800431

GI number: 108800431

Start: 3674782

End: 3679167

Strand: Reverse

Name: lgrD [H]

Synonym: Mmcs_3465

Alternate gene names: 108800431

Gene position: 3679167-3674782 (Counterclockwise)

Preceding gene: 108800432

Following gene: 108800430

Centisome position: 64.49

GC content: 72.48

Gene sequence:

>4386_bases
GTGACGCGGACCCAGGCCGCTGCCAACGCGATCGAGGACGTGATGGCGCTGAGCCCGCTGCAGCAGGGGCTGTACTCGAT
GACGATGCTCGCGGACTCCGAGCACGCCGACGGCGATCCCCGTCCGGATCCCTACGTGATCGCGATGGCCGCCGACGTCA
CCGGGACGCTGGACACCGCCCTGCTGCGCGACTGCGCGACGGCGCTGCTGACGCGGCATCCGAACCTGCGGGCCGGCTTC
TTCCGCGGTGACCTGCCCCGTCCGGTCCAGGTCGTCCCCGCCCGCGTCGACCTGCCCTGGCAGCATGTGCGCGCCCGGAC
CGCCGAGAAGGCGGCCGAACTCGAGCACCGTGAGCGACGGCGCCCCTTCGACCTCGAACGGGGGCCTGCGATCCGGTTTC
TGCTCATCGAATTGCCGGGTCCTGCTTGGCGATTGGTGATCGTCGCGCACCACATCGTGATCGACGGCTGGTCGCTTCCG
CTGTTCGTCGGCGAAATGCTGACGCTCTACCGCGCCGGCGGGGATCCGGGTGCGCTGGGCGACCCGCCGCGGCCCTACCG
TGACTACATCGGCTGGCTGGCCGGTCGTGACCAGGCGGCGAGTCGGGCGCTGTGGACCGAGCACCTCGCCGGCATCGACG
CTCCGACGCTGCTCACCCCGGCGCTGTCCGCCGTCGAACCCGCCGCCGGGCTGCCGCGGCGCACCGAGGTCGCACTGGAC
GCCGGCGCCAGCCGACGGCTCACCGAGACGGCCCGCTCGCGGGGCGTGACCGTCAACACGCTGGTGCAGATGGCCTGGGC
GGCAATGCTGTCGGTGTTCACCGACCGCCGTGACGTGACGTTCGGGATGACGGTGTCGGGACGCCCGGGTGAACTCGCGG
GCGTCGAGACGATGGTCGGCCTGTTCATCAACACCGTCCCGCTGCGGGTGCGGCTCGACCCGGTGGACACCGTTGGCAGT
CAATGCCTTTCATTGCAGCGCACCGCCGCCGCGCTGCGCGAGCACAGCTACCTCGCCCACTCCGAGCTGCGGGCGCTGGC
CGGGGTGGGGGAGATGTTCGACTCGCTGCTGGTCTACGAGAACTTCCCACCGGGCGGGCTGGTCGGCGGCGACCACCGCT
TCGAAGCCGCCGGCGCCACCTTCATCCCCGCGGCCCTCGAGAGCCTGTCGCACTTCCCGGTCACCATCGCCGCCCACATG
GCCGACGAGCGGTTGACCGTATTGGTGGAGACCCTCGACGGCGCCCTGGGCGCGCTGACCCCGCACGACGTCGGGCAGGG
CCTGCTCGACACGGTCGAGCGGCTGATCGCCCTCTGGGACCGGCCACTTCGCGACGTGCGGATGCTGTCCGGCGACGACC
CTGCGGTGCCGGCTGTCACGGAACCGCCGCCGCGGACCGGCGTGCACTGCGCGTTCACCGAGGCGGCGCGCCGCACCCCG
GATGCGGTCGCGCTCAGCTGGGACGGCGGCACGCTCACCTACCGCGAGGTCGACGCGGCCGCCGACCGGCTGGCCGCCGG
CCTGACCGCACGCGGTGTCGGCGCCGAAACGCCGGTCGCCGTGAGGCTCTCGCGCGGACCCGATTACGTGATCGCGATGC
TTGCCGTCCTCAAGGCGGGCGGCATGATCGTGCCGCTCGATCCCGGCATGGCCGGGGAGCGGATCGAGGAGATCCTGCGC
CAGACTGCGGCGCCCGTCGTCGTCGACGATGCGCTGTCGGCCGGCGTCGGTGCACCCGACGGGGCGTGGGCACCGGCGAC
CGTCGCCCCGGGGCAGGCCGCCTATGCGGTGTTCACCTCCGGCACCACCGGCATCCCCAAGGGTGTGGTCGGCACCCACG
ACGCGGTGCTCGCCTACGCAGACGACCACGCCCGCCACGTCCTACGGCCGGCGGCGACACGGCTGGGCCGTCCGCTCCGG
ATCGCGCACGCCTGGTCGTTCACCTTCGACGCAGCGTGGCAGCCGCTCGTCGCGTTGTTCGAGGGGCATTCGGTGCACAT
CATCGGCGACGCGGTCCAGCGCGATGCCGAAGCGCTGGTCGACACCATCGACCGGTATGACATCGACATGATCGACACCA
CCCCGTCGATGTTCGCTCAGCTCAAGGCTTTCGGGTTGATGTCGCGGGTGCCGCTGGCGGTGCTGGCACTCGGTGGCGAA
GCCGTGGGCTCCGGCGCGTGGCGGTTCATCCGCGAGGAGTGCGCGCGCACCTCGATGACGGCCTTCAACTGTTACGGCCC
CACCGAGACCACCGTGGAGTCCGTCGTCGCCGCCATCGCGGAACACCCCCAGCCGGTGATCGGATCGCCGACCCGCCACG
CCCGCGCCTACGTGCTCGACGCCTGGCTGCGTCCGGTTCCCGACGGCGTCGCGGGGGAGCTCTACCTGTCCGGCGCCCAA
CTGGCCCGCGGCTATCTGGACCGGGCCTGCGAGACGGCAGGCCGGTTCGTCGCAGACCCGTTCCTGGCCGGGAACCGGAT
GTACCGCACCGGCGACGTGGTACGCCGTGACGCCACCGGCGCCCTGCAGTACCTGGGCCGCAGCGACGATCAGGTCAAGA
TCCGCGGCTTCCGGGTCGAACCCGGCGAGGTGTGCGCGGTGTTGCAGACCCATCCCGCCGTGCGGGCCGCCCATGTCACC
GTGCGCCGCCACGGCGCCGGGCCCCGATTGACGGCCTATGCGGCCACCGGAGGCACCGACGTCGCCGTCGCCGAACTGCG
CCACATGCTCAGCACGCGGCTGCCGCGCTATCTGGTCCCGCACCACATCGCGGTGCTCGACGAACTGCCGCTGACCGCGC
ACGGCAAGATCGACGACGCCACGCTCGCCACGTACGACGCCGCCGCGGCCGGGCCGGCGGCCGCCCCCGAGACGCCCACC
GAGGCCGCCCTGGCCGAGGCGGTCGCCGAACTGCTGGGCACCACCGCGGTGGACGTGAACGCGGATCTGCTCTCGCTGGG
ACTGGACAGCATCGTGGCACTCTCGGTGGTGCAGGCCGCGCGCCGCCGCGGTGTCGCGCTGCGGGCCCGACTCATGCTCG
AGTGCGGTTCGATCCGCGAACTCGCCACGGCCGTCGACGCCGAGGCCGGTATCGAATCCTCCTCGCAGGCAACCGAAGCG
GCCTCGTCGGACCCGATCCCGGTGCTGCCCAACGTGCACTGGCTCTACGAGTACGGCCACCCGCGCCGGCTGGCGCAGAC
CGAGGCGATCCCGCTGCCCGACGGCATCACCGCCGACGCGCTGCGCACCGTGCTGCGCACCGTCCTCGACGGCCACGAGG
TGCTGCGCACCCGGTTCGACCGCACCGCCATGACGCTGGTGCCGCAGGCGGAGACGCCCGCCGACGAGCTGCTGTCGGAA
GTCGCGGTGAGCGGTGACCTCGCCGACGCGGTCGCCGAACACACCGAAACCGCGGTGCAGAGGCTGGATCCGGAACGTGG
CCGGCTGTGGTCGGCGCTGTGGCTGCGCCCGGCGCACGGCCCGGGGGTGCTCGTGGTGACCGCGCACGTGTTGGCGATCG
ATCCGGCGTCGTGGCGGGTCGTCATCGGTGAACTCGACACCGCCTGGCACGCGCTGAGGGCAGGGCGCACACCCACACCC
ACACGCGAACACACCACCTACCGGCAGTGGTCGGCGCGCGTGCGCGAGCGGGCCCACCGGCTCGACACGGCCGACTTCTG
GGCCGCGCAGCTCGACGGCGCCGACCCGGAACTCGGGGCGCGCCGAGTGCGCCCGGAGACCGACCGCGCAGGCGATCTCG
AGGTCAGCGTCGCCATCACCGAACCCGATCTCACCGCCCGGCTGATCGCCTCGGCGCAGGCCATGCCGACGCTGCTGACC
CTGGCGGCGGCGCGCACCGTCACCGCCTGGCGACGGCGCCGCGGTCAACCCACACCGCCGCCGCTGCTGGCGCTGGAGAC
CCACGGCCGCGCCGACAGCGCGGTGAGCGCCGACGCCGACACCGGCGACACCGTCGGACTGTTCAGCGCGATCTACCCCG
TACGGGTCGATCCCGATGCCGGGCCGGTCGAGATCCCCGGTGAGGGAATCGATTTCGGTCTGCTGCGATACCTGCGGGCC
GACACCGCGGAACGGCTCTGCGCCTACCGGCAACCGCAGCTGCTGCTGAACTACCTGGGCCGCGCCGACGTCGGCGGCGC
CGGGACGTTCAACGTCGACAAGGGTCTGCTGCGCGCGGTGTCGGTGCTACCGGAACCGGAACTGGCCGTCCGGCACGAGG
TGACCGTGATGGCCGCGATCCTTCCCCAGGGTGACGCGCCCGTCCTGGCCACCCAGTGGCGGACGCTGCCCGAGGTGCTC
TCCGCCGACGACGTCGCGGTCCTGCAGACCCTGTGGCAGGACGCGCTGCAGGAGGTTGCCCGATGA

Upstream 100 bases:

>100_bases
CGGGGGACACCGCCCACGCACCGATGAGCGCCTCGGGCCTGTCCGCGGACGAACTCGCGGCGCTGACGGCGTCGTGGAAC
GCGTCGCAGGAGGACACGCC

Downstream 100 bases:

>100_bases
CCGCGACGCTGGCGGTGATCGGTGCCGGCCCGAAGGCCGTCGCCGTCGCCGCGAAGGCCGCCGAACTGCGCAACATGGGC
GTCGACGCACCGGATGTGGT

Product: amino acid adenylation

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent D-leucine adenylase; D-LeuA; D-Leucine activase; Leucine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent glycine adenylase; GlyA; Glycine activase; Linear gramicidin--PCP reductase [H]

Number of amino acids: Translated: 1461; Mature: 1460

Protein sequence:

>1461_residues
MTRTQAAANAIEDVMALSPLQQGLYSMTMLADSEHADGDPRPDPYVIAMAADVTGTLDTALLRDCATALLTRHPNLRAGF
FRGDLPRPVQVVPARVDLPWQHVRARTAEKAAELEHRERRRPFDLERGPAIRFLLIELPGPAWRLVIVAHHIVIDGWSLP
LFVGEMLTLYRAGGDPGALGDPPRPYRDYIGWLAGRDQAASRALWTEHLAGIDAPTLLTPALSAVEPAAGLPRRTEVALD
AGASRRLTETARSRGVTVNTLVQMAWAAMLSVFTDRRDVTFGMTVSGRPGELAGVETMVGLFINTVPLRVRLDPVDTVGS
QCLSLQRTAAALREHSYLAHSELRALAGVGEMFDSLLVYENFPPGGLVGGDHRFEAAGATFIPAALESLSHFPVTIAAHM
ADERLTVLVETLDGALGALTPHDVGQGLLDTVERLIALWDRPLRDVRMLSGDDPAVPAVTEPPPRTGVHCAFTEAARRTP
DAVALSWDGGTLTYREVDAAADRLAAGLTARGVGAETPVAVRLSRGPDYVIAMLAVLKAGGMIVPLDPGMAGERIEEILR
QTAAPVVVDDALSAGVGAPDGAWAPATVAPGQAAYAVFTSGTTGIPKGVVGTHDAVLAYADDHARHVLRPAATRLGRPLR
IAHAWSFTFDAAWQPLVALFEGHSVHIIGDAVQRDAEALVDTIDRYDIDMIDTTPSMFAQLKAFGLMSRVPLAVLALGGE
AVGSGAWRFIREECARTSMTAFNCYGPTETTVESVVAAIAEHPQPVIGSPTRHARAYVLDAWLRPVPDGVAGELYLSGAQ
LARGYLDRACETAGRFVADPFLAGNRMYRTGDVVRRDATGALQYLGRSDDQVKIRGFRVEPGEVCAVLQTHPAVRAAHVT
VRRHGAGPRLTAYAATGGTDVAVAELRHMLSTRLPRYLVPHHIAVLDELPLTAHGKIDDATLATYDAAAAGPAAAPETPT
EAALAEAVAELLGTTAVDVNADLLSLGLDSIVALSVVQAARRRGVALRARLMLECGSIRELATAVDAEAGIESSSQATEA
ASSDPIPVLPNVHWLYEYGHPRRLAQTEAIPLPDGITADALRTVLRTVLDGHEVLRTRFDRTAMTLVPQAETPADELLSE
VAVSGDLADAVAEHTETAVQRLDPERGRLWSALWLRPAHGPGVLVVTAHVLAIDPASWRVVIGELDTAWHALRAGRTPTP
TREHTTYRQWSARVRERAHRLDTADFWAAQLDGADPELGARRVRPETDRAGDLEVSVAITEPDLTARLIASAQAMPTLLT
LAAARTVTAWRRRRGQPTPPPLLALETHGRADSAVSADADTGDTVGLFSAIYPVRVDPDAGPVEIPGEGIDFGLLRYLRA
DTAERLCAYRQPQLLLNYLGRADVGGAGTFNVDKGLLRAVSVLPEPELAVRHEVTVMAAILPQGDAPVLATQWRTLPEVL
SADDVAVLQTLWQDALQEVAR

Sequences:

>Translated_1461_residues
MTRTQAAANAIEDVMALSPLQQGLYSMTMLADSEHADGDPRPDPYVIAMAADVTGTLDTALLRDCATALLTRHPNLRAGF
FRGDLPRPVQVVPARVDLPWQHVRARTAEKAAELEHRERRRPFDLERGPAIRFLLIELPGPAWRLVIVAHHIVIDGWSLP
LFVGEMLTLYRAGGDPGALGDPPRPYRDYIGWLAGRDQAASRALWTEHLAGIDAPTLLTPALSAVEPAAGLPRRTEVALD
AGASRRLTETARSRGVTVNTLVQMAWAAMLSVFTDRRDVTFGMTVSGRPGELAGVETMVGLFINTVPLRVRLDPVDTVGS
QCLSLQRTAAALREHSYLAHSELRALAGVGEMFDSLLVYENFPPGGLVGGDHRFEAAGATFIPAALESLSHFPVTIAAHM
ADERLTVLVETLDGALGALTPHDVGQGLLDTVERLIALWDRPLRDVRMLSGDDPAVPAVTEPPPRTGVHCAFTEAARRTP
DAVALSWDGGTLTYREVDAAADRLAAGLTARGVGAETPVAVRLSRGPDYVIAMLAVLKAGGMIVPLDPGMAGERIEEILR
QTAAPVVVDDALSAGVGAPDGAWAPATVAPGQAAYAVFTSGTTGIPKGVVGTHDAVLAYADDHARHVLRPAATRLGRPLR
IAHAWSFTFDAAWQPLVALFEGHSVHIIGDAVQRDAEALVDTIDRYDIDMIDTTPSMFAQLKAFGLMSRVPLAVLALGGE
AVGSGAWRFIREECARTSMTAFNCYGPTETTVESVVAAIAEHPQPVIGSPTRHARAYVLDAWLRPVPDGVAGELYLSGAQ
LARGYLDRACETAGRFVADPFLAGNRMYRTGDVVRRDATGALQYLGRSDDQVKIRGFRVEPGEVCAVLQTHPAVRAAHVT
VRRHGAGPRLTAYAATGGTDVAVAELRHMLSTRLPRYLVPHHIAVLDELPLTAHGKIDDATLATYDAAAAGPAAAPETPT
EAALAEAVAELLGTTAVDVNADLLSLGLDSIVALSVVQAARRRGVALRARLMLECGSIRELATAVDAEAGIESSSQATEA
ASSDPIPVLPNVHWLYEYGHPRRLAQTEAIPLPDGITADALRTVLRTVLDGHEVLRTRFDRTAMTLVPQAETPADELLSE
VAVSGDLADAVAEHTETAVQRLDPERGRLWSALWLRPAHGPGVLVVTAHVLAIDPASWRVVIGELDTAWHALRAGRTPTP
TREHTTYRQWSARVRERAHRLDTADFWAAQLDGADPELGARRVRPETDRAGDLEVSVAITEPDLTARLIASAQAMPTLLT
LAAARTVTAWRRRRGQPTPPPLLALETHGRADSAVSADADTGDTVGLFSAIYPVRVDPDAGPVEIPGEGIDFGLLRYLRA
DTAERLCAYRQPQLLLNYLGRADVGGAGTFNVDKGLLRAVSVLPEPELAVRHEVTVMAAILPQGDAPVLATQWRTLPEVL
SADDVAVLQTLWQDALQEVAR
>Mature_1460_residues
TRTQAAANAIEDVMALSPLQQGLYSMTMLADSEHADGDPRPDPYVIAMAADVTGTLDTALLRDCATALLTRHPNLRAGFF
RGDLPRPVQVVPARVDLPWQHVRARTAEKAAELEHRERRRPFDLERGPAIRFLLIELPGPAWRLVIVAHHIVIDGWSLPL
FVGEMLTLYRAGGDPGALGDPPRPYRDYIGWLAGRDQAASRALWTEHLAGIDAPTLLTPALSAVEPAAGLPRRTEVALDA
GASRRLTETARSRGVTVNTLVQMAWAAMLSVFTDRRDVTFGMTVSGRPGELAGVETMVGLFINTVPLRVRLDPVDTVGSQ
CLSLQRTAAALREHSYLAHSELRALAGVGEMFDSLLVYENFPPGGLVGGDHRFEAAGATFIPAALESLSHFPVTIAAHMA
DERLTVLVETLDGALGALTPHDVGQGLLDTVERLIALWDRPLRDVRMLSGDDPAVPAVTEPPPRTGVHCAFTEAARRTPD
AVALSWDGGTLTYREVDAAADRLAAGLTARGVGAETPVAVRLSRGPDYVIAMLAVLKAGGMIVPLDPGMAGERIEEILRQ
TAAPVVVDDALSAGVGAPDGAWAPATVAPGQAAYAVFTSGTTGIPKGVVGTHDAVLAYADDHARHVLRPAATRLGRPLRI
AHAWSFTFDAAWQPLVALFEGHSVHIIGDAVQRDAEALVDTIDRYDIDMIDTTPSMFAQLKAFGLMSRVPLAVLALGGEA
VGSGAWRFIREECARTSMTAFNCYGPTETTVESVVAAIAEHPQPVIGSPTRHARAYVLDAWLRPVPDGVAGELYLSGAQL
ARGYLDRACETAGRFVADPFLAGNRMYRTGDVVRRDATGALQYLGRSDDQVKIRGFRVEPGEVCAVLQTHPAVRAAHVTV
RRHGAGPRLTAYAATGGTDVAVAELRHMLSTRLPRYLVPHHIAVLDELPLTAHGKIDDATLATYDAAAAGPAAAPETPTE
AALAEAVAELLGTTAVDVNADLLSLGLDSIVALSVVQAARRRGVALRARLMLECGSIRELATAVDAEAGIESSSQATEAA
SSDPIPVLPNVHWLYEYGHPRRLAQTEAIPLPDGITADALRTVLRTVLDGHEVLRTRFDRTAMTLVPQAETPADELLSEV
AVSGDLADAVAEHTETAVQRLDPERGRLWSALWLRPAHGPGVLVVTAHVLAIDPASWRVVIGELDTAWHALRAGRTPTPT
REHTTYRQWSARVRERAHRLDTADFWAAQLDGADPELGARRVRPETDRAGDLEVSVAITEPDLTARLIASAQAMPTLLTL
AAARTVTAWRRRRGQPTPPPLLALETHGRADSAVSADADTGDTVGLFSAIYPVRVDPDAGPVEIPGEGIDFGLLRYLRAD
TAERLCAYRQPQLLLNYLGRADVGGAGTFNVDKGLLRAVSVLPEPELAVRHEVTVMAAILPQGDAPVLATQWRTLPEVLS
ADDVAVLQTLWQDALQEVAR

Specific function: Activates the 13th to the 16th (Trp, D-Leu, Trp and Gly) amino acids in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 14th (D-Leu) amino acid. It also catalyzes

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI28416953, Length=579, Percent_Identity=24.6977547495682, Blast_Score=104, Evalue=8e-22,
Organism=Homo sapiens, GI38505220, Length=370, Percent_Identity=24.5945945945946, Blast_Score=70, Evalue=1e-11,
Organism=Escherichia coli, GI1786801, Length=1062, Percent_Identity=28.6252354048964, Blast_Score=240, Evalue=6e-64,
Organism=Escherichia coli, GI145693145, Length=527, Percent_Identity=24.2884250474383, Blast_Score=97, Evalue=8e-21,
Organism=Escherichia coli, GI1788107, Length=550, Percent_Identity=23.8181818181818, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1786810, Length=519, Percent_Identity=24.6628131021195, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17556356, Length=1171, Percent_Identity=21.1784799316823, Blast_Score=110, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17538037, Length=553, Percent_Identity=22.9656419529837, Blast_Score=78, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71994690, Length=362, Percent_Identity=26.7955801104972, Blast_Score=76, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994694, Length=354, Percent_Identity=27.1186440677966, Blast_Score=76, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994703, Length=354, Percent_Identity=27.1186440677966, Blast_Score=76, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71983001, Length=371, Percent_Identity=25.3369272237197, Blast_Score=70, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71982997, Length=371, Percent_Identity=25.3369272237197, Blast_Score=70, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24648676, Length=634, Percent_Identity=27.2870662460568, Blast_Score=150, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24667959, Length=368, Percent_Identity=25.2717391304348, Blast_Score=78, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24581924, Length=374, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24667955, Length=368, Percent_Identity=25.2717391304348, Blast_Score=76, Evalue=2e-13,
Organism=Drosophila melanogaster, GI62472339, Length=368, Percent_Identity=25.2717391304348, Blast_Score=76, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR013120
- InterPro:   IPR016040
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR010080 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF07993 NAD_binding_4; PF00550 PP-binding [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 156448; Mature: 156316

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50075 ACP_DOMAIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRTQAAANAIEDVMALSPLQQGLYSMTMLADSEHADGDPRPDPYVIAMAADVTGTLDTA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHH
LLRDCATALLTRHPNLRAGFFRGDLPRPVQVVPARVDLPWQHVRARTAEKAAELEHRERR
HHHHHHHHHHHCCCCCCEECCCCCCCCCCEEECEECCCCHHHHHHHHHHHHHHHHHHHHC
RPFDLERGPAIRFLLIELPGPAWRLVIVAHHIVIDGWSLPLFVGEMLTLYRAGGDPGALG
CCCCCCCCCEEEEEEEECCCCCEEHEEEEEEHEEECCCHHHHHHHHHHHHHCCCCCCCCC
DPPRPYRDYIGWLAGRDQAASRALWTEHLAGIDAPTLLTPALSAVEPAAGLPRRTEVALD
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEC
AGASRRLTETARSRGVTVNTLVQMAWAAMLSVFTDRRDVTFGMTVSGRPGELAGVETMVG
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHH
LFINTVPLRVRLDPVDTVGSQCLSLQRTAAALREHSYLAHSELRALAGVGEMFDSLLVYE
HHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NFPPGGLVGGDHRFEAAGATFIPAALESLSHFPVTIAAHMADERLTVLVETLDGALGALT
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEHHCCCHHHHHHHHHCCHHCCCC
PHDVGQGLLDTVERLIALWDRPLRDVRMLSGDDPAVPAVTEPPPRTGVHCAFTEAARRTP
HHHHCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEHHHHCCCC
DAVALSWDGGTLTYREVDAAADRLAAGLTARGVGAETPVAVRLSRGPDYVIAMLAVLKAG
CEEEEEECCCEEEEHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCC
GMIVPLDPGMAGERIEEILRQTAAPVVVDDALSAGVGAPDGAWAPATVAPGQAAYAVFTS
CEEEECCCCCCHHHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEC
GTTGIPKGVVGTHDAVLAYADDHARHVLRPAATRLGRPLRIAHAWSFTFDAAWQPLVALF
CCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHH
EGHSVHIIGDAVQRDAEALVDTIDRYDIDMIDTTPSMFAQLKAFGLMSRVPLAVLALGGE
CCCEEEEECHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHCCHHEEEECCC
AVGSGAWRFIREECARTSMTAFNCYGPTETTVESVVAAIAEHPQPVIGSPTRHARAYVLD
HHCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
AWLRPVPDGVAGELYLSGAQLARGYLDRACETAGRFVADPFLAGNRMYRTGDVVRRDATG
HHHCCCCCCCCCCEEECHHHHHHHHHHHHHHHHCCHHCCHHHCCCCEEECCHHHHHHHHH
ALQYLGRSDDQVKIRGFRVEPGEVCAVLQTHPAVRAAHVTVRRHGAGPRLTAYAATGGTD
HHHHHCCCCCEEEEEEEEECHHHHEEEECCCCCHHEEEEEEEECCCCCCEEEEEECCCCH
VAVAELRHMLSTRLPRYLVPHHIAVLDELPLTAHGKIDDATLATYDAAAAGPAAAPETPT
HHHHHHHHHHHHCCCHHHCCHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCH
EAALAEAVAELLGTTAVDVNADLLSLGLDSIVALSVVQAARRRGVALRARLMLECGSIRE
HHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHH
LATAVDAEAGIESSSQATEAASSDPIPVLPNVHWLYEYGHPRRLAQTEAIPLPDGITADA
HHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCCCHHH
LRTVLRTVLDGHEVLRTRFDRTAMTLVPQAETPADELLSEVAVSGDLADAVAEHTETAVQ
HHHHHHHHHCHHHHHHHHHCCHHEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHH
RLDPERGRLWSALWLRPAHGPGVLVVTAHVLAIDPASWRVVIGELDTAWHALRAGRTPTP
HCCCCCCCEEEHHEEECCCCCCEEEEEEEEEEECCCCCEEEEECHHHHHHHHHCCCCCCC
TREHTTYRQWSARVRERAHRLDTADFWAAQLDGADPELGARRVRPETDRAGDLEVSVAIT
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEEE
EPDLTARLIASAQAMPTLLTLAAARTVTAWRRRRGQPTPPPLLALETHGRADSAVSADAD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCC
TGDTVGLFSAIYPVRVDPDAGPVEIPGEGIDFGLLRYLRADTAERLCAYRQPQLLLNYLG
CCCHHHHHHHCCCEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
RADVGGAGTFNVDKGLLRAVSVLPEPELAVRHEVTVMAAILPQGDAPVLATQWRTLPEVL
CCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHEEEEEECCCCCCCEEHHHHHHHHHHH
SADDVAVLQTLWQDALQEVAR
CCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TRTQAAANAIEDVMALSPLQQGLYSMTMLADSEHADGDPRPDPYVIAMAADVTGTLDTA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHH
LLRDCATALLTRHPNLRAGFFRGDLPRPVQVVPARVDLPWQHVRARTAEKAAELEHRERR
HHHHHHHHHHHCCCCCCEECCCCCCCCCCEEECEECCCCHHHHHHHHHHHHHHHHHHHHC
RPFDLERGPAIRFLLIELPGPAWRLVIVAHHIVIDGWSLPLFVGEMLTLYRAGGDPGALG
CCCCCCCCCEEEEEEEECCCCCEEHEEEEEEHEEECCCHHHHHHHHHHHHHCCCCCCCCC
DPPRPYRDYIGWLAGRDQAASRALWTEHLAGIDAPTLLTPALSAVEPAAGLPRRTEVALD
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEC
AGASRRLTETARSRGVTVNTLVQMAWAAMLSVFTDRRDVTFGMTVSGRPGELAGVETMVG
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHH
LFINTVPLRVRLDPVDTVGSQCLSLQRTAAALREHSYLAHSELRALAGVGEMFDSLLVYE
HHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NFPPGGLVGGDHRFEAAGATFIPAALESLSHFPVTIAAHMADERLTVLVETLDGALGALT
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEHHCCCHHHHHHHHHCCHHCCCC
PHDVGQGLLDTVERLIALWDRPLRDVRMLSGDDPAVPAVTEPPPRTGVHCAFTEAARRTP
HHHHCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEHHHHCCCC
DAVALSWDGGTLTYREVDAAADRLAAGLTARGVGAETPVAVRLSRGPDYVIAMLAVLKAG
CEEEEEECCCEEEEHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCC
GMIVPLDPGMAGERIEEILRQTAAPVVVDDALSAGVGAPDGAWAPATVAPGQAAYAVFTS
CEEEECCCCCCHHHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEC
GTTGIPKGVVGTHDAVLAYADDHARHVLRPAATRLGRPLRIAHAWSFTFDAAWQPLVALF
CCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHH
EGHSVHIIGDAVQRDAEALVDTIDRYDIDMIDTTPSMFAQLKAFGLMSRVPLAVLALGGE
CCCEEEEECHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHCCHHEEEECCC
AVGSGAWRFIREECARTSMTAFNCYGPTETTVESVVAAIAEHPQPVIGSPTRHARAYVLD
HHCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
AWLRPVPDGVAGELYLSGAQLARGYLDRACETAGRFVADPFLAGNRMYRTGDVVRRDATG
HHHCCCCCCCCCCEEECHHHHHHHHHHHHHHHHCCHHCCHHHCCCCEEECCHHHHHHHHH
ALQYLGRSDDQVKIRGFRVEPGEVCAVLQTHPAVRAAHVTVRRHGAGPRLTAYAATGGTD
HHHHHCCCCCEEEEEEEEECHHHHEEEECCCCCHHEEEEEEEECCCCCCEEEEEECCCCH
VAVAELRHMLSTRLPRYLVPHHIAVLDELPLTAHGKIDDATLATYDAAAAGPAAAPETPT
HHHHHHHHHHHHCCCHHHCCHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCH
EAALAEAVAELLGTTAVDVNADLLSLGLDSIVALSVVQAARRRGVALRARLMLECGSIRE
HHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHH
LATAVDAEAGIESSSQATEAASSDPIPVLPNVHWLYEYGHPRRLAQTEAIPLPDGITADA
HHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCCCHHH
LRTVLRTVLDGHEVLRTRFDRTAMTLVPQAETPADELLSEVAVSGDLADAVAEHTETAVQ
HHHHHHHHHCHHHHHHHHHCCHHEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHH
RLDPERGRLWSALWLRPAHGPGVLVVTAHVLAIDPASWRVVIGELDTAWHALRAGRTPTP
HCCCCCCCEEEHHEEECCCCCCEEEEEEEEEEECCCCCEEEEECHHHHHHHHHCCCCCCC
TREHTTYRQWSARVRERAHRLDTADFWAAQLDGADPELGARRVRPETDRAGDLEVSVAIT
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEEE
EPDLTARLIASAQAMPTLLTLAAARTVTAWRRRRGQPTPPPLLALETHGRADSAVSADAD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCC
TGDTVGLFSAIYPVRVDPDAGPVEIPGEGIDFGLLRYLRADTAERLCAYRQPQLLLNYLG
CCCHHHHHHHCCCEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
RADVGGAGTFNVDKGLLRAVSVLPEPELAVRHEVTVMAAILPQGDAPVLATQWRTLPEVL
CCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHEEEEEECCCCCCCEEHHHHHHHHHHH
SADDVAVLQTLWQDALQEVAR
CCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA