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The map label for this gene is nuoM [H]

Identifier: 108798535

GI number: 108798535

Start: 1700854

End: 1702407

Strand: Reverse

Name: nuoM [H]

Synonym: Mmcs_1565

Alternate gene names: 108798535

Gene position: 1702407-1700854 (Counterclockwise)

Preceding gene: 108798536

Following gene: 108798534

Centisome position: 29.84

GC content: 66.92

Gene sequence:

>1554_bases
GTGATTCCCTGGCTGAGCGTGCTGTGGGCGGCGCCGATCGTCGGCGCCGGTGTGGTGATGTTGGTGCCCCGTCGCACTCT
GGCGAAGTGGGTGGCGCTGGCGGTGTCGTTGGTCGCGCTGGCGGTCACCGCGGTCGTCGCGGTCGGCTTCGACCCCGGCG
GCGAGCAGTACCAGTTCGTCGAATCCCGCCAATGGATACCGTCGTTCGGCACGGGCTACATCCTCGGTGTCGACGGTATC
GCCCTGGCGCTGATCGTGTTGACCGCGGTGCTGGTGCCGTTGCTGATCGTCGCCGGGTGGAACGACGCCGACCGCGCACC
GCAACGCCGGTCCGTGCACACCTACCTCGCGCTGACACTGGCCGTCGAGGGCATGGTGTTCATGTCGCTGGTCGCCCTCG
ACGTGCTGCTGTTCTACGTGTTCTTCGAGGCCATGCTGATCCCGATGTACTTCCTCATCGGTGGCTTCGGCGCCGACCGG
GCGGCATCGTCCAAGGCGGCGGTAAAGTTCCTGCTGTACAACCTGTTCGGCGGTCTGATCATGTTGGCGGCGGTGATCGG
TCTGTACGTGACCACGGCGGCCAGCGACGCATTCGAGGGGGGCACCTTCGACTTCCGGGCCATCGTCGCGGCCGTCGCCG
CCGGCGACTTCGCGGTGAACCCCGCGGTCCTCAACTTGATGTTCCTCGGTTTCATGTTCGCGTTCGCGGTGAAGGCGCCG
CTGTGGCCGCTGCACCGCTGGTTGCCCGACGCCGCGGTCGAGGCCACCCCCGCGAGCGCGGTGCTGATGATGGCGGTGAT
GGACAAGGTCGGCACGTTCGGCATGCTGCGCTACTGCCTGCAGTTGTTCCCCGACGCCGCAACGCTGTTCCGTCCGCTGA
TCATCACGCTCGCGGTGGTCGGCATCGTCTACGGGGCGGTGGTCGCCATCGGCCAGACCGACGTGATGCGGTTGATCGCC
TACACGTCGATCTCGCATTTCGGTTTCATCATCCTCGGCATCTTCGTCATGACGAGTCAGGGGCAGTCCGGCTCGGCGCT
GTACATGGTCAACCACGGCATCTCGACCGCGGCACTGTTCCTGATCGCGGGTTTCCTGGTGTCGCAGCGCGGTTCGCGCC
TCATCGCCTCCTACGGCGGCGTGCAGAAGGTGGCGCCGGTACTGGCCGGCACCTTCCTCGTCGCGGGTCTGGCGACGTTG
TCGCTACCCGGGCTGGCCCCGTTCATCAGCGAATTCCTGGTGCTCATCGGCACCTTCACCCGCTACCCGGTGCTGGCGGT
GGTGGCGGCCACCGCGCTGGTGCTCTCCGCGATCTACGTGCTGTGGATGTACCAGCGGATGATGACGGGTCCGGTGCGCG
ACGGCAACGAACGGCTGCGTGACCTGGTGCCGCGGGAGCTCGCGGTCGTGACCCCGCTGATCGCGCTTCTGTTGGTGTTG
GGTGTGTATCCGAAACCCGCACTCGACGTGATCGACCCGGCGGTCGGCCACACGCTGACGACCATCAACCAGCCGGACCC
GACGCCGAAGGTCGCAGAGGGGGCCGCCCGGTGA

Upstream 100 bases:

>100_bases
GATTGCGCGGTCTGCAAACCGGATTCGCCCGGTCCTACGCGCTGGGCATGCTCGGCGGCGCGGCGCTCGTGGTGGCGGCG
ATCCTGGCGGTGAACCTGTG

Downstream 100 bases:

>100_bases
TTCCCACTCCTACCGTCGAATACGGTCTGATCTCGCCCATGCTGATCGTGGTGGGCGCCGCGATCGCCGGTGTGCTCGTC
GAGGCGTTCCTGCCCAGGCG

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MIPWLSVLWAAPIVGAGVVMLVPRRTLAKWVALAVSLVALAVTAVVAVGFDPGGEQYQFVESRQWIPSFGTGYILGVDGI
ALALIVLTAVLVPLLIVAGWNDADRAPQRRSVHTYLALTLAVEGMVFMSLVALDVLLFYVFFEAMLIPMYFLIGGFGADR
AASSKAAVKFLLYNLFGGLIMLAAVIGLYVTTAASDAFEGGTFDFRAIVAAVAAGDFAVNPAVLNLMFLGFMFAFAVKAP
LWPLHRWLPDAAVEATPASAVLMMAVMDKVGTFGMLRYCLQLFPDAATLFRPLIITLAVVGIVYGAVVAIGQTDVMRLIA
YTSISHFGFIILGIFVMTSQGQSGSALYMVNHGISTAALFLIAGFLVSQRGSRLIASYGGVQKVAPVLAGTFLVAGLATL
SLPGLAPFISEFLVLIGTFTRYPVLAVVAATALVLSAIYVLWMYQRMMTGPVRDGNERLRDLVPRELAVVTPLIALLLVL
GVYPKPALDVIDPAVGHTLTTINQPDPTPKVAEGAAR

Sequences:

>Translated_517_residues
MIPWLSVLWAAPIVGAGVVMLVPRRTLAKWVALAVSLVALAVTAVVAVGFDPGGEQYQFVESRQWIPSFGTGYILGVDGI
ALALIVLTAVLVPLLIVAGWNDADRAPQRRSVHTYLALTLAVEGMVFMSLVALDVLLFYVFFEAMLIPMYFLIGGFGADR
AASSKAAVKFLLYNLFGGLIMLAAVIGLYVTTAASDAFEGGTFDFRAIVAAVAAGDFAVNPAVLNLMFLGFMFAFAVKAP
LWPLHRWLPDAAVEATPASAVLMMAVMDKVGTFGMLRYCLQLFPDAATLFRPLIITLAVVGIVYGAVVAIGQTDVMRLIA
YTSISHFGFIILGIFVMTSQGQSGSALYMVNHGISTAALFLIAGFLVSQRGSRLIASYGGVQKVAPVLAGTFLVAGLATL
SLPGLAPFISEFLVLIGTFTRYPVLAVVAATALVLSAIYVLWMYQRMMTGPVRDGNERLRDLVPRELAVVTPLIALLLVL
GVYPKPALDVIDPAVGHTLTTINQPDPTPKVAEGAAR
>Mature_517_residues
MIPWLSVLWAAPIVGAGVVMLVPRRTLAKWVALAVSLVALAVTAVVAVGFDPGGEQYQFVESRQWIPSFGTGYILGVDGI
ALALIVLTAVLVPLLIVAGWNDADRAPQRRSVHTYLALTLAVEGMVFMSLVALDVLLFYVFFEAMLIPMYFLIGGFGADR
AASSKAAVKFLLYNLFGGLIMLAAVIGLYVTTAASDAFEGGTFDFRAIVAAVAAGDFAVNPAVLNLMFLGFMFAFAVKAP
LWPLHRWLPDAAVEATPASAVLMMAVMDKVGTFGMLRYCLQLFPDAATLFRPLIITLAVVGIVYGAVVAIGQTDVMRLIA
YTSISHFGFIILGIFVMTSQGQSGSALYMVNHGISTAALFLIAGFLVSQRGSRLIASYGGVQKVAPVLAGTFLVAGLATL
SLPGLAPFISEFLVLIGTFTRYPVLAVVAATALVLSAIYVLWMYQRMMTGPVRDGNERLRDLVPRELAVVTPLIALLLVL
GVYPKPALDVIDPAVGHTLTTINQPDPTPKVAEGAAR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=389, Percent_Identity=28.7917737789203, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI251831117, Length=265, Percent_Identity=24.5283018867925, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1788613, Length=511, Percent_Identity=33.8551859099804, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788829, Length=418, Percent_Identity=28.4688995215311, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788827, Length=411, Percent_Identity=25.7907542579075, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788614, Length=467, Percent_Identity=28.6937901498929, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788831, Length=296, Percent_Identity=24.3243243243243, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI145693160, Length=344, Percent_Identity=26.453488372093, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54977; Mature: 54977

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS00673 V8_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPWLSVLWAAPIVGAGVVMLVPRRTLAKWVALAVSLVALAVTAVVAVGFDPGGEQYQFV
CCCHHHHHHHHHHHHCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
ESRQWIPSFGTGYILGVDGIALALIVLTAVLVPLLIVAGWNDADRAPQRRSVHTYLALTL
HHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AVEGMVFMSLVALDVLLFYVFFEAMLIPMYFLIGGFGADRAASSKAAVKFLLYNLFGGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
MLAAVIGLYVTTAASDAFEGGTFDFRAIVAAVAAGDFAVNPAVLNLMFLGFMFAFAVKAP
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
LWPLHRWLPDAAVEATPASAVLMMAVMDKVGTFGMLRYCLQLFPDAATLFRPLIITLAVV
CHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
GIVYGAVVAIGQTDVMRLIAYTSISHFGFIILGIFVMTSQGQSGSALYMVNHGISTAALF
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHH
LIAGFLVSQRGSRLIASYGGVQKVAPVLAGTFLVAGLATLSLPGLAPFISEFLVLIGTFT
HHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RYPVLAVVAATALVLSAIYVLWMYQRMMTGPVRDGNERLRDLVPRELAVVTPLIALLLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GVYPKPALDVIDPAVGHTLTTINQPDPTPKVAEGAAR
CCCCCCCHHHHCHHHCCEEEECCCCCCCCHHCCCCCC
>Mature Secondary Structure
MIPWLSVLWAAPIVGAGVVMLVPRRTLAKWVALAVSLVALAVTAVVAVGFDPGGEQYQFV
CCCHHHHHHHHHHHHCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
ESRQWIPSFGTGYILGVDGIALALIVLTAVLVPLLIVAGWNDADRAPQRRSVHTYLALTL
HHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AVEGMVFMSLVALDVLLFYVFFEAMLIPMYFLIGGFGADRAASSKAAVKFLLYNLFGGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
MLAAVIGLYVTTAASDAFEGGTFDFRAIVAAVAAGDFAVNPAVLNLMFLGFMFAFAVKAP
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
LWPLHRWLPDAAVEATPASAVLMMAVMDKVGTFGMLRYCLQLFPDAATLFRPLIITLAVV
CHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
GIVYGAVVAIGQTDVMRLIAYTSISHFGFIILGIFVMTSQGQSGSALYMVNHGISTAALF
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHH
LIAGFLVSQRGSRLIASYGGVQKVAPVLAGTFLVAGLATLSLPGLAPFISEFLVLIGTFT
HHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RYPVLAVVAATALVLSAIYVLWMYQRMMTGPVRDGNERLRDLVPRELAVVTPLIALLLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GVYPKPALDVIDPAVGHTLTTINQPDPTPKVAEGAAR
CCCCCCCHHHHCHHHCCEEEECCCCCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]