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The map label for this gene is bah [H]

Identifier: 108800159

GI number: 108800159

Start: 3384078

End: 3385034

Strand: Reverse

Name: bah [H]

Synonym: Mmcs_3193

Alternate gene names: 108800159

Gene position: 3385034-3384078 (Counterclockwise)

Preceding gene: 108800160

Following gene: 108800158

Centisome position: 59.33

GC content: 62.7

Gene sequence:

>957_bases
ATGGATGCCCCTGACTGGCAGCCCAGTCTTGCCAGTCATCTCGTCGCGATGTCCTCGCGAACCACGCTGCGGCCACTGGC
GCAGCTGATGCCATCAAACGCCTACGGACTTGCGGTGATGGATCGCGTGCTTCGAACAGCGCTCGTAGCCTCACGGCCTC
GGCGCGGCGTCACAGTGCGCAAGGTTGACACTGTATTCGCCGGAGGCCCGGTTCGTGGGGACTGGATCACCACGCCTGCC
ATTAATCCGCATGCCAACCCTTTGCTGTACATCCACGGCGGCGCCTATTCTATGTGCTCGCCGGAGACGCACCGCGGTCT
TCTTGGTGAACTCGCCTCGGCGAGCGGGCGCCCCATCTTCGCAGTGAAGTATCGTCTTGCCCCGCGGTATCCCTATCCCG
CAGCCGCGGACGATGCGCTGAATGCGTATCGCTGGCTTACCAGCGGAGGGTCCCCGGGTTCTTGTCAGCGCACCGTCGCG
GTTGCCGGCGATTCAGCGGGCGGTCAGCTCACGATGGCCACGGCCTTGGGCGCACGTGCAGTTGGATTGCCGCTCCCTGA
TGCGATGCTGCTGATGTCTCCCGTCCTGGATCTCAGGTGCGAACTTGCCAGAGCGCGTGAAATTCGCCGCCGGGATCCTT
TTGCCTCCGCTCAATCAGCGGCGCGCGCTCTTGACCTCTACGTAGGTGGCGCAGATCGCGGAGATCCGCGCCTCAGCGTG
CTTGACGCGGACCTCACCTCGATGCCGCCGATCCTCATTCAGGTGGGCGGGAGAGAAATGTTGATCGATGACTCGCGCCG
TCTCGCCGAGCGACTTCAATCAGCTGGATCCCACGTCGAGATCCAGGTATACCGGGGACAGATCCATGTATTCCAGGCTA
TGTTCCGGATTCTTCCCGAAGCCCGAGACGCGATTCATCGAGCGGGACGCTTCCTTGAAGCCTCGGAAGTCAGGTGA

Upstream 100 bases:

>100_bases
CATCAACGACTCTGGAGACCTATTGGCGGAGCCGCACCTTTCGCCTCTCGGACTACCGATTCGAGAATCGGCCCGAAGAG
GTGTGTCCCCGGTGACCAGA

Downstream 100 bases:

>100_bases
AAGTGTCCGAACAGGCAATGCTCCTACACCTACACCACCTCGACCGCCGCAGCGTGAAGTCAGTCGTCTCTGCCTCATGA
GCAGCAACTTCGCGACGGCC

Product: alpha/beta hydrolase fold-3

Products: alcohol; a carboxylate [C]

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MDAPDWQPSLASHLVAMSSRTTLRPLAQLMPSNAYGLAVMDRVLRTALVASRPRRGVTVRKVDTVFAGGPVRGDWITTPA
INPHANPLLYIHGGAYSMCSPETHRGLLGELASASGRPIFAVKYRLAPRYPYPAAADDALNAYRWLTSGGSPGSCQRTVA
VAGDSAGGQLTMATALGARAVGLPLPDAMLLMSPVLDLRCELARAREIRRRDPFASAQSAARALDLYVGGADRGDPRLSV
LDADLTSMPPILIQVGGREMLIDDSRRLAERLQSAGSHVEIQVYRGQIHVFQAMFRILPEARDAIHRAGRFLEASEVR

Sequences:

>Translated_318_residues
MDAPDWQPSLASHLVAMSSRTTLRPLAQLMPSNAYGLAVMDRVLRTALVASRPRRGVTVRKVDTVFAGGPVRGDWITTPA
INPHANPLLYIHGGAYSMCSPETHRGLLGELASASGRPIFAVKYRLAPRYPYPAAADDALNAYRWLTSGGSPGSCQRTVA
VAGDSAGGQLTMATALGARAVGLPLPDAMLLMSPVLDLRCELARAREIRRRDPFASAQSAARALDLYVGGADRGDPRLSV
LDADLTSMPPILIQVGGREMLIDDSRRLAERLQSAGSHVEIQVYRGQIHVFQAMFRILPEARDAIHRAGRFLEASEVR
>Mature_318_residues
MDAPDWQPSLASHLVAMSSRTTLRPLAQLMPSNAYGLAVMDRVLRTALVASRPRRGVTVRKVDTVFAGGPVRGDWITTPA
INPHANPLLYIHGGAYSMCSPETHRGLLGELASASGRPIFAVKYRLAPRYPYPAAADDALNAYRWLTSGGSPGSCQRTVA
VAGDSAGGQLTMATALGARAVGLPLPDAMLLMSPVLDLRCELARAREIRRRDPFASAQSAARALDLYVGGADRGDPRLSV
LDADLTSMPPILIQVGGREMLIDDSRRLAERLQSAGSHVEIQVYRGQIHVFQAMFRILPEARDAIHRAGRFLEASEVR

Specific function: This protein removes the N-acetyl group from bialaphos as one of the final steps of the bialaphos biosynthetic pathway [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21328446, Length=143, Percent_Identity=30.0699300699301, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786682, Length=232, Percent_Identity=26.2931034482759, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115533410, Length=146, Percent_Identity=28.7671232876712, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI115533412, Length=146, Percent_Identity=28.7671232876712, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24656084, Length=138, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24656076, Length=138, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20130169, Length=138, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: 3.1.1.- [C]

Molecular weight: Translated: 34326; Mature: 34326

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS01173 LIPASE_GDXG_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAPDWQPSLASHLVAMSSRTTLRPLAQLMPSNAYGLAVMDRVLRTALVASRPRRGVTVR
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEE
KVDTVFAGGPVRGDWITTPAINPHANPLLYIHGGAYSMCSPETHRGLLGELASASGRPIF
EEEEEEECCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEE
AVKYRLAPRYPYPAAADDALNAYRWLTSGGSPGSCQRTVAVAGDSAGGQLTMATALGARA
EEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEEEEHHCCCC
VGLPLPDAMLLMSPVLDLRCELARAREIRRRDPFASAQSAARALDLYVGGADRGDPRLSV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEEEEECCCCCCCCCEEE
LDADLTSMPPILIQVGGREMLIDDSRRLAERLQSAGSHVEIQVYRGQIHVFQAMFRILPE
EECCHHHCCCEEEEECCCEEEECCHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHHHH
ARDAIHRAGRFLEASEVR
HHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDAPDWQPSLASHLVAMSSRTTLRPLAQLMPSNAYGLAVMDRVLRTALVASRPRRGVTVR
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEE
KVDTVFAGGPVRGDWITTPAINPHANPLLYIHGGAYSMCSPETHRGLLGELASASGRPIF
EEEEEEECCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEE
AVKYRLAPRYPYPAAADDALNAYRWLTSGGSPGSCQRTVAVAGDSAGGQLTMATALGARA
EEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEEEEHHCCCC
VGLPLPDAMLLMSPVLDLRCELARAREIRRRDPFASAQSAARALDLYVGGADRGDPRLSV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEEEEECCCCCCCCCEEE
LDADLTSMPPILIQVGGREMLIDDSRRLAERLQSAGSHVEIQVYRGQIHVFQAMFRILPE
EECCHHHCCCEEEEECCCEEEECCHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHHHH
ARDAIHRAGRFLEASEVR
HHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Carboxylic ester; H2O [C]

Specific reaction: Carboxylic ester + H2O = an alcohol + carboxylate [C]

General reaction: Hydrolase; Acting on ester bonds; Carboxylic ester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2066341 [H]