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The map label for this gene is mccB [H]

Identifier: 108763912

GI number: 108763912

Start: 1118429

End: 1119559

Strand: Reverse

Name: mccB [H]

Synonym: MXAN_0969

Alternate gene names: 108763912

Gene position: 1119559-1118429 (Counterclockwise)

Preceding gene: 108757174

Following gene: 108763028

Centisome position: 12.25

GC content: 70.38

Gene sequence:

>1131_bases
ATGACATCATCGCCGACCTGGCCCAGGCGCTTCGCGACCCGTCTGCTGCACACGGGGCATGAGCAGGACCCCACCACGGG
CGCCGCCGCTGTCCCCATCTACCAGGTGTCCATGTTCGACCAGCCGGGCCTGGAGACGCCCGGCGAGTTCGACTACGCGC
GCTCCGGCAATCCCACGCGCAAGGCCCTGGAGGGCGTGCTCGCGGCACTGGACGAAGGCCACGCGGCCTTTGCCTTCGGC
TCTGGCATGGCCGCCGTGTCCAGCGTGCTGATGCTCTTCAGCGCGGGGGACCACGTCGTCGTGACGGACGACTGTTACGG
CGGCACCTACCGGGTGCTCACACGCGTCTTCAGCCGCTTCGGCCTGCAGGCCACCTTCGTGGACACCAGCGACCCGGACG
CCGTGCGCGCAGCCCTCCGCCCCAACACACGAGCGCTGCTGGTGGAGAGCGTGAGCAATCCCTTCCTCAAGCGCACCGAC
ATCCCCGCGATGGCGCGGGTGGCCCAGGCGCATGGGGCGCTGCTCATCGTGGACAACACGTTCCTGTCCCCGGCCCTCTC
GCGTCCGCTGACCGAGGGCGCGGACATCGTCATCCACTCCGCCACCAAGTACCTCGGCGGCCACAGTGACGTCGTCGCCG
GTGCGGTGGTGGTGAAGACGCCCGCGCTCGCGCAGGAGCTCGGCTTCCTCCAGAACGCGGTGGGCGCAGTGCTGGGACCC
CAGGACTGCTTCCTCCTCCAGCGGGGCATCAAGACGCTGCAGGTCCGCCTGGAGCGACAGGTGCGCACGGCGGGAGCCCT
GGCGAAGTGGCTCACCGAGCGGCCGGAGGTGCGGCGGGTCTTCTATCCGGGCACGGGCGCGGTGGTGTCGTTCCGGCTGG
CCCAGGACACGCTGGCGGCGCCCTTCGTGGAATCGCTCCAGCTCCCCCTGCTGGGTGTGTCGCTGGGCGCGGTGGAGAGC
ATCGTCACCGTCCCTGCGCGGCACTCCCACGCCTCCGTGCCCGTCGCCGAGCGGGAGCGCCGAGGCATCACCGACGGACT
CATCCGCTTCTCGGTGGGACTGGAGGACCTGGAGGACCTGCAAGAGGACTTCGTGCGGGCATTCACGCAGGCAGACCGCG
CGGCGGCATAG

Upstream 100 bases:

>100_bases
CCCACCACGCAGACCCACGCTGACATCCCCGCCGAGCGCCGGGAGGCGCTGGGCATCTCCGACCGGCTGCTCCGGCTCTC
CGTAGGAATCGAGGACTCCC

Downstream 100 bases:

>100_bases
GCCGTCAGGTTGACATGGCGCGTCGGCTCCATTACCTGTCTGTGCCGATGCTCGCTGGTTGCGCCATGTTCGGATTCTGT
CGCGGAGGCATGTGTTGTCA

Product: Cys/Met metabolism PLP-dependent enzyme

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MTSSPTWPRRFATRLLHTGHEQDPTTGAAAVPIYQVSMFDQPGLETPGEFDYARSGNPTRKALEGVLAALDEGHAAFAFG
SGMAAVSSVLMLFSAGDHVVVTDDCYGGTYRVLTRVFSRFGLQATFVDTSDPDAVRAALRPNTRALLVESVSNPFLKRTD
IPAMARVAQAHGALLIVDNTFLSPALSRPLTEGADIVIHSATKYLGGHSDVVAGAVVVKTPALAQELGFLQNAVGAVLGP
QDCFLLQRGIKTLQVRLERQVRTAGALAKWLTERPEVRRVFYPGTGAVVSFRLAQDTLAAPFVESLQLPLLGVSLGAVES
IVTVPARHSHASVPVAERERRGITDGLIRFSVGLEDLEDLQEDFVRAFTQADRAAA

Sequences:

>Translated_376_residues
MTSSPTWPRRFATRLLHTGHEQDPTTGAAAVPIYQVSMFDQPGLETPGEFDYARSGNPTRKALEGVLAALDEGHAAFAFG
SGMAAVSSVLMLFSAGDHVVVTDDCYGGTYRVLTRVFSRFGLQATFVDTSDPDAVRAALRPNTRALLVESVSNPFLKRTD
IPAMARVAQAHGALLIVDNTFLSPALSRPLTEGADIVIHSATKYLGGHSDVVAGAVVVKTPALAQELGFLQNAVGAVLGP
QDCFLLQRGIKTLQVRLERQVRTAGALAKWLTERPEVRRVFYPGTGAVVSFRLAQDTLAAPFVESLQLPLLGVSLGAVES
IVTVPARHSHASVPVAERERRGITDGLIRFSVGLEDLEDLQEDFVRAFTQADRAAA
>Mature_375_residues
TSSPTWPRRFATRLLHTGHEQDPTTGAAAVPIYQVSMFDQPGLETPGEFDYARSGNPTRKALEGVLAALDEGHAAFAFGS
GMAAVSSVLMLFSAGDHVVVTDDCYGGTYRVLTRVFSRFGLQATFVDTSDPDAVRAALRPNTRALLVESVSNPFLKRTDI
PAMARVAQAHGALLIVDNTFLSPALSRPLTEGADIVIHSATKYLGGHSDVVAGAVVVKTPALAQELGFLQNAVGAVLGPQ
DCFLLQRGIKTLQVRLERQVRTAGALAKWLTERPEVRRVFYPGTGAVVSFRLAQDTLAAPFVESLQLPLLGVSLGAVESI
VTVPARHSHASVPVAERERRGITDGLIRFSVGLEDLEDLQEDFVRAFTQADRAAA

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=366, Percent_Identity=42.3497267759563, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI299473759, Length=366, Percent_Identity=38.2513661202186, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI25453487, Length=365, Percent_Identity=37.8082191780822, Blast_Score=226, Evalue=2e-59,
Organism=Escherichia coli, GI1790375, Length=383, Percent_Identity=39.686684073107, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI1789383, Length=396, Percent_Identity=27.7777777777778, Blast_Score=144, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17560056, Length=371, Percent_Identity=39.622641509434, Blast_Score=267, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI17538055, Length=373, Percent_Identity=41.0187667560322, Blast_Score=265, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI71980708, Length=414, Percent_Identity=34.5410628019324, Blast_Score=220, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6319307, Length=387, Percent_Identity=39.0180878552972, Blast_Score=261, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6321254, Length=406, Percent_Identity=33.0049261083744, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6323333, Length=435, Percent_Identity=32.183908045977, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6321170, Length=278, Percent_Identity=32.3741007194245, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6321904, Length=349, Percent_Identity=28.3667621776504, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI19922554, Length=392, Percent_Identity=40.3061224489796, Blast_Score=295, Evalue=2e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 40285; Mature: 40154

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00120 LIPASE_SER ; PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSPTWPRRFATRLLHTGHEQDPTTGAAAVPIYQVSMFDQPGLETPGEFDYARSGNPTR
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHH
KALEGVLAALDEGHAAFAFGSGMAAVSSVLMLFSAGDHVVVTDDCYGGTYRVLTRVFSRF
HHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH
GLQATFVDTSDPDAVRAALRPNTRALLVESVSNPFLKRTDIPAMARVAQAHGALLIVDNT
CCEEEEECCCCHHHHHHHHCCCCCEEEEEHHCCCCHHHCCCHHHHHHHHHCCCEEEEECC
FLSPALSRPLTEGADIVIHSATKYLGGHSDVVAGAVVVKTPALAQELGFLQNAVGAVLGP
HHCHHHCCCCCCCCCEEEECHHHHHCCCCHHHHCCCEEECHHHHHHHHHHHHHHHHHCCC
QDCFLLQRGIKTLQVRLERQVRTAGALAKWLTERPEVRRVFYPGTGAVVSFRLAQDTLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEHHHHHHH
PFVESLQLPLLGVSLGAVESIVTVPARHSHASVPVAERERRGITDGLIRFSVGLEDLEDL
HHHHHHCCCHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCHHHHHHH
QEDFVRAFTQADRAAA
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSSPTWPRRFATRLLHTGHEQDPTTGAAAVPIYQVSMFDQPGLETPGEFDYARSGNPTR
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHH
KALEGVLAALDEGHAAFAFGSGMAAVSSVLMLFSAGDHVVVTDDCYGGTYRVLTRVFSRF
HHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH
GLQATFVDTSDPDAVRAALRPNTRALLVESVSNPFLKRTDIPAMARVAQAHGALLIVDNT
CCEEEEECCCCHHHHHHHHCCCCCEEEEEHHCCCCHHHCCCHHHHHHHHHCCCEEEEECC
FLSPALSRPLTEGADIVIHSATKYLGGHSDVVAGAVVVKTPALAQELGFLQNAVGAVLGP
HHCHHHCCCCCCCCCEEEECHHHHHCCCCHHHHCCCEEECHHHHHHHHHHHHHHHHHCCC
QDCFLLQRGIKTLQVRLERQVRTAGALAKWLTERPEVRRVFYPGTGAVVSFRLAQDTLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEHHHHHHH
PFVESLQLPLLGVSLGAVESIVTVPARHSHASVPVAERERRGITDGLIRFSVGLEDLEDL
HHHHHHCCCHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCHHHHHHH
QEDFVRAFTQADRAAA
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]