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The map label for this gene is devS [H]

Identifier: 108798050

GI number: 108798050

Start: 1173934

End: 1175634

Strand: Direct

Name: devS [H]

Synonym: Mmcs_1077

Alternate gene names: 108798050

Gene position: 1173934-1175634 (Clockwise)

Preceding gene: 108798049

Following gene: 108798055

Centisome position: 20.58

GC content: 69.66

Gene sequence:

>1701_bases
ATGACCGGGGTCGGGCCGGGCGACCAGTGCAGCGTTCGCCCAATCGGCGAAACGCTGTCGCAGCTGCGGCTGCGTGAGCT
GCTCACCGAGGTTCAGGACCGGGTCGAGGAGATCGTCGAGGGCCGGGACCGGCTCGACGGTCTGGTCGACGCGATGCTCA
CGGTCACCTCCGGACTCGACCTGGACGCCACCCTGCGCACCATCGTGCACACGGCCATCGAGCTGATCGACGCGCGTTAC
GGGGCACTGGGGGTGCGCGGACACGACCACGAGCTGGTCGAGTTCATCTACGAGGGCATCGACGAACCCACCCGGCTGGC
GATCGGACCGCTGCCGCAGGGCCGGGGTGTCCTCGGCGTGCTGATCGACGACCCGCAGCCGATCCGGCTGGAAAACATCC
ACGACCATCCCGCCTCGGTCGGCTTCCCCGAGCACCACCCCCCGATGCGCACCTTCCTCGGTGTGCCGATCCGGATCCGG
GATGAGGTCTTCGGCAACCTGTATCTGTCGGAGAAGACGTCCGGACAACCGTTCAGCGAGGACGACGAGGTGCTGACCCA
GGCCCTCGCGGCCGCCGCAGGCATCGCGATCGACAACGCCCGTCTGTTCGAACAGTCCCGCACGCGCCAGGCGTGGATCG
AGGCGACCCGCGACATCGCGACCGAGTTGCTCGGCGGCGCTGATCCCGCGCGGGTGTACCGCCTGGTGGCCGAGGAGTCG
CTCAAGCTGACCCACGCCGACGTCGCGTTCGTCGCCGTGCCCGCCGACGGTGACGAGCTCGTCATCGCCGACGCCGCCGG
GGATACCCGCACGGACCCATCGGTGGCGTCGCTGATCCCGTTGCAGGGCAACGATATCGGTGAGGCGTTCGTGGCGCGGA
CACCCCGGCTGGTCGAGGTGATCGCCGCGCAGACCGGCCTGCTCGACGACGCCGGCCCCGCGCTGATCCTGCCGATGAGG
ACGACCGAGGCGGTCGCCGGGGTGGTGGTGCTGCTGCGGCGCGCCGGGCGGCCGGCGTTCACCGCCGAGCAGTTGGAGAT
GATGGCGGCTTTCGTCGACCAGGCGGCGCTGGCCTGGCAGTCGGCGGTCGCCCAGCGCCGCATCCGCGAACTCGACGTCC
TGACCGACCGCGATCGCATCGCCCGCGATCTGCACGATCAGGTGATCCAACGGCTGTTCGGGGTGGGGTTGACGCTGCAG
GGCACGATTCCGCGCGCCCGGACGCCGGATGTGCAACGGCGGCTGATCGAATCCGTGGACGATCTGCAGGAGGTGATCCA
GCAGATCCGCACGGCCATCTTCGACCTACAGGGCGGGTCGTCGGGCAGCACCCGGTTGCGCCAACGTCTCGACGAGGCCA
TCGCCCATCTCGCCGGCGCCGAACTGCGGACGACGGTTCAGTACGTCGGGCCGTTGTCCGTGGTCGGTGCCGAACTCGCC
GACCATGCCGAAGCGGTGGTGTCCGAAGCGGTCAGCAACGCCGTGCGTCACGCGCAGGCGACCGAGCTCTCGGTGCTGGT
GACGGTGGACGACGATCTGCGGATCGAGATCAGGGACAACGGCGTCGGGATCCCGGACAACCTCACCGAGAGCGGTCTGG
CCAACCTGCGCCGGCGCGCCGAAGAGGTCGGCGGTGCTCTCACGATCGAACCCGCCGCCGGAGGCGGTACCTGCCTGAGC
TGGACCGCCCCACTGACCTGA

Upstream 100 bases:

>100_bases
TCGTCTCCCGCCTCGACCGGTCGGACGGCGCCGCAGAAGGCTGACCGCTTCGTTTCCTGGATACAGTCCCCTGGCTGGTC
ATCGGTGTGAGAATGCGCCT

Downstream 100 bases:

>100_bases
AAGGCGAACGCGCACCGGGATTCTCGGTCACCCGTAGGGTGCGCCGTCAAGGCACGAGACGACCTCCCGAAGTGGTCGGC
GAGGGGTGGGCGGCAGCGGA

Product: GAF sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 566; Mature: 565

Protein sequence:

>566_residues
MTGVGPGDQCSVRPIGETLSQLRLRELLTEVQDRVEEIVEGRDRLDGLVDAMLTVTSGLDLDATLRTIVHTAIELIDARY
GALGVRGHDHELVEFIYEGIDEPTRLAIGPLPQGRGVLGVLIDDPQPIRLENIHDHPASVGFPEHHPPMRTFLGVPIRIR
DEVFGNLYLSEKTSGQPFSEDDEVLTQALAAAAGIAIDNARLFEQSRTRQAWIEATRDIATELLGGADPARVYRLVAEES
LKLTHADVAFVAVPADGDELVIADAAGDTRTDPSVASLIPLQGNDIGEAFVARTPRLVEVIAAQTGLLDDAGPALILPMR
TTEAVAGVVVLLRRAGRPAFTAEQLEMMAAFVDQAALAWQSAVAQRRIRELDVLTDRDRIARDLHDQVIQRLFGVGLTLQ
GTIPRARTPDVQRRLIESVDDLQEVIQQIRTAIFDLQGGSSGSTRLRQRLDEAIAHLAGAELRTTVQYVGPLSVVGAELA
DHAEAVVSEAVSNAVRHAQATELSVLVTVDDDLRIEIRDNGVGIPDNLTESGLANLRRRAEEVGGALTIEPAAGGGTCLS
WTAPLT

Sequences:

>Translated_566_residues
MTGVGPGDQCSVRPIGETLSQLRLRELLTEVQDRVEEIVEGRDRLDGLVDAMLTVTSGLDLDATLRTIVHTAIELIDARY
GALGVRGHDHELVEFIYEGIDEPTRLAIGPLPQGRGVLGVLIDDPQPIRLENIHDHPASVGFPEHHPPMRTFLGVPIRIR
DEVFGNLYLSEKTSGQPFSEDDEVLTQALAAAAGIAIDNARLFEQSRTRQAWIEATRDIATELLGGADPARVYRLVAEES
LKLTHADVAFVAVPADGDELVIADAAGDTRTDPSVASLIPLQGNDIGEAFVARTPRLVEVIAAQTGLLDDAGPALILPMR
TTEAVAGVVVLLRRAGRPAFTAEQLEMMAAFVDQAALAWQSAVAQRRIRELDVLTDRDRIARDLHDQVIQRLFGVGLTLQ
GTIPRARTPDVQRRLIESVDDLQEVIQQIRTAIFDLQGGSSGSTRLRQRLDEAIAHLAGAELRTTVQYVGPLSVVGAELA
DHAEAVVSEAVSNAVRHAQATELSVLVTVDDDLRIEIRDNGVGIPDNLTESGLANLRRRAEEVGGALTIEPAAGGGTCLS
WTAPLT
>Mature_565_residues
TGVGPGDQCSVRPIGETLSQLRLRELLTEVQDRVEEIVEGRDRLDGLVDAMLTVTSGLDLDATLRTIVHTAIELIDARYG
ALGVRGHDHELVEFIYEGIDEPTRLAIGPLPQGRGVLGVLIDDPQPIRLENIHDHPASVGFPEHHPPMRTFLGVPIRIRD
EVFGNLYLSEKTSGQPFSEDDEVLTQALAAAAGIAIDNARLFEQSRTRQAWIEATRDIATELLGGADPARVYRLVAEESL
KLTHADVAFVAVPADGDELVIADAAGDTRTDPSVASLIPLQGNDIGEAFVARTPRLVEVIAAQTGLLDDAGPALILPMRT
TEAVAGVVVLLRRAGRPAFTAEQLEMMAAFVDQAALAWQSAVAQRRIRELDVLTDRDRIARDLHDQVIQRLFGVGLTLQG
TIPRARTPDVQRRLIESVDDLQEVIQQIRTAIFDLQGGSSGSTRLRQRLDEAIAHLAGAELRTTVQYVGPLSVVGAELAD
HAEAVVSEAVSNAVRHAQATELSVLVTVDDDLRIEIRDNGVGIPDNLTESGLANLRRRAEEVGGALTIEPAAGGGTCLSW
TAPLT

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. May act as a redox sensor (rather than a direct hypoxia sensor); the normal (aerobic growth) state is the Fe(3+) form, while the reduced (anaer

COG id: COG2203

COG function: function code T; FOG: GAF domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788812, Length=213, Percent_Identity=32.3943661971831, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1787474, Length=261, Percent_Identity=27.2030651340996, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016030
- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 61019; Mature: 60888

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGVGPGDQCSVRPIGETLSQLRLRELLTEVQDRVEEIVEGRDRLDGLVDAMLTVTSGLD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LDATLRTIVHTAIELIDARYGALGVRGHDHELVEFIYEGIDEPTRLAIGPLPQGRGVLGV
HHHHHHHHHHHHHHHHHHHHCEECCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEE
LIDDPQPIRLENIHDHPASVGFPEHHPPMRTFLGVPIRIRDEVFGNLYLSEKTSGQPFSE
EECCCCCCEECCCCCCCCCCCCCCCCCCHHHHHCCCEEEEHHHHCCEEEECCCCCCCCCC
DDEVLTQALAAAAGIAIDNARLFEQSRTRQAWIEATRDIATELLGGADPARVYRLVAEES
HHHHHHHHHHHHHCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LKLTHADVAFVAVPADGDELVIADAAGDTRTDPSVASLIPLQGNDIGEAFVARTPRLVEV
CEEEECCEEEEEEECCCCEEEEEECCCCCCCCCCHHHEECCCCCCHHHHHHHCCHHHHHH
IAAQTGLLDDAGPALILPMRTTEAVAGVVVLLRRAGRPAFTAEQLEMMAAFVDQAALAWQ
HHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
SAVAQRRIRELDVLTDRDRIARDLHDQVIQRLFGVGLTLQGTIPRARTPDVQRRLIESVD
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHH
DLQEVIQQIRTAIFDLQGGSSGSTRLRQRLDEAIAHLAGAELRTTVQYVGPLSVVGAELA
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHH
DHAEAVVSEAVSNAVRHAQATELSVLVTVDDDLRIEIRDNGVGIPDNLTESGLANLRRRA
HHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHH
EEVGGALTIEPAAGGGTCLSWTAPLT
HHHCCEEEEEECCCCCCEEECCCCCC
>Mature Secondary Structure 
TGVGPGDQCSVRPIGETLSQLRLRELLTEVQDRVEEIVEGRDRLDGLVDAMLTVTSGLD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LDATLRTIVHTAIELIDARYGALGVRGHDHELVEFIYEGIDEPTRLAIGPLPQGRGVLGV
HHHHHHHHHHHHHHHHHHHHCEECCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEE
LIDDPQPIRLENIHDHPASVGFPEHHPPMRTFLGVPIRIRDEVFGNLYLSEKTSGQPFSE
EECCCCCCEECCCCCCCCCCCCCCCCCCHHHHHCCCEEEEHHHHCCEEEECCCCCCCCCC
DDEVLTQALAAAAGIAIDNARLFEQSRTRQAWIEATRDIATELLGGADPARVYRLVAEES
HHHHHHHHHHHHHCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LKLTHADVAFVAVPADGDELVIADAAGDTRTDPSVASLIPLQGNDIGEAFVARTPRLVEV
CEEEECCEEEEEEECCCCEEEEEECCCCCCCCCCHHHEECCCCCCHHHHHHHCCHHHHHH
IAAQTGLLDDAGPALILPMRTTEAVAGVVVLLRRAGRPAFTAEQLEMMAAFVDQAALAWQ
HHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
SAVAQRRIRELDVLTDRDRIARDLHDQVIQRLFGVGLTLQGTIPRARTPDVQRRLIESVD
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHH
DLQEVIQQIRTAIFDLQGGSSGSTRLRQRLDEAIAHLAGAELRTTVQYVGPLSVVGAELA
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHH
DHAEAVVSEAVSNAVRHAQATELSVLVTVDDDLRIEIRDNGVGIPDNLTESGLANLRRRA
HHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHH
EEVGGALTIEPAAGGGTCLSWTAPLT
HHHCCEEEEEECCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]