Click here to switch to the map view.

The map label for this gene is mbtG

Identifier: 108800430

GI number: 108800430

Start: 3673493

End: 3674785

Strand: Reverse

Name: mbtG

Synonym: Mmcs_3464

Alternate gene names: 108800430

Gene position: 3674785-3673493 (Counterclockwise)

Preceding gene: 108800431

Following gene: 108800429

Centisome position: 64.41

GC content: 69.61

Gene sequence:

>1293_bases
ATGACCGCGACGCTGGCGGTGATCGGTGCCGGCCCGAAGGCCGTCGCCGTCGCCGCGAAGGCCGCCGAACTGCGCAACAT
GGGCGTCGACGCACCGGATGTGGTGGTCGTCGAACGCGCCGGGGTGGGCGCGAACTGGACCGCCGCAGGCGGCTGGACCG
ACGGGCAGCACCGGTTGGGGACCAGCCCGGAGAAGGACATCGGCTTCCCGTACCGCTCGTCGCTGGTGCCGCGGCGCAAC
GCCGAACTCGACGACCGGATGACGCGGCACAGCTGGCAGGCCTACCTGGTGGCCACCTCGCAGTTCGCCGAATGGATCGA
CCGCGGCAGGCCGGCGCCGAACCACCACCGATGGGCGGCCTATCTGCGCTGGGTCGCCGACGCCATCGGGATGAACGTGG
TGCACGGCGAGGTGGAACGCATCTCCATCGGTGGCCGCGGCTGGGAGCTGCACACCCCCGAGTCGACCGTCGCCGCCGAC
GCGGTGATGATCACCGGACCCGGTCAGGCCGAACGGACACTGCTGCCGGGCCATCCGCGGGTGATGTCGATCGCCGACTT
CTGGCGGCGCACCGCCGGGCACGAGCTGATCGTCGCCGAACGCGTGGCGATGATCGGCGGCGGCGAGACCGCCGCGTCGA
TGCTCAACGAGCTGTTCCGCCACCGGGTTTCGACGATCACGGTGATCTCACCTCAGGTCACGCTGTTCACCCGGGGTGAG
GGATTCTTCGAGAACACGTTGTTCTCCGACCCCACCGGCTGGACCAGTCTGACGCTCGCCGAACGCCGCGATGCCATGTT
CCGCACCGACCGCGGCGTGTTCTCCGCCCGTGTGCAGGAGGCCCTGCTGGCCGACGACCGCATCCGGCACCTGCGCGGGC
GCGTCGCCCACGCGGTGCCCCGTGACGGGCGGATCCGGTTGACACTGCACACCGACCGGGCCGGGGAACGTGTGGAGACC
GTGCACGGTTTCGACCTGGTGATCGACGGTCAGGGTGCCGACGCGTTGTGGTTCCTGCCGCTGCTCGGCCAGGATGCGCG
CGATCTGCTCGAACTCGGCCTCGGCGGGCCACTGACCGGCGAGTTGCTGCAGGAGTCGATCGGCCACGATCTCGCGGTCG
GTGGCGTGACCCCGAAGCTGTTCCTGCCCGGGCTCGCCGGTCTCAACCAGGGACCCGGATTTCCCAACCTCAGCTGCCTC
GGCCTGATGTCCGATCGCATCCTCGGCGCGGACCTCGGGGCGAACGCAGCCATGACGAACAGGAGAAGCATTGAGCACCA
ACCCATTCGATGA

Upstream 100 bases:

>100_bases
TCCTGGCCACCCAGTGGCGGACGCTGCCCGAGGTGCTCTCCGCCGACGACGTCGCGGTCCTGCAGACCCTGTGGCAGGAC
GCGCTGCAGGAGGTTGCCCG

Downstream 100 bases:

>100_bases
CGAGAACGGCCGCTTCTACGTCCTGGTGAACGACGAGGAGCAGCACAGCCTGTGGCCGACGTTCGCCGACGTGCCCGCGG
GGTGGCGCGTGGTTTTCGGT

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: Lysine 6-N-hydroxylase; Lysine N(6)-hydroxylase; Lysine-N-oxygenase; Mycobactin synthase protein G

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MTATLAVIGAGPKAVAVAAKAAELRNMGVDAPDVVVVERAGVGANWTAAGGWTDGQHRLGTSPEKDIGFPYRSSLVPRRN
AELDDRMTRHSWQAYLVATSQFAEWIDRGRPAPNHHRWAAYLRWVADAIGMNVVHGEVERISIGGRGWELHTPESTVAAD
AVMITGPGQAERTLLPGHPRVMSIADFWRRTAGHELIVAERVAMIGGGETAASMLNELFRHRVSTITVISPQVTLFTRGE
GFFENTLFSDPTGWTSLTLAERRDAMFRTDRGVFSARVQEALLADDRIRHLRGRVAHAVPRDGRIRLTLHTDRAGERVET
VHGFDLVIDGQGADALWFLPLLGQDARDLLELGLGGPLTGELLQESIGHDLAVGGVTPKLFLPGLAGLNQGPGFPNLSCL
GLMSDRILGADLGANAAMTNRRSIEHQPIR

Sequences:

>Translated_430_residues
MTATLAVIGAGPKAVAVAAKAAELRNMGVDAPDVVVVERAGVGANWTAAGGWTDGQHRLGTSPEKDIGFPYRSSLVPRRN
AELDDRMTRHSWQAYLVATSQFAEWIDRGRPAPNHHRWAAYLRWVADAIGMNVVHGEVERISIGGRGWELHTPESTVAAD
AVMITGPGQAERTLLPGHPRVMSIADFWRRTAGHELIVAERVAMIGGGETAASMLNELFRHRVSTITVISPQVTLFTRGE
GFFENTLFSDPTGWTSLTLAERRDAMFRTDRGVFSARVQEALLADDRIRHLRGRVAHAVPRDGRIRLTLHTDRAGERVET
VHGFDLVIDGQGADALWFLPLLGQDARDLLELGLGGPLTGELLQESIGHDLAVGGVTPKLFLPGLAGLNQGPGFPNLSCL
GLMSDRILGADLGANAAMTNRRSIEHQPIR
>Mature_429_residues
TATLAVIGAGPKAVAVAAKAAELRNMGVDAPDVVVVERAGVGANWTAAGGWTDGQHRLGTSPEKDIGFPYRSSLVPRRNA
ELDDRMTRHSWQAYLVATSQFAEWIDRGRPAPNHHRWAAYLRWVADAIGMNVVHGEVERISIGGRGWELHTPESTVAADA
VMITGPGQAERTLLPGHPRVMSIADFWRRTAGHELIVAERVAMIGGGETAASMLNELFRHRVSTITVISPQVTLFTRGEG
FFENTLFSDPTGWTSLTLAERRDAMFRTDRGVFSARVQEALLADDRIRHLRGRVAHAVPRDGRIRLTLHTDRAGERVETV
HGFDLVIDGQGADALWFLPLLGQDARDLLELGLGGPLTGELLQESIGHDLAVGGVTPKLFLPGLAGLNQGPGFPNLSCLG
LMSDRILGADLGANAAMTNRRSIEHQPIR

Specific function: Flavoprotein monooxygenase required for N-hydroxylation of the two acylated lysine residues during mycobactin assembly, thus producing the hydroxamate groups necessary for iron sequestration. Is also able, but less efficiently, to hydroxylate L-lysine (no

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MBTG_MYCSS (Q1B6B3)

Other databases:

- EMBL:   CP000384
- RefSeq:   YP_640627.1
- ProteinModelPortal:   Q1B6B3
- STRING:   Q1B6B3
- EnsemblBacteria:   EBMYCT00000059553
- GeneID:   4112296
- GenomeReviews:   CP000384_GR
- KEGG:   mmc:Mmcs_3464
- eggNOG:   NOG13470
- GeneTree:   EBGT00050000017267
- HOGENOM:   HBG432039
- OMA:   SIAQFWH
- ProtClustDB:   CLSK791811
- BioCyc:   MSP164756:MMCS_3464-MONOMER
- InterPro:   IPR013027
- PRINTS:   PR00368

Pfam domain/function: PF07992 Pyr_redox_2

EC number: =1.14.13.59

Molecular weight: Translated: 46623; Mature: 46491

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATLAVIGAGPKAVAVAAKAAELRNMGVDAPDVVVVERAGVGANWTAAGGWTDGQHRLG
CCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
TSPEKDIGFPYRSSLVPRRNAELDDRMTRHSWQAYLVATSQFAEWIDRGRPAPNHHRWAA
CCCCCCCCCCHHHCCCCCCCCCHHHHHHHHCCEEEEEEHHHHHHHHHCCCCCCCCHHHHH
YLRWVADAIGMNVVHGEVERISIGGRGWELHTPESTVAADAVMITGPGQAERTLLPGHPR
HHHHHHHHHCCCEEECCEEEEEECCCCCEEECCCCHHEECEEEEECCCCCCCCCCCCCCC
VMSIADFWRRTAGHELIVAERVAMIGGGETAASMLNELFRHRVSTITVISPQVTLFTRGE
EEHHHHHHHHHCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHCCEEEEECCEEEEEECCC
GFFENTLFSDPTGWTSLTLAERRDAMFRTDRGVFSARVQEALLADDRIRHLRGRVAHAVP
CCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RDGRIRLTLHTDRAGERVETVHGFDLVIDGQGADALWFLPLLGQDARDLLELGLGGPLTG
CCCEEEEEEECCCCCCCEEEECCEEEEEECCCCCEEEEEECCCCCHHHHHHHCCCCCCHH
ELLQESIGHDLAVGGVTPKLFLPGLAGLNQGPGFPNLSCLGLMSDRILGADLGANAAMTN
HHHHHHCCCCEEECCCCHHHHCCCCCCCCCCCCCCCCEEEHHHHCCEECCCCCCCCHHCC
RRSIEHQPIR
CCCCCCCCCC
>Mature Secondary Structure 
TATLAVIGAGPKAVAVAAKAAELRNMGVDAPDVVVVERAGVGANWTAAGGWTDGQHRLG
CEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
TSPEKDIGFPYRSSLVPRRNAELDDRMTRHSWQAYLVATSQFAEWIDRGRPAPNHHRWAA
CCCCCCCCCCHHHCCCCCCCCCHHHHHHHHCCEEEEEEHHHHHHHHHCCCCCCCCHHHHH
YLRWVADAIGMNVVHGEVERISIGGRGWELHTPESTVAADAVMITGPGQAERTLLPGHPR
HHHHHHHHHCCCEEECCEEEEEECCCCCEEECCCCHHEECEEEEECCCCCCCCCCCCCCC
VMSIADFWRRTAGHELIVAERVAMIGGGETAASMLNELFRHRVSTITVISPQVTLFTRGE
EEHHHHHHHHHCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHCCEEEEECCEEEEEECCC
GFFENTLFSDPTGWTSLTLAERRDAMFRTDRGVFSARVQEALLADDRIRHLRGRVAHAVP
CCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RDGRIRLTLHTDRAGERVETVHGFDLVIDGQGADALWFLPLLGQDARDLLELGLGGPLTG
CCCEEEEEEECCCCCCCEEEECCEEEEEECCCCCEEEEEECCCCCHHHHHHHCCCCCCHH
ELLQESIGHDLAVGGVTPKLFLPGLAGLNQGPGFPNLSCLGLMSDRILGADLGANAAMTN
HHHHHHCCCCEEECCCCHHHHCCCCCCCCCCCCCCCCEEEHHHHCCEECCCCCCCCHHCC
RRSIEHQPIR
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA