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The map label for this gene is lon

Identifier: 108763822

GI number: 108763822

Start: 4862103

End: 4864586

Strand: Direct

Name: lon

Synonym: MXAN_3993

Alternate gene names: 108763822

Gene position: 4862103-4864586 (Clockwise)

Preceding gene: 108762591

Following gene: 108760188

Centisome position: 53.2

GC content: 67.07

Gene sequence:

>2484_bases
ATGTCCGATGAGAAGAAGAAGGGCTCCGCTGCGAGCGCTATGCCCACCGCGATGGCCCCTCCGGGGCTCATCAACAAGGA
AGACATCCCGCAGGTGCTTCCCATCCTCCCCCTGCGCAACAGTGTCTTCTTCCCGGGCGGGGTGCTTCCGCTGGCCGTCG
GCCGCCAGAAGACCATCGCCCTGATCAAGGACGCCGTGCGTGACGACCAGGTCATCGGTGTCGTCACCCAGCGCCGCGCC
GAAGAAGAAGATCCGGGTGCCGCCGACCTCTACACCATGGGGACGGTCGCCCGCATCGTGAAGCTCCTGAAGATGGGCGA
GGACAACTACTCGCTCGTGGTGCAGGGGCTCGCCCGCTTCCGCGTGGTGGAGCTGGTCCAGGAAGCGCCCTACCTCAAGG
CCCGCGTGGACGCCGTGGAGGACAAGACCTCTTCGGAGAACGTGGAAGTCGAGGCGCTGGGCATCAACCTCAAGAAGCTG
GCGCGCGAGGTCATCGAGCTGATGCCCGAGCTGCCCGCCGCCGCCACCGAGCTGGTGGAGAGCATCACCCACCCCGGCCA
CCTGGCGGACCTGATCGCCGCCAACGTGGACGTGCCCATCGAGGAGAAGCAGGCCGTCCTGGAGACGGTGGACCTCAAGG
CCCGGATGAAGCTCGTGCTGGAGCTGCTCAACCGGAAGCGGGAGATCCTCAAGCTCTCCAACAAGATCGACTCCGCCGTG
AAGGGCGAGATGTCGAAGACCCAGCGCGAGTACTACCTGCGCCAGCAGCTCAAGGCCATCAAGGAAGAGCTGGGGGAGAT
GGGCGAGGAGGAAGAGGAGCTCGACGAGCTGCAGGAGCGCCTGAAGAAGGCCGGCCTGCCGCCCGACGTGGAGAAGGTCG
CCAACAAGGAGCTCAACCGCCTGAAGACCATTCCGGCGGCCTCCAGCGAGTACACCGTCGCGCGCACCTACCTGGATTGG
ATCGCCGACCTGCCGTGGGCGAAGATCTCCGAGGACAACCTCGACATCGAGAACGCGCGCCAGCAGCTGGACAAGGATCA
CTTCGGCATCAAGAAGGTGAAGAAGCGCATCCTGGAGTACCTGGCCGTCCGCAAGCTGAAGAACGACATGCGTGGCCCCA
TCCTGTGCCTCGTCGGTCCGCCGGGCGTCGGCAAGACGTCGCTGGGCCAGAGCGTGGCCAAGGCCACGGGCCGCAAGTTC
GTGCGCCTGTCGCTGGGCGGCGTGCGTGACGAGGCGGAGATCCGCGGCCACCGCCGGACCTATGTCGGCGCCCTCCCCGG
CCGCTTCATCCAGAGCATGAAGAAGGCCGGCACGAAGAACCCGGTCATGATGCTGGACGAAATTGACAAGCTCGGCGCCG
ACTTCCGTGGCGACCCGAGCGCGGCGCTCCTCGAGGTGCTGGATCCGGAGCAGAACAACACGTTCAGCGACCACTACCTC
GACGTGCCCTTCGATTTGTCCAAGGTGATGTTCGTCGCCACGGCGAACCAGCTCGACCCCATCCCCGGTCCGCTGCGTGA
CCGCATGGAGATCATCGAGCTGACGGGCTACACCTTCGAGGAGAAGCAGAGCATCGCCCGCATCCACCTGGTGCCCAAGC
AGCTCAAGGAGCACGGGCTGAGCCCGGACCACATCGACATCACCGACGAGGCGCTGCTCACGCTGACCACCGCGTACACG
CGCGAGGCCGGTGTGCGCAACCTGGAGCGCCGCATCGCGGACATCTGCCGCGCGGTGGCGGTGGAGGTGGCCGGCGGGAA
GACGGAGAAGCAGACCATCAACGCCGACCGGGTGAAGGAGATCCTCGGGCCCGAGATGTTCTACTCCGAGGTCGCCGAGC
GCACCGAGGTTCCGGGTGTGGCCACGGGCCTGGCCTGGACGGCGGCGGGTGGCGACCTGCTCTTCATCGAGGCGACGAAG
ATGGCGGGCAAGGGCGGCATGACGCTCACCGGCCAGTTGGGCGACGTGATGAAGGAGAGCGCCACGGCGGCGCTGAGCTA
CCTGCGCAGCAAGGCCGAGCAGCTCGGCATCAGCCCGAACTTCCTGGAGAAGACGGACCTGCACCTGCACTTCCCGGCGG
GCTCCATTCCGAAGGACGGGCCTTCCGCGGGCGTCACCATCCTGACGGCGCTCACCAGCCTCCTGACGGGCATCCGCGTG
CGTCACGACACGGCGATGACGGGCGAGGCCACGCTGCGTGGCCTGGTGCTGCCGGTGGGTGGCATCAAGGAGAAGGTGCT
GGCGGCGCACCGAGCGGGCATCAAGCGGGTCATCCTGCCCGAGCGGTGCCGCAAGGACCTGATCGACGTGCCGGACCAGG
CGCGCAACGAGCTGGAGTTCATCTTCGTCACCCACATGGACGACGTCCTGAAGGCGGCGCTGGAGACGCCTCCCGTCGGC
GTGGCGGGAACCCCGGGCGGTGAGCCGGGCAAGGAGGCTCCGCTGCCGAAGCCGGCCGAGTCCGCCCCTGAGGTCCGCGC
CTAG

Upstream 100 bases:

>100_bases
CACTGCGTTTGCCATGTCCGTTTTGGTTGTTACGTTGGTTCATCCGCCGCAGAAAACCTGGAAATGTTCACTGGTTGTCG
AAGAGAAAAGGCTGAATTTC

Downstream 100 bases:

>100_bases
CGCACGGCCTTCCAGCCAATAGGAAGTGACACGGGCAGGTTCCCTTCTTCCGGGAACCTGCCCGTTGTCTTTGCGGGGCA
GGTGGCGCTCAGAGCGAGAA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La 2

Number of amino acids: Translated: 827; Mature: 826

Protein sequence:

>827_residues
MSDEKKKGSAASAMPTAMAPPGLINKEDIPQVLPILPLRNSVFFPGGVLPLAVGRQKTIALIKDAVRDDQVIGVVTQRRA
EEEDPGAADLYTMGTVARIVKLLKMGEDNYSLVVQGLARFRVVELVQEAPYLKARVDAVEDKTSSENVEVEALGINLKKL
AREVIELMPELPAAATELVESITHPGHLADLIAANVDVPIEEKQAVLETVDLKARMKLVLELLNRKREILKLSNKIDSAV
KGEMSKTQREYYLRQQLKAIKEELGEMGEEEEELDELQERLKKAGLPPDVEKVANKELNRLKTIPAASSEYTVARTYLDW
IADLPWAKISEDNLDIENARQQLDKDHFGIKKVKKRILEYLAVRKLKNDMRGPILCLVGPPGVGKTSLGQSVAKATGRKF
VRLSLGGVRDEAEIRGHRRTYVGALPGRFIQSMKKAGTKNPVMMLDEIDKLGADFRGDPSAALLEVLDPEQNNTFSDHYL
DVPFDLSKVMFVATANQLDPIPGPLRDRMEIIELTGYTFEEKQSIARIHLVPKQLKEHGLSPDHIDITDEALLTLTTAYT
REAGVRNLERRIADICRAVAVEVAGGKTEKQTINADRVKEILGPEMFYSEVAERTEVPGVATGLAWTAAGGDLLFIEATK
MAGKGGMTLTGQLGDVMKESATAALSYLRSKAEQLGISPNFLEKTDLHLHFPAGSIPKDGPSAGVTILTALTSLLTGIRV
RHDTAMTGEATLRGLVLPVGGIKEKVLAAHRAGIKRVILPERCRKDLIDVPDQARNELEFIFVTHMDDVLKAALETPPVG
VAGTPGGEPGKEAPLPKPAESAPEVRA

Sequences:

>Translated_827_residues
MSDEKKKGSAASAMPTAMAPPGLINKEDIPQVLPILPLRNSVFFPGGVLPLAVGRQKTIALIKDAVRDDQVIGVVTQRRA
EEEDPGAADLYTMGTVARIVKLLKMGEDNYSLVVQGLARFRVVELVQEAPYLKARVDAVEDKTSSENVEVEALGINLKKL
AREVIELMPELPAAATELVESITHPGHLADLIAANVDVPIEEKQAVLETVDLKARMKLVLELLNRKREILKLSNKIDSAV
KGEMSKTQREYYLRQQLKAIKEELGEMGEEEEELDELQERLKKAGLPPDVEKVANKELNRLKTIPAASSEYTVARTYLDW
IADLPWAKISEDNLDIENARQQLDKDHFGIKKVKKRILEYLAVRKLKNDMRGPILCLVGPPGVGKTSLGQSVAKATGRKF
VRLSLGGVRDEAEIRGHRRTYVGALPGRFIQSMKKAGTKNPVMMLDEIDKLGADFRGDPSAALLEVLDPEQNNTFSDHYL
DVPFDLSKVMFVATANQLDPIPGPLRDRMEIIELTGYTFEEKQSIARIHLVPKQLKEHGLSPDHIDITDEALLTLTTAYT
REAGVRNLERRIADICRAVAVEVAGGKTEKQTINADRVKEILGPEMFYSEVAERTEVPGVATGLAWTAAGGDLLFIEATK
MAGKGGMTLTGQLGDVMKESATAALSYLRSKAEQLGISPNFLEKTDLHLHFPAGSIPKDGPSAGVTILTALTSLLTGIRV
RHDTAMTGEATLRGLVLPVGGIKEKVLAAHRAGIKRVILPERCRKDLIDVPDQARNELEFIFVTHMDDVLKAALETPPVG
VAGTPGGEPGKEAPLPKPAESAPEVRA
>Mature_826_residues
SDEKKKGSAASAMPTAMAPPGLINKEDIPQVLPILPLRNSVFFPGGVLPLAVGRQKTIALIKDAVRDDQVIGVVTQRRAE
EEDPGAADLYTMGTVARIVKLLKMGEDNYSLVVQGLARFRVVELVQEAPYLKARVDAVEDKTSSENVEVEALGINLKKLA
REVIELMPELPAAATELVESITHPGHLADLIAANVDVPIEEKQAVLETVDLKARMKLVLELLNRKREILKLSNKIDSAVK
GEMSKTQREYYLRQQLKAIKEELGEMGEEEEELDELQERLKKAGLPPDVEKVANKELNRLKTIPAASSEYTVARTYLDWI
ADLPWAKISEDNLDIENARQQLDKDHFGIKKVKKRILEYLAVRKLKNDMRGPILCLVGPPGVGKTSLGQSVAKATGRKFV
RLSLGGVRDEAEIRGHRRTYVGALPGRFIQSMKKAGTKNPVMMLDEIDKLGADFRGDPSAALLEVLDPEQNNTFSDHYLD
VPFDLSKVMFVATANQLDPIPGPLRDRMEIIELTGYTFEEKQSIARIHLVPKQLKEHGLSPDHIDITDEALLTLTTAYTR
EAGVRNLERRIADICRAVAVEVAGGKTEKQTINADRVKEILGPEMFYSEVAERTEVPGVATGLAWTAAGGDLLFIEATKM
AGKGGMTLTGQLGDVMKESATAALSYLRSKAEQLGISPNFLEKTDLHLHFPAGSIPKDGPSAGVTILTALTSLLTGIRVR
HDTAMTGEATLRGLVLPVGGIKEKVLAAHRAGIKRVILPERCRKDLIDVPDQARNELEFIFVTHMDDVLKAALETPPVGV
AGTPGGEPGKEAPLPKPAESAPEVRA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=835, Percent_Identity=44.4311377245509, Blast_Score=660, Evalue=0.0,
Organism=Homo sapiens, GI21396489, Length=837, Percent_Identity=39.3070489844683, Blast_Score=568, Evalue=1e-161,
Organism=Escherichia coli, GI1786643, Length=770, Percent_Identity=47.9220779220779, Blast_Score=727, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=659, Percent_Identity=42.0333839150228, Blast_Score=516, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17556486, Length=794, Percent_Identity=36.0201511335013, Blast_Score=493, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6319449, Length=696, Percent_Identity=41.5229885057471, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI221513036, Length=709, Percent_Identity=44.0056417489422, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24666867, Length=709, Percent_Identity=44.0056417489422, Blast_Score=578, Evalue=1e-165,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON2_MYXXA (P36774)

Other databases:

- EMBL:   D13204
- EMBL:   L19301
- PIR:   A36895
- ProteinModelPortal:   P36774
- BRENDA:   3.4.21.53
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 90440; Mature: 90308

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 702-702 ACT_SITE 745-745

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDEKKKGSAASAMPTAMAPPGLINKEDIPQVLPILPLRNSVFFPGGVLPLAVGRQKTIA
CCCCCCCCCCHHCCCCCCCCCCCCCHHCCHHHHCCCCCCCCEECCCCCHHHCCCCHHHHH
LIKDAVRDDQVIGVVTQRRAEEEDPGAADLYTMGTVARIVKLLKMGEDNYSLVVQGLARF
HHHHHHCCCCEEEHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
RVVELVQEAPYLKARVDAVEDKTSSENVEVEALGINLKKLAREVIELMPELPAAATELVE
HHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHH
SITHPGHLADLIAANVDVPIEEKQAVLETVDLKARMKLVLELLNRKREILKLSNKIDSAV
HHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGEMSKTQREYYLRQQLKAIKEELGEMGEEEEELDELQERLKKAGLPPDVEKVANKELNR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LKTIPAASSEYTVARTYLDWIADLPWAKISEDNLDIENARQQLDKDHFGIKKVKKRILEY
HHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCHHCCCHHHHHHHHHHH
LAVRKLKNDMRGPILCLVGPPGVGKTSLGQSVAKATGRKFVRLSLGGVRDEAEIRGHRRT
HHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCCHHH
YVGALPGRFIQSMKKAGTKNPVMMLDEIDKLGADFRGDPSAALLEVLDPEQNNTFSDHYL
HHHCCCHHHHHHHHHCCCCCCEEHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEE
DVPFDLSKVMFVATANQLDPIPGPLRDRMEIIELTGYTFEEKQSIARIHLVPKQLKEHGL
CCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHCCC
SPDHIDITDEALLTLTTAYTREAGVRNLERRIADICRAVAVEVAGGKTEKQTINADRVKE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHH
ILGPEMFYSEVAERTEVPGVATGLAWTAAGGDLLFIEATKMAGKGGMTLTGQLGDVMKES
HHCHHHHHHHHHHHHCCCCCHHCCEEEECCCCEEEEEEEHHCCCCCCEEECHHHHHHHHH
ATAALSYLRSKAEQLGISPNFLEKTDLHLHFPAGSIPKDGPSAGVTILTALTSLLTGIRV
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHE
RHDTAMTGEATLRGLVLPVGGIKEKVLAAHRAGIKRVILPERCRKDLIDVPDQARNELEF
ECCCCCCCHHHHHEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHCCCEEE
IFVTHMDDVLKAALETPPVGVAGTPGGEPGKEAPLPKPAESAPEVRA
EEEECHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDEKKKGSAASAMPTAMAPPGLINKEDIPQVLPILPLRNSVFFPGGVLPLAVGRQKTIA
CCCCCCCCCHHCCCCCCCCCCCCCHHCCHHHHCCCCCCCCEECCCCCHHHCCCCHHHHH
LIKDAVRDDQVIGVVTQRRAEEEDPGAADLYTMGTVARIVKLLKMGEDNYSLVVQGLARF
HHHHHHCCCCEEEHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
RVVELVQEAPYLKARVDAVEDKTSSENVEVEALGINLKKLAREVIELMPELPAAATELVE
HHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHH
SITHPGHLADLIAANVDVPIEEKQAVLETVDLKARMKLVLELLNRKREILKLSNKIDSAV
HHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGEMSKTQREYYLRQQLKAIKEELGEMGEEEEELDELQERLKKAGLPPDVEKVANKELNR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LKTIPAASSEYTVARTYLDWIADLPWAKISEDNLDIENARQQLDKDHFGIKKVKKRILEY
HHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCHHCCCHHHHHHHHHHH
LAVRKLKNDMRGPILCLVGPPGVGKTSLGQSVAKATGRKFVRLSLGGVRDEAEIRGHRRT
HHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCCHHH
YVGALPGRFIQSMKKAGTKNPVMMLDEIDKLGADFRGDPSAALLEVLDPEQNNTFSDHYL
HHHCCCHHHHHHHHHCCCCCCEEHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEE
DVPFDLSKVMFVATANQLDPIPGPLRDRMEIIELTGYTFEEKQSIARIHLVPKQLKEHGL
CCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHCCC
SPDHIDITDEALLTLTTAYTREAGVRNLERRIADICRAVAVEVAGGKTEKQTINADRVKE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHH
ILGPEMFYSEVAERTEVPGVATGLAWTAAGGDLLFIEATKMAGKGGMTLTGQLGDVMKES
HHCHHHHHHHHHHHHCCCCCHHCCEEEECCCCEEEEEEEHHCCCCCCEEECHHHHHHHHH
ATAALSYLRSKAEQLGISPNFLEKTDLHLHFPAGSIPKDGPSAGVTILTALTSLLTGIRV
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHE
RHDTAMTGEATLRGLVLPVGGIKEKVLAAHRAGIKRVILPERCRKDLIDVPDQARNELEF
ECCCCCCCHHHHHEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHCCCEEE
IFVTHMDDVLKAALETPPVGVAGTPGGEPGKEAPLPKPAESAPEVRA
EEEECHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8331083; 8331082