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The map label for this gene is hisIE [H]

Identifier: 108763389

GI number: 108763389

Start: 5182654

End: 5183262

Strand: Reverse

Name: hisIE [H]

Synonym: MXAN_4222

Alternate gene names: 108763389

Gene position: 5183262-5182654 (Counterclockwise)

Preceding gene: 108759195

Following gene: 108760530

Centisome position: 56.71

GC content: 71.59

Gene sequence:

>609_bases
ATGCTCGACCTGGACGCGCTCGACTTCGCGAAGGGCAACGGACTGGTGACGGTCGTCACGCAGGACGCGAGCACCGGTGA
CGTGTTGATGGTGGCGCATGCCGACCGGGAAGCCCTGGAGCGCACGCTGGCCACGGGGGAGATGCACTACCGGTCGCGCA
CGCGCGGCCCGTGGCACAAGGGCGCCACCAGTGGAAACGTCCAGCGCGTGGTGGCGCTCCGCGCCGACTGTGACGGTGAC
GCGGTGCTCGCGCGCGTGGCGAAGGCGGGCCCTGCGTGTCACCTGGGGACGAAGACCTGCTTCGGCCCGGGCCGTTGGGA
TGCACTGAGCGCGCTGGATGACACGCTCGCTCGGCGCGCCGCACCAGCGGAGCGGCCCGATGATGCGCCTCCCAGCTACA
CACGCCGCCTGCTGGAGGACCGCAACCTGCGCTTGAAGAAGCTGGGCGAGGAGGCCGCGGAGTTGGTGACGGCGTGCGCG
GACGTGGACCCGTCACGCGCCGCGGAGGAAGCGGCGGACGTGCTCTACCACGTGCTCGTCGCGGTCCGGCCCCTGGGCCT
CTCGCTCGACGACGTGAAGGCAGTCCTCGCCAGGCGCGCTTCGCGCTGA

Upstream 100 bases:

>100_bases
GGACGGGGCGGCGGACCGCGTTCGGCGGAAATGGAATCGCCACCAACGCGGCCATGGCGCGCGTGGTGCGGGAGCGGCTC
GGCGCCGTGGAGACACGCTG

Downstream 100 bases:

>100_bases
TCCGCCGCGCATGTCCGCTGTACGACAGGAACCGGTGAATCCTGGAGATGACGCGGGCGTATACGTGTTTTCCCTGAGTG
TCCGTGTCGGTCCAAGTGGA

Product: phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MLDLDALDFAKGNGLVTVVTQDASTGDVLMVAHADREALERTLATGEMHYRSRTRGPWHKGATSGNVQRVVALRADCDGD
AVLARVAKAGPACHLGTKTCFGPGRWDALSALDDTLARRAAPAERPDDAPPSYTRRLLEDRNLRLKKLGEEAAELVTACA
DVDPSRAAEEAADVLYHVLVAVRPLGLSLDDVKAVLARRASR

Sequences:

>Translated_202_residues
MLDLDALDFAKGNGLVTVVTQDASTGDVLMVAHADREALERTLATGEMHYRSRTRGPWHKGATSGNVQRVVALRADCDGD
AVLARVAKAGPACHLGTKTCFGPGRWDALSALDDTLARRAAPAERPDDAPPSYTRRLLEDRNLRLKKLGEEAAELVTACA
DVDPSRAAEEAADVLYHVLVAVRPLGLSLDDVKAVLARRASR
>Mature_202_residues
MLDLDALDFAKGNGLVTVVTQDASTGDVLMVAHADREALERTLATGEMHYRSRTRGPWHKGATSGNVQRVVALRADCDGD
AVLARVAKAGPACHLGTKTCFGPGRWDALSALDDTLARRAAPAERPDDAPPSYTRRLLEDRNLRLKKLGEEAAELVTACA
DVDPSRAAEEAADVLYHVLVAVRPLGLSLDDVKAVLARRASR

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=197, Percent_Identity=38.5786802030457, Blast_Score=130, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6319819, Length=184, Percent_Identity=34.7826086956522, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 21648; Mature: 21648

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLDALDFAKGNGLVTVVTQDASTGDVLMVAHADREALERTLATGEMHYRSRTRGPWHK
CCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
GATSGNVQRVVALRADCDGDAVLARVAKAGPACHLGTKTCFGPGRWDALSALDDTLARRA
CCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHC
APAERPDDAPPSYTRRLLEDRNLRLKKLGEEAAELVTACADVDPSRAAEEAADVLYHVLV
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AVRPLGLSLDDVKAVLARRASR
HHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDLDALDFAKGNGLVTVVTQDASTGDVLMVAHADREALERTLATGEMHYRSRTRGPWHK
CCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
GATSGNVQRVVALRADCDGDAVLARVAKAGPACHLGTKTCFGPGRWDALSALDDTLARRA
CCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHC
APAERPDDAPPSYTRRLLEDRNLRLKKLGEEAAELVTACADVDPSRAAEEAADVLYHVLV
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AVRPLGLSLDDVKAVLARRASR
HHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]