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The map label for this gene is glmS [H]

Identifier: 108798111

GI number: 108798111

Start: 1238042

End: 1239907

Strand: Direct

Name: glmS [H]

Synonym: Mmcs_1139

Alternate gene names: 108798111

Gene position: 1238042-1239907 (Clockwise)

Preceding gene: 108798108

Following gene: 108798114

Centisome position: 21.7

GC content: 67.74

Gene sequence:

>1866_bases
ATGTGTGGAATCGTCGGCTATGTCGGGCATCGTCCTGCCTGCGCCATCGTGGTCGACGCGCTGCACCGAATGGAATACCG
CGGGTACGACTCGGCGGGCATCGCGCTACTCGACGGGCACGGCGGGATGACCGTCCACCGGCGCGCGGGCCGGCTGACCA
ACCTCGGTGAGGTCCTGGAGTGCTCGGCACCGGACACACTGGTCGGCTGCAGCGGGCTCGGCCACACCCGATGGGCGACG
CACGGCCGACCCACCGACCGCAACGCGCACCCGCACCGGGATGCCGACGGCAAGATCGTCGTCGTCCACAACGGGATCAT
CGAGAACTACGCCCCGCTGCGCGGTGAACTCGAGGCCGAGGGCGTCGAGTTCGCCAGCGACACCGACACCGAGGTCGCCG
TCCACCTGGTCGGGCGCCAGTACCGCTACGGCGACACCGCGGGCGATTTCCCGGCCTCGGTGCTGGCCGTGCTGCGTCGG
TTGGAGGGGCACTTCACGCTGGTCTTCGCCAACGCCGACGAACCGGGCACGATCGTCGCGGCGCGCCGCTCGACGCCGCT
GGTGCTCGGCATCGGCGACGGGGAGATGTTCGTCAGCTCCGACGTCGCGGCGTTCATCGAGCACACCCGCCACGCCGTCG
AACTCGGCCAGGATCAAGCCGTCGTGGTCACCGCCGACGGCTACACCGTCAGCGACTTCCACGGCAACACCGATGTGGAC
TTCCGGGAATTCCACATCGACTGGGACCTGTCGGCCGCCGAGAAGGGCGGCTACGAGTACTTCATGCTCAAGGAGATCGC
CGAGCAACCCGCCGCGGTCTCCGACACGCTGCTCGGCCATTTCATCGACGGCCGCATCGTGCTCGACGAGCAGCGCCTCA
GCGATCAGGAACTGCGCGACATCGACAAGGTGTTCGTGGTGGCCTGCGGGACGGCGTACCACTCGGGTCTGCTGGCCAAG
TACGCGATCGAGCACTGGACACGGCTGCCCGTCGAGATCGAACTCGCCAGCGAGTTCCGCTACCGCGACCCAGTGCTGGA
CCGCAGCACGCTGGTGGTGGCGATCTCGCAGTCCGGGGAGACTGCCGACACCCTCGAAGCGGTGCGGCATGCCAAGAAGC
AGAAGGCCAAGGTGCTGGCGATCTGCAACACGAACGGCAGCCAGATCCCCCGCGAGGCCGACGCGGTGCTCTACACCCGC
GCCGGACCCGAGATCGGCGTCGCGGCCACCAAGACGTTCCTCGCCCAGATCGCCGCCAACTATCTCGTCGGGCTGGCCCT
GGCCCAGGCCCGCGGCACCAAGTACCCCGACGAGGTGGCGCGGGAGTACCACGAACTCGAGGCCATGCCGAAGCTCGTCG
CGCAGGTGCTCAAACAGCTCAACCCGATCGTGGAACTGGCCCACCGTTTCGCCGACAAGCCGACGATCCTGTTCCTCGGC
CGGCACGTCGGCTATCCGGTGGCGCTCGAAGGCGCGCTCAAACTCAAGGAGCTGGCGTACATGCACGCCGAGGGCTTCGC
CGCCGGTGAGCTCAAACACGGTCCCATCGCGCTGATCGACGAGGGTCTGCCGGTGATCGTGGTGATGCCGTCGCCCAAGG
GGGCGTCGATGCTGCACGCCAAGCTGCTGTCGAACATCCGGGAGATCCAGGCCCGCGGCGCGACCACCATCGTGATCGCC
GAGGAGGGTGACGACACGGTGCGGCCGTTTGCGGATCACATCTTCGAGATCCCGGCCACCACAACGCTTTACCAACCGCT
GCTGTCGACGATCCCGCTGCAGGTGTTCGCCGCGGAGGTCGCCAGGGCGCGCGGCTACGACGTCGACAAACCGCGCAACC
TCGCCAAGTCGGTCACCGTCGAATAG

Upstream 100 bases:

>100_bases
GCCGCGGCGGGTCAAAGCCTTGAACAGCTTCTTTGTGCTGGCCACCTGACGACCGTAGCTCACCTCTCCCCGCTCGGCTC
TTGCACTACCCTGGTTCTCT

Downstream 100 bases:

>100_bases
TGGCGGCGAGCTGATCGAAGGTCAGTGTCCAGCCGCTGTGGAAGTTCTGGAATTCCGTTGGCGGGAGCTGTGTGTGCTCG
ATCGACATGAGTGTCTCATC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 621; Mature: 621

Protein sequence:

>621_residues
MCGIVGYVGHRPACAIVVDALHRMEYRGYDSAGIALLDGHGGMTVHRRAGRLTNLGEVLECSAPDTLVGCSGLGHTRWAT
HGRPTDRNAHPHRDADGKIVVVHNGIIENYAPLRGELEAEGVEFASDTDTEVAVHLVGRQYRYGDTAGDFPASVLAVLRR
LEGHFTLVFANADEPGTIVAARRSTPLVLGIGDGEMFVSSDVAAFIEHTRHAVELGQDQAVVVTADGYTVSDFHGNTDVD
FREFHIDWDLSAAEKGGYEYFMLKEIAEQPAAVSDTLLGHFIDGRIVLDEQRLSDQELRDIDKVFVVACGTAYHSGLLAK
YAIEHWTRLPVEIELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKKQKAKVLAICNTNGSQIPREADAVLYTR
AGPEIGVAATKTFLAQIAANYLVGLALAQARGTKYPDEVAREYHELEAMPKLVAQVLKQLNPIVELAHRFADKPTILFLG
RHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIDEGLPVIVVMPSPKGASMLHAKLLSNIREIQARGATTIVIA
EEGDDTVRPFADHIFEIPATTTLYQPLLSTIPLQVFAAEVARARGYDVDKPRNLAKSVTVE

Sequences:

>Translated_621_residues
MCGIVGYVGHRPACAIVVDALHRMEYRGYDSAGIALLDGHGGMTVHRRAGRLTNLGEVLECSAPDTLVGCSGLGHTRWAT
HGRPTDRNAHPHRDADGKIVVVHNGIIENYAPLRGELEAEGVEFASDTDTEVAVHLVGRQYRYGDTAGDFPASVLAVLRR
LEGHFTLVFANADEPGTIVAARRSTPLVLGIGDGEMFVSSDVAAFIEHTRHAVELGQDQAVVVTADGYTVSDFHGNTDVD
FREFHIDWDLSAAEKGGYEYFMLKEIAEQPAAVSDTLLGHFIDGRIVLDEQRLSDQELRDIDKVFVVACGTAYHSGLLAK
YAIEHWTRLPVEIELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKKQKAKVLAICNTNGSQIPREADAVLYTR
AGPEIGVAATKTFLAQIAANYLVGLALAQARGTKYPDEVAREYHELEAMPKLVAQVLKQLNPIVELAHRFADKPTILFLG
RHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIDEGLPVIVVMPSPKGASMLHAKLLSNIREIQARGATTIVIA
EEGDDTVRPFADHIFEIPATTTLYQPLLSTIPLQVFAAEVARARGYDVDKPRNLAKSVTVE
>Mature_621_residues
MCGIVGYVGHRPACAIVVDALHRMEYRGYDSAGIALLDGHGGMTVHRRAGRLTNLGEVLECSAPDTLVGCSGLGHTRWAT
HGRPTDRNAHPHRDADGKIVVVHNGIIENYAPLRGELEAEGVEFASDTDTEVAVHLVGRQYRYGDTAGDFPASVLAVLRR
LEGHFTLVFANADEPGTIVAARRSTPLVLGIGDGEMFVSSDVAAFIEHTRHAVELGQDQAVVVTADGYTVSDFHGNTDVD
FREFHIDWDLSAAEKGGYEYFMLKEIAEQPAAVSDTLLGHFIDGRIVLDEQRLSDQELRDIDKVFVVACGTAYHSGLLAK
YAIEHWTRLPVEIELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKKQKAKVLAICNTNGSQIPREADAVLYTR
AGPEIGVAATKTFLAQIAANYLVGLALAQARGTKYPDEVAREYHELEAMPKLVAQVLKQLNPIVELAHRFADKPTILFLG
RHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIDEGLPVIVVMPSPKGASMLHAKLLSNIREIQARGATTIVIA
EEGDDTVRPFADHIFEIPATTTLYQPLLSTIPLQVFAAEVARARGYDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=694, Percent_Identity=37.0317002881844, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI205277386, Length=694, Percent_Identity=34.7262247838617, Blast_Score=372, Evalue=1e-103,
Organism=Escherichia coli, GI1790167, Length=623, Percent_Identity=44.1412520064205, Blast_Score=487, Evalue=1e-139,
Organism=Escherichia coli, GI1788651, Length=174, Percent_Identity=28.735632183908, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532899, Length=725, Percent_Identity=34.3448275862069, Blast_Score=369, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17539970, Length=436, Percent_Identity=36.9266055045872, Blast_Score=279, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI17532897, Length=438, Percent_Identity=36.986301369863, Blast_Score=277, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6322745, Length=437, Percent_Identity=36.3844393592677, Blast_Score=250, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6323731, Length=440, Percent_Identity=29.7727272727273, Blast_Score=181, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6323730, Length=214, Percent_Identity=35.0467289719626, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI21357745, Length=699, Percent_Identity=36.0515021459227, Blast_Score=395, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67530; Mature: 67530

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYVGHRPACAIVVDALHRMEYRGYDSAGIALLDGHGGMTVHRRAGRLTNLGEVLE
CCCEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCCCCCHHHC
CSAPDTLVGCSGLGHTRWATHGRPTDRNAHPHRDADGKIVVVHNGIIENYAPLRGELEAE
CCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHCCCCCCCCCCCC
GVEFASDTDTEVAVHLVGRQYRYGDTAGDFPASVLAVLRRLEGHFTLVFANADEPGTIVA
CCEECCCCCCCEEEEEECCEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEE
ARRSTPLVLGIGDGEMFVSSDVAAFIEHTRHAVELGQDQAVVVTADGYTVSDFHGNTDVD
EECCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEECCCCCCCCC
FREFHIDWDLSAAEKGGYEYFMLKEIAEQPAAVSDTLLGHFIDGRIVLDEQRLSDQELRD
EEEEEEEECCCHHCCCCCEEEEHHHHHHCCCHHHHHHHHHHCCCEEEEEHHHCCHHHHHH
IDKVFVVACGTAYHSGLLAKYAIEHWTRLPVEIELASEFRYRDPVLDRSTLVVAISQSGE
HHHEEEEEECHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCC
TADTLEAVRHAKKQKAKVLAICNTNGSQIPREADAVLYTRAGPEIGVAATKTFLAQIAAN
CHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHH
YLVGLALAQARGTKYPDEVAREYHELEAMPKLVAQVLKQLNPIVELAHRFADKPTILFLG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
RHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIDEGLPVIVVMPSPKGASMLHA
CCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEECCCCHHHHHH
KLLSNIREIQARGATTIVIAEEGDDTVRPFADHIFEIPATTTLYQPLLSTIPLQVFAAEV
HHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHEECCCHHHHHHHHHHHCCHHHHHHHH
ARARGYDVDKPRNLAKSVTVE
HHHCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYVGHRPACAIVVDALHRMEYRGYDSAGIALLDGHGGMTVHRRAGRLTNLGEVLE
CCCEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCCCCCHHHC
CSAPDTLVGCSGLGHTRWATHGRPTDRNAHPHRDADGKIVVVHNGIIENYAPLRGELEAE
CCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHCCCCCCCCCCCC
GVEFASDTDTEVAVHLVGRQYRYGDTAGDFPASVLAVLRRLEGHFTLVFANADEPGTIVA
CCEECCCCCCCEEEEEECCEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEE
ARRSTPLVLGIGDGEMFVSSDVAAFIEHTRHAVELGQDQAVVVTADGYTVSDFHGNTDVD
EECCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEECCCCCCCCC
FREFHIDWDLSAAEKGGYEYFMLKEIAEQPAAVSDTLLGHFIDGRIVLDEQRLSDQELRD
EEEEEEEECCCHHCCCCCEEEEHHHHHHCCCHHHHHHHHHHCCCEEEEEHHHCCHHHHHH
IDKVFVVACGTAYHSGLLAKYAIEHWTRLPVEIELASEFRYRDPVLDRSTLVVAISQSGE
HHHEEEEEECHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCC
TADTLEAVRHAKKQKAKVLAICNTNGSQIPREADAVLYTRAGPEIGVAATKTFLAQIAAN
CHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHH
YLVGLALAQARGTKYPDEVAREYHELEAMPKLVAQVLKQLNPIVELAHRFADKPTILFLG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
RHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIDEGLPVIVVMPSPKGASMLHA
CCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEECCCCHHHHHH
KLLSNIREIQARGATTIVIAEEGDDTVRPFADHIFEIPATTTLYQPLLSTIPLQVFAAEV
HHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHEECCCHHHHHHHHHHHCCHHHHHHHH
ARARGYDVDKPRNLAKSVTVE
HHHCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA