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The map label for this gene is purK [H]

Identifier: 108798269

GI number: 108798269

Start: 1402796

End: 1403986

Strand: Direct

Name: purK [H]

Synonym: Mmcs_1298

Alternate gene names: 108798269

Gene position: 1402796-1403986 (Clockwise)

Preceding gene: 108798267

Following gene: 108798270

Centisome position: 24.59

GC content: 71.62

Gene sequence:

>1191_bases
GTGGTGGCCATGATCGGCGGGGGTCAACTCGCCCGGATGACCCACCAGGCGGCGATCGCGCTGGGCCAGACTCTGCGGGT
GCTCGCCACCGGCCCGCAGGAGCCGGCCGCCCAGGTGACCCCCGACGTGGTGATCGGATCGCATACCGACCTCGACGCGC
TCCGGCGCGCGGCCGCCGGTGCGACCGTACTGACCTTCGACCACGAACACGTCCCCACCGAAGCACTCGAGACGCTGGTG
GCCGAGGGGGTCAACGTGGCGCCGCCGCCGGCCGCGCTGGTGCACGCGCAGGACAAGCTGGTGATGCGCAGGCGACTCGA
AGCGATGGGTGCGCCGATCCCGCGCTACACCGCCGTCGACACCGTCGACGACGTCGTGGCCTTCTCGTCCGAGGTCGATG
GCCCGGTCGTGCTCAAGACGGTCCGCGGGGGATACGACGGCCGCGGCGTGGTGCTGACCGCCGACGCCGAGGAGGCGCGC
GACGTGGCCGCCCGCTACCTCGCCGACGGTGTGCCGATCCTGGCCGAGGAGCGTGTCGACATGCGCCGCGAGCTCGCGGC
CCTGGTGGCCCGGTCACCGTTCGGGCAGGGTGCGGCGTGGCCGGTGGTCGAGACCGTGCAGCGCGACGGCATCTGCGTCG
TGGTGCTGGCCCCGGCGCCGGAGTTGTCCGACGACCTGGGCTCGAGCGCCCAGCAGCTGGGGTTGAAGCTGGCCGCCGAA
CTCGGCGTGGTCGGGGTGCTCGCCGTCGAACTCTTCGAAACGGTCGACGGCCGGCTGCTGGTCAACGAATTGGCGATGCG
GCCGCACAACTCCGGGCACTGGAGCATGGACGGCGCGGTCACCGGCCAGTTCGAACAGCACGTCCGCGCGGTGCTGGACT
ATCCGCTCGGCGACACCTCGCTGCTCGCCCCGGCCACCGTGATGGCCAATGTCCTCGGGGCGCCGCAGACTCCGGCGATG
ACGATGGACGAACGGGTGCACCACCTGTTCGCCCGCATGCCGGACGCCAAGGTGCACCTGTACGGCAAGGGGGAGCGGCC
CGGCCGCAAGATCGGCCACGTCAACCTCACCGGTGACGATCCGGCGGTGTTGCGTGAGCGGGCCGAGCGGGCCGCGCACT
GGTTGTCCCACGCCGAGTGGACCGACGGATGGGATCCGCACGCCGAAGTCAGGGAAGGAATCTCGAGGTGA

Upstream 100 bases:

>100_bases
CGCTGCTTCGTTCCTGGTCAATGCGCCCCACCCGGGCCATGACACGATAGGCGGCGTGCCGAGCCATACTCCTTCCACCT
CTTCGGCCTCTTCGCCACCG

Downstream 100 bases:

>100_bases
ACGCACCCGCCCCGCGCGTCGGGGTCATCATGGGCAGCGACAGCGACTGGTCGGTGATGGCCGACGCCGCCGAAGCGCTC
GCCGAGTTCGAGGTGGCCTT

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MVAMIGGGQLARMTHQAAIALGQTLRVLATGPQEPAAQVTPDVVIGSHTDLDALRRAAAGATVLTFDHEHVPTEALETLV
AEGVNVAPPPAALVHAQDKLVMRRRLEAMGAPIPRYTAVDTVDDVVAFSSEVDGPVVLKTVRGGYDGRGVVLTADAEEAR
DVAARYLADGVPILAEERVDMRRELAALVARSPFGQGAAWPVVETVQRDGICVVVLAPAPELSDDLGSSAQQLGLKLAAE
LGVVGVLAVELFETVDGRLLVNELAMRPHNSGHWSMDGAVTGQFEQHVRAVLDYPLGDTSLLAPATVMANVLGAPQTPAM
TMDERVHHLFARMPDAKVHLYGKGERPGRKIGHVNLTGDDPAVLRERAERAAHWLSHAEWTDGWDPHAEVREGISR

Sequences:

>Translated_396_residues
MVAMIGGGQLARMTHQAAIALGQTLRVLATGPQEPAAQVTPDVVIGSHTDLDALRRAAAGATVLTFDHEHVPTEALETLV
AEGVNVAPPPAALVHAQDKLVMRRRLEAMGAPIPRYTAVDTVDDVVAFSSEVDGPVVLKTVRGGYDGRGVVLTADAEEAR
DVAARYLADGVPILAEERVDMRRELAALVARSPFGQGAAWPVVETVQRDGICVVVLAPAPELSDDLGSSAQQLGLKLAAE
LGVVGVLAVELFETVDGRLLVNELAMRPHNSGHWSMDGAVTGQFEQHVRAVLDYPLGDTSLLAPATVMANVLGAPQTPAM
TMDERVHHLFARMPDAKVHLYGKGERPGRKIGHVNLTGDDPAVLRERAERAAHWLSHAEWTDGWDPHAEVREGISR
>Mature_396_residues
MVAMIGGGQLARMTHQAAIALGQTLRVLATGPQEPAAQVTPDVVIGSHTDLDALRRAAAGATVLTFDHEHVPTEALETLV
AEGVNVAPPPAALVHAQDKLVMRRRLEAMGAPIPRYTAVDTVDDVVAFSSEVDGPVVLKTVRGGYDGRGVVLTADAEEAR
DVAARYLADGVPILAEERVDMRRELAALVARSPFGQGAAWPVVETVQRDGICVVVLAPAPELSDDLGSSAQQLGLKLAAE
LGVVGVLAVELFETVDGRLLVNELAMRPHNSGHWSMDGAVTGQFEQHVRAVLDYPLGDTSLLAPATVMANVLGAPQTPAM
TMDERVHHLFARMPDAKVHLYGKGERPGRKIGHVNLTGDDPAVLRERAERAAHWLSHAEWTDGWDPHAEVREGISR

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=372, Percent_Identity=29.5698924731183, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788155, Length=386, Percent_Identity=25.6476683937824, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324702, Length=381, Percent_Identity=33.0708661417323, Blast_Score=184, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 42221; Mature: 42221

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAMIGGGQLARMTHQAAIALGQTLRVLATGPQEPAAQVTPDVVIGSHTDLDALRRAAAG
CEEEECCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCEEECCCCCHHHHHHHHCC
ATVLTFDHEHVPTEALETLVAEGVNVAPPPAALVHAQDKLVMRRRLEAMGAPIPRYTAVD
CEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
TVDDVVAFSSEVDGPVVLKTVRGGYDGRGVVLTADAEEARDVAARYLADGVPILAEERVD
HHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCHHHHHHH
MRRELAALVARSPFGQGAAWPVVETVQRDGICVVVLAPAPELSDDLGSSAQQLGLKLAAE
HHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCHHHCCHHHHHHHHHHHH
LGVVGVLAVELFETVDGRLLVNELAMRPHNSGHWSMDGAVTGQFEQHVRAVLDYPLGDTS
HHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCCCH
LLAPATVMANVLGAPQTPAMTMDERVHHLFARMPDAKVHLYGKGERPGRKIGHVNLTGDD
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEECEEEECCCC
PAVLRERAERAAHWLSHAEWTDGWDPHAEVREGISR
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MVAMIGGGQLARMTHQAAIALGQTLRVLATGPQEPAAQVTPDVVIGSHTDLDALRRAAAG
CEEEECCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCEEECCCCCHHHHHHHHCC
ATVLTFDHEHVPTEALETLVAEGVNVAPPPAALVHAQDKLVMRRRLEAMGAPIPRYTAVD
CEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
TVDDVVAFSSEVDGPVVLKTVRGGYDGRGVVLTADAEEARDVAARYLADGVPILAEERVD
HHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCHHHHHHH
MRRELAALVARSPFGQGAAWPVVETVQRDGICVVVLAPAPELSDDLGSSAQQLGLKLAAE
HHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCHHHCCHHHHHHHHHHHH
LGVVGVLAVELFETVDGRLLVNELAMRPHNSGHWSMDGAVTGQFEQHVRAVLDYPLGDTS
HHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCCCH
LLAPATVMANVLGAPQTPAMTMDERVHHLFARMPDAKVHLYGKGERPGRKIGHVNLTGDD
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEECEEEECCCC
PAVLRERAERAAHWLSHAEWTDGWDPHAEVREGISR
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]