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The map label for this gene is ribA [H]

Identifier: 108762929

GI number: 108762929

Start: 5172459

End: 5173133

Strand: Direct

Name: ribA [H]

Synonym: MXAN_4213

Alternate gene names: 108762929

Gene position: 5172459-5173133 (Clockwise)

Preceding gene: 108758916

Following gene: 108757191

Centisome position: 56.59

GC content: 64.74

Gene sequence:

>675_bases
ATGTCGGACACACGCTCACCTCAGGTCCTTCCGACCCGTAAGCACACGCAACACCTGGAACGGTTCTCGGAGGCGGACAT
CCCGACCGAGCGCGGCTCGCTGCGGACCATCGTGTTCCGGGACAAGCGCAACGGGCGGGAGCATGTCGCGCTCGTGGTGG
GACAGGTTTCAGGACACGAGGGTGTGCCGGTGCGCATCCACTCCGAGTGCCTCACGAGCGAGGTCTTCGGCAGCCTGAAG
TGCGACTGCCGCGAGCAACTGGACCGCTCGCTCGACTTCATCACCCAGGCGGGACAGGGCGTCGTGCTTTACCTGCGGCA
GGAGGGGCGCGGCATCGGCCTGGGGAACAAGATCAAGGCCTACGCCCTGCAGTCCAAGGGCCTGGACACCTACGAAGCCA
ACCGGCAGCTGGGTTTCGCGGACGACCTGCGCACCTACGACATCGCGGCGGAGATGCTGCGGAGCCTGGATGTGCGCTCG
GTGGACCTGATGACCAACAACCCGCTGAAGATCGCGGGCATGGTCGAAGAAGGCATTCCCGTCCGGCGTCGAATCCCTTC
CCGGACCGAGCACAATCCGCATAACGTCGACTACCTGAGGACGAAGCGCGAGCGTACGGGGCACCTGATTGAGCTCTTCG
CCGAGGACGACGACACGGAAGCCAAGACAGGCTGA

Upstream 100 bases:

>100_bases
TGGAGCATCCTCTTGGGGGCTCGTGCTCGAAAGCACGAGCCGCCTTGACTTGAGAACCTGAGGACTCCAAACAGGGGCCC
GCATCTGGAGAGGACTCAAC

Downstream 100 bases:

>100_bases
GAAGCCCCTCACGAGGCGACGGAACACCGTCGCGCGCAACCAGGTCCGCGTGCCCTTCGAGGTGCGCTTCTGGGGTGTGC
GCGGCTCCATTCCTTCACCG

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MSDTRSPQVLPTRKHTQHLERFSEADIPTERGSLRTIVFRDKRNGREHVALVVGQVSGHEGVPVRIHSECLTSEVFGSLK
CDCREQLDRSLDFITQAGQGVVLYLRQEGRGIGLGNKIKAYALQSKGLDTYEANRQLGFADDLRTYDIAAEMLRSLDVRS
VDLMTNNPLKIAGMVEEGIPVRRRIPSRTEHNPHNVDYLRTKRERTGHLIELFAEDDDTEAKTG

Sequences:

>Translated_224_residues
MSDTRSPQVLPTRKHTQHLERFSEADIPTERGSLRTIVFRDKRNGREHVALVVGQVSGHEGVPVRIHSECLTSEVFGSLK
CDCREQLDRSLDFITQAGQGVVLYLRQEGRGIGLGNKIKAYALQSKGLDTYEANRQLGFADDLRTYDIAAEMLRSLDVRS
VDLMTNNPLKIAGMVEEGIPVRRRIPSRTEHNPHNVDYLRTKRERTGHLIELFAEDDDTEAKTG
>Mature_223_residues
SDTRSPQVLPTRKHTQHLERFSEADIPTERGSLRTIVFRDKRNGREHVALVVGQVSGHEGVPVRIHSECLTSEVFGSLKC
DCREQLDRSLDFITQAGQGVVLYLRQEGRGIGLGNKIKAYALQSKGLDTYEANRQLGFADDLRTYDIAAEMLRSLDVRSV
DLMTNNPLKIAGMVEEGIPVRRRIPSRTEHNPHNVDYLRTKRERTGHLIELFAEDDDTEAKTG

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=192, Percent_Identity=49.4791666666667, Blast_Score=192, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6319438, Length=176, Percent_Identity=40.9090909090909, Blast_Score=115, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 25294; Mature: 25163

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTRSPQVLPTRKHTQHLERFSEADIPTERGSLRTIVFRDKRNGREHVALVVGQVSGHE
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCEEEEEEEEECCCCC
GVPVRIHSECLTSEVFGSLKCDCREQLDRSLDFITQAGQGVVLYLRQEGRGIGLGNKIKA
CCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEE
YALQSKGLDTYEANRQLGFADDLRTYDIAAEMLRSLDVRSVDLMTNNPLKIAGMVEEGIP
EEECCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEHHCCCC
VRRRIPSRTEHNPHNVDYLRTKRERTGHLIELFAEDDDTEAKTG
HHHCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure 
SDTRSPQVLPTRKHTQHLERFSEADIPTERGSLRTIVFRDKRNGREHVALVVGQVSGHE
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCEEEEEEEEECCCCC
GVPVRIHSECLTSEVFGSLKCDCREQLDRSLDFITQAGQGVVLYLRQEGRGIGLGNKIKA
CCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEE
YALQSKGLDTYEANRQLGFADDLRTYDIAAEMLRSLDVRSVDLMTNNPLKIAGMVEEGIP
EEECCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEHHCCCC
VRRRIPSRTEHNPHNVDYLRTKRERTGHLIELFAEDDDTEAKTG
HHHCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA