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The map label for this gene is groEL [H]

Identifier: 108798126

GI number: 108798126

Start: 1251505

End: 1253127

Strand: Direct

Name: groEL [H]

Synonym: Mmcs_1154

Alternate gene names: 108798126

Gene position: 1251505-1253127 (Clockwise)

Preceding gene: 108798125

Following gene: 108798128

Centisome position: 21.94

GC content: 69.5

Gene sequence:

>1623_bases
ATGAGCAAGCAGATCGAATTCAACGAAACTGCGCGCCGCGCAATGGAGATCGGCGTAGACAAGCTCGCCGACGCGGTGAA
GGTGACCCTGGGGCCGCGCGGTCGCAACGTGGTGCTCGCCAAGTCGTGGGGCGGCCCGACCGTCACCAACGACGGTGTCA
CCATCGCCCGTGAGATCGACCTCGAGGATCCGTTCGAGAACCTCGGCGCCCAGCTGGTCAAGTCGGTGGCGACCAAGACC
AACGACGTCGCCGGCGACGGCACCACCACCGCCACCGTGCTGGCGCAGGCGCTGGTGCGCGCCGGTCTGCGCAACGTCGC
GGCCGGCGCCAACCCGATCGCCCTGGGCGCGGGGATCAGCAAGGCCGCCGACGCCGTGTCCGAGGCGCTGCTGGCCGCGG
CCACCCCCGTCGACGACAAGAGCGGTATCGCCCAGGTCGCCACGGTCAGCTCACGCGACGAGCAGATCGGCGAGCTGGTC
GGCGAGGCGATGACCAAGGTCGGCCACGACGGTGTCGTGACCGTCGAGGAGTCCTCGACCCTGAACACCGAACTCGAGGT
CACCGAGGGCGTCGGCTTCGACAAGGGGTTCATCTCGGCGTACTTCGTCACCGACTTCGACTCCCAGGAAGCGGTGCTCG
AGGACGCGCTGGTGCTGCTGCACCGCGAGAAGGTCAGCTCGCTGCCGGACCTGCTGCCGCTGCTGGAGAAGGTCGCCGAA
GCCGGTAAGCCGCTGCTGATCATCGCCGAGGACGTCGAGGGTGAGGCGCTGTCCACACTGGTGGTCAACGCGATCCGTAA
GACGCTCAAGGCCGTCGCCGTCAAGGCGCCGTTCTTCGGTGACCGTCGCAAGGCGTTCCTCGACGACCTCGCCGTCGTCA
CCGGCGGCCAGGTGATCAACCCCGACGTCGGCCTGGTGCTGCGCGAGGTCGGCCTCGACGTCCTGGGCACCGCGCGCCGC
GTGGTGGTCACCAAGGACAGCACCGTGATCGTCGACGGCGGCGGCAGCGCCGACGCCATCGCCGACCGGGCCAAGCAGCT
GCGGGCCGAGATCGAGGCGACCGACTCCGACTGGGATCGCGAGAAGCTCGAGGAGCGGCTGGCCAAGCTGGCCGGCGGCG
TCGCGGTGATCAAGGTCGGTGCGGCCACCGAGACCGATCTGAAGAAGCGCAAGGAAGCCGTCGAGGACGCGGTCTCCGCG
GCCAAGGCGGCCGTCGAGGAGGGCATCGTCACCGGCGGCGGTGCCGCCCTGGTGCAGGCCCGCAAGGCGCTGGACAGCCT
GCGGGGCTCGGTCTCCGGCGACGAGGCGCTCGGTGTCGAGGTGTTCAACTCCGCGCTGTCGGCTCCGCTGTACTGGATCG
CCACCAACGCCGGGCTCGACGGTTCGGTCGTGGTGAACAAGGTCAGCGAACTGCCTGCGGGACAGGGCTTCAACGCCGCG
ACGCTCGAGTTCGGCGACCTGCTCGCCGACGGCGTCGTCGACCCGGTCAAGGTGACGCGATCGGCGGTGCTCAACGCCGC
GTCGGTCGCCCGCATGGTGCTCACCACCGAGACCGCGATCGTCGACAAGCCGGCCGAGGAAGAGGATCACGGCCACGGCC
ACCATCACGGCCACGCTCACTGA

Upstream 100 bases:

>100_bases
CGTCAACAAGTAAGCACCCGTGTCCGCCCCGGAGATCCCCGTATTGCACGGGTGATGTCCGGGGCGGCATGCGTTGCATG
CCAAAAACAGGAAGACACAT

Downstream 100 bases:

>100_bases
GTAGTCCGCACGACGCACCCCCGGTCCTGTTGGGCCGGGGGTGCGTTCGTTGGGCGTAGAAGTCTTCAGATCCGCCGACC
CCGGCAGCGCTCAGGGAGCC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MSKQIEFNETARRAMEIGVDKLADAVKVTLGPRGRNVVLAKSWGGPTVTNDGVTIAREIDLEDPFENLGAQLVKSVATKT
NDVAGDGTTTATVLAQALVRAGLRNVAAGANPIALGAGISKAADAVSEALLAAATPVDDKSGIAQVATVSSRDEQIGELV
GEAMTKVGHDGVVTVEESSTLNTELEVTEGVGFDKGFISAYFVTDFDSQEAVLEDALVLLHREKVSSLPDLLPLLEKVAE
AGKPLLIIAEDVEGEALSTLVVNAIRKTLKAVAVKAPFFGDRRKAFLDDLAVVTGGQVINPDVGLVLREVGLDVLGTARR
VVVTKDSTVIVDGGGSADAIADRAKQLRAEIEATDSDWDREKLEERLAKLAGGVAVIKVGAATETDLKKRKEAVEDAVSA
AKAAVEEGIVTGGGAALVQARKALDSLRGSVSGDEALGVEVFNSALSAPLYWIATNAGLDGSVVVNKVSELPAGQGFNAA
TLEFGDLLADGVVDPVKVTRSAVLNAASVARMVLTTETAIVDKPAEEEDHGHGHHHGHAH

Sequences:

>Translated_540_residues
MSKQIEFNETARRAMEIGVDKLADAVKVTLGPRGRNVVLAKSWGGPTVTNDGVTIAREIDLEDPFENLGAQLVKSVATKT
NDVAGDGTTTATVLAQALVRAGLRNVAAGANPIALGAGISKAADAVSEALLAAATPVDDKSGIAQVATVSSRDEQIGELV
GEAMTKVGHDGVVTVEESSTLNTELEVTEGVGFDKGFISAYFVTDFDSQEAVLEDALVLLHREKVSSLPDLLPLLEKVAE
AGKPLLIIAEDVEGEALSTLVVNAIRKTLKAVAVKAPFFGDRRKAFLDDLAVVTGGQVINPDVGLVLREVGLDVLGTARR
VVVTKDSTVIVDGGGSADAIADRAKQLRAEIEATDSDWDREKLEERLAKLAGGVAVIKVGAATETDLKKRKEAVEDAVSA
AKAAVEEGIVTGGGAALVQARKALDSLRGSVSGDEALGVEVFNSALSAPLYWIATNAGLDGSVVVNKVSELPAGQGFNAA
TLEFGDLLADGVVDPVKVTRSAVLNAASVARMVLTTETAIVDKPAEEEDHGHGHHHGHAH
>Mature_539_residues
SKQIEFNETARRAMEIGVDKLADAVKVTLGPRGRNVVLAKSWGGPTVTNDGVTIAREIDLEDPFENLGAQLVKSVATKTN
DVAGDGTTTATVLAQALVRAGLRNVAAGANPIALGAGISKAADAVSEALLAAATPVDDKSGIAQVATVSSRDEQIGELVG
EAMTKVGHDGVVTVEESSTLNTELEVTEGVGFDKGFISAYFVTDFDSQEAVLEDALVLLHREKVSSLPDLLPLLEKVAEA
GKPLLIIAEDVEGEALSTLVVNAIRKTLKAVAVKAPFFGDRRKAFLDDLAVVTGGQVINPDVGLVLREVGLDVLGTARRV
VVTKDSTVIVDGGGSADAIADRAKQLRAEIEATDSDWDREKLEERLAKLAGGVAVIKVGAATETDLKKRKEAVEDAVSAA
KAAVEEGIVTGGGAALVQARKALDSLRGSVSGDEALGVEVFNSALSAPLYWIATNAGLDGSVVVNKVSELPAGQGFNAAT
LEFGDLLADGVVDPVKVTRSAVLNAASVARMVLTTETAIVDKPAEEEDHGHGHHHGHAH

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=45.6603773584906, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=45.6603773584906, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI38455427, Length=569, Percent_Identity=21.0896309314587, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI5453603, Length=131, Percent_Identity=38.1679389312977, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1790586, Length=524, Percent_Identity=54.9618320610687, Blast_Score=545, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=43.0188679245283, Blast_Score=432, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=39.3364928909953, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17564182, Length=528, Percent_Identity=22.5378787878788, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323288, Length=525, Percent_Identity=45.9047619047619, Blast_Score=452, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6322524, Length=113, Percent_Identity=36.283185840708, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320393, Length=548, Percent_Identity=22.0802919708029, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=46.4015151515151, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=46.4015151515151, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=44.3181818181818, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=44.3181818181818, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=44.3181818181818, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI17864606, Length=524, Percent_Identity=39.8854961832061, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24584129, Length=529, Percent_Identity=33.4593572778828, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI19921262, Length=529, Percent_Identity=33.4593572778828, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24645179, Length=479, Percent_Identity=21.294363256785, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24583944, Length=132, Percent_Identity=30.3030303030303, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI18858175, Length=134, Percent_Identity=35.8208955223881, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28571140, Length=134, Percent_Identity=35.8208955223881, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 56004; Mature: 55873

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQIEFNETARRAMEIGVDKLADAVKVTLGPRGRNVVLAKSWGGPTVTNDGVTIAREID
CCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCEEEEEECC
LEDPFENLGAQLVKSVATKTNDVAGDGTTTATVLAQALVRAGLRNVAAGANPIALGAGIS
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHH
KAADAVSEALLAAATPVDDKSGIAQVATVSSRDEQIGELVGEAMTKVGHDGVVTVEESST
HHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCC
LNTELEVTEGVGFDKGFISAYFVTDFDSQEAVLEDALVLLHREKVSSLPDLLPLLEKVAE
CCCEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AGKPLLIIAEDVEGEALSTLVVNAIRKTLKAVAVKAPFFGDRRKAFLDDLAVVTGGQVIN
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEC
PDVGLVLREVGLDVLGTARRVVVTKDSTVIVDGGGSADAIADRAKQLRAEIEATDSDWDR
CCHHHHHHHHCHHHHCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCH
EKLEERLAKLAGGVAVIKVGAATETDLKKRKEAVEDAVSAAKAAVEEGIVTGGGAALVQA
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
RKALDSLRGSVSGDEALGVEVFNSALSAPLYWIATNAGLDGSVVVNKVSELPAGQGFNAA
HHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCH
TLEFGDLLADGVVDPVKVTRSAVLNAASVARMVLTTETAIVDKPAEEEDHGHGHHHGHAH
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKQIEFNETARRAMEIGVDKLADAVKVTLGPRGRNVVLAKSWGGPTVTNDGVTIAREID
CCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCEEEEEECC
LEDPFENLGAQLVKSVATKTNDVAGDGTTTATVLAQALVRAGLRNVAAGANPIALGAGIS
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHH
KAADAVSEALLAAATPVDDKSGIAQVATVSSRDEQIGELVGEAMTKVGHDGVVTVEESST
HHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCC
LNTELEVTEGVGFDKGFISAYFVTDFDSQEAVLEDALVLLHREKVSSLPDLLPLLEKVAE
CCCEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AGKPLLIIAEDVEGEALSTLVVNAIRKTLKAVAVKAPFFGDRRKAFLDDLAVVTGGQVIN
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEC
PDVGLVLREVGLDVLGTARRVVVTKDSTVIVDGGGSADAIADRAKQLRAEIEATDSDWDR
CCHHHHHHHHCHHHHCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCH
EKLEERLAKLAGGVAVIKVGAATETDLKKRKEAVEDAVSAAKAAVEEGIVTGGGAALVQA
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
RKALDSLRGSVSGDEALGVEVFNSALSAPLYWIATNAGLDGSVVVNKVSELPAGQGFNAA
HHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCH
TLEFGDLLADGVVDPVKVTRSAVLNAASVARMVLTTETAIVDKPAEEEDHGHGHHHGHAH
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA