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The map label for this gene is pbpC [H]

Identifier: 108764031

GI number: 108764031

Start: 2821222

End: 2823612

Strand: Direct

Name: pbpC [H]

Synonym: MXAN_2419

Alternate gene names: 108764031

Gene position: 2821222-2823612 (Clockwise)

Preceding gene: 108757684

Following gene: 108758736

Centisome position: 30.87

GC content: 72.15

Gene sequence:

>2391_bases
ATGCCTGGGATTCACCGTCTCATGAGCCGTGCCCGTCGAATCACCCGGAAGCTCTTGCCCGTCGGCCTGGGGTTGCTAGG
CCTCACCGTGGCCGCGTATGTGGCCGCCTGGCGCGTACCCCTGCCGGCCCGTCTCTTCGCGCCCGCATCGGTGGTGATGG
AGTACCGGGACGGCACGCCGGCCCACGTCTTCCTGGCCCCGGACGAGCGCTGGCGCATCCCCACGCAACTGGAGCGCGTG
GACCCGGACTATGTCCAGGCCCTGCTGGCCCTGGAGGACAAGCGCTTCTTCCACCACCCGGGCGTGGACCCGCTGGCGGT
GCTGCGCGCGGCGACACGCAACCTGGCCACGGGGCGGCGAGTGTCCGGTGCCTCGACTTTGACGATGCAGTTGGTCCGCG
TGTTGGAGCCGCGGCCTCGCACCTTCACGTCGAAAGTCATCGAGTCCTTCCGGGCGATGCAGTTGGAGGTGCGGCTGTCC
AAGCAGGAGGTGCTCGCGGCCTATCTCCAGTTCGTCCCGTACGGGCGCAACGTCGAAGGCGTGGAGGCGGCCGCGCTGGC
GTACTTCGGCCACACGGCGGCGAACCTGAGCCCCGCGGAGATTGCCACGCTGCTGGCGGTGCCGCAGAACCCGAACCGGC
GCTTCCCCACGGCGCAGAACACGGCCCGGTTGAAGTCGGCGCGGGACGGCGTGGCGCGAAGGCTGCTGGACGTGGAGGCG
CTTCCCCGAGGGCCCGAGGCGGCCCGCGTGTCGGCGGAGACGGTGCTGCGTGAGGTGCGCGACACGCCTGTGCCCACCGA
CCTGAAGCCCTTTCCCCGTGAGGCGCCACACGTGGCGGTGTGGCTGCGCACGCAGCGGCCGGCGAATGCCCGGCTGCACA
CCACGCTGGATGCAGGCACGCAGCGGATGGTGGAGCGGTTGATGCGGGACGCGGCGGTGGGGCTGGCGCCGCGAGGCATC
TACAACGGGACGGCGGTGGTGGTGGACCGGCAGCAGGCGGAGGTGCTCGCGCTGGTGGGCAACTTCGACTTCTTCGACCA
GAAGCACGGCGGGCAGATTATCGGCTTCGCCACGCCGCGCTCGCCGGGCTCGGCGCTCAAGCCCCTGCTGTATGCCATGG
GCATCGACCTGGGAATGGTGGGACCGGAGCAGTTGGTGGCGGACGTGCCCACGGCCTACGGCGGCTATGCGCCGCGCAAC
TTCGACGGCCGCTTCCAAGGTCTGGTGCGCCTGGAGTACGCGCTGTCCCAGTCGCTCAACATGCCCTTCGTGCGGCTCTT
GGAGCGCGTGGGGGTGGAGCGCTTCCTGGGCGCCCTGCAAGCGGCGGGAGTCACGAGCCTGGTGCAGGAGCCCGGGTACT
ACGGCCTGTCCGCGGCGGTGGGCGGCATCGAGCTGACGCCGCTGGAGCTCGCGGGCGTCTACGTCGCGCTGGCGGGGGAT
GGACGCGCGCCGCCGCTGCGGCTCCTGTTGGACGAGAAGGCGGCCGCGCCGGTGGAGGTGCTGTCCCCGGGCGCGGCCTG
GCTGACGCGCCAGGCGCTGTCGCTGAGAGACCGGCCCGATTTCCCGGCACGCCGTCGGCTGACGGGCATGCCGGCGCGCG
TGCACTGGAAGACAGGGACCAGCTTCGGCCACCGCGACGCGTGGGCGGCGGGCTCGGGGCCCCGGCACACGGCGGTCGTC
TGGCTGGGGAATTTCAATCACAGGCCCAGCGTGCACCTGGTGGGCGCTGACGCGGCGGGGCCGGTGCTGTTCGACATCCT
GGAGGGCGTGGGCCCGCGCGGCCTCAACCTGCCGGATGAGAGCGTGAATCCGCCCGATGACCTGGCCGTGGTGGAGGTCT
GCGCCTATTCGGGCCACCTGCCGACGGACGCCTGCGTGCAGCGCAAGCACGTCTACGCGCGGCGCTCGGCGGTGCCCACC
GCGCGCTGCCCGTACCACCAGCACGTGGAGGTGGACGTGGCCACGGGGCTGTCGGTGGGGCCCATGTGCCGGACGGGGCG
GAAGACGGAGCCGCGGGTGTATGTGACCTGGCCGGCCACCATCCGCCGCTGGCTGGAGGAGCAGCACCGGCGCCTGCCGG
AGCCGCCCGCCGCCGCGCCTGGCTGCGAGCCCGGAGGGGCGCGCGCGGCCCCGTCCATTGTCTCCCCCGCGCCGGGACAT
GTGGCCGTGCTGATTCCCGGTGTCCCGGCCTCGCAACAGGAGGTGCCGCTGGAGGCGGAGGCCTCACACGAGCGGGCACT
GACGTGGTTCGTGGACGGGGCCCTGCTGGGGACGGCGCGCGCCGATGAGCGCGTGTGGTGGACGCCGTCCGTGGGCTCCC
ACGAGATTCTCGTCACCGATGACCGGGGACTGAGCGCGAAGCGGACGCTGGAGGTCCGCATGCGACCCTGA

Upstream 100 bases:

>100_bases
CGGCCTGCAACGCCTGCCGCTCGGTGGGGGTCAGCCGCCGGTCGTCGAGAATGGACGTCAGGATGGCGTCGACTTCAAAG
GCATTCATTGCGCGTAGTAT

Downstream 100 bases:

>100_bases
AACGCAGCGCGGCGCCCCCGGAGGACAGGAGCGCCGCGCTCAGGTGCGGCTCGCCGCCGCGCTCAGCGCACTTCCCAGCC
CCGCGAGCCGCGCTCGTAGC

Product: penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 796; Mature: 795

Protein sequence:

>796_residues
MPGIHRLMSRARRITRKLLPVGLGLLGLTVAAYVAAWRVPLPARLFAPASVVMEYRDGTPAHVFLAPDERWRIPTQLERV
DPDYVQALLALEDKRFFHHPGVDPLAVLRAATRNLATGRRVSGASTLTMQLVRVLEPRPRTFTSKVIESFRAMQLEVRLS
KQEVLAAYLQFVPYGRNVEGVEAAALAYFGHTAANLSPAEIATLLAVPQNPNRRFPTAQNTARLKSARDGVARRLLDVEA
LPRGPEAARVSAETVLREVRDTPVPTDLKPFPREAPHVAVWLRTQRPANARLHTTLDAGTQRMVERLMRDAAVGLAPRGI
YNGTAVVVDRQQAEVLALVGNFDFFDQKHGGQIIGFATPRSPGSALKPLLYAMGIDLGMVGPEQLVADVPTAYGGYAPRN
FDGRFQGLVRLEYALSQSLNMPFVRLLERVGVERFLGALQAAGVTSLVQEPGYYGLSAAVGGIELTPLELAGVYVALAGD
GRAPPLRLLLDEKAAAPVEVLSPGAAWLTRQALSLRDRPDFPARRRLTGMPARVHWKTGTSFGHRDAWAAGSGPRHTAVV
WLGNFNHRPSVHLVGADAAGPVLFDILEGVGPRGLNLPDESVNPPDDLAVVEVCAYSGHLPTDACVQRKHVYARRSAVPT
ARCPYHQHVEVDVATGLSVGPMCRTGRKTEPRVYVTWPATIRRWLEEQHRRLPEPPAAAPGCEPGGARAAPSIVSPAPGH
VAVLIPGVPASQQEVPLEAEASHERALTWFVDGALLGTARADERVWWTPSVGSHEILVTDDRGLSAKRTLEVRMRP

Sequences:

>Translated_796_residues
MPGIHRLMSRARRITRKLLPVGLGLLGLTVAAYVAAWRVPLPARLFAPASVVMEYRDGTPAHVFLAPDERWRIPTQLERV
DPDYVQALLALEDKRFFHHPGVDPLAVLRAATRNLATGRRVSGASTLTMQLVRVLEPRPRTFTSKVIESFRAMQLEVRLS
KQEVLAAYLQFVPYGRNVEGVEAAALAYFGHTAANLSPAEIATLLAVPQNPNRRFPTAQNTARLKSARDGVARRLLDVEA
LPRGPEAARVSAETVLREVRDTPVPTDLKPFPREAPHVAVWLRTQRPANARLHTTLDAGTQRMVERLMRDAAVGLAPRGI
YNGTAVVVDRQQAEVLALVGNFDFFDQKHGGQIIGFATPRSPGSALKPLLYAMGIDLGMVGPEQLVADVPTAYGGYAPRN
FDGRFQGLVRLEYALSQSLNMPFVRLLERVGVERFLGALQAAGVTSLVQEPGYYGLSAAVGGIELTPLELAGVYVALAGD
GRAPPLRLLLDEKAAAPVEVLSPGAAWLTRQALSLRDRPDFPARRRLTGMPARVHWKTGTSFGHRDAWAAGSGPRHTAVV
WLGNFNHRPSVHLVGADAAGPVLFDILEGVGPRGLNLPDESVNPPDDLAVVEVCAYSGHLPTDACVQRKHVYARRSAVPT
ARCPYHQHVEVDVATGLSVGPMCRTGRKTEPRVYVTWPATIRRWLEEQHRRLPEPPAAAPGCEPGGARAAPSIVSPAPGH
VAVLIPGVPASQQEVPLEAEASHERALTWFVDGALLGTARADERVWWTPSVGSHEILVTDDRGLSAKRTLEVRMRP
>Mature_795_residues
PGIHRLMSRARRITRKLLPVGLGLLGLTVAAYVAAWRVPLPARLFAPASVVMEYRDGTPAHVFLAPDERWRIPTQLERVD
PDYVQALLALEDKRFFHHPGVDPLAVLRAATRNLATGRRVSGASTLTMQLVRVLEPRPRTFTSKVIESFRAMQLEVRLSK
QEVLAAYLQFVPYGRNVEGVEAAALAYFGHTAANLSPAEIATLLAVPQNPNRRFPTAQNTARLKSARDGVARRLLDVEAL
PRGPEAARVSAETVLREVRDTPVPTDLKPFPREAPHVAVWLRTQRPANARLHTTLDAGTQRMVERLMRDAAVGLAPRGIY
NGTAVVVDRQQAEVLALVGNFDFFDQKHGGQIIGFATPRSPGSALKPLLYAMGIDLGMVGPEQLVADVPTAYGGYAPRNF
DGRFQGLVRLEYALSQSLNMPFVRLLERVGVERFLGALQAAGVTSLVQEPGYYGLSAAVGGIELTPLELAGVYVALAGDG
RAPPLRLLLDEKAAAPVEVLSPGAAWLTRQALSLRDRPDFPARRRLTGMPARVHWKTGTSFGHRDAWAAGSGPRHTAVVW
LGNFNHRPSVHLVGADAAGPVLFDILEGVGPRGLNLPDESVNPPDDLAVVEVCAYSGHLPTDACVQRKHVYARRSAVPTA
RCPYHQHVEVDVATGLSVGPMCRTGRKTEPRVYVTWPATIRRWLEEQHRRLPEPPAAAPGCEPGGARAAPSIVSPAPGHV
AVLIPGVPASQQEVPLEAEASHERALTWFVDGALLGTARADERVWWTPSVGSHEILVTDDRGLSAKRTLEVRMRP

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=772, Percent_Identity=33.5492227979275, Blast_Score=340, Evalue=2e-94,
Organism=Escherichia coli, GI1786343, Length=574, Percent_Identity=27.3519163763066, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI87082258, Length=264, Percent_Identity=31.8181818181818, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1789601, Length=167, Percent_Identity=30.5389221556886, Blast_Score=76, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 86612; Mature: 86480

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGIHRLMSRARRITRKLLPVGLGLLGLTVAAYVAAWRVPLPARLFAPASVVMEYRDGTP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHEEECCCCC
AHVFLAPDERWRIPTQLERVDPDYVQALLALEDKRFFHHPGVDPLAVLRAATRNLATGRR
EEEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHCHHHCCCCCCHHHHHHHHHHHHCCCCC
VSGASTLTMQLVRVLEPRPRTFTSKVIESFRAMQLEVRLSKQEVLAAYLQFVPYGRNVEG
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEEEECHHHHHHHHHHHCCCCCCCCC
VEAAALAYFGHTAANLSPAEIATLLAVPQNPNRRFPTAQNTARLKSARDGVARRLLDVEA
HHHHHHHHHCCCCCCCCHHHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
LPRGPEAARVSAETVLREVRDTPVPTDLKPFPREAPHVAVWLRTQRPANARLHTTLDAGT
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEHHHHH
QRMVERLMRDAAVGLAPRGIYNGTAVVVDRQQAEVLALVGNFDFFDQKHGGQIIGFATPR
HHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCEEEEEECCC
SPGSALKPLLYAMGIDLGMVGPEQLVADVPTAYGGYAPRNFDGRFQGLVRLEYALSQSLN
CCCHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCC
MPFVRLLERVGVERFLGALQAAGVTSLVQEPGYYGLSAAVGGIELTPLELAGVYVALAGD
CHHHHHHHHHCHHHHHHHHHHCCHHHHHHCCCCCCHHHHCCCEEECEEEEEEEEEEEECC
GRAPPLRLLLDEKAAAPVEVLSPGAAWLTRQALSLRDRPDFPARRRLTGMPARVHWKTGT
CCCCCEEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEECCC
SFGHRDAWAAGSGPRHTAVVWLGNFNHRPSVHLVGADAAGPVLFDILEGVGPRGLNLPDE
CCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCC
SVNPPDDLAVVEVCAYSGHLPTDACVQRKHVYARRSAVPTARCPYHQHVEVDVATGLSVG
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCC
PMCRTGRKTEPRVYVTWPATIRRWLEEQHRRLPEPPAAAPGCEPGGARAAPSIVSPAPGH
CHHCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VAVLIPGVPASQQEVPLEAEASHERALTWFVDGALLGTARADERVWWTPSVGSHEILVTD
EEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCEEEECCCCCCEEEECCCCCCCEEEEEC
DRGLSAKRTLEVRMRP
CCCCCCCEEEEEEECC
>Mature Secondary Structure 
PGIHRLMSRARRITRKLLPVGLGLLGLTVAAYVAAWRVPLPARLFAPASVVMEYRDGTP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHEEECCCCC
AHVFLAPDERWRIPTQLERVDPDYVQALLALEDKRFFHHPGVDPLAVLRAATRNLATGRR
EEEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHCHHHCCCCCCHHHHHHHHHHHHCCCCC
VSGASTLTMQLVRVLEPRPRTFTSKVIESFRAMQLEVRLSKQEVLAAYLQFVPYGRNVEG
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEEEECHHHHHHHHHHHCCCCCCCCC
VEAAALAYFGHTAANLSPAEIATLLAVPQNPNRRFPTAQNTARLKSARDGVARRLLDVEA
HHHHHHHHHCCCCCCCCHHHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
LPRGPEAARVSAETVLREVRDTPVPTDLKPFPREAPHVAVWLRTQRPANARLHTTLDAGT
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEHHHHH
QRMVERLMRDAAVGLAPRGIYNGTAVVVDRQQAEVLALVGNFDFFDQKHGGQIIGFATPR
HHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCEEEEEECCC
SPGSALKPLLYAMGIDLGMVGPEQLVADVPTAYGGYAPRNFDGRFQGLVRLEYALSQSLN
CCCHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCC
MPFVRLLERVGVERFLGALQAAGVTSLVQEPGYYGLSAAVGGIELTPLELAGVYVALAGD
CHHHHHHHHHCHHHHHHHHHHCCHHHHHHCCCCCCHHHHCCCEEECEEEEEEEEEEEECC
GRAPPLRLLLDEKAAAPVEVLSPGAAWLTRQALSLRDRPDFPARRRLTGMPARVHWKTGT
CCCCCEEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEECCC
SFGHRDAWAAGSGPRHTAVVWLGNFNHRPSVHLVGADAAGPVLFDILEGVGPRGLNLPDE
CCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCC
SVNPPDDLAVVEVCAYSGHLPTDACVQRKHVYARRSAVPTARCPYHQHVEVDVATGLSVG
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCC
PMCRTGRKTEPRVYVTWPATIRRWLEEQHRRLPEPPAAAPGCEPGGARAAPSIVSPAPGH
CHHCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VAVLIPGVPASQQEVPLEAEASHERALTWFVDGALLGTARADERVWWTPSVGSHEILVTD
EEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCEEEECCCCCCEEEECCCCCCCEEEEEC
DRGLSAKRTLEVRMRP
CCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]