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The map label for this gene is guaA [H]

Identifier: 108798144

GI number: 108798144

Start: 1271062

End: 1272621

Strand: Direct

Name: guaA [H]

Synonym: Mmcs_1173

Alternate gene names: 108798144

Gene position: 1271062-1272621 (Clockwise)

Preceding gene: 108798141

Following gene: 108798145

Centisome position: 22.28

GC content: 70.0

Gene sequence:

>1560_bases
GTGAATTCCCCATCCCCGCGGCCCGTCCTGGTGGTCGACTTCGGCGCGCAGTATGCGCAGCTGATCGCGCGTCGGGTCCG
CGAAGCCCGGGTCTTCTCCGAGGTCGTCCCGCACACCGCCACCGTCGAGGAGATCAAGGCGAAGGACCCGCAGGCGATCG
TGCTGTCCGGCGGTCCGGCGAGCGTCTACGCCGACGGCGCCCCGCAGCTCGACCCGGCGCTGTTCGACCTCGACGTCCCG
GTGTTCGGCATCTGCTACGGCTTTCAGGCCATGGCGCAGGCGCTCGGTGGCACGGTCACGCACACCGGCACCAGGGAGTA
CGGCCGCACCGAGCTGAAAGTGGCTGGGGGAGAGCTTCATTCGGACCTGCCCGCCGTCCAGCCGGTGTGGATGAGCCACG
GTGACGCGGTCACCGAGGCGCCGTCCGGTTTCGAGGTGGTGGCGACCAGCGCCGGTGCGCCGGTCGCGGCCTTCGAGAAC
CGGGCCCGCCGCCTCGCCGGGGTGCAGTACCACCCCGAGGTGCTGCACTCCCCGCACGGCCAGCAGGTGCTCAGCCGGTT
CCTGCACGAGTTCGCCGGTATCGGCGCCAAATGGACCCCGGCCAACATCGCCGATGCGCTCGTCGAGCAGGTGCGCGAGC
AGATCGGTGACGGTCGCGCCATCTGCGGGCTGTCGGGCGGGGTGGACTCCGCGGTGGCGGCCGCGCTGGTGCAGCGCGCC
ATCGGCGACCGGCTGACCTGTGTGTTCGTCGACCACGGACTGCTGCGCTCGGGGGAGCGGGCACAGGTGCAGCGCGATTT
CGTCGCCGCCACGGGCGCCAATCTGGTCACCGTCGACGTCGCCGACCGCTTCCTCCAGGAACTGTCCGGGGTGACCAACC
CCGAGGGCAAGCGCAAGATCATCGGCCGCGAATTCATCAGCGCCTTCGACGATGCGGTGGTCGACATCGTGGGCGACAGC
GGAGCGCCGGTCGAATTCCTGGTGCAGGGGACCCTCTACCCCGACGTCGTCGAATCCGGCGGCGGCTCGGGTACGGCGAA
CATCAAGAGCCACCACAACGTGGGCGGCCTGCCCGCCGACCTGAAGTTCAAACTCGTCGAACCGCTGCGGCTGCTGTTCA
AGGACGAGGTGCGAGCGGTCGGACGTGAACTCGGGCTGCCCGAGGACATCGTTGCGCGCCAACCCTTCCCGGGTCCGGGG
CTGGGGATCCGCATCGTCGGTGAGGTGACGCGCGGGCGGTTGGAGACGCTGCGGCACGCCGATGCGATCGCCCGTGAGGA
GCTCACCGCCGCGGGTCTGGACAACCAGATCTGGCAGTGCCCGGTGGTGCTGCTGGCCGATGTCCGGTCGGTGGGGGTGC
AGGGCGACGGCCGTACCTACGGCCATCCGATCGTGCTGCGGCCGGTGTCCAGCGAGGACGCCATGACCGCCGACTGGACG
CGGGTGCCCTACGAGGTGCTCGAGCGGATCTCCACCCGCATCACCAACGAGGTGCCCGAGGTGAACCGGGTCGTGCTCGA
CGTCACGAGCAAGCCGCCCGGCACCATCGAGTGGGAATAG

Upstream 100 bases:

>100_bases
AGCGGACCTCGCTTCCAGGTTCGGGTTCCCCGCTGGGGTAACCATTGCCGCCTCGACACTAACGTGACGGCCGAAATCGG
GCCGCCTCTAGAATGAGGCG

Downstream 100 bases:

>100_bases
TCGGGACCAGCGACGACCTGGCGCACAAGCCCGGCGGGGACACCTGCCGGGCTTGACGCTTGTCGGTGGGTCGGTGTTTA
CTCGTCGTATCGAACATGAG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MNSPSPRPVLVVDFGAQYAQLIARRVREARVFSEVVPHTATVEEIKAKDPQAIVLSGGPASVYADGAPQLDPALFDLDVP
VFGICYGFQAMAQALGGTVTHTGTREYGRTELKVAGGELHSDLPAVQPVWMSHGDAVTEAPSGFEVVATSAGAPVAAFEN
RARRLAGVQYHPEVLHSPHGQQVLSRFLHEFAGIGAKWTPANIADALVEQVREQIGDGRAICGLSGGVDSAVAAALVQRA
IGDRLTCVFVDHGLLRSGERAQVQRDFVAATGANLVTVDVADRFLQELSGVTNPEGKRKIIGREFISAFDDAVVDIVGDS
GAPVEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPADLKFKLVEPLRLLFKDEVRAVGRELGLPEDIVARQPFPGPG
LGIRIVGEVTRGRLETLRHADAIAREELTAAGLDNQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWT
RVPYEVLERISTRITNEVPEVNRVVLDVTSKPPGTIEWE

Sequences:

>Translated_519_residues
MNSPSPRPVLVVDFGAQYAQLIARRVREARVFSEVVPHTATVEEIKAKDPQAIVLSGGPASVYADGAPQLDPALFDLDVP
VFGICYGFQAMAQALGGTVTHTGTREYGRTELKVAGGELHSDLPAVQPVWMSHGDAVTEAPSGFEVVATSAGAPVAAFEN
RARRLAGVQYHPEVLHSPHGQQVLSRFLHEFAGIGAKWTPANIADALVEQVREQIGDGRAICGLSGGVDSAVAAALVQRA
IGDRLTCVFVDHGLLRSGERAQVQRDFVAATGANLVTVDVADRFLQELSGVTNPEGKRKIIGREFISAFDDAVVDIVGDS
GAPVEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPADLKFKLVEPLRLLFKDEVRAVGRELGLPEDIVARQPFPGPG
LGIRIVGEVTRGRLETLRHADAIAREELTAAGLDNQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWT
RVPYEVLERISTRITNEVPEVNRVVLDVTSKPPGTIEWE
>Mature_519_residues
MNSPSPRPVLVVDFGAQYAQLIARRVREARVFSEVVPHTATVEEIKAKDPQAIVLSGGPASVYADGAPQLDPALFDLDVP
VFGICYGFQAMAQALGGTVTHTGTREYGRTELKVAGGELHSDLPAVQPVWMSHGDAVTEAPSGFEVVATSAGAPVAAFEN
RARRLAGVQYHPEVLHSPHGQQVLSRFLHEFAGIGAKWTPANIADALVEQVREQIGDGRAICGLSGGVDSAVAAALVQRA
IGDRLTCVFVDHGLLRSGERAQVQRDFVAATGANLVTVDVADRFLQELSGVTNPEGKRKIIGREFISAFDDAVVDIVGDS
GAPVEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPADLKFKLVEPLRLLFKDEVRAVGRELGLPEDIVARQPFPGPG
LGIRIVGEVTRGRLETLRHADAIAREELTAAGLDNQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWT
RVPYEVLERISTRITNEVPEVNRVVLDVTSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=550, Percent_Identity=35.4545454545455, Blast_Score=288, Evalue=9e-78,
Organism=Escherichia coli, GI1788854, Length=522, Percent_Identity=49.2337164750958, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI1789760, Length=160, Percent_Identity=35, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71992717, Length=569, Percent_Identity=35.5008787346221, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI71992710, Length=569, Percent_Identity=35.5008787346221, Blast_Score=286, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI133901714, Length=569, Percent_Identity=35.5008787346221, Blast_Score=285, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6323873, Length=515, Percent_Identity=46.6019417475728, Blast_Score=473, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6322638, Length=192, Percent_Identity=27.6041666666667, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281365319, Length=507, Percent_Identity=34.5167652859961, Blast_Score=276, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 55462; Mature: 55462

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSPSPRPVLVVDFGAQYAQLIARRVREARVFSEVVPHTATVEEIKAKDPQAIVLSGGPA
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEECCCC
SVYADGAPQLDPALFDLDVPVFGICYGFQAMAQALGGTVTHTGTREYGRTELKVAGGELH
EEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCEEECCCHHCCCEEEEEECCHHH
SDLPAVQPVWMSHGDAVTEAPSGFEVVATSAGAPVAAFENRARRLAGVQYHPEVLHSPHG
CCCCCCCCHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHCCCCH
QQVLSRFLHEFAGIGAKWTPANIADALVEQVREQIGDGRAICGLSGGVDSAVAAALVQRA
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHH
IGDRLTCVFVDHGLLRSGERAQVQRDFVAATGANLVTVDVADRFLQELSGVTNPEGKRKI
HCCCEEEEEECCHHHCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCHHHHH
IGREFISAFDDAVVDIVGDSGAPVEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPAD
HHHHHHHHHHHHEEEEECCCCCCEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCCC
LKFKLVEPLRLLFKDEVRAVGRELGLPEDIVARQPFPGPGLGIRIVGEVTRGRLETLRHA
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHH
DAIAREELTAAGLDNQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWT
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCHH
RVPYEVLERISTRITNEVPEVNRVVLDVTSKPPGTIEWE
CCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MNSPSPRPVLVVDFGAQYAQLIARRVREARVFSEVVPHTATVEEIKAKDPQAIVLSGGPA
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEECCCC
SVYADGAPQLDPALFDLDVPVFGICYGFQAMAQALGGTVTHTGTREYGRTELKVAGGELH
EEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCEEECCCHHCCCEEEEEECCHHH
SDLPAVQPVWMSHGDAVTEAPSGFEVVATSAGAPVAAFENRARRLAGVQYHPEVLHSPHG
CCCCCCCCHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHCCCCH
QQVLSRFLHEFAGIGAKWTPANIADALVEQVREQIGDGRAICGLSGGVDSAVAAALVQRA
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHH
IGDRLTCVFVDHGLLRSGERAQVQRDFVAATGANLVTVDVADRFLQELSGVTNPEGKRKI
HCCCEEEEEECCHHHCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCHHHHH
IGREFISAFDDAVVDIVGDSGAPVEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPAD
HHHHHHHHHHHHEEEEECCCCCCEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCCC
LKFKLVEPLRLLFKDEVRAVGRELGLPEDIVARQPFPGPGLGIRIVGEVTRGRLETLRHA
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHH
DAIAREELTAAGLDNQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWT
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCHH
RVPYEVLERISTRITNEVPEVNRVVLDVTSKPPGTIEWE
CCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA