Click here to switch to the map view.

The map label for this gene is pat [H]

Identifier: 108799901

GI number: 108799901

Start: 3092668

End: 3093729

Strand: Reverse

Name: pat [H]

Synonym: Mmcs_2935

Alternate gene names: 108799901

Gene position: 3093729-3092668 (Counterclockwise)

Preceding gene: 108799902

Following gene: 108799900

Centisome position: 54.22

GC content: 69.4

Gene sequence:

>1062_bases
ATGACCATCGTCGCCGAACCGGGACCAGCAACGTCACCACCGGGGCCCGTGCAGCCCAGGATCTCCTCACTGCCCACGGC
GGTCGATCCGATGGCGTTGTCGCTCAACGAGAATCCGTTCCCGCCGCTGCCCGCCGTGCAAACCGCCATGATCGAGTCGA
TCCAGGCGGCCAACAGATACCCGGAGTTCCTTCCGGAATCCCTGCGGCACCTGATCGCCGACCACGTCGCCGTGCCGGAC
GAACAGGTCGTCGTCGGCGCTGGGGCGACCGGGGTGCTGGTCCAGGTCATGCACGCCTTCACCTCGCCGGGGGACCGGAT
CGTCCTGCCGGTCCCGACGTTCGAGGGCTACACCATCGCGTCGGCGATGACCAGGTTGCAGGTGGAGGCGGTTCCGCTGC
TGGCCGACGGCCACCACGACCTGGACGCCATGGCGGACGCGGCGTCCGGTGCCCGGCTCGTCGTGGTCTGCCGGCCGCAC
AACCCGACCGGCACCGTGGAGAGCGCCGCGACGCTCGAGGCCTTCCTGGCCCGGTTGTCCAGCGACACCATCGTCATCCT
CGACGAGGCGTACGTGGAATTCGTCGCGCCACAATGGCGGATCGACGCCGTCGACCTCATCCAACGGTTCCCCAACGTGC
TGGTCCTGCGCACCTTCTCCAAGGCCTACGGGCTCGCGGGTCTGCGCATCGGCTACGCGATCGGCTCCTGGGGGCTGACC
GCCGAACTGTGGGCGATGCAGCTCCCGTTCGGGATGGGCAGCACCGGCCTCGTGGCCGTCGCCGCTTCCTATCAGGCGGA
AAGTCAGCTGCGGCAACGTATCCGGCTGATCACCTCGGAGCGCCGCCATCTGCGGATGCGGTTGCGCGCGATGGGCGTCC
CGAGTATCGACGGACACGCCAACTTCGTGTACCTGCCGGTCGGCGACCGCCCGTGGCGCGAGGTCTTCGACGGCGCCGAC
GGTGTGCGGGTCAAACATTGCGCCGACGGCGGAGTCCGGATCACCGTGGGCGGACGCTCGTCGACCGGTGCCGTGCTGGC
CGCGCTGCGCGGCCGAGGGTGA

Upstream 100 bases:

>100_bases
ACGGCCAACTCAAACGCGGCGACACCGTGCTGATGGCCGCGTTCGCCCACGCCGGCGACTTCGCCGGCGCCGCGGCCGTG
CGGTGGGGTGGTCGATCAGC

Downstream 100 bases:

>100_bases
CGGCCATGCGCGATCATCAGGTCGTCGTCATCGGGGCCGGGCCGTCGGGGGTCGCGGCCGCGCTGAGCCTGCGCGACAGG
GGTCTGCGCCCGGTGCTCAT

Product: aminotransferase

Products: 2-Oxoglutarate; L-Histidinol phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MTIVAEPGPATSPPGPVQPRISSLPTAVDPMALSLNENPFPPLPAVQTAMIESIQAANRYPEFLPESLRHLIADHVAVPD
EQVVVGAGATGVLVQVMHAFTSPGDRIVLPVPTFEGYTIASAMTRLQVEAVPLLADGHHDLDAMADAASGARLVVVCRPH
NPTGTVESAATLEAFLARLSSDTIVILDEAYVEFVAPQWRIDAVDLIQRFPNVLVLRTFSKAYGLAGLRIGYAIGSWGLT
AELWAMQLPFGMGSTGLVAVAASYQAESQLRQRIRLITSERRHLRMRLRAMGVPSIDGHANFVYLPVGDRPWREVFDGAD
GVRVKHCADGGVRITVGGRSSTGAVLAALRGRG

Sequences:

>Translated_353_residues
MTIVAEPGPATSPPGPVQPRISSLPTAVDPMALSLNENPFPPLPAVQTAMIESIQAANRYPEFLPESLRHLIADHVAVPD
EQVVVGAGATGVLVQVMHAFTSPGDRIVLPVPTFEGYTIASAMTRLQVEAVPLLADGHHDLDAMADAASGARLVVVCRPH
NPTGTVESAATLEAFLARLSSDTIVILDEAYVEFVAPQWRIDAVDLIQRFPNVLVLRTFSKAYGLAGLRIGYAIGSWGLT
AELWAMQLPFGMGSTGLVAVAASYQAESQLRQRIRLITSERRHLRMRLRAMGVPSIDGHANFVYLPVGDRPWREVFDGAD
GVRVKHCADGGVRITVGGRSSTGAVLAALRGRG
>Mature_352_residues
TIVAEPGPATSPPGPVQPRISSLPTAVDPMALSLNENPFPPLPAVQTAMIESIQAANRYPEFLPESLRHLIADHVAVPDE
QVVVGAGATGVLVQVMHAFTSPGDRIVLPVPTFEGYTIASAMTRLQVEAVPLLADGHHDLDAMADAASGARLVVVCRPHN
PTGTVESAATLEAFLARLSSDTIVILDEAYVEFVAPQWRIDAVDLIQRFPNVLVLRTFSKAYGLAGLRIGYAIGSWGLTA
ELWAMQLPFGMGSTGLVAVAASYQAESQLRQRIRLITSERRHLRMRLRAMGVPSIDGHANFVYLPVGDRPWREVFDGADG
VRVKHCADGGVRITVGGRSSTGAVLAALRGRG

Specific function: May catalyze the transamination reaction in phenylalanine biosynthesis [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=330, Percent_Identity=29.6969696969697, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1788722, Length=212, Percent_Identity=25.4716981132075, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=280, Percent_Identity=27.1428571428571, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9 [C]

Molecular weight: Translated: 37716; Mature: 37585

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIVAEPGPATSPPGPVQPRISSLPTAVDPMALSLNENPFPPLPAVQTAMIESIQAANRY
CEEEECCCCCCCCCCCCCCCHHHCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCC
PEFLPESLRHLIADHVAVPDEQVVVGAGATGVLVQVMHAFTSPGDRIVLPVPTFEGYTIA
HHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHH
SAMTRLQVEAVPLLADGHHDLDAMADAASGARLVVVCRPHNPTGTVESAATLEAFLARLS
HHHHHHEEEEEEEEECCCCCHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHC
SDTIVILDEAYVEFVAPQWRIDAVDLIQRFPNVLVLRTFSKAYGLAGLRIGYAIGSWGLT
CCEEEEEEHHHHHHHCCCCCCCHHHHHHHCCCEEEEEEHHHHHCCCCEEEEEEECCCCCH
AELWAMQLPFGMGSTGLVAVAASYQAESQLRQRIRLITSERRHLRMRLRAMGVPSIDGHA
HHHHHEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NFVYLPVGDRPWREVFDGADGVRVKHCADGGVRITVGGRSSTGAVLAALRGRG
CEEEEECCCCHHHHHHCCCCCCEEEEECCCCEEEEECCCCCCCHHHHEECCCC
>Mature Secondary Structure 
TIVAEPGPATSPPGPVQPRISSLPTAVDPMALSLNENPFPPLPAVQTAMIESIQAANRY
EEEECCCCCCCCCCCCCCCHHHCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCC
PEFLPESLRHLIADHVAVPDEQVVVGAGATGVLVQVMHAFTSPGDRIVLPVPTFEGYTIA
HHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHH
SAMTRLQVEAVPLLADGHHDLDAMADAASGARLVVVCRPHNPTGTVESAATLEAFLARLS
HHHHHHEEEEEEEEECCCCCHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHC
SDTIVILDEAYVEFVAPQWRIDAVDLIQRFPNVLVLRTFSKAYGLAGLRIGYAIGSWGLT
CCEEEEEEHHHHHHHCCCCCCCHHHHHHHCCCEEEEEEHHHHHCCCCEEEEEEECCCCCH
AELWAMQLPFGMGSTGLVAVAASYQAESQLRQRIRLITSERRHLRMRLRAMGVPSIDGHA
HHHHHEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NFVYLPVGDRPWREVFDGADGVRVKHCADGGVRITVGGRSSTGAVLAALRGRG
CEEEEECCCCHHHHHHCCCCCCEEEEECCCCEEEEECCCCCCCHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-Glutamate; 3-(Imidazol-4-yl)-2-oxopropyl phosphate [C]

Specific reaction: L-Glutamate + 3-(Imidazol-4-yl)-2-oxopropyl phosphate --> 2-Oxoglutarate + L-Histidinol phosphate [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]