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The map label for this gene is murC

Identifier: 108800221

GI number: 108800221

Start: 3449159

End: 3450613

Strand: Reverse

Name: murC

Synonym: Mmcs_3255

Alternate gene names: 108800221

Gene position: 3450613-3449159 (Counterclockwise)

Preceding gene: 108800222

Following gene: 108800220

Centisome position: 60.48

GC content: 72.99

Gene sequence:

>1455_bases
GTGAGCACCCCACCCCTGCCCGACGAACTGCGCCGGGTCCACATGGTCGGCATCGGGGGCGCGGGAATGTCGGGCATCGC
GCGCATCCTGCTCGACCGCGGGGCGATGGTCTCCGGTTCCGACGCCAAGGAATCCCGCGCCGTGGTTGCGCTGCGCGCCC
GCGGAGCGGCCATCCGGATCGGCCATGACGCCTCGTCGCTCGACCTGCTGCCGGGCGGGCCGACCGCCGTCGTCACCACG
CACGCGGCGATCCCGAAGACCAATCCCGAACTGGTCGAGGCGCGGCGGCGGGCGATCCCGATCGTCCTGCGGCCGGTCGT
GCTGGCCAAGCTGATGGCCGGGCACACCACGCTGATGGTGACCGGCACCCACGGCAAGACCACGACCACCTCGATGCTCA
TCGTCGCCCTGCAGCACTGCGGTTTCGACCCGAGCTTCGCCGTCGGCGGTGACCTCGGCGAGGCGGGCACCAACGCCCAC
CACGGCAGCGGCGAGTGCTTCGTGGCCGAGGCCGACGAGAGCGACGGTTCGCTGCTCGAATACACCCCCGATGTCGCCGT
GGTCACCAACATCGAAGCCGACCATTTGGACTTCTTCGGCAGCGCCGAGGCCTACACCGCGGTGTTCGACGCGTTCGTCG
AGCGGCTCACCCCGGGTGGGGCGCTGATCGCGTGCGTCGACGATCCCGGCTCCGCCGCGCTCGCCGAACGCACTGCGGCC
CTTGGTGTTCGGGTGTTGCGCTACGGTTCGGCCGGCGGTCGGGACCTCGCCGGTGCGCTGGTCGGCTGGGAGCAGCAGGG
GACCGGTGCGGTGGCCCACATCCAGCTGGCGGGGGAGAGCGCCCCGCGGGCGATGCGGCTCTCGGTGCCGGGCCGCCACA
TGGCGCTCAACGCGCTGGGCGCGCTGCTGGCCGCGCTGCAGGTCGGGGCCGACCCCGACACCGTGCTCGACGGGCTGGCC
GGATTCGAGGGGGTGCGCCGCCGCTTCGAACTGGTCGGGACGGCGACCGGGGTCCGGGTCTTCGATGACTACGCCCACCA
CCCGACCGAGGTCGCGGCGACGCTGGCGGCGCTGCGCGCGGTCACCGATCAGGCCGGCGACGGGCGCGCGGTGGTGGTGT
TCCAGCCGCATCTGTACTCGAGGACCGAGACGTTCGCGCGCGAGTTCGGCGCCGCGCTGAGCGCGGCCGACCTGGTGTTC
GTGCTCGACGTCTACGGCGCCCGGGAACAGCCGATCGCCGGGGTGAGCGGGGCCAGCATCGTCGAGCACGTCGGCGTGCC
GGTCACCTATGTGCCCGACTTCTCCGCGGTGGCCGCGCAGGTCGCCGGTGCGGTGCGGCCCGGCGATGTGGTCGTGACCA
TGGGCGCGGGTGACGTGACGATGCTGGGTCCGGAGATCATCGCGGCGCTGCAGGCCAGGGCGAACCGGACCGTCCCGGGG
GCCGGCGCGCGATGA

Upstream 100 bases:

>100_bases
CGGGAGCCGCGCTGTCCGGGCACCGGGATGCGGCCCGGCACGTCGCCCACGTGGCGCTCGACGTGGCGCGCGAAGCGGCC
GGCGGGCGGAAGGGGGTGCG

Downstream 100 bases:

>100_bases
CGGTGCCTCCGGAGAACCCCGAGCCGCCGGAGGAACCCACCCCGCCGCCGGCGGCCCCACCGGCCGAGGACCCGACCGCG
CCGGCGCCGTCCGCCGACGA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSTPPLPDELRRVHMVGIGGAGMSGIARILLDRGAMVSGSDAKESRAVVALRARGAAIRIGHDASSLDLLPGGPTAVVTT
HAAIPKTNPELVEARRRAIPIVLRPVVLAKLMAGHTTLMVTGTHGKTTTTSMLIVALQHCGFDPSFAVGGDLGEAGTNAH
HGSGECFVAEADESDGSLLEYTPDVAVVTNIEADHLDFFGSAEAYTAVFDAFVERLTPGGALIACVDDPGSAALAERTAA
LGVRVLRYGSAGGRDLAGALVGWEQQGTGAVAHIQLAGESAPRAMRLSVPGRHMALNALGALLAALQVGADPDTVLDGLA
GFEGVRRRFELVGTATGVRVFDDYAHHPTEVAATLAALRAVTDQAGDGRAVVVFQPHLYSRTETFAREFGAALSAADLVF
VLDVYGAREQPIAGVSGASIVEHVGVPVTYVPDFSAVAAQVAGAVRPGDVVVTMGAGDVTMLGPEIIAALQARANRTVPG
AGAR

Sequences:

>Translated_484_residues
MSTPPLPDELRRVHMVGIGGAGMSGIARILLDRGAMVSGSDAKESRAVVALRARGAAIRIGHDASSLDLLPGGPTAVVTT
HAAIPKTNPELVEARRRAIPIVLRPVVLAKLMAGHTTLMVTGTHGKTTTTSMLIVALQHCGFDPSFAVGGDLGEAGTNAH
HGSGECFVAEADESDGSLLEYTPDVAVVTNIEADHLDFFGSAEAYTAVFDAFVERLTPGGALIACVDDPGSAALAERTAA
LGVRVLRYGSAGGRDLAGALVGWEQQGTGAVAHIQLAGESAPRAMRLSVPGRHMALNALGALLAALQVGADPDTVLDGLA
GFEGVRRRFELVGTATGVRVFDDYAHHPTEVAATLAALRAVTDQAGDGRAVVVFQPHLYSRTETFAREFGAALSAADLVF
VLDVYGAREQPIAGVSGASIVEHVGVPVTYVPDFSAVAAQVAGAVRPGDVVVTMGAGDVTMLGPEIIAALQARANRTVPG
AGAR
>Mature_483_residues
STPPLPDELRRVHMVGIGGAGMSGIARILLDRGAMVSGSDAKESRAVVALRARGAAIRIGHDASSLDLLPGGPTAVVTTH
AAIPKTNPELVEARRRAIPIVLRPVVLAKLMAGHTTLMVTGTHGKTTTTSMLIVALQHCGFDPSFAVGGDLGEAGTNAHH
GSGECFVAEADESDGSLLEYTPDVAVVTNIEADHLDFFGSAEAYTAVFDAFVERLTPGGALIACVDDPGSAALAERTAAL
GVRVLRYGSAGGRDLAGALVGWEQQGTGAVAHIQLAGESAPRAMRLSVPGRHMALNALGALLAALQVGADPDTVLDGLAG
FEGVRRRFELVGTATGVRVFDDYAHHPTEVAATLAALRAVTDQAGDGRAVVVFQPHLYSRTETFAREFGAALSAADLVFV
LDVYGAREQPIAGVSGASIVEHVGVPVTYVPDFSAVAAQVAGAVRPGDVVVTMGAGDVTMLGPEIIAALQARANRTVPGA
GAR

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=466, Percent_Identity=36.6952789699571, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1790680, Length=476, Percent_Identity=30.8823529411765, Blast_Score=180, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_MYCSJ (A3Q1L7)

Other databases:

- EMBL:   CP000580
- RefSeq:   YP_001071535.1
- ProteinModelPortal:   A3Q1L7
- SMR:   A3Q1L7
- STRING:   A3Q1L7
- EnsemblBacteria:   EBMYCT00000049681
- GeneID:   4878978
- GenomeReviews:   CP000580_GR
- KEGG:   mjl:Mjls_3266
- eggNOG:   COG0773
- GeneTree:   EBGT00050000015779
- HOGENOM:   HBG476594
- OMA:   EPNFSAV
- PhylomeDB:   A3Q1L7
- ProtClustDB:   PRK00421
- BioCyc:   MSP164757:MJLS_3266-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49638; Mature: 49507

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPPLPDELRRVHMVGIGGAGMSGIARILLDRGAMVSGSDAKESRAVVALRARGAAIRI
CCCCCCCHHHCEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCEEEEEEECCEEEEE
GHDASSLDLLPGGPTAVVTTHAAIPKTNPELVEARRRAIPIVLRPVVLAKLMAGHTTLMV
CCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEE
TGTHGKTTTTSMLIVALQHCGFDPSFAVGGDLGEAGTNAHHGSGECFVAEADESDGSLLE
ECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEE
YTPDVAVVTNIEADHLDFFGSAEAYTAVFDAFVERLTPGGALIACVDDPGSAALAERTAA
ECCCEEEEEECCHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
LGVRVLRYGSAGGRDLAGALVGWEQQGTGAVAHIQLAGESAPRAMRLSVPGRHMALNALG
HHHHEEEECCCCCCHHHHHHCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHH
ALLAALQVGADPDTVLDGLAGFEGVRRRFELVGTATGVRVFDDYAHHPTEVAATLAALRA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHCCCHHHHHHHHHHHHH
VTDQAGDGRAVVVFQPHLYSRTETFAREFGAALSAADLVFVLDVYGAREQPIAGVSGASI
HHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHH
VEHVGVPVTYVPDFSAVAAQVAGAVRPGDVVVTMGAGDVTMLGPEIIAALQARANRTVPG
HHHCCCCEEECCCHHHHHHHHHCCCCCCCEEEEECCCCEEEECHHHHHHHHHHCCCCCCC
AGAR
CCCC
>Mature Secondary Structure 
STPPLPDELRRVHMVGIGGAGMSGIARILLDRGAMVSGSDAKESRAVVALRARGAAIRI
CCCCCCHHHCEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCEEEEEEECCEEEEE
GHDASSLDLLPGGPTAVVTTHAAIPKTNPELVEARRRAIPIVLRPVVLAKLMAGHTTLMV
CCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEE
TGTHGKTTTTSMLIVALQHCGFDPSFAVGGDLGEAGTNAHHGSGECFVAEADESDGSLLE
ECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEE
YTPDVAVVTNIEADHLDFFGSAEAYTAVFDAFVERLTPGGALIACVDDPGSAALAERTAA
ECCCEEEEEECCHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
LGVRVLRYGSAGGRDLAGALVGWEQQGTGAVAHIQLAGESAPRAMRLSVPGRHMALNALG
HHHHEEEECCCCCCHHHHHHCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHH
ALLAALQVGADPDTVLDGLAGFEGVRRRFELVGTATGVRVFDDYAHHPTEVAATLAALRA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHCCCHHHHHHHHHHHHH
VTDQAGDGRAVVVFQPHLYSRTETFAREFGAALSAADLVFVLDVYGAREQPIAGVSGASI
HHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHH
VEHVGVPVTYVPDFSAVAAQVAGAVRPGDVVVTMGAGDVTMLGPEIIAALQARANRTVPG
HHHCCCCEEECCCHHHHHHHHHCCCCCCCEEEEECCCCEEEECHHHHHHHHHHCCCCCCC
AGAR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA