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The map label for this gene is merA [H]

Identifier: 108763795

GI number: 108763795

Start: 331739

End: 333130

Strand: Reverse

Name: merA [H]

Synonym: MXAN_0278

Alternate gene names: 108763795

Gene position: 333130-331739 (Counterclockwise)

Preceding gene: 108760444

Following gene: 108758210

Centisome position: 3.64

GC content: 70.76

Gene sequence:

>1392_bases
ATGGCGGAAGCGTTCGACGTGGTGGTGATAGGGGCAGGCCCCGCGGGTGAGGTCGCCGGTGCGCGCGCCGCGGAGGCCGG
GCTGTCAGTGGCGTTGGTGGAGCATGAGCTGCTCGGCGGCGAGTGCTCATACTGGGCCTGCATCCCCAGCAAGGCCTTGC
TGCGCCCGAGCGAAGCGCGGTGGCTGGCGGAGCATGCCGCCGGCGTGCGCGAGAAGCTCCAGGAGGGCATCGACGCGCGT
GCGGTGCTGGCCCACCGGGATTCGATGGTCAACAACTACCAGGACGACTCCCAGGTGAAGTGGGCCGAGAATGCGAAGCT
GAAGGTGGTGCGGGGCACCGGCAAGCTCACTGGCCCTCGCAAGGTGCGTGTGGAGGACAAGGACGGCGCCGTGCGGGAGC
TGGAGGCCCGAAAAGCCGTGGTGCTGGCCACCGGCAGCCATCCGCGCATCCCGGACATCCCGGGGCTGAAGGACGCCCAG
CCCTGGGACAACCGCCAGGGCACTGCGGCGAGGCAGGTGCCCAAGCGGCTGGTGGTGCTGGGCGGCGGCGCGGTCGGGGT
GGAGCTGGCCCAGGCGTGGCGCTCGCTGGGCTCCGAGGTGACGCTGGTGCAGCGCGGAAAGAGATTGCTGTCCCGCGCGG
AGCCCTTCGCCGGAGAGCAGGTGGCCCAGGCGCTGCGAGATGCCGGCGCGCGCGTGCTGCTTGGAATGAACGCGACGCGC
GTCCAGCGGCCCGGCGGCAAGGGCGAGGTGACGGTGACGCTGTCCAATGGCGAGCAGGTCGTCGCGGACGAAATCCTGGT
GGCCATGGGCCGCGTGCCCCGCACGGAAGGAATCGGGCTGGAGACGGTGGGGCTCGTGGGCGGCAAGCCCGTGGAGGTGG
ATGACCAGCTCCGCGCGAAGGGCGTGGACGGCGGCTGGCTCTACGCGTGCGGCGACACCAATGGCCGCAACCTCCTCACC
CATATGGGCAAGTACCAGGCCCGCATGGTGGGCGACGTCATCGCGGGCAAGCAGGCAAGGGCCTGGGCGGACGCGAAGGC
CACCCCGCAAGTCGTCTTCACCCACCCACAGGTGGCCAGCGTGGGCCTCACCGAGGCCAAGGCACGCGAGGCCGGGCTGC
CGGTACGCACGGTGGAGCAGCAACTCCAGGACGTGTCCGGCACCTCGCTGGTGGGCAAGGGCCTCACTGGCACCGTGAAG
TGGGTGGTGGACGAGAAGCGCCGGGTGCTCGTGGGCGCCACGTTCACCGGGCCGGAGGTGGGAGAGATGCTCCATGCGGC
CACCATCGCCGTGGCGGGGGAGGTGCCGCTCGACACGTTGTGGCACGCGGTGCCGTCGTTCCCCACCATGAGCGAGGTGT
GGTTGAAGCTGCTGGAGGCGTACGGCCTCTAG

Upstream 100 bases:

>100_bases
CGGGTGACCACCCTCACTTTCCAGCAGCGGACGTGCGTCTCAACGCGACCGTGGGCATGGCCCGCCGCCGCGCTACGCAG
CGGGCACGAGGTGAAGGCAC

Downstream 100 bases:

>100_bases
CGCGCCGCCCCCTCCGTTGCGTGCGCGGGGGTGGGCGTGGAATGGTGCCGCTGCCCACCCCACCCCACCCTACCGATGAC
CGCCGTCGCCCCGGGGCCCT

Product: mercuric reductase, truncated

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MAEAFDVVVIGAGPAGEVAGARAAEAGLSVALVEHELLGGECSYWACIPSKALLRPSEARWLAEHAAGVREKLQEGIDAR
AVLAHRDSMVNNYQDDSQVKWAENAKLKVVRGTGKLTGPRKVRVEDKDGAVRELEARKAVVLATGSHPRIPDIPGLKDAQ
PWDNRQGTAARQVPKRLVVLGGGAVGVELAQAWRSLGSEVTLVQRGKRLLSRAEPFAGEQVAQALRDAGARVLLGMNATR
VQRPGGKGEVTVTLSNGEQVVADEILVAMGRVPRTEGIGLETVGLVGGKPVEVDDQLRAKGVDGGWLYACGDTNGRNLLT
HMGKYQARMVGDVIAGKQARAWADAKATPQVVFTHPQVASVGLTEAKAREAGLPVRTVEQQLQDVSGTSLVGKGLTGTVK
WVVDEKRRVLVGATFTGPEVGEMLHAATIAVAGEVPLDTLWHAVPSFPTMSEVWLKLLEAYGL

Sequences:

>Translated_463_residues
MAEAFDVVVIGAGPAGEVAGARAAEAGLSVALVEHELLGGECSYWACIPSKALLRPSEARWLAEHAAGVREKLQEGIDAR
AVLAHRDSMVNNYQDDSQVKWAENAKLKVVRGTGKLTGPRKVRVEDKDGAVRELEARKAVVLATGSHPRIPDIPGLKDAQ
PWDNRQGTAARQVPKRLVVLGGGAVGVELAQAWRSLGSEVTLVQRGKRLLSRAEPFAGEQVAQALRDAGARVLLGMNATR
VQRPGGKGEVTVTLSNGEQVVADEILVAMGRVPRTEGIGLETVGLVGGKPVEVDDQLRAKGVDGGWLYACGDTNGRNLLT
HMGKYQARMVGDVIAGKQARAWADAKATPQVVFTHPQVASVGLTEAKAREAGLPVRTVEQQLQDVSGTSLVGKGLTGTVK
WVVDEKRRVLVGATFTGPEVGEMLHAATIAVAGEVPLDTLWHAVPSFPTMSEVWLKLLEAYGL
>Mature_462_residues
AEAFDVVVIGAGPAGEVAGARAAEAGLSVALVEHELLGGECSYWACIPSKALLRPSEARWLAEHAAGVREKLQEGIDARA
VLAHRDSMVNNYQDDSQVKWAENAKLKVVRGTGKLTGPRKVRVEDKDGAVRELEARKAVVLATGSHPRIPDIPGLKDAQP
WDNRQGTAARQVPKRLVVLGGGAVGVELAQAWRSLGSEVTLVQRGKRLLSRAEPFAGEQVAQALRDAGARVLLGMNATRV
QRPGGKGEVTVTLSNGEQVVADEILVAMGRVPRTEGIGLETVGLVGGKPVEVDDQLRAKGVDGGWLYACGDTNGRNLLTH
MGKYQARMVGDVIAGKQARAWADAKATPQVVFTHPQVASVGLTEAKAREAGLPVRTVEQQLQDVSGTSLVGKGLTGTVKW
VVDEKRRVLVGATFTGPEVGEMLHAATIAVAGEVPLDTLWHAVPSFPTMSEVWLKLLEAYGL

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=474, Percent_Identity=28.6919831223629, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI50301238, Length=472, Percent_Identity=26.4830508474576, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI33519430, Length=358, Percent_Identity=25.4189944134078, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI33519428, Length=358, Percent_Identity=25.4189944134078, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI33519426, Length=358, Percent_Identity=25.4189944134078, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI148277065, Length=358, Percent_Identity=25.4189944134078, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI148277071, Length=358, Percent_Identity=25.4189944134078, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI22035672, Length=467, Percent_Identity=25.2676659528908, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786307, Length=465, Percent_Identity=30.3225806451613, Blast_Score=179, Evalue=5e-46,
Organism=Escherichia coli, GI87081717, Length=460, Percent_Identity=26.7391304347826, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI87082354, Length=466, Percent_Identity=24.0343347639485, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789915, Length=363, Percent_Identity=27.5482093663912, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI32565766, Length=463, Percent_Identity=29.1576673866091, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17557007, Length=502, Percent_Identity=25.8964143426295, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71983429, Length=373, Percent_Identity=27.6139410187668, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71983419, Length=373, Percent_Identity=27.6139410187668, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71982272, Length=396, Percent_Identity=25.7575757575758, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321091, Length=477, Percent_Identity=28.0922431865828, Blast_Score=143, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6325240, Length=473, Percent_Identity=25.369978858351, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6325166, Length=380, Percent_Identity=26.5789473684211, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21358499, Length=463, Percent_Identity=29.1576673866091, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24640549, Length=479, Percent_Identity=25.2609603340292, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17737741, Length=511, Percent_Identity=24.6575342465753, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640553, Length=479, Percent_Identity=25.2609603340292, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640551, Length=479, Percent_Identity=25.2609603340292, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 49112; Mature: 48981

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAFDVVVIGAGPAGEVAGARAAEAGLSVALVEHELLGGECSYWACIPSKALLRPSEAR
CCCEEEEEEECCCCCCCCCCCHHHHCCCEEEEEEHHHCCCCCCEEEECCCHHHCCCHHHH
WLAEHAAGVREKLQEGIDARAVLAHRDSMVNNYQDDSQVKWAENAKLKVVRGTGKLTGPR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEECCCCCCCCE
KVRVEDKDGAVRELEARKAVVLATGSHPRIPDIPGLKDAQPWDNRQGTAARQVPKRLVVL
EEEEECCCCCHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEEE
GGGAVGVELAQAWRSLGSEVTLVQRGKRLLSRAEPFAGEQVAQALRDAGARVLLGMNATR
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCHHH
VQRPGGKGEVTVTLSNGEQVVADEILVAMGRVPRTEGIGLETVGLVGGKPVEVDDQLRAK
EECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHHHC
GVDGGWLYACGDTNGRNLLTHMGKYQARMVGDVIAGKQARAWADAKATPQVVFTHPQVAS
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCEEEECCCHHH
VGLTEAKAREAGLPVRTVEQQLQDVSGTSLVGKGLTGTVKWVVDEKRRVLVGATFTGPEV
CCCCHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCEEEEEEECCCEEEEEEECCCHHH
GEMLHAATIAVAGEVPLDTLWHAVPSFPTMSEVWLKLLEAYGL
HHHHHHHHHEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AEAFDVVVIGAGPAGEVAGARAAEAGLSVALVEHELLGGECSYWACIPSKALLRPSEAR
CCEEEEEEECCCCCCCCCCCHHHHCCCEEEEEEHHHCCCCCCEEEECCCHHHCCCHHHH
WLAEHAAGVREKLQEGIDARAVLAHRDSMVNNYQDDSQVKWAENAKLKVVRGTGKLTGPR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEECCCCCCCCE
KVRVEDKDGAVRELEARKAVVLATGSHPRIPDIPGLKDAQPWDNRQGTAARQVPKRLVVL
EEEEECCCCCHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEEE
GGGAVGVELAQAWRSLGSEVTLVQRGKRLLSRAEPFAGEQVAQALRDAGARVLLGMNATR
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCHHH
VQRPGGKGEVTVTLSNGEQVVADEILVAMGRVPRTEGIGLETVGLVGGKPVEVDDQLRAK
EECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHHHC
GVDGGWLYACGDTNGRNLLTHMGKYQARMVGDVIAGKQARAWADAKATPQVVFTHPQVAS
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCEEEECCCHHH
VGLTEAKAREAGLPVRTVEQQLQDVSGTSLVGKGLTGTVKWVVDEKRRVLVGATFTGPEV
CCCCHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCEEEEEEECCCEEEEEEECCCHHH
GEMLHAATIAVAGEVPLDTLWHAVPSFPTMSEVWLKLLEAYGL
HHHHHHHHHEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]