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The map label for this gene is drrB [H]

Identifier: 108799796

GI number: 108799796

Start: 2980453

End: 2981262

Strand: Reverse

Name: drrB [H]

Synonym: Mmcs_2830

Alternate gene names: 108799796

Gene position: 2981262-2980453 (Counterclockwise)

Preceding gene: 108799797

Following gene: 108799795

Centisome position: 52.25

GC content: 65.8

Gene sequence:

>810_bases
ATGACGGCTGCCCTGACCGACCCCAGGCCGGAGCCGAGAACAGTCGGACAGTGGTGGGTACTGACCAACCGGCTGGTGTC
GCCCACCCTGCGCAACGGTGAGGTCGCCACCGCTCTCGTCGCGTCGGTGGTGTTCACCGTGGGCTGGTACATCCCGCTGA
ACAACATCCTCGGTCCCAGGTCAGGGATGAGCAGCTACGCGCAGTTCCTGATGCCCCTCGTTGCGCTGCAGGGGATCTCG
TTCGCGGCGATCACCGGCGCACTGCGCGCGGCGACTGATTCGGTGAAGGGCATCAACAGGCGGTTCGACTCCATGCCGAT
CCCCGCCTTCACGCCGCTGGCGGCGCGCATGTCGGCCGGCCTCTACCGGTGCGCCGTCGGCACGTTCGCGGCTTTGGTCA
GTGGGCACATTATCGGGTTCCGGTTCCACGGCGGTCTGGTGAACGCCGTGCTGTTCTGTGTGTTGCTGCTGGCGATCGGG
CTGGTGCTGTCGTTCCTGGCGGACCTGCTGGGCAGCAATTCGAAGAACCCCGAGGCGACGTCGCAGTGGCTGATGTTGCC
GCAGTTGATCTTCGGGTTGATCTCGGTGGGCATCCAGCCGGCGGAGAACTTCCCGGAGTGGATCCAACCGATCGTGCGGA
ACCAGCCGATCTCGCAGTTCATCTACGCGCTGCGCGCACTCGGGGGTGACACCACACCGGGTGCCGGCGAGGTCAGCTGG
CCGGTCATCGGCCCGTCGGTGGCATGGCTGGTCGGGGTGATGGTGATCATGGTGCCGGTGTCGGTGATGCTACTTCGGAG
GCGATCCTGA

Upstream 100 bases:

>100_bases
ACGACGGGAAATCCAAAGAGCTGGTGGGCAGCTCGGCCGGCGGTTCGGGCCGGCACCGGCGCAACGGACGGGGCTCGCTG
ACGACGTCGGATCTGGCGTC

Downstream 100 bases:

>100_bases
TGACGATGACGCACAACGGGACTCGGCCGGCCGACTCCACGATCCTGCAGGAGGACAGCTTCCCGAAGATCAACCGACCC
CGTCGGGAGAACTCGCCGCG

Product: ABC transporter efflux protein DrrB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MTAALTDPRPEPRTVGQWWVLTNRLVSPTLRNGEVATALVASVVFTVGWYIPLNNILGPRSGMSSYAQFLMPLVALQGIS
FAAITGALRAATDSVKGINRRFDSMPIPAFTPLAARMSAGLYRCAVGTFAALVSGHIIGFRFHGGLVNAVLFCVLLLAIG
LVLSFLADLLGSNSKNPEATSQWLMLPQLIFGLISVGIQPAENFPEWIQPIVRNQPISQFIYALRALGGDTTPGAGEVSW
PVIGPSVAWLVGVMVIMVPVSVMLLRRRS

Sequences:

>Translated_269_residues
MTAALTDPRPEPRTVGQWWVLTNRLVSPTLRNGEVATALVASVVFTVGWYIPLNNILGPRSGMSSYAQFLMPLVALQGIS
FAAITGALRAATDSVKGINRRFDSMPIPAFTPLAARMSAGLYRCAVGTFAALVSGHIIGFRFHGGLVNAVLFCVLLLAIG
LVLSFLADLLGSNSKNPEATSQWLMLPQLIFGLISVGIQPAENFPEWIQPIVRNQPISQFIYALRALGGDTTPGAGEVSW
PVIGPSVAWLVGVMVIMVPVSVMLLRRRS
>Mature_268_residues
TAALTDPRPEPRTVGQWWVLTNRLVSPTLRNGEVATALVASVVFTVGWYIPLNNILGPRSGMSSYAQFLMPLVALQGISF
AAITGALRAATDSVKGINRRFDSMPIPAFTPLAARMSAGLYRCAVGTFAALVSGHIIGFRFHGGLVNAVLFCVLLLAIGL
VLSFLADLLGSNSKNPEATSQWLMLPQLIFGLISVGIQPAENFPEWIQPIVRNQPISQFIYALRALGGDTTPGAGEVSWP
VIGPSVAWLVGVMVIMVPVSVMLLRRRS

Specific function: Part of the ABC transporter complex drrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004377 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 28855; Mature: 28724

Theoretical pI: Translated: 10.61; Mature: 10.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAALTDPRPEPRTVGQWWVLTNRLVSPTLRNGEVATALVASVVFTVGWYIPLNNILGPR
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
SGMSSYAQFLMPLVALQGISFAAITGALRAATDSVKGINRRFDSMPIPAFTPLAARMSAG
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LYRCAVGTFAALVSGHIIGFRFHGGLVNAVLFCVLLLAIGLVLSFLADLLGSNSKNPEAT
HHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
SQWLMLPQLIFGLISVGIQPAENFPEWIQPIVRNQPISQFIYALRALGGDTTPGAGEVSW
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCC
PVIGPSVAWLVGVMVIMVPVSVMLLRRRS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TAALTDPRPEPRTVGQWWVLTNRLVSPTLRNGEVATALVASVVFTVGWYIPLNNILGPR
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
SGMSSYAQFLMPLVALQGISFAAITGALRAATDSVKGINRRFDSMPIPAFTPLAARMSAG
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LYRCAVGTFAALVSGHIIGFRFHGGLVNAVLFCVLLLAIGLVLSFLADLLGSNSKNPEAT
HHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
SQWLMLPQLIFGLISVGIQPAENFPEWIQPIVRNQPISQFIYALRALGGDTTPGAGEVSW
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCC
PVIGPSVAWLVGVMVIMVPVSVMLLRRRS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]