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The map label for this gene is birA [H]

Identifier: 108763373

GI number: 108763373

Start: 5100003

End: 5101007

Strand: Reverse

Name: birA [H]

Synonym: MXAN_4152

Alternate gene names: 108763373

Gene position: 5101007-5100003 (Counterclockwise)

Preceding gene: 108757466

Following gene: 108763851

Centisome position: 55.81

GC content: 70.95

Gene sequence:

>1005_bases
GTGGCCGCCAATGCGAACGAGCAGACCCAGGAAGAGCTCATCCTGAGCTTCCTGTCGGAAAGCGGGGGCGATTACACCTC
CGGTGAGGCGCTCTCCAGCAAGCTGGGCCTGTCGCGCACGGCGGTGTGGAAGCACGTGGAGGCCCTGCGCGCGAAGGGGT
ACCGCATCGAGGCGGTGTCCGCGCGAGGCTACCGGCTGGTGGCGGTGCCGGACCGGCTCACCTCGCTCGAGGTGGGCCCG
CTGCTGGACACCCGCGACCTGGGCCGCACCATCCACCATCACGAATCGCTGCCTTCCACCAACGAGAAGGCCTTCCGCCT
GGCCCAGGACGGCGCCAGGCACGGTGAGGTCGTGGTGGCCGAGCAGCAGACCGCGGGCAAGGGGCGCCGGGGCCGCACTT
GGGTGTCTCCGCCGGGCCTCAATCTCTACTTCTCCGCCATCCTCCGTCCCGGCCTGCCGCCCCAGCGCGCGCCGGAGCTG
ACGTTGGTGGCGGCCGTGGCGCTGGCGGAGTCGCTGCGCGACGCGGGCGTGGAGGCCGCCATCAAGTGGCCCAACGACGT
CCACATCGACGGCCTCAAGGTCGCGGGAATCCTCACCGAGCTGTCCGCCGAACCCGAGCGCGTGCACTTCGTCATCGTGG
GCGTGGGGGTCAATCTCAACTCCCAGGTCGAACACTTTCCGGAGGAGCTGCGGGCCACCGCCACGTCGTTGTCGCTGGCC
CTGGGGCAGCCGGTACACCGGGCTCGCTTCGCTGCGTCGCTCTGGACGCGGCTGGAGGAGTGGTTGGACCTCTACCTGGA
CACGGGCTTCGACGCGGTGCGTGCCCGCTGGAAGGCGCTGTCCTCCACTCTGGGGCAGGACGTGCTGGTGCGCACCGACC
GGCACGAGCTGCGGGGGCGGGCCGAGGACATCGACCCATCCGGGGCGCTGCTGGTCCGGACGGCGGAGGGCTCGCTCGAA
CGTGTGTTGGCGGGCGACGTGGAGCAGCTGCGCCCACGGCGGTAG

Upstream 100 bases:

>100_bases
GATGCCGCAGACCTCCCTGGAGCTGACGGCCTGGCAGCTTCGGGACGGCGCGGCGCCGCCTTCGGGCTGATACGGTGGAG
ACTCTCCACGAGGTGCCGCT

Downstream 100 bases:

>100_bases
AGTGCGCGGTGTCATGCTCCTGGCCATCGACGTCGGCAACACCAATACCGTGCTCGGAGTGTTCGAGGGCCGGCGCCTGC
TCGACCACTGGCGCGTAGAG

Product: BirA bifunctional protein

Products: NA

Alternate protein names: Biotin operon repressor; Biotin--[acetyl-CoA-carboxylase] synthetase; Biotin--protein ligase [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MAANANEQTQEELILSFLSESGGDYTSGEALSSKLGLSRTAVWKHVEALRAKGYRIEAVSARGYRLVAVPDRLTSLEVGP
LLDTRDLGRTIHHHESLPSTNEKAFRLAQDGARHGEVVVAEQQTAGKGRRGRTWVSPPGLNLYFSAILRPGLPPQRAPEL
TLVAAVALAESLRDAGVEAAIKWPNDVHIDGLKVAGILTELSAEPERVHFVIVGVGVNLNSQVEHFPEELRATATSLSLA
LGQPVHRARFAASLWTRLEEWLDLYLDTGFDAVRARWKALSSTLGQDVLVRTDRHELRGRAEDIDPSGALLVRTAEGSLE
RVLAGDVEQLRPRR

Sequences:

>Translated_334_residues
MAANANEQTQEELILSFLSESGGDYTSGEALSSKLGLSRTAVWKHVEALRAKGYRIEAVSARGYRLVAVPDRLTSLEVGP
LLDTRDLGRTIHHHESLPSTNEKAFRLAQDGARHGEVVVAEQQTAGKGRRGRTWVSPPGLNLYFSAILRPGLPPQRAPEL
TLVAAVALAESLRDAGVEAAIKWPNDVHIDGLKVAGILTELSAEPERVHFVIVGVGVNLNSQVEHFPEELRATATSLSLA
LGQPVHRARFAASLWTRLEEWLDLYLDTGFDAVRARWKALSSTLGQDVLVRTDRHELRGRAEDIDPSGALLVRTAEGSLE
RVLAGDVEQLRPRR
>Mature_333_residues
AANANEQTQEELILSFLSESGGDYTSGEALSSKLGLSRTAVWKHVEALRAKGYRIEAVSARGYRLVAVPDRLTSLEVGPL
LDTRDLGRTIHHHESLPSTNEKAFRLAQDGARHGEVVVAEQQTAGKGRRGRTWVSPPGLNLYFSAILRPGLPPQRAPELT
LVAAVALAESLRDAGVEAAIKWPNDVHIDGLKVAGILTELSAEPERVHFVIVGVGVNLNSQVEHFPEELRATATSLSLAL
GQPVHRARFAASLWTRLEEWLDLYLDTGFDAVRARWKALSSTLGQDVLVRTDRHELRGRAEDIDPSGALLVRTAEGSLER
VLAGDVEQLRPRR

Specific function: BirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl-CoA:carbon-dioxide ligase. This protein also activates biotin to form biotinyl-5'- adenylate and transfers the biotin moiety to biotin-accepting protein

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biotin--protein ligase family [H]

Homologues:

Organism=Homo sapiens, GI46255045, Length=205, Percent_Identity=29.7560975609756, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1790408, Length=309, Percent_Identity=31.7152103559871, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24644246, Length=269, Percent_Identity=26.0223048327138, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =6.3.4.15 [H]

Molecular weight: Translated: 36523; Mature: 36392

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAANANEQTQEELILSFLSESGGDYTSGEALSSKLGLSRTAVWKHVEALRAKGYRIEAVS
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEC
ARGYRLVAVPDRLTSLEVGPLLDTRDLGRTIHHHESLPSTNEKAFRLAQDGARHGEVVVA
CCCEEEEECCCCCCCEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCEEEE
EQQTAGKGRRGRTWVSPPGLNLYFSAILRPGLPPQRAPELTLVAAVALAESLRDAGVEAA
ECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEE
IKWPNDVHIDGLKVAGILTELSAEPERVHFVIVGVGVNLNSQVEHFPEELRATATSLSLA
EECCCCEEECCCHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
LGQPVHRARFAASLWTRLEEWLDLYLDTGFDAVRARWKALSSTLGQDVLVRTDRHELRGR
HCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHEEECCHHHHCCC
AEDIDPSGALLVRTAEGSLERVLAGDVEQLRPRR
CCCCCCCCEEEEEECCCCHHHHHHCCHHHHCCCC
>Mature Secondary Structure 
AANANEQTQEELILSFLSESGGDYTSGEALSSKLGLSRTAVWKHVEALRAKGYRIEAVS
CCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEC
ARGYRLVAVPDRLTSLEVGPLLDTRDLGRTIHHHESLPSTNEKAFRLAQDGARHGEVVVA
CCCEEEEECCCCCCCEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCEEEE
EQQTAGKGRRGRTWVSPPGLNLYFSAILRPGLPPQRAPELTLVAAVALAESLRDAGVEAA
ECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEE
IKWPNDVHIDGLKVAGILTELSAEPERVHFVIVGVGVNLNSQVEHFPEELRATATSLSLA
EECCCCEEECCCHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
LGQPVHRARFAASLWTRLEEWLDLYLDTGFDAVRARWKALSSTLGQDVLVRTDRHELRGR
HCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHEEECCHHHHCCC
AEDIDPSGALLVRTAEGSLERVLAGDVEQLRPRR
CCCCCCCCEEEEEECCCCHHHHHHCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7730294 [H]