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The map label for this gene is rmlA2 [C]

Identifier: 108762954

GI number: 108762954

Start: 2372511

End: 2373539

Strand: Direct

Name: rmlA2 [C]

Synonym: MXAN_2043

Alternate gene names: 108762954

Gene position: 2372511-2373539 (Clockwise)

Preceding gene: 108762035

Following gene: 108758130

Centisome position: 25.96

GC content: 73.76

Gene sequence:

>1029_bases
ATGAAGGCCATGGTCCTCTGCGCGGGCCTGGGCACGCGCCTGCGCCCGCTCACCGAACGCTGGCCCAAGCCGGCGATGCC
ATTCTTGGGACAGCCGCTGCTGCGCTACCACCTGGCAGTGCTGAAGGCCGCGGGCGTGACGGCGGTGGGCATCAACACCC
ACCACCTGCCAGACACCATGGAGGCGGTGGCCCGCGCCGAGTGCGCTCGCGCGGGGCTGCCGCTGCACGTGGTGAACGAG
CCCGTCATCCAGGGCACCGGCGGCGGCATCCGCGGCCTGCGGGACTTCCTGTCGGACGGCGACTTCATCGTCTTCAACGG
CGACATCCTCTACCCGGTGGACCTGCGGCCGGTGGTGGCCCTGCACCAGGCGTCCGGCGCGCTGGCCACCATGGTGCTGC
AGCCCATGCCAGCGGGGGAGACGTACGCCGCGGTGGAGCTGGACGCGGAAGGGCGCGTGCGCCGCATCGCCGGCCACGGC
CCTGGAGGTGAAGGCTTGTCGCCGTGGCACTTCACCGGCGTGCACGTGATGTCGCCGCGCGTCTTCGACTTCATGTCGCC
GCGAGGTGAGGAGGACATCAACCGCGGCGTCTATGTCCGTGCCATGGAGGCCGGGCAGATGGTGCGCGGCGTGCGGGTGG
ACGGGTACTGGTCCGACCTGGGCACGCCGTCGCGCTACCTCGCCACCGTGCAGGACGTGCTCGCCGGGCACGTGCGGCTG
GAGTGGCTGGGCGCGGACTCACCGCTGGCGGGGACCGTGCGCGGCGCGAGTGGCACCTGGGCGCACGCGGAGGCCCGCCT
GGACGGCACGGCGGAGGGCCCGGTGTACCTGGGGCGGGGCAGCGCGGTGGCCGCCGGAGCCGCCGTGGGGCCGGGCGTGT
CGCTGGAGCCGGGCGCGAAGGTGGCTGCGGGGGCGCGGCTCTCGCGAGCCACCGTCTTCGAGGACACCGAGGTGTCCTCC
GGGGAGTCGCTCTCCGAGGTGCTCGCCTGGGGCGCGCACCGGATTGCCGCGCCGCTGAAGGGGCGCTGA

Upstream 100 bases:

>100_bases
GCGTCGCTGCGCTACGTGCGTGACGGCTTCGCGCGGCGGCCGGAGCTGCGCAAGCTGCAGGACCTGGTGGCGAAGTACGT
CCCGGAGCTGGCGGCCTGAG

Downstream 100 bases:

>100_bases
GCGCCGCCGCTCAGGCGGCGTGGTAGCGGGCCAGCACGCAGGTGACGTTGTCGTTGCCACCTGCGGCGTTGGCCATGTCG
ATGAGCTGCGAGCAGGCCTT

Product: nucleotidyltransferase family protein

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKAMVLCAGLGTRLRPLTERWPKPAMPFLGQPLLRYHLAVLKAAGVTAVGINTHHLPDTMEAVARAECARAGLPLHVVNE
PVIQGTGGGIRGLRDFLSDGDFIVFNGDILYPVDLRPVVALHQASGALATMVLQPMPAGETYAAVELDAEGRVRRIAGHG
PGGEGLSPWHFTGVHVMSPRVFDFMSPRGEEDINRGVYVRAMEAGQMVRGVRVDGYWSDLGTPSRYLATVQDVLAGHVRL
EWLGADSPLAGTVRGASGTWAHAEARLDGTAEGPVYLGRGSAVAAGAAVGPGVSLEPGAKVAAGARLSRATVFEDTEVSS
GESLSEVLAWGAHRIAAPLKGR

Sequences:

>Translated_342_residues
MKAMVLCAGLGTRLRPLTERWPKPAMPFLGQPLLRYHLAVLKAAGVTAVGINTHHLPDTMEAVARAECARAGLPLHVVNE
PVIQGTGGGIRGLRDFLSDGDFIVFNGDILYPVDLRPVVALHQASGALATMVLQPMPAGETYAAVELDAEGRVRRIAGHG
PGGEGLSPWHFTGVHVMSPRVFDFMSPRGEEDINRGVYVRAMEAGQMVRGVRVDGYWSDLGTPSRYLATVQDVLAGHVRL
EWLGADSPLAGTVRGASGTWAHAEARLDGTAEGPVYLGRGSAVAAGAAVGPGVSLEPGAKVAAGARLSRATVFEDTEVSS
GESLSEVLAWGAHRIAAPLKGR
>Mature_342_residues
MKAMVLCAGLGTRLRPLTERWPKPAMPFLGQPLLRYHLAVLKAAGVTAVGINTHHLPDTMEAVARAECARAGLPLHVVNE
PVIQGTGGGIRGLRDFLSDGDFIVFNGDILYPVDLRPVVALHQASGALATMVLQPMPAGETYAAVELDAEGRVRRIAGHG
PGGEGLSPWHFTGVHVMSPRVFDFMSPRGEEDINRGVYVRAMEAGQMVRGVRVDGYWSDLGTPSRYLATVQDVLAGHVRL
EWLGADSPLAGTVRGASGTWAHAEARLDGTAEGPVYLGRGSAVAAGAAVGPGVSLEPGAKVAAGARLSRATVFEDTEVSS
GESLSEVLAWGAHRIAAPLKGR

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=340, Percent_Identity=26.7647058823529, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI11761621, Length=340, Percent_Identity=26.7647058823529, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI133931050, Length=320, Percent_Identity=23.75, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320148, Length=346, Percent_Identity=23.9884393063584, Blast_Score=99, Evalue=8e-22,
Organism=Drosophila melanogaster, GI21355443, Length=332, Percent_Identity=25.3012048192771, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24644084, Length=332, Percent_Identity=25.3012048192771, Blast_Score=98, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 35952; Mature: 35952

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMVLCAGLGTRLRPLTERWPKPAMPFLGQPLLRYHLAVLKAAGVTAVGINTHHLPDTM
CCEEEEEECCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCHHH
EAVARAECARAGLPLHVVNEPVIQGTGGGIRGLRDFLSDGDFIVFNGDILYPVDLRPVVA
HHHHHHHHHHCCCCEEECCCCEEECCCCCHHHHHHHHCCCCEEEECCCEEEECCCCCEEE
LHQASGALATMVLQPMPAGETYAAVELDAEGRVRRIAGHGPGGEGLSPWHFTGVHVMSPR
EECCCCCEEEHEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCEECCEEEECCH
VFDFMSPRGEEDINRGVYVRAMEAGQMVRGVRVDGYWSDLGTPSRYLATVQDVLAGHVRL
HHHHCCCCCCCHHCCCEEEEEECCCHHHHCEEECCCHHCCCCCHHHHHHHHHHHHCCEEE
EWLGADSPLAGTVRGASGTWAHAEARLDGTAEGPVYLGRGSAVAAGAAVGPGVSLEPGAK
EEECCCCCCCEEEECCCCCEEEEEEECCCCCCCCEEEECCCCEECCCCCCCCCCCCCCCC
VAAGARLSRATVFEDTEVSSGESLSEVLAWGAHRIAAPLKGR
CHHCCCCCCEEEECCCCCCCCCHHHHHHHHCHHHCCCCCCCC
>Mature Secondary Structure
MKAMVLCAGLGTRLRPLTERWPKPAMPFLGQPLLRYHLAVLKAAGVTAVGINTHHLPDTM
CCEEEEEECCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCHHH
EAVARAECARAGLPLHVVNEPVIQGTGGGIRGLRDFLSDGDFIVFNGDILYPVDLRPVVA
HHHHHHHHHHCCCCEEECCCCEEECCCCCHHHHHHHHCCCCEEEECCCEEEECCCCCEEE
LHQASGALATMVLQPMPAGETYAAVELDAEGRVRRIAGHGPGGEGLSPWHFTGVHVMSPR
EECCCCCEEEHEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCEECCEEEECCH
VFDFMSPRGEEDINRGVYVRAMEAGQMVRGVRVDGYWSDLGTPSRYLATVQDVLAGHVRL
HHHHCCCCCCCHHCCCEEEEEECCCHHHHCEEECCCHHCCCCCHHHHHHHHHHHHCCEEE
EWLGADSPLAGTVRGASGTWAHAEARLDGTAEGPVYLGRGSAVAAGAAVGPGVSLEPGAK
EEECCCCCCCEEEECCCCCEEEEEEECCCCCCCCEEEECCCCEECCCCCCCCCCCCCCCC
VAAGARLSRATVFEDTEVSSGESLSEVLAWGAHRIAAPLKGR
CHHCCCCCCEEEECCCCCCCCCHHHHHHHHCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA