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The map label for this gene is fdh [H]

Identifier: 108763600

GI number: 108763600

Start: 2083831

End: 2084862

Strand: Direct

Name: fdh [H]

Synonym: MXAN_1758

Alternate gene names: 108763600

Gene position: 2083831-2084862 (Clockwise)

Preceding gene: 108757132

Following gene: 108762680

Centisome position: 22.8

GC content: 65.31

Gene sequence:

>1032_bases
ATGAAAGGAGCTGCTATGCGTGCCACCGTTCTCCACAAGCCCGGCGACGTCCGCTTCGAGGAGCGCGCCGAGCCGAAGAT
TCTCGCGCCGACGGATGCCATCATCCGTCTCTCGGCTACATGTGTCTGCGGCTCGGACCTATGGCCCTACCGAGGCGTGC
AGGCGGTGACTGAGCCGACGCCGATGGGGCACGAGTACTGCGGCATCGTCGAAGAGGTCGGAAGCGCTGTCGCTTCGGTC
AAGCCAGGGCAGTTCGTCATCGGTTCGTTCTTCGCCTCCGACAACACGTGCCCTCACTGCAAGGCGGGTTACCAAACGTC
GTGCCAGCACCGAGAGCCGGTGAGTGGGGCTCAGGCGCCAAGGATGCGAGTGCCGCTCGCCGACGGCACGCTGGTCGTGA
CGGCCGAGGTGCCGCCCGATGCGCTTGTGCCCAGCCTGCTGGCCGTGTCGGACGTGTTTGGTACCGGTTGGTTCGCAGCC
GACGCCGCCAACGTGAATCCCGGCTCGACAGTCGTGGTCGTCGGCGACGGTGCCGTCGGGCTCCTGGCGGTACTCTCCGC
GAAGCAGATGGGAGCCGAGCGCATCATCGCGATGAGCCGCCATGAGACGCGCCAGGCGCTCGCTCGTGAGTTTGGTGCCA
CGGACATTGTGTCCGTGCGAGGCGACGAGGGCGTTGCTCGCATCAAAGAACTGACCCGGGGGATTGGTGCCGATTCGGTG
CTGGAGTGCGTGGGCACACAGGAGTCCATGCTCCAGGCTATCGGCGCCGCGAGGCCCGGAGGCTTCGTCAGCTACGTGGG
CGTGCCTCATGGCGTGAGCCTGGACGGCGAGAAGCTCTTTTTCTCGCACGTTCATCTCCACGGTGGCCCTGCGCCGGTAC
GTCGGTTCATGCCTCAACTGATTGACCTGGTCTGGAGCAGGAAGGTCAATCCCGGGAAAGTCTTCGACCTCACCCTGCCG
CTCGAGAAGGTCGCCGAGGGCTATCGCGCGATGGACGAAAGGCGCGCAATCAAGGCGCTGCTTCGCCCGTGA

Upstream 100 bases:

>100_bases
CGAGTGGCGGCTGTCAAGTGCAGCTTGACAGCCCATCCTCAACCAGCATCTTCACGGGGCGAGCGCGGGTACGCATGTTC
CATCCGTAATCCACTCCGAG

Downstream 100 bases:

>100_bases
GTGACTGGTGGCGACTTGGCGGGACGTGGGGGCTGCGGCAGAAGAACGAGTTGCGCTCGCCGCGGAACTGAGCACTCCCC
CCGATGGGGTGCTCGGAGGG

Product: zinc-binding dehydrogenase family oxidoreductase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MKGAAMRATVLHKPGDVRFEERAEPKILAPTDAIIRLSATCVCGSDLWPYRGVQAVTEPTPMGHEYCGIVEEVGSAVASV
KPGQFVIGSFFASDNTCPHCKAGYQTSCQHREPVSGAQAPRMRVPLADGTLVVTAEVPPDALVPSLLAVSDVFGTGWFAA
DAANVNPGSTVVVVGDGAVGLLAVLSAKQMGAERIIAMSRHETRQALAREFGATDIVSVRGDEGVARIKELTRGIGADSV
LECVGTQESMLQAIGAARPGGFVSYVGVPHGVSLDGEKLFFSHVHLHGGPAPVRRFMPQLIDLVWSRKVNPGKVFDLTLP
LEKVAEGYRAMDERRAIKALLRP

Sequences:

>Translated_343_residues
MKGAAMRATVLHKPGDVRFEERAEPKILAPTDAIIRLSATCVCGSDLWPYRGVQAVTEPTPMGHEYCGIVEEVGSAVASV
KPGQFVIGSFFASDNTCPHCKAGYQTSCQHREPVSGAQAPRMRVPLADGTLVVTAEVPPDALVPSLLAVSDVFGTGWFAA
DAANVNPGSTVVVVGDGAVGLLAVLSAKQMGAERIIAMSRHETRQALAREFGATDIVSVRGDEGVARIKELTRGIGADSV
LECVGTQESMLQAIGAARPGGFVSYVGVPHGVSLDGEKLFFSHVHLHGGPAPVRRFMPQLIDLVWSRKVNPGKVFDLTLP
LEKVAEGYRAMDERRAIKALLRP
>Mature_343_residues
MKGAAMRATVLHKPGDVRFEERAEPKILAPTDAIIRLSATCVCGSDLWPYRGVQAVTEPTPMGHEYCGIVEEVGSAVASV
KPGQFVIGSFFASDNTCPHCKAGYQTSCQHREPVSGAQAPRMRVPLADGTLVVTAEVPPDALVPSLLAVSDVFGTGWFAA
DAANVNPGSTVVVVGDGAVGLLAVLSAKQMGAERIIAMSRHETRQALAREFGATDIVSVRGDEGVARIKELTRGIGADSV
LECVGTQESMLQAIGAARPGGFVSYVGVPHGVSLDGEKLFFSHVHLHGGPAPVRRFMPQLIDLVWSRKVNPGKVFDLTLP
LEKVAEGYRAMDERRAIKALLRP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565152, Length=342, Percent_Identity=28.3625730994152, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI4501929, Length=370, Percent_Identity=28.3783783783784, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI156627571, Length=358, Percent_Identity=28.2122905027933, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI156523966, Length=374, Percent_Identity=29.6791443850267, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI34577061, Length=367, Percent_Identity=28.0653950953678, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI262073058, Length=365, Percent_Identity=27.3972602739726, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI71743840, Length=343, Percent_Identity=27.6967930029155, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4501939, Length=364, Percent_Identity=29.9450549450549, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI4501933, Length=367, Percent_Identity=28.3378746594005, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI71565154, Length=361, Percent_Identity=25.207756232687, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786825, Length=383, Percent_Identity=29.5039164490862, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI226510992, Length=353, Percent_Identity=25.7790368271955, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790045, Length=270, Percent_Identity=27.037037037037, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788075, Length=343, Percent_Identity=27.1137026239067, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788073, Length=272, Percent_Identity=27.5735294117647, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082125, Length=330, Percent_Identity=26.0606060606061, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788407, Length=269, Percent_Identity=25.6505576208178, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786552, Length=381, Percent_Identity=26.509186351706, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081918, Length=337, Percent_Identity=25.8160237388724, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=348, Percent_Identity=27.8735632183908, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562878, Length=263, Percent_Identity=28.5171102661597, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=278, Percent_Identity=30.9352517985612, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=278, Percent_Identity=30.9352517985612, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=260, Percent_Identity=31.1538461538462, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=282, Percent_Identity=31.2056737588652, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=298, Percent_Identity=27.1812080536913, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=255, Percent_Identity=26.2745098039216, Blast_Score=66, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=266, Percent_Identity=25.9398496240602, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137530, Length=260, Percent_Identity=28.8461538461538, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17737897, Length=260, Percent_Identity=28.4615384615385, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI221457811, Length=324, Percent_Identity=25.3086419753086, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550770, Length=324, Percent_Identity=25.3086419753086, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551930, Length=324, Percent_Identity=25.3086419753086, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 36399; Mature: 36399

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGAAMRATVLHKPGDVRFEERAEPKILAPTDAIIRLSATCVCGSDLWPYRGVQAVTEPT
CCCCCEEEEEEECCCCCCCCCCCCCCEECCCHHHEEEEEEEEECCCCCCCCCCHHHCCCC
PMGHEYCGIVEEVGSAVASVKPGQFVIGSFFASDNTCPHCKAGYQTSCQHREPVSGAQAP
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RMRVPLADGTLVVTAEVPPDALVPSLLAVSDVFGTGWFAADAANVNPGSTVVVVGDGAVG
CEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECCCHHH
LLAVLSAKQMGAERIIAMSRHETRQALAREFGATDIVSVRGDEGVARIKELTRGIGADSV
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCHHHH
LECVGTQESMLQAIGAARPGGFVSYVGVPHGVSLDGEKLFFSHVHLHGGPAPVRRFMPQL
HHHHCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHH
IDLVWSRKVNPGKVFDLTLPLEKVAEGYRAMDERRAIKALLRP
HHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKGAAMRATVLHKPGDVRFEERAEPKILAPTDAIIRLSATCVCGSDLWPYRGVQAVTEPT
CCCCCEEEEEEECCCCCCCCCCCCCCEECCCHHHEEEEEEEEECCCCCCCCCCHHHCCCC
PMGHEYCGIVEEVGSAVASVKPGQFVIGSFFASDNTCPHCKAGYQTSCQHREPVSGAQAP
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RMRVPLADGTLVVTAEVPPDALVPSLLAVSDVFGTGWFAADAANVNPGSTVVVVGDGAVG
CEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECCCHHH
LLAVLSAKQMGAERIIAMSRHETRQALAREFGATDIVSVRGDEGVARIKELTRGIGADSV
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCHHHH
LECVGTQESMLQAIGAARPGGFVSYVGVPHGVSLDGEKLFFSHVHLHGGPAPVRRFMPQL
HHHHCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHH
IDLVWSRKVNPGKVFDLTLPLEKVAEGYRAMDERRAIKALLRP
HHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]