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The map label for this gene is yjcE [H]

Identifier: 108763123

GI number: 108763123

Start: 6386468

End: 6388078

Strand: Direct

Name: yjcE [H]

Synonym: MXAN_5112

Alternate gene names: 108763123

Gene position: 6386468-6388078 (Clockwise)

Preceding gene: 108757375

Following gene: 108763909

Centisome position: 69.88

GC content: 66.6

Gene sequence:

>1611_bases
ATGCATTTCGAGTTGGCCTTCGTACTGATTTTCGCCATCGCGACCGCCGTGGCCATCGCCGCGCGGTACTTCAAAATCCC
CTATACGGTTGCCCTGGTCGTCGCGGGCCTGCTGTTGGGTACGTTCAAGGCGTTCGAGCCGCCGCACCTCACGAAGGAGC
TGCTCTTCGCCATCATCCTCCCAGGTCTGCTCTTCGAAGCGGCCTTCCACGTCGAGTTCCGCAAGTTCTGGAAGAACAAG
ATGGCCATCCACGCCCTGGCCATTCCAGGGCTCCTGGCCTCCGCGGGGCTCACGGCCTTCATCCTCACGCGCGTGGTGGA
TGGGTTGGACTTCGTCCATGGCTTCGGGATGCTGTCCGCGCTGGTGTTCGCGTCCGTCATCGTGTCCACGGACCCCATCG
CCGTGGTGGCGCTCTTCAAGTCGCTGGGCGCGCCCAAGCGGCTGCTCATCCTGGTGGAGGGAGAGAGCCTGCTGAACGAC
GGTTCCGCCGTCGTGCTCTTCACGCTCATCGTCGCGGTCGCCACGGGTGGCCAGTTCACGGTGGGCGGCGCCCTGTTCGA
CTTCATCAAGGTCTTCGGCATGGGCGTGCTGATGGGCAGCGCGGTGGGCTTCGCCGTCGCGCAGGTCATCAAGCGCGTAG
ACGACGCCATGGTGGAAATCACCCTCACGGTCATCGCGGCGTACGGCTCGTTCGTGCTCGCCGAGCACTTCCACTACTCG
GGCGTCATCGCGTCGGTGGTGGCCGGCATGCTGTGCGGCAACTGGGCCACGCACGAGGGCATGAGCCCCGCCACCCGCAT
CGCGGTGGAGAGCTTCTGGGAGTACCTGGCGTTCGCGCTCAACTCCGTGGTGTTCCTCCTCATCGGCCTGGAGGTGCAGC
TCTCCTCGCTGCTGGCCTCGTGGAAGCCCATCCTCGCCGCCTATGTGGCGGTGATGGTGGCCCGCGCCGTGGTCGTCTAC
GGCGTGTCCGCGCTGCTCCGCTTCACCAAGGAGAAGATGCCGTGGACCTGGAGCGCGGTGCTCACCTGGAGCGGCCTGCG
TGGCGCCATCTCCATGGTGCTGGTGCTCGGTCTTCCCACGGACTTCCCGCACCGCGAGCTGCTGGTGAACATGACGTTCG
GCGTGGTGGTCCTCTCCATCATCTTCCAGGGCCTCACCATGGCGCCGCTGCTGCGCAAGCTGCGCATCACCGGCCTCAAG
GACGCGTTCCAGGAGCAGTACGAGCTGGCCCGCGGCCGCCTGGGCGCCATCCACGCAGCGCAGGCCGCGCTGGAGAGCAT
GCGCCGCGCCCGGGAGATTCCGGGGGATGTGGTGACGCAGTTGGAGAAGGACTACCAGGAGAAGGAAGTCGTCGCGGAGA
AGGAGCTGACGGCGCTGAAGCAGCAGTCGATGCGCTTCCACGAGGAGGAGCACCAGGAAGCGGTTCGCCGCGTGCTCATC
GTGGAGAAGGCGGCGCTGCTCAAGGCCTACCAGTCCGCCACCATTGGCAAGGAGGCCTTCGCACGGCTGACGGCGGATCT
GGATGAGCGCATCGCCGCCGCGGACGCCGCGGAGAACCACGTGCCGCCAGAGGGTGAGACTCCGGCCGTGGCCGGCGCCG
CGAGCGCCTGA

Upstream 100 bases:

>100_bases
TGCGATGCCCTCCGTACAAGCAAGAACAACATCGAGTGCGTCTCTGTCCAGCGCAACTGCGCTATCGTCCCGCGCTTTGA
GTCTAAACAGGTAAGGACGA

Downstream 100 bases:

>100_bases
TTCATCCGGGCACGGCACATCCGCCTGATGACATTCAGGCGGGTTTGCCGTGCCTGCTGCGTCTGGGCCTCCTAGACTCT
CGTGTGTGAAACCACGAAAG

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MHFELAFVLIFAIATAVAIAARYFKIPYTVALVVAGLLLGTFKAFEPPHLTKELLFAIILPGLLFEAAFHVEFRKFWKNK
MAIHALAIPGLLASAGLTAFILTRVVDGLDFVHGFGMLSALVFASVIVSTDPIAVVALFKSLGAPKRLLILVEGESLLND
GSAVVLFTLIVAVATGGQFTVGGALFDFIKVFGMGVLMGSAVGFAVAQVIKRVDDAMVEITLTVIAAYGSFVLAEHFHYS
GVIASVVAGMLCGNWATHEGMSPATRIAVESFWEYLAFALNSVVFLLIGLEVQLSSLLASWKPILAAYVAVMVARAVVVY
GVSALLRFTKEKMPWTWSAVLTWSGLRGAISMVLVLGLPTDFPHRELLVNMTFGVVVLSIIFQGLTMAPLLRKLRITGLK
DAFQEQYELARGRLGAIHAAQAALESMRRAREIPGDVVTQLEKDYQEKEVVAEKELTALKQQSMRFHEEEHQEAVRRVLI
VEKAALLKAYQSATIGKEAFARLTADLDERIAAADAAENHVPPEGETPAVAGAASA

Sequences:

>Translated_536_residues
MHFELAFVLIFAIATAVAIAARYFKIPYTVALVVAGLLLGTFKAFEPPHLTKELLFAIILPGLLFEAAFHVEFRKFWKNK
MAIHALAIPGLLASAGLTAFILTRVVDGLDFVHGFGMLSALVFASVIVSTDPIAVVALFKSLGAPKRLLILVEGESLLND
GSAVVLFTLIVAVATGGQFTVGGALFDFIKVFGMGVLMGSAVGFAVAQVIKRVDDAMVEITLTVIAAYGSFVLAEHFHYS
GVIASVVAGMLCGNWATHEGMSPATRIAVESFWEYLAFALNSVVFLLIGLEVQLSSLLASWKPILAAYVAVMVARAVVVY
GVSALLRFTKEKMPWTWSAVLTWSGLRGAISMVLVLGLPTDFPHRELLVNMTFGVVVLSIIFQGLTMAPLLRKLRITGLK
DAFQEQYELARGRLGAIHAAQAALESMRRAREIPGDVVTQLEKDYQEKEVVAEKELTALKQQSMRFHEEEHQEAVRRVLI
VEKAALLKAYQSATIGKEAFARLTADLDERIAAADAAENHVPPEGETPAVAGAASA
>Mature_536_residues
MHFELAFVLIFAIATAVAIAARYFKIPYTVALVVAGLLLGTFKAFEPPHLTKELLFAIILPGLLFEAAFHVEFRKFWKNK
MAIHALAIPGLLASAGLTAFILTRVVDGLDFVHGFGMLSALVFASVIVSTDPIAVVALFKSLGAPKRLLILVEGESLLND
GSAVVLFTLIVAVATGGQFTVGGALFDFIKVFGMGVLMGSAVGFAVAQVIKRVDDAMVEITLTVIAAYGSFVLAEHFHYS
GVIASVVAGMLCGNWATHEGMSPATRIAVESFWEYLAFALNSVVFLLIGLEVQLSSLLASWKPILAAYVAVMVARAVVVY
GVSALLRFTKEKMPWTWSAVLTWSGLRGAISMVLVLGLPTDFPHRELLVNMTFGVVVLSIIFQGLTMAPLLRKLRITGLK
DAFQEQYELARGRLGAIHAAQAALESMRRAREIPGDVVTQLEKDYQEKEVVAEKELTALKQQSMRFHEEEHQEAVRRVLI
VEKAALLKAYQSATIGKEAFARLTADLDERIAAADAAENHVPPEGETPAVAGAASA

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI41872703, Length=422, Percent_Identity=27.9620853080569, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI15529998, Length=389, Percent_Identity=27.5064267352185, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI27734935, Length=405, Percent_Identity=26.1728395061728, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI148727259, Length=395, Percent_Identity=26.5822784810127, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI14211919, Length=380, Percent_Identity=27.6315789473684, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI194239733, Length=358, Percent_Identity=29.0502793296089, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI27777632, Length=471, Percent_Identity=24.8407643312102, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI294997330, Length=385, Percent_Identity=26.7532467532467, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI110227626, Length=385, Percent_Identity=26.7532467532467, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI5454070, Length=384, Percent_Identity=26.8229166666667, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI4759144, Length=369, Percent_Identity=29.2682926829268, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI56786136, Length=493, Percent_Identity=22.7180527383367, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1790501, Length=527, Percent_Identity=27.8937381404175, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87081854, Length=377, Percent_Identity=26.2599469496021, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71987545, Length=432, Percent_Identity=27.3148148148148, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71987559, Length=432, Percent_Identity=27.3148148148148, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71992101, Length=372, Percent_Identity=26.0752688172043, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71992107, Length=372, Percent_Identity=26.0752688172043, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71980847, Length=473, Percent_Identity=25.5813953488372, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71999821, Length=386, Percent_Identity=26.6839378238342, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71999817, Length=386, Percent_Identity=26.6839378238342, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71999819, Length=386, Percent_Identity=26.6839378238342, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71987535, Length=385, Percent_Identity=25.974025974026, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71987537, Length=385, Percent_Identity=25.974025974026, Blast_Score=112, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI25147678, Length=493, Percent_Identity=24.5436105476673, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71990932, Length=359, Percent_Identity=28.133704735376, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25150332, Length=390, Percent_Identity=25.3846153846154, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71990924, Length=359, Percent_Identity=28.133704735376, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71993590, Length=413, Percent_Identity=25.181598062954, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71993582, Length=413, Percent_Identity=25.181598062954, Blast_Score=104, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320663, Length=372, Percent_Identity=23.3870967741935, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI221473215, Length=418, Percent_Identity=28.9473684210526, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI221473212, Length=377, Percent_Identity=29.973474801061, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI281364513, Length=377, Percent_Identity=29.973474801061, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI221473222, Length=377, Percent_Identity=29.973474801061, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281360447, Length=423, Percent_Identity=26.4775413711584, Blast_Score=122, Evalue=9e-28,
Organism=Drosophila melanogaster, GI221510738, Length=365, Percent_Identity=26.5753424657534, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221510734, Length=365, Percent_Identity=26.5753424657534, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221510732, Length=365, Percent_Identity=26.8493150684932, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI221510736, Length=365, Percent_Identity=26.8493150684932, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585580, Length=365, Percent_Identity=26.8493150684932, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585578, Length=365, Percent_Identity=26.8493150684932, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI221510740, Length=365, Percent_Identity=26.8493150684932, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 57869; Mature: 57869

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]