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The map label for this gene is gltC [H]

Identifier: 108799978

GI number: 108799978

Start: 3183929

End: 3184819

Strand: Reverse

Name: gltC [H]

Synonym: Mmcs_3012

Alternate gene names: 108799978

Gene position: 3184819-3183929 (Counterclockwise)

Preceding gene: 108799982

Following gene: 108799977

Centisome position: 55.82

GC content: 73.4

Gene sequence:

>891_bases
ATGGAATTGCGGCAGCTCGAGTACTTCGTCGCCGTCGCCGAGGAGGCCAACTTCACCCGGGCGGCGCGGCGGGTTCATGT
GGCGCAACCGGCGGTCAGCGCTCAGATCGCCCGCCTGGAGCGCGAACTGGGCCAACCGCTGCTGGACCGGTCGCGCCGGC
AGGTGCGCCTGACGGGGGCGGGTGAGGCCGTCCTGCCGCACGCACGAGCGGCGCTCGCCGCGGTCACGGATGTGCGCACG
GCCGTCGACGACTTGACGGACCTCGTCCGAGGATCGGTGTCGATCGGCACCGTCACCGCGCACAACGTCGACATGCCGGC
GATGCTGGCCGCATTCCACCGCGCCCACCCCGCGGTCGAGATCACGCTGAGCACCGCCGACTCCGAATCGCTGGTGGACG
GTGTGCGGACCGGCCGCCTCGATCTGGCCATCGCCTCCGTCGGCTCCGGGGAAGTGCCCGACGGTCTCGCGGTCGAGGTG
ACCACCGACGAGGCGATCGACGCGGCCGTCCACCTCGCAGATCCGTGGCGGAGACGGCGGTCGGTGCCGCTGGCCGCGCT
CGCCGAGCGCACGCTGATCGCCCTACCGGTCGGGACGGGTATCCGCAGGCGGCTCGAGGAGGCGTTCACCGCGGCCGGTC
TCATGCCACGGATCGCGTTCGAGGCCAGCACCCCGCAGGAGCTGGCCGACCTCGCCGCGCGCGGACTCGGGGTCGCCGTC
GTCCCGCAGTCGCTGGCCCGCAACCGGGCCGACCTGCACGCGGTGTCGATCACTCCGCAGCTGCGCGGACGTCTCGTGCT
GGCGTGGCGAGCGAGCGGGCCGGTGAGCCCGGCGGCGCGGGTGCTCATCGGCATGGCCCGGGAGCACCTGCGTGTCGGCG
GGGGTGCATAG

Upstream 100 bases:

>100_bases
GCGCCGGGAATGAGAACGAAGGTGGCCATGGATTTCACGCTGCCCGCGTGAGCTTCATAAGTCCAATACATGTTCAGAAC
ACAAACTATTGTGATCGCTT

Downstream 100 bases:

>100_bases
AGTTGAGCCCGTGAGCCCAGCCAGCACCTCGACCGACAAGAAGACGGCCACCAGCCAGAAGGCGGACGACAAGCCGACAC
TGATGCTGCTGGACGGCAAC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MELRQLEYFVAVAEEANFTRAARRVHVAQPAVSAQIARLERELGQPLLDRSRRQVRLTGAGEAVLPHARAALAAVTDVRT
AVDDLTDLVRGSVSIGTVTAHNVDMPAMLAAFHRAHPAVEITLSTADSESLVDGVRTGRLDLAIASVGSGEVPDGLAVEV
TTDEAIDAAVHLADPWRRRRSVPLAALAERTLIALPVGTGIRRRLEEAFTAAGLMPRIAFEASTPQELADLAARGLGVAV
VPQSLARNRADLHAVSITPQLRGRLVLAWRASGPVSPAARVLIGMAREHLRVGGGA

Sequences:

>Translated_296_residues
MELRQLEYFVAVAEEANFTRAARRVHVAQPAVSAQIARLERELGQPLLDRSRRQVRLTGAGEAVLPHARAALAAVTDVRT
AVDDLTDLVRGSVSIGTVTAHNVDMPAMLAAFHRAHPAVEITLSTADSESLVDGVRTGRLDLAIASVGSGEVPDGLAVEV
TTDEAIDAAVHLADPWRRRRSVPLAALAERTLIALPVGTGIRRRLEEAFTAAGLMPRIAFEASTPQELADLAARGLGVAV
VPQSLARNRADLHAVSITPQLRGRLVLAWRASGPVSPAARVLIGMAREHLRVGGGA
>Mature_296_residues
MELRQLEYFVAVAEEANFTRAARRVHVAQPAVSAQIARLERELGQPLLDRSRRQVRLTGAGEAVLPHARAALAAVTDVRT
AVDDLTDLVRGSVSIGTVTAHNVDMPAMLAAFHRAHPAVEITLSTADSESLVDGVRTGRLDLAIASVGSGEVPDGLAVEV
TTDEAIDAAVHLADPWRRRRSVPLAALAERTLIALPVGTGIRRRLEEAFTAAGLMPRIAFEASTPQELADLAARGLGVAV
VPQSLARNRADLHAVSITPQLRGRLVLAWRASGPVSPAARVLIGMAREHLRVGGGA

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=294, Percent_Identity=32.9931972789116, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI1790399, Length=283, Percent_Identity=32.1554770318021, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788887, Length=300, Percent_Identity=31.3333333333333, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1790208, Length=252, Percent_Identity=34.5238095238095, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788297, Length=251, Percent_Identity=32.6693227091633, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787879, Length=288, Percent_Identity=30.2083333333333, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787806, Length=283, Percent_Identity=30.0353356890459, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1788748, Length=293, Percent_Identity=28.3276450511945, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1787530, Length=253, Percent_Identity=28.0632411067194, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI2367136, Length=247, Percent_Identity=27.1255060728745, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081904, Length=204, Percent_Identity=28.4313725490196, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI145693105, Length=293, Percent_Identity=23.8907849829352, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787601, Length=265, Percent_Identity=25.6603773584906, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787589, Length=252, Percent_Identity=32.5396825396825, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788296, Length=259, Percent_Identity=26.2548262548263, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI48994962, Length=150, Percent_Identity=30, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789204, Length=244, Percent_Identity=23.3606557377049, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1786401, Length=142, Percent_Identity=30.9859154929577, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31369; Mature: 31369

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRQLEYFVAVAEEANFTRAARRVHVAQPAVSAQIARLERELGQPLLDRSRRQVRLTGA
CCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHCCCCEEEEECC
GEAVLPHARAALAAVTDVRTAVDDLTDLVRGSVSIGTVTAHNVDMPAMLAAFHRAHPAVE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCEEE
ITLSTADSESLVDGVRTGRLDLAIASVGSGEVPDGLAVEVTTDEAIDAAVHLADPWRRRR
EEEECCCCHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEECCHHHHHHHCCCCHHHHHC
SVPLAALAERTLIALPVGTGIRRRLEEAFTAAGLMPRIAFEASTPQELADLAARGLGVAV
CCCHHHHHCCEEEEEECCHHHHHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHCCCCEEE
VPQSLARNRADLHAVSITPQLRGRLVLAWRASGPVSPAARVLIGMAREHLRVGGGA
CCHHHHCCCCCEEEEEECHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MELRQLEYFVAVAEEANFTRAARRVHVAQPAVSAQIARLERELGQPLLDRSRRQVRLTGA
CCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHCCCCEEEEECC
GEAVLPHARAALAAVTDVRTAVDDLTDLVRGSVSIGTVTAHNVDMPAMLAAFHRAHPAVE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCEEE
ITLSTADSESLVDGVRTGRLDLAIASVGSGEVPDGLAVEVTTDEAIDAAVHLADPWRRRR
EEEECCCCHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEECCHHHHHHHCCCCHHHHHC
SVPLAALAERTLIALPVGTGIRRRLEEAFTAAGLMPRIAFEASTPQELADLAARGLGVAV
CCCHHHHHCCEEEEEECCHHHHHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHCCCCEEE
VPQSLARNRADLHAVSITPQLRGRLVLAWRASGPVSPAARVLIGMAREHLRVGGGA
CCHHHHCCCCCEEEEEECHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]