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The map label for this gene is devR [H]

Identifier: 108798049

GI number: 108798049

Start: 1173191

End: 1173877

Strand: Direct

Name: devR [H]

Synonym: Mmcs_1076

Alternate gene names: 108798049

Gene position: 1173191-1173877 (Clockwise)

Preceding gene: 108798048

Following gene: 108798050

Centisome position: 20.56

GC content: 67.83

Gene sequence:

>687_bases
GTGACCGGGGATCCCACGCCCCAAACCCGCAAGCCCCCCGTGACCGTGTTCCTCGTCGACGACCACGAGGTGGTGCGTCG
CGGGTTGATCGATGTGCTCAGCGCCGAACCGGACCTCGAGGTGATCGGCGAAGCGGGCTCGGTCTCCGAGGCGCTGGCCC
GCATCCCGGCGCTGCAGCCCCAGGTCGCCGTGCTCGACGTGCGGCTGCCCGACGGCAACGGCATAGAGCTGTGCCGCGAT
CTCCTGTCGCGGCTGCCGGATCTGCGGTGTCTGATGTTGACGTCCTTCACCTCCGACGAGGCGATGATCGACGCGATCCT
CGCCGGCGCGAGTGGATACGTGATCAAGGACATCAAGGGTATGGAACTGGCCAAGGCGATCAGGGAGATCGGGGCGGGCC
GGTCCCTGCTCGACAACCGGGCGGCCGCCGCACTGATGGCCAAGCTGCGCCGGGCCACCGAGCATTCCGATCCGCTGTCC
GGCCTCAGTGATCAGGAGCGGGTCCTGCTGGGGTTGCTCGGAGAGGGGTTGACCAACAAGCAGATCGCCGCGCGGATGTT
CCTGTCGGAGAAGACGGTGAAGAACTACGTGTCGCGACTGCTCGCGAAGCTGGGGGTGGAACGTCGCACCCAGGCCGCGG
TGTTCGTCTCCCGCCTCGACCGGTCGGACGGCGCCGCAGAAGGCTGA

Upstream 100 bases:

>100_bases
TGCCGCAGGTGCTGATCCGCGTCGGGGCGGCGCCCGCCTACGATCCCGTCCCGCCGCCGACGCCCCGGCGTCGGCTCGAG
GATGTGCTCGAGGTGCGGCT

Downstream 100 bases:

>100_bases
CCGCTTCGTTTCCTGGATACAGTCCCCTGGCTGGTCATCGGTGTGAGAATGCGCCTATGACCGGGGTCGGGCCGGGCGAC
CAGTGCAGCGTTCGCCCAAT

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MTGDPTPQTRKPPVTVFLVDDHEVVRRGLIDVLSAEPDLEVIGEAGSVSEALARIPALQPQVAVLDVRLPDGNGIELCRD
LLSRLPDLRCLMLTSFTSDEAMIDAILAGASGYVIKDIKGMELAKAIREIGAGRSLLDNRAAAALMAKLRRATEHSDPLS
GLSDQERVLLGLLGEGLTNKQIAARMFLSEKTVKNYVSRLLAKLGVERRTQAAVFVSRLDRSDGAAEG

Sequences:

>Translated_228_residues
MTGDPTPQTRKPPVTVFLVDDHEVVRRGLIDVLSAEPDLEVIGEAGSVSEALARIPALQPQVAVLDVRLPDGNGIELCRD
LLSRLPDLRCLMLTSFTSDEAMIDAILAGASGYVIKDIKGMELAKAIREIGAGRSLLDNRAAAALMAKLRRATEHSDPLS
GLSDQERVLLGLLGEGLTNKQIAARMFLSEKTVKNYVSRLLAKLGVERRTQAAVFVSRLDRSDGAAEG
>Mature_227_residues
TGDPTPQTRKPPVTVFLVDDHEVVRRGLIDVLSAEPDLEVIGEAGSVSEALARIPALQPQVAVLDVRLPDGNGIELCRDL
LSRLPDLRCLMLTSFTSDEAMIDAILAGASGYVIKDIKGMELAKAIREIGAGRSLLDNRAAAALMAKLRRATEHSDPLSG
LSDQERVLLGLLGEGLTNKQIAARMFLSEKTVKNYVSRLLAKLGVERRTQAAVFVSRLDRSDGAAEG

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. When phosphorylated binds the promoter of at least its own and Acr (hspX) gene in response to hypoxia. Activates its own transcription under hy

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790102, Length=201, Percent_Identity=36.318407960199, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787473, Length=212, Percent_Identity=33.4905660377358, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788521, Length=203, Percent_Identity=33.0049261083744, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1788222, Length=194, Percent_Identity=27.8350515463918, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786747, Length=195, Percent_Identity=24.1025641025641, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788712, Length=208, Percent_Identity=26.4423076923077, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR011990
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24524; Mature: 24392

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGDPTPQTRKPPVTVFLVDDHEVVRRGLIDVLSAEPDLEVIGEAGSVSEALARIPALQP
CCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHCCCCCC
QVAVLDVRLPDGNGIELCRDLLSRLPDLRCLMLTSFTSDEAMIDAILAGASGYVIKDIKG
CEEEEEEECCCCCCHHHHHHHHHHCCCCEEHHHHCCCCHHHHHHHHHHCCCCCEECCCCH
MELAKAIREIGAGRSLLDNRAAAALMAKLRRATEHSDPLSGLSDQERVLLGLLGEGLTNK
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHH
QIAARMFLSEKTVKNYVSRLLAKLGVERRTQAAVFVSRLDRSDGAAEG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TGDPTPQTRKPPVTVFLVDDHEVVRRGLIDVLSAEPDLEVIGEAGSVSEALARIPALQP
CCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHCCCCCC
QVAVLDVRLPDGNGIELCRDLLSRLPDLRCLMLTSFTSDEAMIDAILAGASGYVIKDIKG
CEEEEEEECCCCCCHHHHHHHHHHCCCCEEHHHHCCCCHHHHHHHHHHCCCCCEECCCCH
MELAKAIREIGAGRSLLDNRAAAALMAKLRRATEHSDPLSGLSDQERVLLGLLGEGLTNK
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHH
QIAARMFLSEKTVKNYVSRLLAKLGVERRTQAAVFVSRLDRSDGAAEG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]