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The map label for this gene is pgsA1 [H]

Identifier: 108799815

GI number: 108799815

Start: 3012867

End: 3013469

Strand: Reverse

Name: pgsA1 [H]

Synonym: Mmcs_2849

Alternate gene names: 108799815

Gene position: 3013469-3012867 (Counterclockwise)

Preceding gene: 108799816

Following gene: 108799814

Centisome position: 52.82

GC content: 68.99

Gene sequence:

>603_bases
ATGGACGCATCTGCGTCAGGGGAGCGGGACCGCGTACTGACGGTGCCCAATGCACTGTCCGTGCTGCGCCTGGTGCTGGT
TCCGGTGTTCCTCTGGCTGCTGTTCGGCGCGCACGCCAACGCGTGGGCGGTCGGCGTGCTGATGTTCAGCGGGTTCTCCG
ACTGGGCCGACGGCAAGATCGCGCGGCTGGTCGACAACCAGTCGTCGCGGCTGGGCGAGCTGCTCGACCCGCTGGTCGAC
CGGATCTACATGGTGACGGTTCCGCTGGCGCTGGCGGTCCACGGCACCGTCCCGTGGTGGTTCGTGGTCACGCTGCTCGG
CCGCGACGTGGTGCTCGCCGCGACGTTGCCGCTGCTGCGAAGCCGGGGGCTGGCGGCGCTCCCGGTCACCTACCTCGGAA
AGGCCGCCACGTTCGCGTTGATGTCCGGATTCCCGCTGGTGCTGCTGGGCCAATGGGATGCGCTCTGGAGCCGGGTGGTG
CTGGCCTGCGGTTGGGGTTTCCTGGGCTGGGGGATGGCGCTGTACCTGTGGTCCGGGGTGCTGTATCTGGTGCAGGTGGT
GATGGTCGCCCAGCGATTGCCGAAGGTCCGGACCGGTGGCTGA

Upstream 100 bases:

>100_bases
CCGACCTCCACGTGGACCTACATGGTCCACGACAACCCGTTGGCCGACGACACGATGGCGGCGCTGAGCCTGCCGGGGGT
GTTCCGCTAGGTTTACCGGC

Downstream 100 bases:

>100_bases
GCCGAACAGACTGCTGGGCGGATTCGACCCCGAGGCGGGTCTCAAGCATCACGACGCCGCCGGGCCCCAGAAGATCCCGG
TGCCCTCGCTGCTGCGGTCA

Product: CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MDASASGERDRVLTVPNALSVLRLVLVPVFLWLLFGAHANAWAVGVLMFSGFSDWADGKIARLVDNQSSRLGELLDPLVD
RIYMVTVPLALAVHGTVPWWFVVTLLGRDVVLAATLPLLRSRGLAALPVTYLGKAATFALMSGFPLVLLGQWDALWSRVV
LACGWGFLGWGMALYLWSGVLYLVQVVMVAQRLPKVRTGG

Sequences:

>Translated_200_residues
MDASASGERDRVLTVPNALSVLRLVLVPVFLWLLFGAHANAWAVGVLMFSGFSDWADGKIARLVDNQSSRLGELLDPLVD
RIYMVTVPLALAVHGTVPWWFVVTLLGRDVVLAATLPLLRSRGLAALPVTYLGKAATFALMSGFPLVLLGQWDALWSRVV
LACGWGFLGWGMALYLWSGVLYLVQVVMVAQRLPKVRTGG
>Mature_200_residues
MDASASGERDRVLTVPNALSVLRLVLVPVFLWLLFGAHANAWAVGVLMFSGFSDWADGKIARLVDNQSSRLGELLDPLVD
RIYMVTVPLALAVHGTVPWWFVVTLLGRDVVLAATLPLLRSRGLAALPVTYLGKAATFALMSGFPLVLLGQWDALWSRVV
LACGWGFLGWGMALYLWSGVLYLVQVVMVAQRLPKVRTGG

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=111, Percent_Identity=37.8378378378378, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI10092647, Length=111, Percent_Identity=37.8378378378378, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320059, Length=131, Percent_Identity=32.824427480916, Blast_Score=62, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24650130, Length=105, Percent_Identity=32.3809523809524, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24650126, Length=105, Percent_Identity=32.3809523809524, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24650128, Length=105, Percent_Identity=32.3809523809524, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 21760; Mature: 21760

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDASASGERDRVLTVPNALSVLRLVLVPVFLWLLFGAHANAWAVGVLMFSGFSDWADGKI
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHH
ARLVDNQSSRLGELLDPLVDRIYMVTVPLALAVHGTVPWWFVVTLLGRDVVLAATLPLLR
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHH
SRGLAALPVTYLGKAATFALMSGFPLVLLGQWDALWSRVVLACGWGFLGWGMALYLWSGV
HCCCCCCHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LYLVQVVMVAQRLPKVRTGG
HHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDASASGERDRVLTVPNALSVLRLVLVPVFLWLLFGAHANAWAVGVLMFSGFSDWADGKI
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHH
ARLVDNQSSRLGELLDPLVDRIYMVTVPLALAVHGTVPWWFVVTLLGRDVVLAATLPLLR
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHH
SRGLAALPVTYLGKAATFALMSGFPLVLLGQWDALWSRVVLACGWGFLGWGMALYLWSGV
HCCCCCCHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LYLVQVVMVAQRLPKVRTGG
HHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]