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The map label for this gene is pdhA [H]

Identifier: 108798063

GI number: 108798063

Start: 1190358

End: 1191335

Strand: Direct

Name: pdhA [H]

Synonym: Mmcs_1091

Alternate gene names: 108798063

Gene position: 1190358-1191335 (Clockwise)

Preceding gene: 108798062

Following gene: 108798064

Centisome position: 20.86

GC content: 65.44

Gene sequence:

>978_bases
GTGATCGATGCAGTTCTCGCCCGGGAGCTCCTGTCCGGCATGGTGCGTGTGCGCCGGATGGAAGAAGAGTGCGCAAAGCT
CTACGGTGACGGCAAGATTCGCGGGTTCCTCCACCTCTATGTCGGGGAGGAGGCGGTAGCGGCGGGCTCACTGCGGGCGT
TGCGTCCCGATGACGCCGTGGTGGGCACCTACCGTGAACACGCCCACGCGCTTCTCCGGGGCGTGCCGATGACGTCGATC
ATGGCCGAGATGTTCGGCAAGCAGGAGGGCTGCTCAGGTGGGCGTGGTGGATCGATGCACCTTTTCGACGCCGGGACGCG
GTTCTACGGCGGGAACGCGATCGTCGGTGGCGGATTGCCGCTTGCGACGGGGCTCGCCCTCGCCGATGCGCAACAACGAC
GGCGCCGGATCACGGCCTGCTTCTTCGGGGACGGCGCCGTAGCCGAGGGAGTCTTCCACGAATCGCTCAACATGGCCGCG
CTGTGGCGGCTACCCGTCCTGTTCTGCTGCGAGAACAACCTCTACGCCATGGGCACCGCGCTGGAACGGGCTCAGTCGCA
GACCGACCTCGCCGCGAAGGCGGCGTCCTACAAGGTCCCGACCGCGACGGTCGACGGTATGGATGTGCTCGCGTGTCATA
CGGCGACAGTGCAGGCCGCCGACCACATCCGTGACACCGGTGGACCCTTCTTCATCGAGTTCCGCACATACCGTTTCCGC
GCCCATTCGATGTTCGATCCTGAGCTGTACCGCGACAAGGCCGAGGTGGACGTGTGGCGTACCCGCGACCCGATCACGAC
GTTCACCGATCGATGCGCCAACGAGGGTGTGCTGGACGCGCAGTGTGTCCGGGAGATCGAGCAAGCCGCGGAAAACGAAG
TGCAAGAGGCTGTCTCATTCGCCGAGGCCGGAACGTGGGAGGACATCGGCGATCTCGAACGTGACGTGCTCACCCCGGCA
CCGAGGAGCATCCGATGA

Upstream 100 bases:

>100_bases
TCATGCGCCGACTGCTCAAAGCCCGTGAACTGGGCCTGCCCGAGGGTGACACATCGACGATCGAGTCGGGCAGCGGGTCG
GATACCGAGACGGTGACGCT

Downstream 100 bases:

>100_bases
AGACCAGTTACCGCGCCGCCGTGCACGACGCCCTGCGCGACGCTCTGCGCGACGACGACAGGGTGCTACTCATGGGTGAG
GACGTCGGTCGCTACGGCGG

Product: pyruvate dehydrogenase (lipoamide)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MIDAVLARELLSGMVRVRRMEEECAKLYGDGKIRGFLHLYVGEEAVAAGSLRALRPDDAVVGTYREHAHALLRGVPMTSI
MAEMFGKQEGCSGGRGGSMHLFDAGTRFYGGNAIVGGGLPLATGLALADAQQRRRRITACFFGDGAVAEGVFHESLNMAA
LWRLPVLFCCENNLYAMGTALERAQSQTDLAAKAASYKVPTATVDGMDVLACHTATVQAADHIRDTGGPFFIEFRTYRFR
AHSMFDPELYRDKAEVDVWRTRDPITTFTDRCANEGVLDAQCVREIEQAAENEVQEAVSFAEAGTWEDIGDLERDVLTPA
PRSIR

Sequences:

>Translated_325_residues
MIDAVLARELLSGMVRVRRMEEECAKLYGDGKIRGFLHLYVGEEAVAAGSLRALRPDDAVVGTYREHAHALLRGVPMTSI
MAEMFGKQEGCSGGRGGSMHLFDAGTRFYGGNAIVGGGLPLATGLALADAQQRRRRITACFFGDGAVAEGVFHESLNMAA
LWRLPVLFCCENNLYAMGTALERAQSQTDLAAKAASYKVPTATVDGMDVLACHTATVQAADHIRDTGGPFFIEFRTYRFR
AHSMFDPELYRDKAEVDVWRTRDPITTFTDRCANEGVLDAQCVREIEQAAENEVQEAVSFAEAGTWEDIGDLERDVLTPA
PRSIR
>Mature_325_residues
MIDAVLARELLSGMVRVRRMEEECAKLYGDGKIRGFLHLYVGEEAVAAGSLRALRPDDAVVGTYREHAHALLRGVPMTSI
MAEMFGKQEGCSGGRGGSMHLFDAGTRFYGGNAIVGGGLPLATGLALADAQQRRRRITACFFGDGAVAEGVFHESLNMAA
LWRLPVLFCCENNLYAMGTALERAQSQTDLAAKAASYKVPTATVDGMDVLACHTATVQAADHIRDTGGPFFIEFRTYRFR
AHSMFDPELYRDKAEVDVWRTRDPITTFTDRCANEGVLDAQCVREIEQAAENEVQEAVSFAEAGTWEDIGDLERDVLTPA
PRSIR

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=290, Percent_Identity=42.4137931034483, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI291084742, Length=326, Percent_Identity=38.3435582822086, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI4505685, Length=326, Percent_Identity=38.3435582822086, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI291084744, Length=333, Percent_Identity=37.5375375375375, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI291084757, Length=326, Percent_Identity=35.5828220858896, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI11386135, Length=319, Percent_Identity=29.7805642633229, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI258645172, Length=319, Percent_Identity=30.0940438871473, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI32564172, Length=292, Percent_Identity=41.7808219178082, Blast_Score=227, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI17536047, Length=292, Percent_Identity=41.7808219178082, Blast_Score=227, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI86563355, Length=302, Percent_Identity=33.112582781457, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI86563357, Length=302, Percent_Identity=33.112582781457, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321026, Length=297, Percent_Identity=41.0774410774411, Blast_Score=228, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24639744, Length=314, Percent_Identity=40.7643312101911, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI28571106, Length=314, Percent_Identity=40.7643312101911, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI24639740, Length=314, Percent_Identity=40.7643312101911, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24639746, Length=307, Percent_Identity=41.3680781758958, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24639748, Length=321, Percent_Identity=39.5638629283489, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI21355903, Length=307, Percent_Identity=25.7328990228013, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35563; Mature: 35563

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDAVLARELLSGMVRVRRMEEECAKLYGDGKIRGFLHLYVGEEAVAAGSLRALRPDDAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCHHHHHCCCCCCCCCCCE
VGTYREHAHALLRGVPMTSIMAEMFGKQEGCSGGRGGSMHLFDAGTRFYGGNAIVGGGLP
ECHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCEEECCCEEEECCCH
LATGLALADAQQRRRRITACFFGDGAVAEGVFHESLNMAALWRLPVLFCCENNLYAMGTA
HHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHCCCHHHHHHCCEEEEECCCEEEHHHH
LERAQSQTDLAAKAASYKVPTATVDGMDVLACHTATVQAADHIRDTGGPFFIEFRTYRFR
HHHHHHHHHHHHHHHCCCCCCCEECCCCEEEEHHHHHHHHHHHHCCCCCEEEEEEEEEEE
AHSMFDPELYRDKAEVDVWRTRDPITTFTDRCANEGVLDAQCVREIEQAAENEVQEAVSF
ECCCCCHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AEAGTWEDIGDLERDVLTPAPRSIR
HHCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIDAVLARELLSGMVRVRRMEEECAKLYGDGKIRGFLHLYVGEEAVAAGSLRALRPDDAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCHHHHHCCCCCCCCCCCE
VGTYREHAHALLRGVPMTSIMAEMFGKQEGCSGGRGGSMHLFDAGTRFYGGNAIVGGGLP
ECHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCEEECCCEEEECCCH
LATGLALADAQQRRRRITACFFGDGAVAEGVFHESLNMAALWRLPVLFCCENNLYAMGTA
HHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHCCCHHHHHHCCEEEEECCCEEEHHHH
LERAQSQTDLAAKAASYKVPTATVDGMDVLACHTATVQAADHIRDTGGPFFIEFRTYRFR
HHHHHHHHHHHHHHHCCCCCCCEECCCCEEEEHHHHHHHHHHHHCCCCCEEEEEEEEEEE
AHSMFDPELYRDKAEVDVWRTRDPITTFTDRCANEGVLDAQCVREIEQAAENEVQEAVSF
ECCCCCHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AEAGTWEDIGDLERDVLTPAPRSIR
HHCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA