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The map label for this gene is lpd [H]

Identifier: 108797611

GI number: 108797611

Start: 694904

End: 696304

Strand: Direct

Name: lpd [H]

Synonym: Mmcs_0631

Alternate gene names: 108797611

Gene position: 694904-696304 (Clockwise)

Preceding gene: 108797610

Following gene: 108797612

Centisome position: 12.18

GC content: 64.6

Gene sequence:

>1401_bases
GTGACCCACTATGACGTCGTCGTTCTCGGAGCCGGTCCCGGCGGATACGTCGCGGCTATTCGCGCTGCCCAACTCGGGCT
GAACACCGCAATCGTCGAACCCAAGTACTGGGGCGGCGTATGCCTCAACGTGGGGTGCATCCCGTCGAAGGCGTTGCTGC
GCAACGCCGAACTGGCGCACATCTTCACCAAGGAGGCCAAGACCTTCGGCATCAGCGGGGAGGCCACGTTCGACTACGGC
GCCGCCTTCGACCGCAGCCGCAAGGTCGCCGAGGGCCGCGTCGCCGGTGTGCACTTCCTGATGAAGAAGAACAAGATCAC
CGAGGTTCACGGGTACGGGAAGTTCACCGACGACCACACCATCGAGGTCGATCTCAACGAGGGCGGGACCGAGACGCTCA
CGTTCGACAACGCGATCATCTCGACCGGCGCGAGCACCAAGCTGGTGCCCAACACGTCGCTGTCGGAGAACGTCGTCACC
TACGAAGAACAGATCATGGAGCGCGAACTGCCCGGCTCGATCGTCATCGCCGGCGCCGGCGCGATCGGCATGGAATTCGG
CTACGTGATGAAGAACTACGGCGTCGACGTCACGATCGTGGAGTTCCTGCCGCGCGCGCTGCCCAACGAGGACGCCGAGG
TCTCCAAGGAGATCGAGAAGCAGTTCAAGAAGCTGGGCGTCAAGATCATGACCGGCACCAAGGTCGAGTCCATCAAGGAC
GAAGGAGGCGACGGCTCCGTCACCGTCACCGTCAGCAAGGACGGCAAGTCCCAGGAACTCAAGACCGACAAGGTGCTGCA
GGCCATCGGCTTCGCGCCCAACGTCGAGGGTTACGGCCTGGACAAGGCCGGGGTCGAGTTGACAGACCGCAAGGCCATCG
GCATCGACGACTACATGCGCACCAACAAGCCGCACATCTACGCGATCGGCGACGTCACCGGGAAACTGCAACTCGCGCAC
GTCGCCGAGGCGATGGGCGTGGTGGCCGCCGAGACGATCGCCGGTGCCGAGACCCTGCCGCTGGGCGACTACCGCATGAT
GCCGCGGGCCACGTTCTGCCAGCCGCAGGTCGCGAGCTTCGGGCTGACCGAGGAGCAGGCCCGCGAGGAGGGCTACGACG
TCAAGGTCGCGAAGTTCCCCTTCACCGCGAACGGCAAGGCGCACGGTATGGGCGCCCCCGGCGGTTTCGTCAAGCTCATC
GCAGACGCCAAGTACGGCGAACTGATCGGCGGGCACCTCATCGGCCACGACGTCTCCGAATTGCTGCCCGAACTCACGCT
GGCGCAGAAGTGGGATCTGACCGCCAACGAACTGGCCCGCAACGTGCACACCCACCCGACGCTGTCGGAGGCGCTGCAGG
AGGCCTTCCACGGGCTTGCCGGCCACATGATCAACTTTTGA

Upstream 100 bases:

>100_bases
CCGCCGGCGTCCACCGCAGGCGCCGCCGCGCTCTACGGCGCCTACGTTTTCGGCTGGATCGCACACTGACACAGCGGCCG
CGACCACTAGGGTGGTGAGG

Downstream 100 bases:

>100_bases
GAAACGAGATCGTCGCCGGTGTCGGCGGATTCGTGATCGGCCACATCCTGTGGCTGATCGCGATCACGCTCGCCACCAAC
ACCTCCGACGTCAGTACCTG

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of alpha keto acid dehydrogenase complexes [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MTHYDVVVLGAGPGGYVAAIRAAQLGLNTAIVEPKYWGGVCLNVGCIPSKALLRNAELAHIFTKEAKTFGISGEATFDYG
AAFDRSRKVAEGRVAGVHFLMKKNKITEVHGYGKFTDDHTIEVDLNEGGTETLTFDNAIISTGASTKLVPNTSLSENVVT
YEEQIMERELPGSIVIAGAGAIGMEFGYVMKNYGVDVTIVEFLPRALPNEDAEVSKEIEKQFKKLGVKIMTGTKVESIKD
EGGDGSVTVTVSKDGKSQELKTDKVLQAIGFAPNVEGYGLDKAGVELTDRKAIGIDDYMRTNKPHIYAIGDVTGKLQLAH
VAEAMGVVAAETIAGAETLPLGDYRMMPRATFCQPQVASFGLTEEQAREEGYDVKVAKFPFTANGKAHGMGAPGGFVKLI
ADAKYGELIGGHLIGHDVSELLPELTLAQKWDLTANELARNVHTHPTLSEALQEAFHGLAGHMINF

Sequences:

>Translated_466_residues
MTHYDVVVLGAGPGGYVAAIRAAQLGLNTAIVEPKYWGGVCLNVGCIPSKALLRNAELAHIFTKEAKTFGISGEATFDYG
AAFDRSRKVAEGRVAGVHFLMKKNKITEVHGYGKFTDDHTIEVDLNEGGTETLTFDNAIISTGASTKLVPNTSLSENVVT
YEEQIMERELPGSIVIAGAGAIGMEFGYVMKNYGVDVTIVEFLPRALPNEDAEVSKEIEKQFKKLGVKIMTGTKVESIKD
EGGDGSVTVTVSKDGKSQELKTDKVLQAIGFAPNVEGYGLDKAGVELTDRKAIGIDDYMRTNKPHIYAIGDVTGKLQLAH
VAEAMGVVAAETIAGAETLPLGDYRMMPRATFCQPQVASFGLTEEQAREEGYDVKVAKFPFTANGKAHGMGAPGGFVKLI
ADAKYGELIGGHLIGHDVSELLPELTLAQKWDLTANELARNVHTHPTLSEALQEAFHGLAGHMINF
>Mature_465_residues
THYDVVVLGAGPGGYVAAIRAAQLGLNTAIVEPKYWGGVCLNVGCIPSKALLRNAELAHIFTKEAKTFGISGEATFDYGA
AFDRSRKVAEGRVAGVHFLMKKNKITEVHGYGKFTDDHTIEVDLNEGGTETLTFDNAIISTGASTKLVPNTSLSENVVTY
EEQIMERELPGSIVIAGAGAIGMEFGYVMKNYGVDVTIVEFLPRALPNEDAEVSKEIEKQFKKLGVKIMTGTKVESIKDE
GGDGSVTVTVSKDGKSQELKTDKVLQAIGFAPNVEGYGLDKAGVELTDRKAIGIDDYMRTNKPHIYAIGDVTGKLQLAHV
AEAMGVVAAETIAGAETLPLGDYRMMPRATFCQPQVASFGLTEEQAREEGYDVKVAKFPFTANGKAHGMGAPGGFVKLIA
DAKYGELIGGHLIGHDVSELLPELTLAQKWDLTANELARNVHTHPTLSEALQEAFHGLAGHMINF

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=469, Percent_Identity=36.8869936034115, Blast_Score=288, Evalue=9e-78,
Organism=Homo sapiens, GI50301238, Length=469, Percent_Identity=29.2110874200426, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI22035672, Length=475, Percent_Identity=28.8421052631579, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI33519430, Length=441, Percent_Identity=25.6235827664399, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI33519428, Length=441, Percent_Identity=25.6235827664399, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI33519426, Length=441, Percent_Identity=25.6235827664399, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI148277065, Length=441, Percent_Identity=25.6235827664399, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI148277071, Length=441, Percent_Identity=25.6235827664399, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI291045266, Length=436, Percent_Identity=24.5412844036697, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI291045268, Length=429, Percent_Identity=22.3776223776224, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786307, Length=463, Percent_Identity=38.2289416846652, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI87081717, Length=461, Percent_Identity=28.8503253796095, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI87082354, Length=467, Percent_Identity=28.051391862955, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789915, Length=451, Percent_Identity=29.0465631929047, Blast_Score=152, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI32565766, Length=466, Percent_Identity=37.7682403433476, Blast_Score=303, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=27.5423728813559, Blast_Score=131, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI71983429, Length=439, Percent_Identity=27.1070615034169, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71983419, Length=439, Percent_Identity=27.1070615034169, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71982272, Length=482, Percent_Identity=27.3858921161826, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17559934, Length=235, Percent_Identity=29.7872340425532, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321091, Length=468, Percent_Identity=39.5299145299145, Blast_Score=283, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6325240, Length=471, Percent_Identity=25.9023354564756, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6325166, Length=468, Percent_Identity=28.2051282051282, Blast_Score=155, Evalue=9e-39,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=38.6752136752137, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24640553, Length=477, Percent_Identity=27.2536687631027, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24640549, Length=477, Percent_Identity=27.2536687631027, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24640551, Length=477, Percent_Identity=27.2536687631027, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI17737741, Length=484, Percent_Identity=27.0661157024793, Blast_Score=116, Evalue=4e-26,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49947; Mature: 49816

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHYDVVVLGAGPGGYVAAIRAAQLGLNTAIVEPKYWGGVCLNVGCIPSKALLRNAELAH
CCCEEEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCEEEEECCCCCHHHHCCCHHHH
IFTKEAKTFGISGEATFDYGAAFDRSRKVAEGRVAGVHFLMKKNKITEVHGYGKFTDDHT
HHHHCCCEECCCCCCCCCCCCHHHCCCHHHCCCHHEEEEEEECCCEEEEECCCCCCCCEE
IEVDLNEGGTETLTFDNAIISTGASTKLVPNTSLSENVVTYEEQIMERELPGSIVIAGAG
EEEEECCCCCEEEEECCCEEECCCCCEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECC
AIGMEFGYVMKNYGVDVTIVEFLPRALPNEDAEVSKEIEKQFKKLGVKIMTGTKVESIKD
HHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHC
EGGDGSVTVTVSKDGKSQELKTDKVLQAIGFAPNVEGYGLDKAGVELTDRKAIGIDDYMR
CCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCHHHHH
TNKPHIYAIGDVTGKLQLAHVAEAMGVVAAETIAGAETLPLGDYRMMPRATFCQPQVASF
CCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHC
GLTEEQAREEGYDVKVAKFPFTANGKAHGMGAPGGFVKLIADAKYGELIGGHLIGHDVSE
CCCHHHHHHCCCEEEEEECCEECCCCCCCCCCCCCEEEEEECCCHHHHHCCHHHCCCHHH
LLPELTLAQKWDLTANELARNVHTHPTLSEALQEAFHGLAGHMINF
HHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
THYDVVVLGAGPGGYVAAIRAAQLGLNTAIVEPKYWGGVCLNVGCIPSKALLRNAELAH
CCEEEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCEEEEECCCCCHHHHCCCHHHH
IFTKEAKTFGISGEATFDYGAAFDRSRKVAEGRVAGVHFLMKKNKITEVHGYGKFTDDHT
HHHHCCCEECCCCCCCCCCCCHHHCCCHHHCCCHHEEEEEEECCCEEEEECCCCCCCCEE
IEVDLNEGGTETLTFDNAIISTGASTKLVPNTSLSENVVTYEEQIMERELPGSIVIAGAG
EEEEECCCCCEEEEECCCEEECCCCCEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECC
AIGMEFGYVMKNYGVDVTIVEFLPRALPNEDAEVSKEIEKQFKKLGVKIMTGTKVESIKD
HHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHC
EGGDGSVTVTVSKDGKSQELKTDKVLQAIGFAPNVEGYGLDKAGVELTDRKAIGIDDYMR
CCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCHHHHH
TNKPHIYAIGDVTGKLQLAHVAEAMGVVAAETIAGAETLPLGDYRMMPRATFCQPQVASF
CCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHC
GLTEEQAREEGYDVKVAKFPFTANGKAHGMGAPGGFVKLIADAKYGELIGGHLIGHDVSE
CCCHHHHHHCCCEEEEEECCEECCCCCCCCCCCCCEEEEEECCCHHHHHCCHHHCCCHHH
LLPELTLAQKWDLTANELARNVHTHPTLSEALQEAFHGLAGHMINF
HHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]