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The map label for this gene is hapE [H]

Identifier: 108799706

GI number: 108799706

Start: 2884429

End: 2886354

Strand: Reverse

Name: hapE [H]

Synonym: Mmcs_2740

Alternate gene names: 108799706

Gene position: 2886354-2884429 (Counterclockwise)

Preceding gene: 108799709

Following gene: 108799701

Centisome position: 50.59

GC content: 67.34

Gene sequence:

>1926_bases
GTGCGCAACCCACATGCCGGACAACCATTCACCGACCCGGACGAACGCATCGCCGATGCGCTGCTCGACGTCAGCATCCC
GACACTGATGATGTCGCTGGTCCACATGTCCGGCGACGCGTCCCTGATCCGCGGGGCGCTCCGGCCCGCCGGCCTGTTCC
TCAACGAGGTGCAGGGTTACATGTCCGAGGAGGACAAGGCCGCGGTCCGCGCGCTCGCCCTGCCGATCATCGCGGACTAC
CGGGACCGCGGATGCCCCGAACCCGCACCGATCCGACCGGAACTCCTGCACGAGATGATGCAGTGGCTGGTCTGCGAAGA
GGTGCCTGCCGAGTACGTGCCGATGCTGCTCGAGGAGATGGAACTCGACGGTCGCGACGACCGCGCGGTGCCACCGCCGG
CCGACCCCGCGCGTGCCGAGTTCCCCGTGCTGGTGATCGGCTGCGGCGAGTCCGGTCTGCTGGCGGGGATCCGTCTCAAG
GAGGCCGGCATCCCGTTCACGATCGTCGAACGCAACACCGGGGTGGGTGGCACCTGGTGGCAGAACACCTATCCGGGCGC
GCGGGTCGACGTCGGCAACCACTTCTACTGCTACAGCTTCGAACCGTCTGACCGGTGGACCCACTTCTTCGCCGAACAGC
CCGAACTGCAGGCCTACTTCCAGGAGGTGTTCGACCGCCACGAAATGTCGCCCCACGTCCGGTTCGGCACCGAGGTCACC
GAGCTGGTCTGGGACGAAGACACCGGTACGTGGACCGCGCACATGCGCGAACTCGAGGGCGCGGTGACCAGTGTGCGGGC
GCGCGCGGTGATCAGCGCGGTGGGCCAGCTCAACCGCCCGCACACCCCGGCGATCGAGGGACAGCACGACTTCGGCGGAC
CGGCCTTTCACTCCGCCGAATGGGACCACTCGGTGGACCTGCGCGGCCGCGAGGTCGCGATGATCGGCGCGGGGGCCAGC
GGTTTCCAGATCGCACCGGCCATCGCACCGAAAGTCAACCGCCTCACCGTCTTTCAGCGCACCGCCCAGTGGATGTTCCC
CAATCCGAACTATCACGCGCCGGTCGGCGACGGGGTGCGCTGGGCGCTGCGGCACCTCCCGTTCTACGGTCGTTGGTACC
GCTTCCTGCTGTTCTGGCCGGGCTGCGACAAGGGACTGGCGGCGGCCAGGGTCGATCCGGACTACCCCGACCCGCAGCGC
GCGGTCAGCGAGGTCAACGACATCGCACGGATGATGTTCACGGAGTGGATCACCAGCCAGGTGGGCGACGACGCCGATCT
GCTGGCCAAGGTGCTGCCGGACTACCCGGCCACCGGCAAACGCACGCTGCAGGACAACGGCAGCTGGTTGCGCACGCTCA
CCCGCGACAATGTGGAACTGGTCCGCACCGGCATCGCCCGCATCGAGCCCGACGCCGTCGTCACCGAGGACGGGACCCGC
TACCCGGCCGATGTCATCGTGTATGCCACCGGGTTTCACGCCAACCGGATGCTGTGGCCGATGCGCGTCGTCGGTCGCGG
CGGGGCGGTGCTCGGGGAGGTGTGGGGTGAACGGCCGTCGGCGTACCTCGGCATCACGGTGCCGGAGTTTCCCAACTTCT
TCTGCATGTACGGGCCCGGCACCAACCTCGCGCACGGTGGCAGCCTGATCTTCCATTCCGAATGTCAGATGCGTTACATC
GCACAGTGTTTGGAGTTGCTGATCGACGGCGGCCACCGCTGGCTGCAGCCTCGGGAGCAGTGCGCTCAGGATTGGTGCAG
ACGCACCCAGGAAGAACTCGGCAGACTGGTCTGGTCGCAGCCGTCGGTCGAGCACTCCTTCTACAAGAACTCCCACGGTG
AGATCTACACGCTCAGCCCGTGGCGCCTCGTCGACTACTGGACGTGGACCCGCCGCCCGGAACCGCGCGACTTCGAGTTC
GGCTAA

Upstream 100 bases:

>100_bases
TCGGGTAACTGACGGTCGTAGTCGGCCGGCTTGTCGGATGGTTCTGTCACCGGACCCAGATACCCGCCCCGGCAGGGTGG
AAACGTGATAGCACCGGACC

Downstream 100 bases:

>100_bases
CCCTCCGCGCCCTCCACCACGGATCGGATGCGTTCCAGTGTCTTGCGCATGTCCCGCAGGTTGCGACGCCGACGCAACTG
GCCGCCGGCCACCGCGAAGA

Product: hypothetical protein

Products: NA

Alternate protein names: HAPMO; Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 641; Mature: 641

Protein sequence:

>641_residues
MRNPHAGQPFTDPDERIADALLDVSIPTLMMSLVHMSGDASLIRGALRPAGLFLNEVQGYMSEEDKAAVRALALPIIADY
RDRGCPEPAPIRPELLHEMMQWLVCEEVPAEYVPMLLEEMELDGRDDRAVPPPADPARAEFPVLVIGCGESGLLAGIRLK
EAGIPFTIVERNTGVGGTWWQNTYPGARVDVGNHFYCYSFEPSDRWTHFFAEQPELQAYFQEVFDRHEMSPHVRFGTEVT
ELVWDEDTGTWTAHMRELEGAVTSVRARAVISAVGQLNRPHTPAIEGQHDFGGPAFHSAEWDHSVDLRGREVAMIGAGAS
GFQIAPAIAPKVNRLTVFQRTAQWMFPNPNYHAPVGDGVRWALRHLPFYGRWYRFLLFWPGCDKGLAAARVDPDYPDPQR
AVSEVNDIARMMFTEWITSQVGDDADLLAKVLPDYPATGKRTLQDNGSWLRTLTRDNVELVRTGIARIEPDAVVTEDGTR
YPADVIVYATGFHANRMLWPMRVVGRGGAVLGEVWGERPSAYLGITVPEFPNFFCMYGPGTNLAHGGSLIFHSECQMRYI
AQCLELLIDGGHRWLQPREQCAQDWCRRTQEELGRLVWSQPSVEHSFYKNSHGEIYTLSPWRLVDYWTWTRRPEPRDFEF
G

Sequences:

>Translated_641_residues
MRNPHAGQPFTDPDERIADALLDVSIPTLMMSLVHMSGDASLIRGALRPAGLFLNEVQGYMSEEDKAAVRALALPIIADY
RDRGCPEPAPIRPELLHEMMQWLVCEEVPAEYVPMLLEEMELDGRDDRAVPPPADPARAEFPVLVIGCGESGLLAGIRLK
EAGIPFTIVERNTGVGGTWWQNTYPGARVDVGNHFYCYSFEPSDRWTHFFAEQPELQAYFQEVFDRHEMSPHVRFGTEVT
ELVWDEDTGTWTAHMRELEGAVTSVRARAVISAVGQLNRPHTPAIEGQHDFGGPAFHSAEWDHSVDLRGREVAMIGAGAS
GFQIAPAIAPKVNRLTVFQRTAQWMFPNPNYHAPVGDGVRWALRHLPFYGRWYRFLLFWPGCDKGLAAARVDPDYPDPQR
AVSEVNDIARMMFTEWITSQVGDDADLLAKVLPDYPATGKRTLQDNGSWLRTLTRDNVELVRTGIARIEPDAVVTEDGTR
YPADVIVYATGFHANRMLWPMRVVGRGGAVLGEVWGERPSAYLGITVPEFPNFFCMYGPGTNLAHGGSLIFHSECQMRYI
AQCLELLIDGGHRWLQPREQCAQDWCRRTQEELGRLVWSQPSVEHSFYKNSHGEIYTLSPWRLVDYWTWTRRPEPRDFEF
G
>Mature_641_residues
MRNPHAGQPFTDPDERIADALLDVSIPTLMMSLVHMSGDASLIRGALRPAGLFLNEVQGYMSEEDKAAVRALALPIIADY
RDRGCPEPAPIRPELLHEMMQWLVCEEVPAEYVPMLLEEMELDGRDDRAVPPPADPARAEFPVLVIGCGESGLLAGIRLK
EAGIPFTIVERNTGVGGTWWQNTYPGARVDVGNHFYCYSFEPSDRWTHFFAEQPELQAYFQEVFDRHEMSPHVRFGTEVT
ELVWDEDTGTWTAHMRELEGAVTSVRARAVISAVGQLNRPHTPAIEGQHDFGGPAFHSAEWDHSVDLRGREVAMIGAGAS
GFQIAPAIAPKVNRLTVFQRTAQWMFPNPNYHAPVGDGVRWALRHLPFYGRWYRFLLFWPGCDKGLAAARVDPDYPDPQR
AVSEVNDIARMMFTEWITSQVGDDADLLAKVLPDYPATGKRTLQDNGSWLRTLTRDNVELVRTGIARIEPDAVVTEDGTR
YPADVIVYATGFHANRMLWPMRVVGRGGAVLGEVWGERPSAYLGITVPEFPNFFCMYGPGTNLAHGGSLIFHSECQMRYI
AQCLELLIDGGHRWLQPREQCAQDWCRRTQEELGRLVWSQPSVEHSFYKNSHGEIYTLSPWRLVDYWTWTRRPEPRDFEF
G

Specific function: Catalyzes a Baeyer-Villiger oxidation reaction, i.e., the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Can oxidize a wide range of acetophenone derivatives. Highest activity occurs with co

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503759, Length=218, Percent_Identity=27.0642201834862, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4503757, Length=217, Percent_Identity=24.8847926267281, Blast_Score=69, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25150462, Length=217, Percent_Identity=24.8847926267281, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR020946 [H]

Pfam domain/function: PF00743 FMO-like [H]

EC number: =1.14.13.84 [H]

Molecular weight: Translated: 72364; Mature: 72364

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNPHAGQPFTDPDERIADALLDVSIPTLMMSLVHMSGDASLIRGALRPAGLFLNEVQGY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
MSEEDKAAVRALALPIIADYRDRGCPEPAPIRPELLHEMMQWLVCEEVPAEYVPMLLEEM
HCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
ELDGRDDRAVPPPADPARAEFPVLVIGCGESGLLAGIRLKEAGIPFTIVERNTGVGGTWW
CCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCEEEEECCCCCCCCCC
QNTYPGARVDVGNHFYCYSFEPSDRWTHFFAEQPELQAYFQEVFDRHEMSPHVRFGTEVT
CCCCCCCEEECCCEEEEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCEEECCHHH
ELVWDEDTGTWTAHMRELEGAVTSVRARAVISAVGQLNRPHTPAIEGQHDFGGPAFHSAE
HHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
WDHSVDLRGREVAMIGAGASGFQIAPAIAPKVNRLTVFQRTAQWMFPNPNYHAPVGDGVR
CCCCCCCCCCEEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHH
WALRHLPFYGRWYRFLLFWPGCDKGLAAARVDPDYPDPQRAVSEVNDIARMMFTEWITSQ
HHHHHCCHHHCEEEEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VGDDADLLAKVLPDYPATGKRTLQDNGSWLRTLTRDNVELVRTGIARIEPDAVVTEDGTR
CCCCHHHHHHHCCCCCCCCCCEECCCCCEEEHHHHCCHHHHHHHHHHCCCCEEEECCCCC
YPADVIVYATGFHANRMLWPMRVVGRGGAVLGEVWGERPSAYLGITVPEFPNFFCMYGPG
CCCEEEEEEECCCCCCEECHHHHHCCCCCHHHHHHCCCCCEEEEEECCCCCCEEEEECCC
TNLAHGGSLIFHSECQMRYIAQCLELLIDGGHRWLQPREQCAQDWCRRTQEELGRLVWSQ
CCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PSVEHSFYKNSHGEIYTLSPWRLVDYWTWTRRPEPRDFEFG
CCCCHHHHCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MRNPHAGQPFTDPDERIADALLDVSIPTLMMSLVHMSGDASLIRGALRPAGLFLNEVQGY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
MSEEDKAAVRALALPIIADYRDRGCPEPAPIRPELLHEMMQWLVCEEVPAEYVPMLLEEM
HCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
ELDGRDDRAVPPPADPARAEFPVLVIGCGESGLLAGIRLKEAGIPFTIVERNTGVGGTWW
CCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCEEEEECCCCCCCCCC
QNTYPGARVDVGNHFYCYSFEPSDRWTHFFAEQPELQAYFQEVFDRHEMSPHVRFGTEVT
CCCCCCCEEECCCEEEEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCEEECCHHH
ELVWDEDTGTWTAHMRELEGAVTSVRARAVISAVGQLNRPHTPAIEGQHDFGGPAFHSAE
HHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
WDHSVDLRGREVAMIGAGASGFQIAPAIAPKVNRLTVFQRTAQWMFPNPNYHAPVGDGVR
CCCCCCCCCCEEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHH
WALRHLPFYGRWYRFLLFWPGCDKGLAAARVDPDYPDPQRAVSEVNDIARMMFTEWITSQ
HHHHHCCHHHCEEEEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VGDDADLLAKVLPDYPATGKRTLQDNGSWLRTLTRDNVELVRTGIARIEPDAVVTEDGTR
CCCCHHHHHHHCCCCCCCCCCEECCCCCEEEHHHHCCHHHHHHHHHHCCCCEEEECCCCC
YPADVIVYATGFHANRMLWPMRVVGRGGAVLGEVWGERPSAYLGITVPEFPNFFCMYGPG
CCCEEEEEEECCCCCCEECHHHHHCCCCCHHHHHHCCCCCEEEEEECCCCCCEEEEECCC
TNLAHGGSLIFHSECQMRYIAQCLELLIDGGHRWLQPREQCAQDWCRRTQEELGRLVWSQ
CCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PSVEHSFYKNSHGEIYTLSPWRLVDYWTWTRRPEPRDFEFG
CCCCHHHHCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11322873 [H]