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The map label for this gene is csgA [H]

Identifier: 108763063

GI number: 108763063

Start: 1520199

End: 1520888

Strand: Direct

Name: csgA [H]

Synonym: MXAN_1294

Alternate gene names: 108763063

Gene position: 1520199-1520888 (Clockwise)

Preceding gene: 108763650

Following gene: 108760408

Centisome position: 16.63

GC content: 68.7

Gene sequence:

>690_bases
ATGCGCTACGTCATCACCGGAGCGAGCAGGGGGATTGGTTTCGAATTCGTCCAGCAGCTCCTGCTGCGGGGCGATACCGT
CGAAGCCGGGGTCAGGTCGCCAGAGGGAGCACGGCGGCTGGAGCCGTTGAAACAGAAGGCGGGCAACCGCCTGCGCATCC
ATGCGCTGGACGTGGGAGACGACGACAGCGTGCGCGCGTTCGCCACCAACGTGTGTACCGGTCCCGTGGACGTGCTCATC
AACAACGCCGGTGTCTCCGGCTTGTGGTGCGCGTTGGGTGACGTGGACTACGCGGACATGGCGCGCACGTTCACCATCAA
CGCCCTGGGGCCGCTGCGTGTCACCAGCGCGATGCTGCCGGGCTTGCGGCAAGGCGCCTTGCGGCGGGTGGCGCACGTCA
CCTCGCGGATGGGCTCGTTGGCGGCGAACACCGACGGCGGGGCCTATGCGTACCGCATGTCGAAGGCCGCGCTGAACATG
GCCGTGCGCTCCATGTCCACGGACCTGCGCCCGGAGGGCTTCGTCACCGTGCTGCTCCACCCCGGTTGGGTGCAGACGGA
CATGGGCGGCCCGGACGCCACGCTGCCGGCGCCGGATTCGGTGCGCGGCATGCTGCGGGTCATCGACGGGCTGAACCCGG
AGCACAGCGGCCGGTTCTTCGACTACCAGGGGACCGAAGTGCCCTGGTAG

Upstream 100 bases:

>100_bases
TGTCCTCGGCATGTGGTGCATCCGGTTACCAGCGTGCACTCCCTGGTCGTCAACACGCGTGTTTTGCCAGCGGAAGGCAT
TCAGCGCGTTAATGCCATGC

Downstream 100 bases:

>100_bases
CCGTGCCCTCATGGGTAGAGCATCTGCGTGCGCCAGCCGCCGTCCTCGCGCAGGTAGACGTGCCGGTCGTGGAGCCGGCT
CTCCTGGGCGTGCCAGAACT

Product: CsgA protein

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MRYVITGASRGIGFEFVQQLLLRGDTVEAGVRSPEGARRLEPLKQKAGNRLRIHALDVGDDDSVRAFATNVCTGPVDVLI
NNAGVSGLWCALGDVDYADMARTFTINALGPLRVTSAMLPGLRQGALRRVAHVTSRMGSLAANTDGGAYAYRMSKAALNM
AVRSMSTDLRPEGFVTVLLHPGWVQTDMGGPDATLPAPDSVRGMLRVIDGLNPEHSGRFFDYQGTEVPW

Sequences:

>Translated_229_residues
MRYVITGASRGIGFEFVQQLLLRGDTVEAGVRSPEGARRLEPLKQKAGNRLRIHALDVGDDDSVRAFATNVCTGPVDVLI
NNAGVSGLWCALGDVDYADMARTFTINALGPLRVTSAMLPGLRQGALRRVAHVTSRMGSLAANTDGGAYAYRMSKAALNM
AVRSMSTDLRPEGFVTVLLHPGWVQTDMGGPDATLPAPDSVRGMLRVIDGLNPEHSGRFFDYQGTEVPW
>Mature_229_residues
MRYVITGASRGIGFEFVQQLLLRGDTVEAGVRSPEGARRLEPLKQKAGNRLRIHALDVGDDDSVRAFATNVCTGPVDVLI
NNAGVSGLWCALGDVDYADMARTFTINALGPLRVTSAMLPGLRQGALRRVAHVTSRMGSLAANTDGGAYAYRMSKAALNM
AVRSMSTDLRPEGFVTVLLHPGWVQTDMGGPDATLPAPDSVRGMLRVIDGLNPEHSGRFFDYQGTEVPW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Homo sapiens, GI7657478, Length=194, Percent_Identity=32.9896907216495, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI50726952, Length=186, Percent_Identity=35.4838709677419, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=189, Percent_Identity=27.5132275132275, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1786701, Length=185, Percent_Identity=29.7297297297297, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17558994, Length=240, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17558992, Length=238, Percent_Identity=33.1932773109244, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17541382, Length=249, Percent_Identity=32.5301204819277, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17542178, Length=238, Percent_Identity=32.7731092436975, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17558996, Length=246, Percent_Identity=28.8617886178862, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17559962, Length=245, Percent_Identity=30.2040816326531, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI193207563, Length=236, Percent_Identity=27.5423728813559, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17532177, Length=240, Percent_Identity=32.0833333333333, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17559964, Length=245, Percent_Identity=30.2040816326531, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI72001658, Length=238, Percent_Identity=29.8319327731092, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17558990, Length=246, Percent_Identity=30.0813008130081, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17558006, Length=204, Percent_Identity=33.8235294117647, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322779, Length=248, Percent_Identity=31.4516129032258, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322067, Length=194, Percent_Identity=27.8350515463918, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24640547, Length=244, Percent_Identity=33.1967213114754, Blast_Score=130, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24647946, Length=196, Percent_Identity=30.1020408163265, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45553409, Length=196, Percent_Identity=30.1020408163265, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24647948, Length=196, Percent_Identity=30.1020408163265, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24656154, Length=216, Percent_Identity=35.6481481481481, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19922628, Length=216, Percent_Identity=35.6481481481481, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24643142, Length=194, Percent_Identity=31.4432989690722, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 24628; Mature: 24628

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYVITGASRGIGFEFVQQLLLRGDTVEAGVRSPEGARRLEPLKQKAGNRLRIHALDVGD
CEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCC
DDSVRAFATNVCTGPVDVLINNAGVSGLWCALGDVDYADMARTFTINALGPLRVTSAMLP
CCCHHHHHHHCCCCCHHEEEECCCCCEEEEECCCCCHHHHHEEEEEECCCHHHHHHHHCC
GLRQGALRRVAHVTSRMGSLAANTDGGAYAYRMSKAALNMAVRSMSTDLRPEGFVTVLLH
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
PGWVQTDMGGPDATLPAPDSVRGMLRVIDGLNPEHSGRFFDYQGTEVPW
CCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCCC
>Mature Secondary Structure
MRYVITGASRGIGFEFVQQLLLRGDTVEAGVRSPEGARRLEPLKQKAGNRLRIHALDVGD
CEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCC
DDSVRAFATNVCTGPVDVLINNAGVSGLWCALGDVDYADMARTFTINALGPLRVTSAMLP
CCCHHHHHHHCCCCCHHEEEECCCCCEEEEECCCCCHHHHHEEEEEECCCHHHHHHHHCC
GLRQGALRRVAHVTSRMGSLAANTDGGAYAYRMSKAALNMAVRSMSTDLRPEGFVTVLLH
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
PGWVQTDMGGPDATLPAPDSVRGMLRVIDGLNPEHSGRFFDYQGTEVPW
CCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]