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The map label for this gene is hemL [H]

Identifier: 108797670

GI number: 108797670

Start: 743680

End: 744996

Strand: Direct

Name: hemL [H]

Synonym: Mmcs_0690

Alternate gene names: 108797670

Gene position: 743680-744996 (Clockwise)

Preceding gene: 108797669

Following gene: 108797671

Centisome position: 13.03

GC content: 71.83

Gene sequence:

>1317_bases
ATGGGTGCTCACCACACCGCGACCGAGCAGTCGGCGCGGCTGTTCGCTGATGCGTGCGCTGTCATCCCCGGCGGGGTCAA
CTCCCCGGTCCGGGCGTTCAACGCCGTCGGCGGAACACCCCGCTTCATCACCTCGGCCAACGGCTACTGGCTGACCGACG
CCGATGACAACCGCTACGTCGACCTGGTGTGCTCCTGGGGGCCGATGATCCTCGGCCACGCCCACCCGGCCGTCGTCGAG
GCGGTGCAGCGCGTCGCCGCCGACGGTCTGTCGTTCGGTGCGCCGACGCCGTCGGAGACCGAACTGGCCTCCGAGATCAT
CTCCCGTGTCGCGCCCGTCGAGCGGTTGCGGATGGTCAACTCCGGCACCGAGGCCACGATGAGCGCGATCCGGTTGGCCC
GCGGGTTCACCGGCCGACCCAAGATCGTCAAGTTCTCCGGCTGCTACCACGGCCACAGCGACGCGCTGCTCGCCGACGCC
GGGTCGGGTGTCGCCACGCTGGGCCTGCCGTCCTCGCCGGGTGTGACGGGTGCGGCCACCGCCGACACCATCGTGCTGCC
CTACAACGACGTCGACGCCGTCGAGGAGATCTTCGAGCAGGTCGGCGACCAGATCGCCGCCGTCATCACCGAGGCCAGCC
CGGGCAACATGGGTGCCGTCCCACCGGAGCCCGGCTTCAACGCCGCACTGCGGCGCATCACCGAAGAACACGGCGCGCTG
CTGATCCTCGACGAGGTGATGACCGGGTTCCGGGTCAGCCGGTCGGGGTGGTACGGCCTCGATCCGGTCGACGGCGACCT
GTTCACCTTCGGCAAGGTGATGAGCGGCGGCCTGCCCGCCGCGGCGTTCGGCGGTCGCGCCGAGGTGATGGAACGGCTCG
CGCCGCTGGGCCCGGTGTACCAGGCCGGCACCCTGTCGGGGAACCCCGTGGCGATGGCCGCCGGATTGGCGACGCTGCGC
ACCGCCGACGATGCGGTGTACGCGGCGCTGGACAAGAACGCCGACCGGCTGGCCGGTCTGCTCACCGACGCCCTCACCGA
CGCCGGTGTCACCCACCGCGTCCAGCGCGGCGGCAACATGCTGTCGGTGTTCTTCACCGCCGAACCGGTCGGCGACTTCG
CCACCGCCCGCGCGAGCGAGACCTGGCGCTTCCCGCCGTTCTTCCACGCCCTGCTCGACGCCGGCGTCTATCCGCCGCCC
AGCGCGTTCGAGGCGTGGTTCGTCTCGGCGGCCCTCGACGACGAGGCGTTCGACCGCATCGCCGCCGCCCTGCCCGGCGC
GGCCCGTGCCGCCGCGGAAGCGAGTAGGCCCGCATGA

Upstream 100 bases:

>100_bases
CCGACCATCCGGTGTTCGCGCTCGTGCCGAAATAGCGGTATGACAGTTCCCACTACACCCTGTAGTTGACGGGTTCGACG
CGGCTGGGACACTGGTGGTC

Downstream 100 bases:

>100_bases
CCGAGAAGACGATCGTGCACGTGATGCGGCACGGTGAGGTGCACAACCCCGAGGGGATCCTGTACGGCCGGCTGCCGGAC
TACCACCTGTCCGAACGCGG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MGAHHTATEQSARLFADACAVIPGGVNSPVRAFNAVGGTPRFITSANGYWLTDADDNRYVDLVCSWGPMILGHAHPAVVE
AVQRVAADGLSFGAPTPSETELASEIISRVAPVERLRMVNSGTEATMSAIRLARGFTGRPKIVKFSGCYHGHSDALLADA
GSGVATLGLPSSPGVTGAATADTIVLPYNDVDAVEEIFEQVGDQIAAVITEASPGNMGAVPPEPGFNAALRRITEEHGAL
LILDEVMTGFRVSRSGWYGLDPVDGDLFTFGKVMSGGLPAAAFGGRAEVMERLAPLGPVYQAGTLSGNPVAMAAGLATLR
TADDAVYAALDKNADRLAGLLTDALTDAGVTHRVQRGGNMLSVFFTAEPVGDFATARASETWRFPPFFHALLDAGVYPPP
SAFEAWFVSAALDDEAFDRIAAALPGAARAAAEASRPA

Sequences:

>Translated_438_residues
MGAHHTATEQSARLFADACAVIPGGVNSPVRAFNAVGGTPRFITSANGYWLTDADDNRYVDLVCSWGPMILGHAHPAVVE
AVQRVAADGLSFGAPTPSETELASEIISRVAPVERLRMVNSGTEATMSAIRLARGFTGRPKIVKFSGCYHGHSDALLADA
GSGVATLGLPSSPGVTGAATADTIVLPYNDVDAVEEIFEQVGDQIAAVITEASPGNMGAVPPEPGFNAALRRITEEHGAL
LILDEVMTGFRVSRSGWYGLDPVDGDLFTFGKVMSGGLPAAAFGGRAEVMERLAPLGPVYQAGTLSGNPVAMAAGLATLR
TADDAVYAALDKNADRLAGLLTDALTDAGVTHRVQRGGNMLSVFFTAEPVGDFATARASETWRFPPFFHALLDAGVYPPP
SAFEAWFVSAALDDEAFDRIAAALPGAARAAAEASRPA
>Mature_437_residues
GAHHTATEQSARLFADACAVIPGGVNSPVRAFNAVGGTPRFITSANGYWLTDADDNRYVDLVCSWGPMILGHAHPAVVEA
VQRVAADGLSFGAPTPSETELASEIISRVAPVERLRMVNSGTEATMSAIRLARGFTGRPKIVKFSGCYHGHSDALLADAG
SGVATLGLPSSPGVTGAATADTIVLPYNDVDAVEEIFEQVGDQIAAVITEASPGNMGAVPPEPGFNAALRRITEEHGALL
ILDEVMTGFRVSRSGWYGLDPVDGDLFTFGKVMSGGLPAAAFGGRAEVMERLAPLGPVYQAGTLSGNPVAMAAGLATLRT
ADDAVYAALDKNADRLAGLLTDALTDAGVTHRVQRGGNMLSVFFTAEPVGDFATARASETWRFPPFFHALLDAGVYPPPS
AFEAWFVSAALDDEAFDRIAAALPGAARAAAEASRPA

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=321, Percent_Identity=27.7258566978193, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI37574042, Length=334, Percent_Identity=29.940119760479, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI226442709, Length=303, Percent_Identity=30.6930693069307, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI24119277, Length=386, Percent_Identity=26.6839378238342, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI226442705, Length=333, Percent_Identity=28.8288288288288, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI13994255, Length=320, Percent_Identity=25.9375, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI284507298, Length=240, Percent_Identity=29.5833333333333, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1786349, Length=407, Percent_Identity=54.2997542997543, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1787560, Length=372, Percent_Identity=30.9139784946237, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1789016, Length=329, Percent_Identity=31.306990881459, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI145693181, Length=348, Percent_Identity=28.448275862069, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1789759, Length=284, Percent_Identity=29.5774647887324, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788044, Length=280, Percent_Identity=31.0714285714286, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71992977, Length=349, Percent_Identity=28.080229226361, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI25144271, Length=325, Percent_Identity=26.7692307692308, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI32564660, Length=323, Percent_Identity=24.1486068111455, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324432, Length=398, Percent_Identity=26.1306532663317, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6323470, Length=304, Percent_Identity=25.6578947368421, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21356575, Length=308, Percent_Identity=27.9220779220779, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21357415, Length=322, Percent_Identity=23.9130434782609, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 45482; Mature: 45350

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAHHTATEQSARLFADACAVIPGGVNSPVRAFNAVGGTPRFITSANGYWLTDADDNRYV
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCEEECCCCEEEECCCCCCEE
DLVCSWGPMILGHAHPAVVEAVQRVAADGLSFGAPTPSETELASEIISRVAPVERLRMVN
EEEECCCCEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHC
SGTEATMSAIRLARGFTGRPKIVKFSGCYHGHSDALLADAGSGVATLGLPSSPGVTGAAT
CCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCC
ADTIVLPYNDVDAVEEIFEQVGDQIAAVITEASPGNMGAVPPEPGFNAALRRITEEHGAL
CCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCE
LILDEVMTGFRVSRSGWYGLDPVDGDLFTFGKVMSGGLPAAAFGGRAEVMERLAPLGPVY
EEEHHHHHCEEECCCCCCCCCCCCCCHHHHHHHHCCCCCHHHCCCHHHHHHHHCCCCCCC
QAGTLSGNPVAMAAGLATLRTADDAVYAALDKNADRLAGLLTDALTDAGVTHRVQRGGNM
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHCCCCE
LSVFFTAEPVGDFATARASETWRFPPFFHALLDAGVYPPPSAFEAWFVSAALDDEAFDRI
EEEEEECCCCCCHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHH
AAALPGAARAAAEASRPA
HHHCCCHHHHHHHCCCCC
>Mature Secondary Structure 
GAHHTATEQSARLFADACAVIPGGVNSPVRAFNAVGGTPRFITSANGYWLTDADDNRYV
CCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCEEECCCCEEEECCCCCCEE
DLVCSWGPMILGHAHPAVVEAVQRVAADGLSFGAPTPSETELASEIISRVAPVERLRMVN
EEEECCCCEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHC
SGTEATMSAIRLARGFTGRPKIVKFSGCYHGHSDALLADAGSGVATLGLPSSPGVTGAAT
CCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCC
ADTIVLPYNDVDAVEEIFEQVGDQIAAVITEASPGNMGAVPPEPGFNAALRRITEEHGAL
CCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCE
LILDEVMTGFRVSRSGWYGLDPVDGDLFTFGKVMSGGLPAAAFGGRAEVMERLAPLGPVY
EEEHHHHHCEEECCCCCCCCCCCCCCHHHHHHHHCCCCCHHHCCCHHHHHHHHCCCCCCC
QAGTLSGNPVAMAAGLATLRTADDAVYAALDKNADRLAGLLTDALTDAGVTHRVQRGGNM
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHCCCCE
LSVFFTAEPVGDFATARASETWRFPPFFHALLDAGVYPPPSAFEAWFVSAALDDEAFDRI
EEEEEECCCCCCHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHH
AAALPGAARAAAEASRPA
HHHCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA