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The map label for this gene is comEC [H]

Identifier: 108763415

GI number: 108763415

Start: 7089265

End: 7090608

Strand: Direct

Name: comEC [H]

Synonym: MXAN_5721

Alternate gene names: 108763415

Gene position: 7089265-7090608 (Clockwise)

Preceding gene: 108757009

Following gene: 108758196

Centisome position: 77.57

GC content: 72.62

Gene sequence:

>1344_bases
ATGAGCTTCCGCCCGCGCGTCCTCCTCCCTGTCCTGCTGGCACTGGCCGCCTGCAAGGAATCACCGCCACCTCCCCCGCA
GCCGGTAGCCACGCGACCGGCGGAGCCCCCTCGGCGCTACTTCGGTGGCACCCCGGACGGGAAGCTCCACGTCTACTTCT
TCGACGTCGGCCAGGGCGACGCCGCGCTCATCGTGTCGCCGGACGGGTACACCGCGCTGGTGGACACGGGCCCCGCTTCC
GCGGCGGAGCACCTGGTCAACCGGCTGCCCGAGCTGCTCACGCAGCGGCTGGACCTGGTGGTGCTCACCCACCCGCATTC
GGACCACCATGGCGCGCTGGAGCCGGTGTTGAAGCGCGTGGGCGCCAGGCAACTGCTGGAGCCGCAGCTCGGCGCCACGC
CCAAGGCCTATGACGCCCTGCTCGGCGCCGTGGCCAGCCAGGGCGTGGAGTTCATCTCCCCCTCCCCCTCCCCCGCCACG
CCCAATGCGCTCCAGCGGCTGCCCCTGGGCGCGGGCGTGTCCCTCACGGTGCTGTGGCCCCGCGCGCCCACCGAGCCGCT
GCTCGACGTGCCCGAGGCCGCGCTGGAGGCCAACTCCGTCATCCTTCGGCTCACCTATGGGGACACCGCGGTGCTCTTCA
TGGCGGACGCGCATGCCCGGACGGTGGACCACCTGCTGGCGCGCAACGCCCCCATGCAGGCCACGCTGCTCAAGGTGGCC
GCGCACGGCACCGAAGGGCCCACCACCGCCGCCTTCCTGACGGCCGTGGGGCCTCGCGCCGCCGTCATCTCCGCGGGTGA
AGGCAACCTGATTGGCGCCCCCGCGCCGGCCATGCTCAAGCAGTTGGAGGCCACCGGCGCGCAGGTGTTCCGCACCGACC
TTCACGGCGAGGTGCAGGTGGTGAGCGACGGGAAGACGCTCGTCGTCACGCCGCAGCGCCTGTCGGCGGGCGTCCCGGAG
GACACGCGCTACAGCTACCCGGGCCTGGGCACGCCCATGCCCCGGGACGCCGCGCTCGCGGGAGATTCCCAGCGCGCGAC
GGGCCGCTCCGGCACGCGTGACGGCTCGGGCAAGCAGCCCACGGGGAAGATGTACACCCTGAGCCTCGACGACCCGACAG
ACGAAGGGGCGCCCCCCTCTCGCGCGGGCTCGCGCTCGCGAAGCGAGGCCTCCGACTCAGGCGCCGTGAAGGTGGGCGCC
TACGTCGGCAGCGTCCGCAGCGACGTGTTCCACAGGCCCACCTGCCGCAACGTCGTGAAGATCAAGTCATCGAACCTGGT
GACCTTCTCCAGCCGGGAAGAGGCCTCGCGTGGACGGCGGCCTGCCCGGGACTGCAACCCCTGA

Upstream 100 bases:

>100_bases
AGAGCTGCCGGACCCTGAAGCGCTCCAAGTCGGACCGCACCGCCTATTCGAGCCGCGCCGAAGCCATGCGCGAGCGCCGC
CCCGCCGAGGACTGCCACCC

Downstream 100 bases:

>100_bases
GGAGCCACGCCCCATGACGACCCGGGCCACGCTGGACCGAATCGAAGACGACATCGCCGTGCTGGTGGTGGAGGGCCGCG
AGCTGACGCGCCCCCTGAGC

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSFRPRVLLPVLLALAACKESPPPPPQPVATRPAEPPRRYFGGTPDGKLHVYFFDVGQGDAALIVSPDGYTALVDTGPAS
AAEHLVNRLPELLTQRLDLVVLTHPHSDHHGALEPVLKRVGARQLLEPQLGATPKAYDALLGAVASQGVEFISPSPSPAT
PNALQRLPLGAGVSLTVLWPRAPTEPLLDVPEAALEANSVILRLTYGDTAVLFMADAHARTVDHLLARNAPMQATLLKVA
AHGTEGPTTAAFLTAVGPRAAVISAGEGNLIGAPAPAMLKQLEATGAQVFRTDLHGEVQVVSDGKTLVVTPQRLSAGVPE
DTRYSYPGLGTPMPRDAALAGDSQRATGRSGTRDGSGKQPTGKMYTLSLDDPTDEGAPPSRAGSRSRSEASDSGAVKVGA
YVGSVRSDVFHRPTCRNVVKIKSSNLVTFSSREEASRGRRPARDCNP

Sequences:

>Translated_447_residues
MSFRPRVLLPVLLALAACKESPPPPPQPVATRPAEPPRRYFGGTPDGKLHVYFFDVGQGDAALIVSPDGYTALVDTGPAS
AAEHLVNRLPELLTQRLDLVVLTHPHSDHHGALEPVLKRVGARQLLEPQLGATPKAYDALLGAVASQGVEFISPSPSPAT
PNALQRLPLGAGVSLTVLWPRAPTEPLLDVPEAALEANSVILRLTYGDTAVLFMADAHARTVDHLLARNAPMQATLLKVA
AHGTEGPTTAAFLTAVGPRAAVISAGEGNLIGAPAPAMLKQLEATGAQVFRTDLHGEVQVVSDGKTLVVTPQRLSAGVPE
DTRYSYPGLGTPMPRDAALAGDSQRATGRSGTRDGSGKQPTGKMYTLSLDDPTDEGAPPSRAGSRSRSEASDSGAVKVGA
YVGSVRSDVFHRPTCRNVVKIKSSNLVTFSSREEASRGRRPARDCNP
>Mature_446_residues
SFRPRVLLPVLLALAACKESPPPPPQPVATRPAEPPRRYFGGTPDGKLHVYFFDVGQGDAALIVSPDGYTALVDTGPASA
AEHLVNRLPELLTQRLDLVVLTHPHSDHHGALEPVLKRVGARQLLEPQLGATPKAYDALLGAVASQGVEFISPSPSPATP
NALQRLPLGAGVSLTVLWPRAPTEPLLDVPEAALEANSVILRLTYGDTAVLFMADAHARTVDHLLARNAPMQATLLKVAA
HGTEGPTTAAFLTAVGPRAAVISAGEGNLIGAPAPAMLKQLEATGAQVFRTDLHGEVQVVSDGKTLVVTPQRLSAGVPED
TRYSYPGLGTPMPRDAALAGDSQRATGRSGTRDGSGKQPTGKMYTLSLDDPTDEGAPPSRAGSRSRSEASDSGAVKVGAY
VGSVRSDVFHRPTCRNVVKIKSSNLVTFSSREEASRGRRPARDCNP

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 46923; Mature: 46792

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFRPRVLLPVLLALAACKESPPPPPQPVATRPAEPPRRYFGGTPDGKLHVYFFDVGQGD
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEEEEEECCCC
AALIVSPDGYTALVDTGPASAAEHLVNRLPELLTQRLDLVVLTHPHSDHHGALEPVLKRV
EEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHH
GARQLLEPQLGATPKAYDALLGAVASQGVEFISPSPSPATPNALQRLPLGAGVSLTVLWP
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHCCCCCCCEEEEEEC
RAPTEPLLDVPEAALEANSVILRLTYGDTAVLFMADAHARTVDHLLARNAPMQATLLKVA
CCCCCCHHCCCHHHHCCCCEEEEEEECCEEEEEEECCHHHHHHHHHHCCCCCHHHHHHHH
AHGTEGPTTAAFLTAVGPRAAVISAGEGNLIGAPAPAMLKQLEATGAQVFRTDLHGEVQV
HCCCCCCCHHHHHHHCCCCEEEEECCCCCEECCCHHHHHHHHHHCCHHHHHHCCCCEEEE
VSDGKTLVVTPQRLSAGVPEDTRYSYPGLGTPMPRDAALAGDSQRATGRSGTRDGSGKQP
EECCCEEEEEHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TGKMYTLSLDDPTDEGAPPSRAGSRSRSEASDSGAVKVGAYVGSVRSDVFHRPTCRNVVK
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCCEEE
IKSSNLVTFSSREEASRGRRPARDCNP
ECCCCEEEECCHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SFRPRVLLPVLLALAACKESPPPPPQPVATRPAEPPRRYFGGTPDGKLHVYFFDVGQGD
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEEEEEECCCC
AALIVSPDGYTALVDTGPASAAEHLVNRLPELLTQRLDLVVLTHPHSDHHGALEPVLKRV
EEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHH
GARQLLEPQLGATPKAYDALLGAVASQGVEFISPSPSPATPNALQRLPLGAGVSLTVLWP
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHCCCCCCCEEEEEEC
RAPTEPLLDVPEAALEANSVILRLTYGDTAVLFMADAHARTVDHLLARNAPMQATLLKVA
CCCCCCHHCCCHHHHCCCCEEEEEEECCEEEEEEECCHHHHHHHHHHCCCCCHHHHHHHH
AHGTEGPTTAAFLTAVGPRAAVISAGEGNLIGAPAPAMLKQLEATGAQVFRTDLHGEVQV
HCCCCCCCHHHHHHHCCCCEEEEECCCCCEECCCHHHHHHHHHHCCHHHHHHCCCCEEEE
VSDGKTLVVTPQRLSAGVPEDTRYSYPGLGTPMPRDAALAGDSQRATGRSGTRDGSGKQP
EECCCEEEEEHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TGKMYTLSLDDPTDEGAPPSRAGSRSRSEASDSGAVKVGAYVGSVRSDVFHRPTCRNVVK
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCCEEE
IKSSNLVTFSSREEASRGRRPARDCNP
ECCCCEEEECCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]