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The map label for this gene is pbpA [H]

Identifier: 108796998

GI number: 108796998

Start: 20047

End: 21522

Strand: Reverse

Name: pbpA [H]

Synonym: Mmcs_0017

Alternate gene names: 108796998

Gene position: 21522-20047 (Counterclockwise)

Preceding gene: 108796999

Following gene: 108796997

Centisome position: 0.38

GC content: 68.97

Gene sequence:

>1476_bases
ATGAACACCTCACTGCGGCGCATCGCGGTCACGATCATGGTGCTGATCGTGCTGTTGCTCGGCAACGCCACCGTCACCCA
GGTCTTCACCGCGGATGGACTGCGCACCGATCCGCGCAACCAGCGCGTACTGCTCGACGAGTACTCCCGCCAGCGCGGAC
AGATCACCGCCGGCGGTCAACTGCTGGCGTATTCGGTGTCCACTCCGGGCCGGTTCCGGTTCCTGCGGGTGTATCCGAAT
GCGCAGGCCTACGCGCCGGTCACCGGGTTCTACTCGCTGACCTACTCGAGCACCGGACTGGAACGGGCCGAGGACACGAT
CCTCAACGGCTCCGACGAGCGGCTGTTCGGCCGCCGGCTGGCCGACTTCTTCACCGGCCGCGATCCGCGGGGCGGCAACG
TGGTCACCACCATCAACCCGCGGGTGCAGCAGGCCGCCTGGGAGGCGATGGAACAGGGCTGCAACGGACCGTGCAAGGGT
TCGGTCGTGGCGCTGGAACCGTCGACGGGCAAGATCCTCGCGATGGTGTCCGCGCCGTCCTACGATCCGAACCTGCTGGC
CACCCACGACGTCGAGGAACAGACCGCGGCGTGGCAGCAGTTGCGCGACAACCCGGACAACCCGCTGGTCAACCGCGCGA
TCTCGGAGACCTACCCGCCCGGTTCCACGTTCAAGGTCATCACCACCGCCGCCGCTCTGCAGAACGGCGCGACCCCGGAC
ACCCAGTTGACCGCGGCGCCACGCATCCCGCTGCCCAACAGTTCGGTGACGCTCGAGAACTTCGGCGGCTCGGCCTGCGG
CGGCGGCCCCACCGCACCGCTGCGCGAAGCGTTCGCCCGATCGTGCAACACCGCCTTCGTCGAGTTGGGCACCGACACCG
GTACGGAGGCTCTGAAGAACACCGCGTCCGCCTTCGGGCTCGACACCCCGCCCGCGCCGATTCCACTGCAGGTCGCCGAG
TCCACGGTCGGCCCCATCGGTGACGCCGCGGCGCTGGGCATGTCGAGCATCGGGCAGCGGGACGTGGCGTTGACACCGCT
GCAGAACGCGATGGTCGCTGCCACCGTCGCGAATGAGGGGGTAACCATGCGGCCCTACCTGGTCGACAGCCTCCGGGGAC
CCGACCTGGCAAACATCACCACGACCGAACCGGTCGAAGAGCGCCGGGCGGTGACACCCGAAGTCGCGGCTACACTGACT
GATCTGATGGTCGGCGCCGAGCAGCAGACGCAGCAGAAGGGAGCCATCGCCGGCGTGCAGATCGCTTCGAAGACAGGCAC
TGCGGAGCACGGGACCGACCCGCGCAACACTCCGCCCCATGCCTGGTACATCGCCTTCGCACCGGCGCAGGCGCCCAAGG
TCGCCGTCGCGGTTCTCGTGGAGAACGGCGGCAACCGGCTCTCGGCGACCGGGGGACAGGTCGCCGCGCCGATCGGACGC
GCCACCATCGCCGCCGCGCTGCGGGAGGGCTCATGA

Upstream 100 bases:

>100_bases
TCCTGCTGCGCATCTCGCATGCGGCCCGCAGACCCATCAGCACCAAACCGGTGACGCAGACACCGATCGCCGCTGCCAGC
ACCGAGGTGATCGACAAGGT

Downstream 100 bases:

>100_bases
CTGCGCGAAGCCGAGCGAAGCGAGGCGAGCAATGAGCCCCCGCGTCGGCGTCACCCTGTCCGGCCGCTACCGGCTCCAGC
GACTCATCGCCACCGGCGGT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBPA [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNTSLRRIAVTIMVLIVLLLGNATVTQVFTADGLRTDPRNQRVLLDEYSRQRGQITAGGQLLAYSVSTPGRFRFLRVYPN
AQAYAPVTGFYSLTYSSTGLERAEDTILNGSDERLFGRRLADFFTGRDPRGGNVVTTINPRVQQAAWEAMEQGCNGPCKG
SVVALEPSTGKILAMVSAPSYDPNLLATHDVEEQTAAWQQLRDNPDNPLVNRAISETYPPGSTFKVITTAAALQNGATPD
TQLTAAPRIPLPNSSVTLENFGGSACGGGPTAPLREAFARSCNTAFVELGTDTGTEALKNTASAFGLDTPPAPIPLQVAE
STVGPIGDAAALGMSSIGQRDVALTPLQNAMVAATVANEGVTMRPYLVDSLRGPDLANITTTEPVEERRAVTPEVAATLT
DLMVGAEQQTQQKGAIAGVQIASKTGTAEHGTDPRNTPPHAWYIAFAPAQAPKVAVAVLVENGGNRLSATGGQVAAPIGR
ATIAAALREGS

Sequences:

>Translated_491_residues
MNTSLRRIAVTIMVLIVLLLGNATVTQVFTADGLRTDPRNQRVLLDEYSRQRGQITAGGQLLAYSVSTPGRFRFLRVYPN
AQAYAPVTGFYSLTYSSTGLERAEDTILNGSDERLFGRRLADFFTGRDPRGGNVVTTINPRVQQAAWEAMEQGCNGPCKG
SVVALEPSTGKILAMVSAPSYDPNLLATHDVEEQTAAWQQLRDNPDNPLVNRAISETYPPGSTFKVITTAAALQNGATPD
TQLTAAPRIPLPNSSVTLENFGGSACGGGPTAPLREAFARSCNTAFVELGTDTGTEALKNTASAFGLDTPPAPIPLQVAE
STVGPIGDAAALGMSSIGQRDVALTPLQNAMVAATVANEGVTMRPYLVDSLRGPDLANITTTEPVEERRAVTPEVAATLT
DLMVGAEQQTQQKGAIAGVQIASKTGTAEHGTDPRNTPPHAWYIAFAPAQAPKVAVAVLVENGGNRLSATGGQVAAPIGR
ATIAAALREGS
>Mature_491_residues
MNTSLRRIAVTIMVLIVLLLGNATVTQVFTADGLRTDPRNQRVLLDEYSRQRGQITAGGQLLAYSVSTPGRFRFLRVYPN
AQAYAPVTGFYSLTYSSTGLERAEDTILNGSDERLFGRRLADFFTGRDPRGGNVVTTINPRVQQAAWEAMEQGCNGPCKG
SVVALEPSTGKILAMVSAPSYDPNLLATHDVEEQTAAWQQLRDNPDNPLVNRAISETYPPGSTFKVITTAAALQNGATPD
TQLTAAPRIPLPNSSVTLENFGGSACGGGPTAPLREAFARSCNTAFVELGTDTGTEALKNTASAFGLDTPPAPIPLQVAE
STVGPIGDAAALGMSSIGQRDVALTPLQNAMVAATVANEGVTMRPYLVDSLRGPDLANITTTEPVEERRAVTPEVAATLT
DLMVGAEQQTQQKGAIAGVQIASKTGTAEHGTDPRNTPPHAWYIAFAPAQAPKVAVAVLVENGGNRLSATGGQVAAPIGR
ATIAAALREGS

Specific function: Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Probable). Note=Localized to the division site (septum) along with newly synthesized peptidoglycan, between segregated nucleoids (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=370, Percent_Identity=28.9189189189189, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786272, Length=438, Percent_Identity=26.4840182648402, Blast_Score=99, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 51494; Mature: 51494

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSLRRIAVTIMVLIVLLLGNATVTQVFTADGLRTDPRNQRVLLDEYSRQRGQITAGGQ
CCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEHHHHHHHCCCEEECCE
LLAYSVSTPGRFRFLRVYPNAQAYAPVTGFYSLTYSSTGLERAEDTILNGSDERLFGRRL
EEEEEECCCCCEEEEEECCCCCCCCCEEEEEEEEECCCCCHHHHHHHCCCCCHHHHHHHH
ADFFTGRDPRGGNVVTTINPRVQQAAWEAMEQGCNGPCKGSVVALEPSTGKILAMVSAPS
HHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEEECCC
YDPNLLATHDVEEQTAAWQQLRDNPDNPLVNRAISETYPPGSTFKVITTAAALQNGATPD
CCCCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEHEEHHHHHHCCCCCC
TQLTAAPRIPLPNSSVTLENFGGSACGGGPTAPLREAFARSCNTAFVELGTDTGTEALKN
CEEECCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHH
TASAFGLDTPPAPIPLQVAESTVGPIGDAAALGMSSIGQRDVALTPLQNAMVAATVANEG
HHHHCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHCCCCCEEECCCCCCEEEEEECCCC
VTMRPYLVDSLRGPDLANITTTEPVEERRAVTPEVAATLTDLMVGAEQQTQQKGAIAGVQ
EEECHHHHHCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCCEEEEE
IASKTGTAEHGTDPRNTPPHAWYIAFAPAQAPKVAVAVLVENGGNRLSATGGQVAAPIGR
EECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCEEECCCCCEECCHHH
ATIAAALREGS
HHHHHHHHCCC
>Mature Secondary Structure
MNTSLRRIAVTIMVLIVLLLGNATVTQVFTADGLRTDPRNQRVLLDEYSRQRGQITAGGQ
CCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEHHHHHHHCCCEEECCE
LLAYSVSTPGRFRFLRVYPNAQAYAPVTGFYSLTYSSTGLERAEDTILNGSDERLFGRRL
EEEEEECCCCCEEEEEECCCCCCCCCEEEEEEEEECCCCCHHHHHHHCCCCCHHHHHHHH
ADFFTGRDPRGGNVVTTINPRVQQAAWEAMEQGCNGPCKGSVVALEPSTGKILAMVSAPS
HHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEEECCC
YDPNLLATHDVEEQTAAWQQLRDNPDNPLVNRAISETYPPGSTFKVITTAAALQNGATPD
CCCCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEHEEHHHHHHCCCCCC
TQLTAAPRIPLPNSSVTLENFGGSACGGGPTAPLREAFARSCNTAFVELGTDTGTEALKN
CEEECCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHH
TASAFGLDTPPAPIPLQVAESTVGPIGDAAALGMSSIGQRDVALTPLQNAMVAATVANEG
HHHHCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHCCCCCEEECCCCCCEEEEEECCCC
VTMRPYLVDSLRGPDLANITTTEPVEERRAVTPEVAATLTDLMVGAEQQTQQKGAIAGVQ
EEECHHHHHCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCCEEEEE
IASKTGTAEHGTDPRNTPPHAWYIAFAPAQAPKVAVAVLVENGGNRLSATGGQVAAPIGR
EECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCEEECCCCCEECCHHH
ATIAAALREGS
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA