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The map label for this gene is upp [H]

Identifier: 108798211

GI number: 108798211

Start: 1343081

End: 1343698

Strand: Direct

Name: upp [H]

Synonym: Mmcs_1240

Alternate gene names: 108798211

Gene position: 1343081-1343698 (Clockwise)

Preceding gene: 108798209

Following gene: 108798214

Centisome position: 23.54

GC content: 72.01

Gene sequence:

>618_bases
GTGCGCGTCGTCGATCACCCGCTGGCCGCTGCTCGACTGACCACGCTGCGCGACCAGTCCACCGACAATGCGGCATTCCG
TTCGGCGTTGCGCGATCTCACGCTGATGCTGGTCTACGAGGCCACCCGCGACGCCGCCCGCGAGGACGTCGAGGTGCGCA
CCCCGCTGGCGGTGACGACCGGGTCGCGGCTGGCGCGCCCGCCGCTGCTGGTTCCGGTCCTGCGCGCCGGGCTCGGGATG
GTCGACCAGGCGCACGCGCTGATCCCCGAGGCGCGGGTGGGGTTCGTCGGCGTGGCCCGCAACGAGGAAACCCACGAGCC
GACACCGTATCTGGAGTCGCTGCCCGCCGACCTGAGCACACAGCCGGTGTTCGTGCTCGATCCGATGCTCGCCACCGGCG
GGTCGCTGGCCCACACCGTCGGGCTGTTGCAGGCGCGCGGCGCCGTCGACATCACCGCCATCTGTGTGGTGGTCGCGCCG
GAGGGTGTCGCCACCCTCGAACGGGCCGCGCCGCACATGCGGCTGTTCACCGCGACGATCGACGAATGCCTCGACGAGGC
CGCCTACATCGTGCCCGGACTCGGTGACGCCGGAGACCGGCAGTTCGGTCCGCGCTGA

Upstream 100 bases:

>100_bases
TCGGCGCGGGCCAGCGCGCGGATGGCGTCGGTGTCGGCGAGCATGCGAATACGACGTTGAGAACGCCCGCGCGGTTCCCG
CTAAGGTCGGCGCCATGGAT

Downstream 100 bases:

>100_bases
GGCTCACCACTGTTGCGCCAGGGCCACCAGCTCGTCGCGCAGCCGCTGCGCCTCGGCGCGCGCCCGCCCCACGTCGCCGG
CGCAGGCGCGTCGAACCTCG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MRVVDHPLAAARLTTLRDQSTDNAAFRSALRDLTLMLVYEATRDAAREDVEVRTPLAVTTGSRLARPPLLVPVLRAGLGM
VDQAHALIPEARVGFVGVARNEETHEPTPYLESLPADLSTQPVFVLDPMLATGGSLAHTVGLLQARGAVDITAICVVVAP
EGVATLERAAPHMRLFTATIDECLDEAAYIVPGLGDAGDRQFGPR

Sequences:

>Translated_205_residues
MRVVDHPLAAARLTTLRDQSTDNAAFRSALRDLTLMLVYEATRDAAREDVEVRTPLAVTTGSRLARPPLLVPVLRAGLGM
VDQAHALIPEARVGFVGVARNEETHEPTPYLESLPADLSTQPVFVLDPMLATGGSLAHTVGLLQARGAVDITAICVVVAP
EGVATLERAAPHMRLFTATIDECLDEAAYIVPGLGDAGDRQFGPR
>Mature_205_residues
MRVVDHPLAAARLTTLRDQSTDNAAFRSALRDLTLMLVYEATRDAAREDVEVRTPLAVTTGSRLARPPLLVPVLRAGLGM
VDQAHALIPEARVGFVGVARNEETHEPTPYLESLPADLSTQPVFVLDPMLATGGSLAHTVGLLQARGAVDITAICVVVAP
EGVATLERAAPHMRLFTATIDECLDEAAYIVPGLGDAGDRQFGPR

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=194, Percent_Identity=27.319587628866, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI57863312, Length=194, Percent_Identity=27.319587628866, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI87082118, Length=212, Percent_Identity=41.5094339622642, Blast_Score=171, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17539892, Length=202, Percent_Identity=27.2277227722772, Blast_Score=76, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17539894, Length=202, Percent_Identity=27.2277227722772, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321920, Length=134, Percent_Identity=39.5522388059701, Blast_Score=99, Evalue=7e-22,
Organism=Drosophila melanogaster, GI45550449, Length=191, Percent_Identity=27.7486910994764, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28573516, Length=191, Percent_Identity=27.7486910994764, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28573514, Length=191, Percent_Identity=27.7486910994764, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28573512, Length=191, Percent_Identity=27.7486910994764, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 21851; Mature: 21851

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVDHPLAAARLTTLRDQSTDNAAFRSALRDLTLMLVYEATRDAAREDVEVRTPLAVTT
CCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCEEEEC
GSRLARPPLLVPVLRAGLGMVDQAHALIPEARVGFVGVARNEETHEPTPYLESLPADLST
CCCCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHCCCCCCC
QPVFVLDPMLATGGSLAHTVGLLQARGAVDITAICVVVAPEGVATLERAAPHMRLFTATI
CCEEEECCHHHCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHCCCHHHHHHHHH
DECLDEAAYIVPGLGDAGDRQFGPR
HHHHHHHHEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MRVVDHPLAAARLTTLRDQSTDNAAFRSALRDLTLMLVYEATRDAAREDVEVRTPLAVTT
CCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCEEEEC
GSRLARPPLLVPVLRAGLGMVDQAHALIPEARVGFVGVARNEETHEPTPYLESLPADLST
CCCCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHCCCCCCC
QPVFVLDPMLATGGSLAHTVGLLQARGAVDITAICVVVAPEGVATLERAAPHMRLFTATI
CCEEEECCHHHCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHCCCHHHHHHHHH
DECLDEAAYIVPGLGDAGDRQFGPR
HHHHHHHHEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]