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The map label for this gene is gyrA [H]

Identifier: 108763597

GI number: 108763597

Start: 2895037

End: 2897478

Strand: Reverse

Name: gyrA [H]

Synonym: MXAN_2485

Alternate gene names: 108763597

Gene position: 2897478-2895037 (Counterclockwise)

Preceding gene: 108763568

Following gene: 108763546

Centisome position: 31.7

GC content: 66.58

Gene sequence:

>2442_bases
GTGCGCGGGTCGCGCGCCGCGTTCGGGGTGCGGGGCGTTCTCACCTGTGGATTGACGACCATGCTCGCAGAAGCCGAATC
GAAATCGCGAAAGAAGCAGGGGGCCGGGGGAGGCAGCGGTGGCGGCGGGAGTGGCGGCGGCGCGGGTGGCAACGGCGACG
GCTCCGTGCCGGCTTCGCTCGCGGACGAGGCGCGCCGCCGGTACATCAACTACGCCCTGTCGGTCATCACCTCGCGCGCC
CTGCCGGACGTGCGTGACGGCCTCAAGCCGGTGCAGCGCCGCATCCTGTTCGGCATGTTCCACGACCACCGGCTGACGCA
CGAAGCCAAGTACCAGAAGTCCGCCAAGGTGGTTGGCAGTGTCATGGGTCAGTACCACCCGCACGGTGACGCCTCCATCT
ACGAGGCGCTGGTGCGCATGGCGCAGGACTTCTCGTTGCGCTACCCGCTGGTGGACGGCCACGGCAACTTCGGCTCGCTC
GACGGCGACGGCGCGGCGGCCATGCGCTACACCGAGTGCCGTCTGGCGATGCTGTCCAGCGAGCTCCTGACGGAGCTGGG
CAAGAAGACGGTGGCCTTCCGGCCGACCTACGACGGCACGCTGCAGGAGCCGGTGGTCATCCCCGCGCGGGTGCCGCAGT
TGCTGATGAACGGCACCACGGGCATCGCCGTGGGCATGGCCACCAACATCCCGCCGCACCACCTGGGCGAGCTGGTGGAC
GCGCTGGTGGCGCTCATTGAGAACCCGCAGCTCCTGACGAAGGACCTGCTCAAGTGGGTGAAGGGTCCGGACTTCCCCAC
CGGCGGGCAGATCCTCAACGACAAGAAGGAGCTGCGCGACATCTACGAGTCGGGCCAGGGGAGCATCCGCATCCGTGGTG
AGTACAAGCTGGAGGACCTCAAGCGAGGCGGCCAGCAAATCGTCATCACCTCCATCCCCTACACGGTGAACAAGTCCACG
CTGGTGGCCAAGTTCGGCGACCTGGTGCGCGAGCGGAAGCTGCCGCTCATCACCGACGTGCGCGACGAATCCACCAAGGA
CGTGCGCATCGTCCTGGAGCTGAAGAAGGACGCCAACCCCGAGCTGGTGATGGCGTACCTGTACAAGCAGACGCCGCTGC
AGACGAACTTCGGCGTCAACCTCACCTGCCTGGTACCCATCAAGGACAAGCCAGAGTTGAGCACGCCCGAGCGGCTCAAC
CTCAGGGACATCCTCTGGTACTTCCTCACCTTCCGCTTCGACGTGGTGACGAAGCGCTTCGAGCACGAGCTGGGCGAGCT
GCTGCGGCGCGTCCATATCCTGGAGGGTTTCGAGAAGGTCTACGACGCGCTCGACGAGATGATCAAAATCATCCGCGCGT
CGGAAGGAAAGCAGGACGCGGCCCGGAAGCTCATCGCCCGCTTCAAGCTGGATGAAGCCCAGGTGGACGCCATCCTGGAG
ATGAAGCTCTACAAGCTGGCCCGCCTGGAGATTCTCGTCGTGGAGAAGGAGCTCAAGGAGAAGCGCGCCGAAATCAAGCG
CATCCAGGGCATCCTCAAGGACAAGAACAAGGTGTGGGGCACCGTCCGGGACGAACTGGGCGAGATGAAGGCCCGCTACA
ACGACAAGCGTCGCACGCGCATTGGCGGCGCGGGCTCCGAGGAGATGGAGTTCAGCGCCGAGGCGTTCATCGCGGACGAG
GACGCGCACGTGGTCATCACCCGCGACGGCTGGGTCAAGCGCGTGCGCGAGGTGAAGGACCCGTCCACCACGCGCCTGCG
TGAAGGCGACGCGGTGATGGCGGTGCTGGCCGGCAGCCTGAAGGCGAACCTGGTGCTGTTCAGCAACTTCGGCACCGCGT
ACGTCACCCGCTTCAACGACGTGCCCGCCTCCACGGGCTACGGCGAGCCGGTGCAGAAGTTCTTCAAGTTCGACGACGGC
GAGCGCGTGGTGTCCGCCCTGTCGCTGGACGCGCGGCTGCCGCGCCCGCAGAAACTGGTGGGCGTGACGAAGCAGGGCAT
GGGCATGCGCTTCCTGCTGGAGCCGCACCTGGAGGTCTCCACGCGCGCGGGCCGCCGCTACGCGAAGACGGGCGAAGGCG
ACGAAATCATCGGCGTGCAGCCGGTGACGGACCGCGACCTGTTGGCGGTGCTGACGGAGAAGACCAGCGCCCTGGTGTGC
AAGGTGGCGGAGGTCAACGAGCTGGCCGGCCCGGGCAAGGGCGTCACCGTCATCAAGGTGGACGGCGGCGACCGCGTGGT
GGACTTCCTCGCCGTGTCGCCCGCGCAGAAGGACGCGAAGCTGGAGTTCGAAACGCAGAAGGGCCGCAAGCTGCACCTGT
CCCCGGCGAAGTACGAGGTGACGGGCCGCGGCGGCAAGGGCCATGAGATGTCGAAGCGCGACGCCGTGAAGGAGGTGGCG
CGTGCCGTCACCTTCATCCCGTTGCCCGAGAAGAAGGACTAG

Upstream 100 bases:

>100_bases
ACTGTTGGAGAGTGCGCAACCCCCCGAATTCGTTCCCAATGTCAGGGTGGCATGGTAGTCCCGGCGCCCTGTTACATACC
TCTGCCCCCCAACGTGAGGA

Downstream 100 bases:

>100_bases
GCAGAGGACGCCATGGCGACGAAGAAGGAAACCTACACAGGCGCGGACATCCAGGTCCTGGAAGGCCTGGAGCCGGTGCG
CAAGCGCCCGGCCATGTACA

Product: type II DNA topoisomerase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 813; Mature: 813

Protein sequence:

>813_residues
MRGSRAAFGVRGVLTCGLTTMLAEAESKSRKKQGAGGGSGGGGSGGGAGGNGDGSVPASLADEARRRYINYALSVITSRA
LPDVRDGLKPVQRRILFGMFHDHRLTHEAKYQKSAKVVGSVMGQYHPHGDASIYEALVRMAQDFSLRYPLVDGHGNFGSL
DGDGAAAMRYTECRLAMLSSELLTELGKKTVAFRPTYDGTLQEPVVIPARVPQLLMNGTTGIAVGMATNIPPHHLGELVD
ALVALIENPQLLTKDLLKWVKGPDFPTGGQILNDKKELRDIYESGQGSIRIRGEYKLEDLKRGGQQIVITSIPYTVNKST
LVAKFGDLVRERKLPLITDVRDESTKDVRIVLELKKDANPELVMAYLYKQTPLQTNFGVNLTCLVPIKDKPELSTPERLN
LRDILWYFLTFRFDVVTKRFEHELGELLRRVHILEGFEKVYDALDEMIKIIRASEGKQDAARKLIARFKLDEAQVDAILE
MKLYKLARLEILVVEKELKEKRAEIKRIQGILKDKNKVWGTVRDELGEMKARYNDKRRTRIGGAGSEEMEFSAEAFIADE
DAHVVITRDGWVKRVREVKDPSTTRLREGDAVMAVLAGSLKANLVLFSNFGTAYVTRFNDVPASTGYGEPVQKFFKFDDG
ERVVSALSLDARLPRPQKLVGVTKQGMGMRFLLEPHLEVSTRAGRRYAKTGEGDEIIGVQPVTDRDLLAVLTEKTSALVC
KVAEVNELAGPGKGVTVIKVDGGDRVVDFLAVSPAQKDAKLEFETQKGRKLHLSPAKYEVTGRGGKGHEMSKRDAVKEVA
RAVTFIPLPEKKD

Sequences:

>Translated_813_residues
MRGSRAAFGVRGVLTCGLTTMLAEAESKSRKKQGAGGGSGGGGSGGGAGGNGDGSVPASLADEARRRYINYALSVITSRA
LPDVRDGLKPVQRRILFGMFHDHRLTHEAKYQKSAKVVGSVMGQYHPHGDASIYEALVRMAQDFSLRYPLVDGHGNFGSL
DGDGAAAMRYTECRLAMLSSELLTELGKKTVAFRPTYDGTLQEPVVIPARVPQLLMNGTTGIAVGMATNIPPHHLGELVD
ALVALIENPQLLTKDLLKWVKGPDFPTGGQILNDKKELRDIYESGQGSIRIRGEYKLEDLKRGGQQIVITSIPYTVNKST
LVAKFGDLVRERKLPLITDVRDESTKDVRIVLELKKDANPELVMAYLYKQTPLQTNFGVNLTCLVPIKDKPELSTPERLN
LRDILWYFLTFRFDVVTKRFEHELGELLRRVHILEGFEKVYDALDEMIKIIRASEGKQDAARKLIARFKLDEAQVDAILE
MKLYKLARLEILVVEKELKEKRAEIKRIQGILKDKNKVWGTVRDELGEMKARYNDKRRTRIGGAGSEEMEFSAEAFIADE
DAHVVITRDGWVKRVREVKDPSTTRLREGDAVMAVLAGSLKANLVLFSNFGTAYVTRFNDVPASTGYGEPVQKFFKFDDG
ERVVSALSLDARLPRPQKLVGVTKQGMGMRFLLEPHLEVSTRAGRRYAKTGEGDEIIGVQPVTDRDLLAVLTEKTSALVC
KVAEVNELAGPGKGVTVIKVDGGDRVVDFLAVSPAQKDAKLEFETQKGRKLHLSPAKYEVTGRGGKGHEMSKRDAVKEVA
RAVTFIPLPEKKD
>Mature_813_residues
MRGSRAAFGVRGVLTCGLTTMLAEAESKSRKKQGAGGGSGGGGSGGGAGGNGDGSVPASLADEARRRYINYALSVITSRA
LPDVRDGLKPVQRRILFGMFHDHRLTHEAKYQKSAKVVGSVMGQYHPHGDASIYEALVRMAQDFSLRYPLVDGHGNFGSL
DGDGAAAMRYTECRLAMLSSELLTELGKKTVAFRPTYDGTLQEPVVIPARVPQLLMNGTTGIAVGMATNIPPHHLGELVD
ALVALIENPQLLTKDLLKWVKGPDFPTGGQILNDKKELRDIYESGQGSIRIRGEYKLEDLKRGGQQIVITSIPYTVNKST
LVAKFGDLVRERKLPLITDVRDESTKDVRIVLELKKDANPELVMAYLYKQTPLQTNFGVNLTCLVPIKDKPELSTPERLN
LRDILWYFLTFRFDVVTKRFEHELGELLRRVHILEGFEKVYDALDEMIKIIRASEGKQDAARKLIARFKLDEAQVDAILE
MKLYKLARLEILVVEKELKEKRAEIKRIQGILKDKNKVWGTVRDELGEMKARYNDKRRTRIGGAGSEEMEFSAEAFIADE
DAHVVITRDGWVKRVREVKDPSTTRLREGDAVMAVLAGSLKANLVLFSNFGTAYVTRFNDVPASTGYGEPVQKFFKFDDG
ERVVSALSLDARLPRPQKLVGVTKQGMGMRFLLEPHLEVSTRAGRRYAKTGEGDEIIGVQPVTDRDLLAVLTEKTSALVC
KVAEVNELAGPGKGVTVIKVDGGDRVVDFLAVSPAQKDAKLEFETQKGRKLHLSPAKYEVTGRGGKGHEMSKRDAVKEVA
RAVTFIPLPEKKD

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=332, Percent_Identity=26.8072289156627, Blast_Score=80, Evalue=1e-14,
Organism=Homo sapiens, GI19913408, Length=338, Percent_Identity=26.6272189349112, Blast_Score=75, Evalue=3e-13,
Organism=Escherichia coli, GI1788562, Length=778, Percent_Identity=35.6041131105398, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1789396, Length=739, Percent_Identity=37.0771312584574, Blast_Score=419, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI212645845, Length=168, Percent_Identity=31.547619047619, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17535065, Length=208, Percent_Identity=29.3269230769231, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=188, Percent_Identity=29.7872340425532, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136538, Length=189, Percent_Identity=29.1005291005291, Blast_Score=74, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 89837; Mature: 89837

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGSRAAFGVRGVLTCGLTTMLAEAESKSRKKQGAGGGSGGGGSGGGAGGNGDGSVPASL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHH
ADEARRRYINYALSVITSRALPDVRDGLKPVQRRILFGMFHDHRLTHEAKYQKSAKVVGS
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VMGQYHPHGDASIYEALVRMAQDFSLRYPLVDGHGNFGSLDGDGAAAMRYTECRLAMLSS
HHHCCCCCCCHHHHHHHHHHHHCCCEECCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
ELLTELGKKTVAFRPTYDGTLQEPVVIPARVPQLLMNGTTGIAVGMATNIPPHHLGELVD
HHHHHHCCCEEEECCCCCCCCCCCEECHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHH
ALVALIENPQLLTKDLLKWVKGPDFPTGGQILNDKKELRDIYESGQGSIRIRGEYKLEDL
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCHHHH
KRGGQQIVITSIPYTVNKSTLVAKFGDLVRERKLPLITDVRDESTKDVRIVLELKKDANP
HCCCCEEEEEECCCEECCHHHHHHHHHHHHHCCCCCEECCCCCCCCCEEEEEEECCCCCC
ELVMAYLYKQTPLQTNFGVNLTCLVPIKDKPELSTPERLNLRDILWYFLTFRFDVVTKRF
CEEEEEHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EHELGELLRRVHILEGFEKVYDALDEMIKIIRASEGKQDAARKLIARFKLDEAQVDAILE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHH
MKLYKLARLEILVVEKELKEKRAEIKRIQGILKDKNKVWGTVRDELGEMKARYNDKRRTR
HHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHC
IGGAGSEEMEFSAEAFIADEDAHVVITRDGWVKRVREVKDPSTTRLREGDAVMAVLAGSL
CCCCCCCCCCCCCCEEEECCCCEEEEECCHHHHHHHHCCCCCCCEECCCCCEEEHHHCCC
KANLVLFSNFGTAYVTRFNDVPASTGYGEPVQKFFKFDDGERVVSALSLDARLPRPQKLV
EEEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHH
GVTKQGMGMRFLLEPHLEVSTRAGRRYAKTGEGDEIIGVQPVTDRDLLAVLTEKTSALVC
CCCCCCCCEEEEECCCCCHHHHCCCHHCCCCCCCEEEEECCCCCCHHHHHHHHCCHHHEE
KVAEVNELAGPGKGVTVIKVDGGDRVVDFLAVSPAQKDAKLEFETQKGRKLHLSPAKYEV
EHHHHHHHCCCCCCEEEEEECCCCEEEEEEEECCCCCCCEEEEECCCCCEEECCCCEEEE
TGRGGKGHEMSKRDAVKEVARAVTFIPLPEKKD
ECCCCCCCCCHHHHHHHHHHHHHEEECCCCCCC
>Mature Secondary Structure
MRGSRAAFGVRGVLTCGLTTMLAEAESKSRKKQGAGGGSGGGGSGGGAGGNGDGSVPASL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHH
ADEARRRYINYALSVITSRALPDVRDGLKPVQRRILFGMFHDHRLTHEAKYQKSAKVVGS
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VMGQYHPHGDASIYEALVRMAQDFSLRYPLVDGHGNFGSLDGDGAAAMRYTECRLAMLSS
HHHCCCCCCCHHHHHHHHHHHHCCCEECCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
ELLTELGKKTVAFRPTYDGTLQEPVVIPARVPQLLMNGTTGIAVGMATNIPPHHLGELVD
HHHHHHCCCEEEECCCCCCCCCCCEECHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHH
ALVALIENPQLLTKDLLKWVKGPDFPTGGQILNDKKELRDIYESGQGSIRIRGEYKLEDL
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCHHHH
KRGGQQIVITSIPYTVNKSTLVAKFGDLVRERKLPLITDVRDESTKDVRIVLELKKDANP
HCCCCEEEEEECCCEECCHHHHHHHHHHHHHCCCCCEECCCCCCCCCEEEEEEECCCCCC
ELVMAYLYKQTPLQTNFGVNLTCLVPIKDKPELSTPERLNLRDILWYFLTFRFDVVTKRF
CEEEEEHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EHELGELLRRVHILEGFEKVYDALDEMIKIIRASEGKQDAARKLIARFKLDEAQVDAILE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHH
MKLYKLARLEILVVEKELKEKRAEIKRIQGILKDKNKVWGTVRDELGEMKARYNDKRRTR
HHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHC
IGGAGSEEMEFSAEAFIADEDAHVVITRDGWVKRVREVKDPSTTRLREGDAVMAVLAGSL
CCCCCCCCCCCCCCEEEECCCCEEEEECCHHHHHHHHCCCCCCCEECCCCCEEEHHHCCC
KANLVLFSNFGTAYVTRFNDVPASTGYGEPVQKFFKFDDGERVVSALSLDARLPRPQKLV
EEEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHH
GVTKQGMGMRFLLEPHLEVSTRAGRRYAKTGEGDEIIGVQPVTDRDLLAVLTEKTSALVC
CCCCCCCCEEEEECCCCCHHHHCCCHHCCCCCCCEEEEECCCCCCHHHHHHHHCCHHHEE
KVAEVNELAGPGKGVTVIKVDGGDRVVDFLAVSPAQKDAKLEFETQKGRKLHLSPAKYEV
EHHHHHHHCCCCCCEEEEEECCCCEEEEEEEECCCCCCCEEEEECCCCCEEECCCCEEEE
TGRGGKGHEMSKRDAVKEVARAVTFIPLPEKKD
ECCCCCCCCCHHHHHHHHHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]