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The map label for this gene is ubiE [H]

Identifier: 108797742

GI number: 108797742

Start: 816733

End: 817425

Strand: Direct

Name: ubiE [H]

Synonym: Mmcs_0763

Alternate gene names: 108797742

Gene position: 816733-817425 (Clockwise)

Preceding gene: 108797740

Following gene: 108797743

Centisome position: 14.31

GC content: 71.57

Gene sequence:

>693_bases
GTGAGCCGGGCGACGTTGGACAAGAACCCCCACGAGGTCGCGTCGATGTTCGACGCGGTAGCCCGCCGCTACGACCTGAC
CAACACCGTGCTCTCGCTCGGACAGGACCGGTTCTGGCGGCGCGAGACCTGTGCGGCGCTGGGCATCGGCCCCGGCGACA
GGGTGCTCGACCTGGCCGCCGGCACCGCGGTGTCGACGGTCGAACTCGCCGCCTCCGGTGCGTGGTGCGTGGCCGCGGAC
TTCTCGGTCGGGATGCTCTCGGCGGGCCGGCAGCGCGACGTGCCGAAGGTCGCCGGCGATGCGACCAGGCTGCCGTTCGC
CGACGAGTCGTTCGACGCGGTCACCATCAGCTTCGGGCTGCGCAACGTGGTCGACCATGTCGCGGGCCTCGAGGAGATGG
CCCGCGTGACCCGGCCGGGTGGCCGGCTGGTGGTGTGCGAGTTCTCCACGCCGACCAACCGTGCGTTCGCCACGCTCTAC
AAGGAGTACCTGATGAAGGCGCTGCCGCGGATGGCGCGGGCGGTGGCCTCCAACCCCGACGCCTACGTGTATCTCGCCGA
ATCGATCCGCGCCTGGCCGGATCAGGCGGGTCTGGCGCGGCGGATCGAGGCCGCCGGCTGGTCGCAGGTGCGGTGGCGCA
ACCTCACCGGAGGCATCGTCGCCCTGCACGCCGCGGTCAAACCACCGCGCTGA

Upstream 100 bases:

>100_bases
CCAGTGATGAACCAGACTTTTCCGCTCATACAGCGTTACAAGGGCACCGGCGGCGTCCCCCATTCCCGGTGGCAGCGGAT
TCACAGGTAGCGTCGGCGTC

Downstream 100 bases:

>100_bases
CGCACCCGACACGCGCAAACCCGGGCCAAATGCGCGGTTGTGACGCGAATCACCATTAACTTATCGCCCTGACGGGGTTC
CGCGACAGGGCGGTGGGTCA

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MSRATLDKNPHEVASMFDAVARRYDLTNTVLSLGQDRFWRRETCAALGIGPGDRVLDLAAGTAVSTVELAASGAWCVAAD
FSVGMLSAGRQRDVPKVAGDATRLPFADESFDAVTISFGLRNVVDHVAGLEEMARVTRPGGRLVVCEFSTPTNRAFATLY
KEYLMKALPRMARAVASNPDAYVYLAESIRAWPDQAGLARRIEAAGWSQVRWRNLTGGIVALHAAVKPPR

Sequences:

>Translated_230_residues
MSRATLDKNPHEVASMFDAVARRYDLTNTVLSLGQDRFWRRETCAALGIGPGDRVLDLAAGTAVSTVELAASGAWCVAAD
FSVGMLSAGRQRDVPKVAGDATRLPFADESFDAVTISFGLRNVVDHVAGLEEMARVTRPGGRLVVCEFSTPTNRAFATLY
KEYLMKALPRMARAVASNPDAYVYLAESIRAWPDQAGLARRIEAAGWSQVRWRNLTGGIVALHAAVKPPR
>Mature_229_residues
SRATLDKNPHEVASMFDAVARRYDLTNTVLSLGQDRFWRRETCAALGIGPGDRVLDLAAGTAVSTVELAASGAWCVAADF
SVGMLSAGRQRDVPKVAGDATRLPFADESFDAVTISFGLRNVVDHVAGLEEMARVTRPGGRLVVCEFSTPTNRAFATLYK
EYLMKALPRMARAVASNPDAYVYLAESIRAWPDQAGLARRIEAAGWSQVRWRNLTGGIVALHAAVKPPR

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=260, Percent_Identity=32.6923076923077, Blast_Score=142, Evalue=3e-34,
Organism=Escherichia coli, GI48994983, Length=226, Percent_Identity=42.9203539823009, Blast_Score=177, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17557039, Length=230, Percent_Identity=33.0434782608696, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323526, Length=241, Percent_Identity=33.195020746888, Blast_Score=111, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24641702, Length=244, Percent_Identity=34.8360655737705, Blast_Score=144, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 24908; Mature: 24776

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRATLDKNPHEVASMFDAVARRYDLTNTVLSLGQDRFWRRETCAALGIGPGDRVLDLAA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCEEHHHC
GTAVSTVELAASGAWCVAADFSVGMLSAGRQRDVPKVAGDATRLPFADESFDAVTISFGL
CCHHHHHHHHCCCCEEEEECCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHH
RNVVDHVAGLEEMARVTRPGGRLVVCEFSTPTNRAFATLYKEYLMKALPRMARAVASNPD
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AYVYLAESIRAWPDQAGLARRIEAAGWSQVRWRNLTGGIVALHAAVKPPR
EEEEEHHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCC
>Mature Secondary Structure 
SRATLDKNPHEVASMFDAVARRYDLTNTVLSLGQDRFWRRETCAALGIGPGDRVLDLAA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCEEHHHC
GTAVSTVELAASGAWCVAADFSVGMLSAGRQRDVPKVAGDATRLPFADESFDAVTISFGL
CCHHHHHHHHCCCCEEEEECCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHH
RNVVDHVAGLEEMARVTRPGGRLVVCEFSTPTNRAFATLYKEYLMKALPRMARAVASNPD
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AYVYLAESIRAWPDQAGLARRIEAAGWSQVRWRNLTGGIVALHAAVKPPR
EEEEEHHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA