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The map label for this gene is ddn [H]

Identifier: 108799597

GI number: 108799597

Start: 2789402

End: 2789863

Strand: Reverse

Name: ddn [H]

Synonym: Mmcs_2630

Alternate gene names: 108799597

Gene position: 2789863-2789402 (Counterclockwise)

Preceding gene: 108799600

Following gene: 108799594

Centisome position: 48.9

GC content: 64.72

Gene sequence:

>462_bases
ATGTTGTCACGCGGCGTGACCGAATACGACCAAGACAGGTTTGTCTCCGACGCGGGTTATGTCAACGAGCTCAATCAGAA
CATCATCGCGGAGTTCCGAGCCAACGCGGGCGTCGTCGCCGCCTATGGCGGCAGTGCTGTGCTGTTGCTGCACACCACCG
GCGCCAAGTCCGGACAGCCGCGGCTCTCTCCGCTGGCGTACTCCCTCGTCGGCGGCAGAATGCTGGTCACCGGCTCGTAT
GCCGGGGCGCCGAGAGATCCGGCGTGGGTGCACAACTTGCGGGCGATCCCGCGTGCACGTATCGAGGTCGGCACCGAGGC
CTACGACATCGACGCCCGCGAGTTGCTCGGCGAAGAACGCGACACGGCCTTCCGGGAAATCACCGATCAGGCGCCGGTAT
TCGCTGACTACCAGGCCAGAACGGCACGCACCATCCCCGTGTTCGAACTCCACCGCGTCTGA

Upstream 100 bases:

>100_bases
ACTCGGCCTGCGCCAGGGCTTTACATTGAGTTGGCCGCTGAACTGCTGACAATTGTCGGTCTGCCCGTCGCGTGGTGAGG
AATACGGGGCCCCGCGTGTG

Downstream 100 bases:

>100_bases
CGGGCGCAGAACGGGATTGCACTCTCCGCGGTGTGAGCGTCGTGCAGCGATCTCACTGCAGTCTCGGGTAGGTACCGCTT
TGGTGTCTCCACTGCTCGCC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MLSRGVTEYDQDRFVSDAGYVNELNQNIIAEFRANAGVVAAYGGSAVLLLHTTGAKSGQPRLSPLAYSLVGGRMLVTGSY
AGAPRDPAWVHNLRAIPRARIEVGTEAYDIDARELLGEERDTAFREITDQAPVFADYQARTARTIPVFELHRV

Sequences:

>Translated_153_residues
MLSRGVTEYDQDRFVSDAGYVNELNQNIIAEFRANAGVVAAYGGSAVLLLHTTGAKSGQPRLSPLAYSLVGGRMLVTGSY
AGAPRDPAWVHNLRAIPRARIEVGTEAYDIDARELLGEERDTAFREITDQAPVFADYQARTARTIPVFELHRV
>Mature_153_residues
MLSRGVTEYDQDRFVSDAGYVNELNQNIIAEFRANAGVVAAYGGSAVLLLHTTGAKSGQPRLSPLAYSLVGGRMLVTGSY
AGAPRDPAWVHNLRAIPRARIEVGTEAYDIDARELLGEERDTAFREITDQAPVFADYQARTARTIPVFELHRV

Specific function: Nitroreductase involved in the bioreductive activation of the antitubercular prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It converts PA-824 into three primary metabolites;

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deazaflavin-dependent nitroreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012349
- InterPro:   IPR009002
- InterPro:   IPR004378 [H]

Pfam domain/function: PF04075 DUF385 [H]

EC number: NA

Molecular weight: Translated: 16751; Mature: 16751

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSRGVTEYDQDRFVSDAGYVNELNQNIIAEFRANAGVVAAYGGSAVLLLHTTGAKSGQP
CCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEEECCCCCCCC
RLSPLAYSLVGGRMLVTGSYAGAPRDPAWVHNLRAIPRARIEVGTEAYDIDARELLGEER
CCCHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHCCCCCEEEECCCEECCCHHHHHCCCH
DTAFREITDQAPVFADYQARTARTIPVFELHRV
HHHHHHHHCCCCEEECCCCCCCCCCCEEEECCC
>Mature Secondary Structure
MLSRGVTEYDQDRFVSDAGYVNELNQNIIAEFRANAGVVAAYGGSAVLLLHTTGAKSGQP
CCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEEECCCCCCCC
RLSPLAYSLVGGRMLVTGSYAGAPRDPAWVHNLRAIPRARIEVGTEAYDIDARELLGEER
CCCHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHCCCCCEEEECCCEECCCHHHHHCCCH
DTAFREITDQAPVFADYQARTARTIPVFELHRV
HHHHHHHHCCCCEEECCCCCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]