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The map label for this gene is pyrD

Identifier: 108763431

GI number: 108763431

Start: 3555539

End: 3556630

Strand: Reverse

Name: pyrD

Synonym: MXAN_3028

Alternate gene names: 108763431

Gene position: 3556630-3555539 (Counterclockwise)

Preceding gene: 108758156

Following gene: 108762688

Centisome position: 38.91

GC content: 72.53

Gene sequence:

>1092_bases
ATGTACGGACTCACCCGCTCGCTCCTCTTCCAGCTCTCCGCGGAGCGCGCGCACCGGCTCGGCATGGCGGGGCTCCACTA
CCTGGGCCGCTCACGGGACTTGTGCGAGTCCCTGCGCGAGAAGGCCCTGGAGGGCGCCCCGCCCGGCCTGGCCGTCGAGG
TGGCCGGGCTGCGCTTCGCCCACCCCGTGGCGCTGGCCGCCGGCCTGGACAAGGACGCGGAGGCGGTGGACGGCCTCTTC
GCCTGCGGCTTCTCCGCAGTGGAGATTGGCACCCTCACGCCCAGGCCCCAGCCCGGCAACCCCAGCCCTCGCCTGTTCCG
CCTGCCGGAGCACCGCGCGCTCATCAACCGCATGGGCTTCAACAACCACGGCGCCACCCAGGCCGCCGCGCGGCTGCGGA
TGCAGACGTGGCGTCCGGGCCCGCTGGGGGTGAACATCGGCAAGAACAAGGACACGCCGCTGGAGCAGGCGGTGGATGAC
TACGTGGCCTGCGTGGACGCGCTGGCGCCCCTGGGCGACTACGTGGTGGTCAACGCCTCGTCCCCCAACACGCCGGGCCT
GCGCAAGCTCCAGGAGCCCGAGCAGTTGGGGCAGCTCCTGGGCGCGGTGCAGGAGCGCCTGGCCACCGTGGCCCCGGGTA
AGCCGCTGTTCCTCAAGATTGCCCCGGATCTGTCCCCCGAGGCAGTGGACGAGGTGGTGGATGTCGCGCGGGCCCAGAAG
CTCGCCGGCCTCATCGCCACCAACACCACCGTGGCCCGGCCCTTCGAGCATCCCCTGGCGAAGGAAGCCGGCGGCCTGTC
CGGCGCGCCCGTCCGCGAGCCCGCCAACGCCGTCATCCGCCGCGCCTGGCTGCGCAGCGGGGGCGCGCTGCCCATCATCG
GCGTGGGGGGTGTCTTCACCGCCCAGGACGTCTACGAAAAGCTGCGCGCGGGCGCGTCGGTGGTGCAGGTGTACACGGGC
TTCATCTACGAGGGCCCGGGCATGGTGGGAAACATCCTCCCCACCCTGGCCACCCTGCTCGCCCGCGACGGCTACAAGCA
GGTCCGCGACGTCATCGGCGCCGAGCACCGGAAGCCGGGCGCACCCAACTGA

Upstream 100 bases:

>100_bases
TCGACATCATCGAACAGAACGGCATCCTCACGCCCGAGCAGGTGGATCAGACGCTCGCCTGGGCCCGTGAGGCCTCGTTC
ATCCCCGCTTGAGCCACGCC

Downstream 100 bases:

>100_bases
CGCGCCGCATCAATCCGCGGACAAAAAATGAGCGCTCGCCGGCGCCTTGGAGTTTCACCGGCGAGCGCCCCGGGCCCAGT
GCTTGACGGGCCTCGAAAGC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MYGLTRSLLFQLSAERAHRLGMAGLHYLGRSRDLCESLREKALEGAPPGLAVEVAGLRFAHPVALAAGLDKDAEAVDGLF
ACGFSAVEIGTLTPRPQPGNPSPRLFRLPEHRALINRMGFNNHGATQAAARLRMQTWRPGPLGVNIGKNKDTPLEQAVDD
YVACVDALAPLGDYVVVNASSPNTPGLRKLQEPEQLGQLLGAVQERLATVAPGKPLFLKIAPDLSPEAVDEVVDVARAQK
LAGLIATNTTVARPFEHPLAKEAGGLSGAPVREPANAVIRRAWLRSGGALPIIGVGGVFTAQDVYEKLRAGASVVQVYTG
FIYEGPGMVGNILPTLATLLARDGYKQVRDVIGAEHRKPGAPN

Sequences:

>Translated_363_residues
MYGLTRSLLFQLSAERAHRLGMAGLHYLGRSRDLCESLREKALEGAPPGLAVEVAGLRFAHPVALAAGLDKDAEAVDGLF
ACGFSAVEIGTLTPRPQPGNPSPRLFRLPEHRALINRMGFNNHGATQAAARLRMQTWRPGPLGVNIGKNKDTPLEQAVDD
YVACVDALAPLGDYVVVNASSPNTPGLRKLQEPEQLGQLLGAVQERLATVAPGKPLFLKIAPDLSPEAVDEVVDVARAQK
LAGLIATNTTVARPFEHPLAKEAGGLSGAPVREPANAVIRRAWLRSGGALPIIGVGGVFTAQDVYEKLRAGASVVQVYTG
FIYEGPGMVGNILPTLATLLARDGYKQVRDVIGAEHRKPGAPN
>Mature_363_residues
MYGLTRSLLFQLSAERAHRLGMAGLHYLGRSRDLCESLREKALEGAPPGLAVEVAGLRFAHPVALAAGLDKDAEAVDGLF
ACGFSAVEIGTLTPRPQPGNPSPRLFRLPEHRALINRMGFNNHGATQAAARLRMQTWRPGPLGVNIGKNKDTPLEQAVDD
YVACVDALAPLGDYVVVNASSPNTPGLRKLQEPEQLGQLLGAVQERLATVAPGKPLFLKIAPDLSPEAVDEVVDVARAQK
LAGLIATNTTVARPFEHPLAKEAGGLSGAPVREPANAVIRRAWLRSGGALPIIGVGGVFTAQDVYEKLRAGASVVQVYTG
FIYEGPGMVGNILPTLATLLARDGYKQVRDVIGAEHRKPGAPN

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=320, Percent_Identity=48.125, Blast_Score=278, Evalue=8e-75,
Organism=Escherichia coli, GI1787177, Length=338, Percent_Identity=44.3786982248521, Blast_Score=272, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17509475, Length=323, Percent_Identity=45.8204334365325, Blast_Score=265, Evalue=2e-71,
Organism=Drosophila melanogaster, GI281361352, Length=318, Percent_Identity=43.3962264150943, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI17137316, Length=318, Percent_Identity=43.3962264150943, Blast_Score=258, Evalue=5e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_MYXXD (Q1D7Y6)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_631237.1
- ProteinModelPortal:   Q1D7Y6
- SMR:   Q1D7Y6
- STRING:   Q1D7Y6
- GeneID:   4107187
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_3028
- TIGR:   MXAN_3028
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   AALNRMG
- PhylomeDB:   Q1D7Y6
- ProtClustDB:   PRK05286
- BioCyc:   MXAN246197:MXAN_3028-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 38476; Mature: 38476

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 181-181

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGLTRSLLFQLSAERAHRLGMAGLHYLGRSRDLCESLREKALEGAPPGLAVEVAGLRFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEECCCHHH
HPVALAAGLDKDAEAVDGLFACGFSAVEIGTLTPRPQPGNPSPRLFRLPEHRALINRMGF
HHHHHHHCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCEEECCHHHHHHHHCCC
NNHGATQAAARLRMQTWRPGPLGVNIGKNKDTPLEQAVDDYVACVDALAPLGDYVVVNAS
CCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECC
SPNTPGLRKLQEPEQLGQLLGAVQERLATVAPGKPLFLKIAPDLSPEAVDEVVDVARAQK
CCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHH
LAGLIATNTTVARPFEHPLAKEAGGLSGAPVREPANAVIRRAWLRSGGALPIIGVGGVFT
HHHHHHCCCHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHH
AQDVYEKLRAGASVVQVYTGFIYEGPGMVGNILPTLATLLARDGYKQVRDVIGAEHRKPG
HHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
APN
CCC
>Mature Secondary Structure
MYGLTRSLLFQLSAERAHRLGMAGLHYLGRSRDLCESLREKALEGAPPGLAVEVAGLRFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEECCCHHH
HPVALAAGLDKDAEAVDGLFACGFSAVEIGTLTPRPQPGNPSPRLFRLPEHRALINRMGF
HHHHHHHCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCEEECCHHHHHHHHCCC
NNHGATQAAARLRMQTWRPGPLGVNIGKNKDTPLEQAVDDYVACVDALAPLGDYVVVNAS
CCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECC
SPNTPGLRKLQEPEQLGQLLGAVQERLATVAPGKPLFLKIAPDLSPEAVDEVVDVARAQK
CCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHH
LAGLIATNTTVARPFEHPLAKEAGGLSGAPVREPANAVIRRAWLRSGGALPIIGVGGVFT
HHHHHHCCCHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHH
AQDVYEKLRAGASVVQVYTGFIYEGPGMVGNILPTLATLLARDGYKQVRDVIGAEHRKPG
HHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
APN
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA