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The map label for this gene is tcmN [H]

Identifier: 108763459

GI number: 108763459

Start: 2669053

End: 2670078

Strand: Reverse

Name: tcmN [H]

Synonym: MXAN_2296

Alternate gene names: 108763459

Gene position: 2670078-2669053 (Counterclockwise)

Preceding gene: 108760856

Following gene: 108757822

Centisome position: 29.21

GC content: 68.62

Gene sequence:

>1026_bases
ATGGACAAGACTCCCGGCGGGACTCCGTTTCCCACGCAGCTACTCTATGAGCGAATCGGCGGCTATTGGCTCACCCAGGT
CATTGGCACGGCGGCCCGTCTGGGAATCGCGGACCTGCTCTCCAAGGGCCCGCGGAGCAGTGACGCGCTGGCGGACGAGC
TCGGCATCAGCGCGGATGGCCTGTACCGGCTGCTGCGAGGCGGCATCTCCGCGGGCGTCTTCCAGGAGGTCGGTGAGCGG
ACCTTTGCCCTGACGCCCATGGGCGAAGGGCTCCGCTCGGATATCCCCGGCTCGCTGCGGGACGTGGCCATCGCGCAGAG
TGACCGCGCCCACTGGCTGCCCTGGGGCCAGCTCATCGAGGCCGTCCGCACCGGGAAGTCCACCGTCCGCGAGGCCCTGG
GGACAGACATCTGGGAGCACTTCGCCAAGCACCCCGAAGAGGCGACGCACTTCGCCCGGGCCATGGGCAACCTGTCGGCC
CTGGTGGCCCATGAGCTGACGCAACAGGTCGACTTCTCCCCCTTCGCCCATGTGGCGGACATCGGCGGCAGCCAGGGCGC
GCTGCTAGCGCGGGTGCTGCGCGCCAACCCCTCCTGCCGGGGCATTCTTTTCGACCTGCCGCACGTGCTCGAAGGCGCGA
AGGCCCCAATGGAAGCCCAGGGCCTCCATGGACGGGTGGAGCTGGTGGGCGGCAGCTTCTTCGAGCCGGGCCTCCCCTCC
GCCGAGGCCTACCTCCTCAAACACATCCTTCACGACTGGGACGAGGAGTCCGCCACCGCCATCCTGCGGAACATCCATGC
CGCGGCGCCCGCGGGAGCCCGGCTCTTCGTGATGGAGCTGGTGATGCCCGACAACCAGACGCCCTCTCCCGTGCCCCTGA
TGGACCTCAACATGATGGTGCTGGCGGACGGACGGGAGCGCACGGCCAACGAATTCCAGACACTGCTGACCCGGACCTCC
TGGGAGTTGGTGGGCATCCGCCCCACCCAGGCCGGCACGTGCATCATCGAAGCCGTGAAGCGCTGA

Upstream 100 bases:

>100_bases
GCGCCGCGCCCTGTCCTGGCGCCGCCGGGGAGTCTCGGATCACGGCTTATTGGCGTCATCCCTGGTGATGACAGGATTTG
AGCGCTGTTAGACTCCAAGC

Downstream 100 bases:

>100_bases
GCTACGGCGCGACCTGTTCGCGGAGGAGGAAGAGCTCCGCGAGCAGGTTGTCCACCGGAGCGAAGTCATCCGTGAGCAGC
AACGCGGGGCCCGCGGCCAG

Product: O-methyltransferase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MDKTPGGTPFPTQLLYERIGGYWLTQVIGTAARLGIADLLSKGPRSSDALADELGISADGLYRLLRGGISAGVFQEVGER
TFALTPMGEGLRSDIPGSLRDVAIAQSDRAHWLPWGQLIEAVRTGKSTVREALGTDIWEHFAKHPEEATHFARAMGNLSA
LVAHELTQQVDFSPFAHVADIGGSQGALLARVLRANPSCRGILFDLPHVLEGAKAPMEAQGLHGRVELVGGSFFEPGLPS
AEAYLLKHILHDWDEESATAILRNIHAAAPAGARLFVMELVMPDNQTPSPVPLMDLNMMVLADGRERTANEFQTLLTRTS
WELVGIRPTQAGTCIIEAVKR

Sequences:

>Translated_341_residues
MDKTPGGTPFPTQLLYERIGGYWLTQVIGTAARLGIADLLSKGPRSSDALADELGISADGLYRLLRGGISAGVFQEVGER
TFALTPMGEGLRSDIPGSLRDVAIAQSDRAHWLPWGQLIEAVRTGKSTVREALGTDIWEHFAKHPEEATHFARAMGNLSA
LVAHELTQQVDFSPFAHVADIGGSQGALLARVLRANPSCRGILFDLPHVLEGAKAPMEAQGLHGRVELVGGSFFEPGLPS
AEAYLLKHILHDWDEESATAILRNIHAAAPAGARLFVMELVMPDNQTPSPVPLMDLNMMVLADGRERTANEFQTLLTRTS
WELVGIRPTQAGTCIIEAVKR
>Mature_341_residues
MDKTPGGTPFPTQLLYERIGGYWLTQVIGTAARLGIADLLSKGPRSSDALADELGISADGLYRLLRGGISAGVFQEVGER
TFALTPMGEGLRSDIPGSLRDVAIAQSDRAHWLPWGQLIEAVRTGKSTVREALGTDIWEHFAKHPEEATHFARAMGNLSA
LVAHELTQQVDFSPFAHVADIGGSQGALLARVLRANPSCRGILFDLPHVLEGAKAPMEAQGLHGRVELVGGSFFEPGLPS
AEAYLLKHILHDWDEESATAILRNIHAAAPAGARLFVMELVMPDNQTPSPVPLMDLNMMVLADGRERTANEFQTLLTRTS
WELVGIRPTQAGTCIIEAVKR

Specific function: The N-terminal domain enhances the formation of an early, partially cyclized intermediate, while the C-terminal domain catalyzes the 3-O-methylation of one or more later intermediates in the biosynthetic pathway. Catalyzes the methylation of tetracenomyci

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI291045183, Length=329, Percent_Identity=31.306990881459, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI117553627, Length=325, Percent_Identity=30.7692307692308, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI291045181, Length=329, Percent_Identity=31.306990881459, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI283549144, Length=356, Percent_Identity=25.2808988764045, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI157168360, Length=356, Percent_Identity=25.2808988764045, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI283549146, Length=328, Percent_Identity=23.4756097560976, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001077
- InterPro:   IPR005031
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00891 Methyltransf_2; PF03364 Polyketide_cyc [H]

EC number: NA

Molecular weight: Translated: 36850; Mature: 36850

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKTPGGTPFPTQLLYERIGGYWLTQVIGTAARLGIADLLSKGPRSSDALADELGISADG
CCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHH
LYRLLRGGISAGVFQEVGERTFALTPMGEGLRSDIPGSLRDVAIAQSDRAHWLPWGQLIE
HHHHHHCCCCHHHHHHHCCCEEEECCCCCCHHHCCCCHHHHHHHHCCCCCCCCCHHHHHH
AVRTGKSTVREALGTDIWEHFAKHPEEATHFARAMGNLSALVAHELTQQVDFSPFAHVAD
HHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
IGGSQGALLARVLRANPSCRGILFDLPHVLEGAKAPMEAQGLHGRVELVGGSFFEPGLPS
CCCCCHHHHHHHHHCCCCCCEEHCCCHHHHCCCCCCCHHCCCCCEEEEECCCCCCCCCCH
AEAYLLKHILHDWDEESATAILRNIHAAAPAGARLFVMELVMPDNQTPSPVPLMDLNMMV
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHEEEEEECCCCCCCCCCCCEECCCEEE
LADGRERTANEFQTLLTRTSWELVGIRPTQAGTCIIEAVKR
EECCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHCC
>Mature Secondary Structure
MDKTPGGTPFPTQLLYERIGGYWLTQVIGTAARLGIADLLSKGPRSSDALADELGISADG
CCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHH
LYRLLRGGISAGVFQEVGERTFALTPMGEGLRSDIPGSLRDVAIAQSDRAHWLPWGQLIE
HHHHHHCCCCHHHHHHHCCCEEEECCCCCCHHHCCCCHHHHHHHHCCCCCCCCCHHHHHH
AVRTGKSTVREALGTDIWEHFAKHPEEATHFARAMGNLSALVAHELTQQVDFSPFAHVAD
HHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
IGGSQGALLARVLRANPSCRGILFDLPHVLEGAKAPMEAQGLHGRVELVGGSFFEPGLPS
CCCCCHHHHHHHHHCCCCCCEEHCCCHHHHCCCCCCCHHCCCCCEEEEECCCCCCCCCCH
AEAYLLKHILHDWDEESATAILRNIHAAAPAGARLFVMELVMPDNQTPSPVPLMDLNMMV
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHEEEEEECCCCCCCCCCCCEECCCEEE
LADGRERTANEFQTLLTRTSWELVGIRPTQAGTCIIEAVKR
EECCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1548230; 2684656 [H]